7CRA
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7cra by Molmil](/molmil-images/mine/7cra) | |
4YPM
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 4ypm by Molmil](/molmil-images/mine/4ypm) | |
4YPN
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 4ypn by Molmil](/molmil-images/mine/4ypn) | |
7CR9
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7cr9 by Molmil](/molmil-images/mine/7cr9) | |
7FIE
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7fie by Molmil](/molmil-images/mine/7fie) | Processive cleavage of substrate at individual proteolytic active sites of the Lon protease complex (conformation 2) | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, Lon protease, PHOSPHOTHIOPHOSPHORIC ACID-ADENYLATE ESTER, ... | Authors: | Li, S, Hsieh, K, Kuo, C, Su, S, Huang, K, Zhang, K, Chang, C.I. | Deposit date: | 2021-07-31 | Release date: | 2021-11-24 | Last modified: | 2024-06-12 | Method: | ELECTRON MICROSCOPY (2.36 Å) | Cite: | Processive cleavage of substrate at individual proteolytic active sites of the Lon protease complex. Sci Adv, 7, 2021
|
|
7FD4
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7fd4 by Molmil](/molmil-images/mine/7fd4) | A complete three-dimensional structure of the Lon protease translocating a protein substrate (conformation 1) | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, Alpha-S1-casein, Lon protease, ... | Authors: | Li, S, Hsieh, K, Kuo, C, Lee, S, Pintilie, G, Zhang, K, Chang, C. | Deposit date: | 2021-07-16 | Release date: | 2021-11-03 | Method: | ELECTRON MICROSCOPY (2.4 Å) | Cite: | Complete three-dimensional structures of the Lon protease translocating a protein substrate. Sci Adv, 7, 2021
|
|
7FD5
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7fd5 by Molmil](/molmil-images/mine/7fd5) | A complete three-dimensional structure of the Lon protease translocating a protein substrate (conformation 2) | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, Alpha-S1-casein, Lon protease, ... | Authors: | Li, S, Hsieh, K, Kuo, C, Lee, S, Pintilie, G, Zhang, K, Chang, C. | Deposit date: | 2021-07-16 | Release date: | 2021-11-03 | Method: | ELECTRON MICROSCOPY (2.4 Å) | Cite: | Complete three-dimensional structures of the Lon protease translocating a protein substrate. Sci Adv, 7, 2021
|
|
7FID
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7fid by Molmil](/molmil-images/mine/7fid) | Processive cleavage of substrate at individual proteolytic active sites of the Lon proteasecomplex (conformation 1) | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, Lon protease, PHOSPHOTHIOPHOSPHORIC ACID-ADENYLATE ESTER, ... | Authors: | Li, S, Hsieh, K, Kuo, C, Su, S, Huang, K, Zhang, K, Chang, C.I. | Deposit date: | 2021-07-31 | Release date: | 2021-11-24 | Last modified: | 2024-06-12 | Method: | ELECTRON MICROSCOPY (2.44 Å) | Cite: | Processive cleavage of substrate at individual proteolytic active sites of the Lon protease complex. Sci Adv, 7, 2021
|
|
5E7S
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 5e7s by Molmil](/molmil-images/mine/5e7s) | |
7FIZ
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7fiz by Molmil](/molmil-images/mine/7fiz) | Processive cleavage of substrate at individual proteolytic active sites of the Lon protease complex (conformation 3) | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, Lon protease, PHOSPHOTHIOPHOSPHORIC ACID-ADENYLATE ESTER, ... | Authors: | Li, S, Hsieh, K, Kuo, C, Su, S, Huang, K, Zhang, K, Chang, C.I. | Deposit date: | 2021-08-01 | Release date: | 2021-11-24 | Last modified: | 2024-06-12 | Method: | ELECTRON MICROSCOPY (3.28 Å) | Cite: | Processive cleavage of substrate at individual proteolytic active sites of the Lon protease complex. Sci Adv, 7, 2021
|
|
7YPK
