4YPM

Crystal structure of a LonA protease domain in complex with bortezomib

Summary for 4YPM

Entry DOI	10.2210/pdb4ypm/pdb
Related	4YPL 4YPN
Descriptor	Lon protease, N-[(1R)-1-(DIHYDROXYBORYL)-3-METHYLBUTYL]-N-(PYRAZIN-2-YLCARBONYL)-L-PHENYLALANINAMIDE, MAGNESIUM ION, ... (6 entities in total)
Functional Keywords	aaa+ domain, lon protease, protease domain, magnesium, bortezomib, hydrolase
Biological source	Meiothermus taiwanensis
Cellular location	Cytoplasm : A0A059VAZ3
Total number of polymer chains	1
Total formula weight	33531.27
Authors	Lin, C.-C.,Chang, C.-I. (deposition date: 2015-03-13, release date: 2016-03-16, Last modification date: 2016-05-18)
Primary citation	Su, S.-C.,Lin, C.-C.,Tai, H.-C.,Chang, M.-Y.,Ho, M.-R.,Babu, C.S.,Liao, J.-H.,Wu, S.-H.,Chang, Y.-C.,Lim, C.,Chang, C.-I. Structural Basis for the Magnesium-Dependent Activation and Hexamerization of the Lon AAA+ Protease Structure, 24:676-686, 2016 Cited by PubMed: 27041593 DOI: 10.1016/j.str.2016.03.003 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.85 Å)

Structure validation