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7ypk by Molmil](/molmil-images/mine/7ypk) | Close-ring hexamer of the substrate-bound Lon protease with an S678A mutation | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, Lon protease, alpha-S1-casein | Authors: | Li, S, Hsieh, K.Y, Kuo, C.I, Lee, S.H, Ho, M.R, Wang, C.H, Zhang, K, Chang, C.I. | Deposit date: | 2022-08-03 | Release date: | 2023-10-25 | Last modified: | 2023-11-29 | Method: | ELECTRON MICROSCOPY (3.4 Å) | Cite: | A 5+1 assemble-to-activate mechanism of the Lon proteolytic machine. Nat Commun, 14, 2023
|
|
4YPL
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 4ypl by Molmil](/molmil-images/mine/4ypl) | Crystal structure of a hexameric LonA protease bound to three ADPs | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, Lon protease, N-[(1R)-1-(dihydroxyboranyl)-2-phenylethyl]-Nalpha-(pyrazin-2-ylcarbonyl)-L-phenylalaninamide | Authors: | Lin, C.-C, Chang, C.-I. | Deposit date: | 2015-03-13 | Release date: | 2016-03-16 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (3.45 Å) | Cite: | Structural Insights into the Allosteric Operation of the Lon AAA+ Protease Structure, 24, 2016
|
|
6WQH
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6wqh by Molmil](/molmil-images/mine/6wqh) | Molecular basis for the ATPase-powered substrate translocation by the Lon AAA+ protease | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, Ig2 substrate, Lon protease, ... | Authors: | Zhang, K, Li, S, Hsiehb, K, Sub, S, Pintilie, G, Chiu, W, Chang, C. | Deposit date: | 2020-04-28 | Release date: | 2021-06-09 | Last modified: | 2021-11-17 | Method: | ELECTRON MICROSCOPY (3.6 Å) | Cite: | Molecular basis for ATPase-powered substrate translocation by the Lon AAA+ protease. J.Biol.Chem., 297, 2021
|
|
7YUW
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7yuw by Molmil](/molmil-images/mine/7yuw) | MtaLon-ADP for the spiral oligomers of pentamer | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, Lon protease | Authors: | Li, S, Hsieh, K, Kuo, C, Lee, S, Ho, M, Wang, C, Zhang, K, Chang, C.I. | Deposit date: | 2022-08-18 | Release date: | 2023-10-25 | Last modified: | 2024-04-03 | Method: | ELECTRON MICROSCOPY (3.6 Å) | Cite: | A 5+1 assemble-to-activate mechanism of the Lon proteolytic machine. Nat Commun, 14, 2023
|
|
7YPH
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7yph by Molmil](/molmil-images/mine/7yph) | Open-spiral pentamer of the substrate-free Lon protease with a Y224S mutation | Descriptor: | Lon protease, PHOSPHOTHIOPHOSPHORIC ACID-ADENYLATE ESTER | Authors: | Li, S, Hsieh, K.Y, Kuo, C.I, Lee, S.H, Ho, M.R, Wang, C.H, Zhang, K, Chang, C.I. | Deposit date: | 2022-08-03 | Release date: | 2023-10-25 | Last modified: | 2023-11-29 | Method: | ELECTRON MICROSCOPY (3.68 Å) | Cite: | A 5+1 assemble-to-activate mechanism of the Lon proteolytic machine. Nat Commun, 14, 2023
|
|
7YUH
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7yuh by Molmil](/molmil-images/mine/7yuh) | MtaLon-Apo for the spiral oligomers of trimer | Descriptor: | Lon protease | Authors: | Li, S, Hsieh, K, Kuo, C, Lee, S, Ho, M, Wang, C, Zhang, K, Chang, C.I. | Deposit date: | 2022-08-17 | Release date: | 2023-10-25 | Last modified: | 2024-04-03 | Method: | ELECTRON MICROSCOPY (3.7 Å) | Cite: | A 5+1 assemble-to-activate mechanism of the Lon proteolytic machine. Nat Commun, 14, 2023
|
|
7YUP
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7yup by Molmil](/molmil-images/mine/7yup) | MtaLon-Apo for the spiral oligomers of pentamer | Descriptor: | Lon protease | Authors: | Li, S, Hsieh, K, Kuo, C, Lee, S, Ho, M, Wang, C, Zhang, K, Chang, C.I. | Deposit date: | 2022-08-17 | Release date: | 2023-10-25 | Last modified: | 2024-04-03 | Method: | ELECTRON MICROSCOPY (3.7 Å) | Cite: | A 5+1 assemble-to-activate mechanism of the Lon proteolytic machine. Nat Commun, 14, 2023
|
|
7YPJ
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7ypj by Molmil](/molmil-images/mine/7ypj) | Spiral pentamer of the substrate-free Lon protease with a S678A mutation | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, Lon protease | Authors: | Li, S, Hsieh, K.Y, Kuo, C.I, Lee, S.H, Ho, M.R, Wang, C.H, Zhang, K, Chang, C.I. | Deposit date: | 2022-08-03 | Release date: | 2023-10-25 | Last modified: | 2023-11-29 | Method: | ELECTRON MICROSCOPY (3.8 Å) | Cite: | A 5+1 assemble-to-activate mechanism of the Lon proteolytic machine. Nat Commun, 14, 2023
|
|
7YUV
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7yuv by Molmil](/molmil-images/mine/7yuv) | MtaLon-ADP for the spiral oligomers of tetramer | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, Lon protease | Authors: | Li, S, Hsieh, K, Kuo, C, Lee, S, Ho, M, Wang, C, Zhang, K, Chang, C.I. | Deposit date: | 2022-08-17 | Release date: | 2023-10-25 | Last modified: | 2024-04-03 | Method: | ELECTRON MICROSCOPY (3.8 Å) | Cite: | A 5+1 assemble-to-activate mechanism of the Lon proteolytic machine. Nat Commun, 14, 2023
|
|
7YUM
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7yum by Molmil](/molmil-images/mine/7yum) | MtaLon-Apo for the spiral oligomers of tetramer | Descriptor: | Lon protease | Authors: | Li, S, Hsieh, K, Kuo, C, Lee, S, Ho, M, Wang, C, Zhang, K, Chang, C.I. | Deposit date: | 2022-08-17 | Release date: | 2023-10-25 | Last modified: | 2024-04-03 | Method: | ELECTRON MICROSCOPY (3.8 Å) | Cite: | A 5+1 assemble-to-activate mechanism of the Lon proteolytic machine. Nat Commun, 14, 2023
|
|
7YPI
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7ypi by Molmil](/molmil-images/mine/7ypi) | Spiral hexamer of the substrate-free Lon protease with a Y224S mutation | Descriptor: | Lon protease, PHOSPHOTHIOPHOSPHORIC ACID-ADENYLATE ESTER | Authors: | Li, S, Hsieh, K.Y, Kuo, C.I, Lee, S.H, Ho, M.R, Wang, C.H, Zhang, K, Chang, C.I. | Deposit date: | 2022-08-03 | Release date: | 2023-10-25 | Last modified: | 2023-11-29 | Method: | ELECTRON MICROSCOPY (3.8 Å) | Cite: | A 5+1 assemble-to-activate mechanism of the Lon proteolytic machine. Nat Commun, 14, 2023
|
|
7YUX
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7yux by Molmil](/molmil-images/mine/7yux) | MtaLon-ADP for the spiral oligomers of hexamer | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, Lon protease | Authors: | Li, S, Hsieh, K, Kuo, C, Lee, S, Ho, M, Wang, C, Zhang, K, Chang, C.I. | Deposit date: | 2022-08-18 | Release date: | 2023-10-25 | Last modified: | 2024-04-03 | Method: | ELECTRON MICROSCOPY (3.8 Å) | Cite: | A 5+1 assemble-to-activate mechanism of the Lon proteolytic machine. Nat Commun, 14, 2023
|
|
7YUT
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7yut by Molmil](/molmil-images/mine/7yut) | MtaLon-Apo for the spiral oligomers of hexamer | Descriptor: | Lon protease | Authors: | Li, S, Hsieh, K, Kuo, C, Lee, S, Ho, M, Wang, C, Zhang, K, Chang, C.I. | Deposit date: | 2022-08-17 | Release date: | 2023-10-25 | Last modified: | 2024-04-03 | Method: | ELECTRON MICROSCOPY (4.1 Å) | Cite: | A 5+1 assemble-to-activate mechanism of the Lon proteolytic machine. Nat Commun, 14, 2023
|
|
8K3Y
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 8k3y by Molmil](/molmil-images/mine/8k3y) | The "5+1" heteromeric structure of Lon protease consisting of a spiral pentamer with Y224S mutation and an N-terminal-truncated monomeric E613K mutant | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, Lon protease | Authors: | Li, S, Hsieh, K.Y, Kuo, C.I, Zhang, K, Chang, C.I. | Deposit date: | 2023-07-17 | Release date: | 2023-10-25 | Last modified: | 2023-11-29 | Method: | ELECTRON MICROSCOPY (4.42 Å) | Cite: | A 5+1 assemble-to-activate mechanism of the Lon proteolytic machine. Nat Commun, 14, 2023
|
|
7YUU
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7yuu by Molmil](/molmil-images/mine/7yuu) | MtaLon-ADP for the spiral oligomers of trimer | Descriptor: | Lon protease | Authors: | Li, S, Hsieh, K, Kuo, C, Lee, S, Ho, M, Wang, C, Zhang, K, Chang, C.I. | Deposit date: | 2022-08-17 | Release date: | 2023-10-25 | Last modified: | 2024-04-03 | Method: | ELECTRON MICROSCOPY (5.8 Å) | Cite: | A 5+1 assemble-to-activate mechanism of the Lon proteolytic machine. Nat Commun, 14, 2023
|
|