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PDB: 6 results

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BU of 6eux by Molmil

Structure of the midlink and cap-binding domains of influenza B polymerase PB2 subunit with a bound azaindazole cap-binding inhibitor
Descriptor:	(2~{S},3~{S})-3-[[5-fluoranyl-2-(5-fluoranyl-1~{H}-pyrazolo[3,4-b]pyridin-3-yl)pyrimidin-4-yl]amino]bicyclo[2.2.2]octane-2-carboxylic acid, Polymerase basic protein 2
Authors:	Cusack, S, Gaudon, S.
Deposit date:	2017-10-31
Release date:	2017-12-13
Last modified:	2024-01-17
Method:	X-RAY DIFFRACTION (2.05 Å)
Cite:	Capped RNA primer binding to influenza polymerase and implications for the mechanism of cap-binding inhibitors. Nucleic Acids Res., 46, 2018

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BU of 6euv by Molmil

Structure of the midlink and cap-binding domains of influenza A polymerase PB2 subunit with a bound azaindole cap-binding inhibitor (VX-787)
Descriptor:	(2S,3S)-3-[[5-fluoranyl-2-(5-fluoranyl-1H-pyrrolo[2,3-b]pyridin-3-yl)pyrimidin-4-yl]amino]bicyclo[2.2.2]octane-2-carboxylic acid, NICKEL (II) ION, Polymerase basic protein 2
Authors:	Cusack, S, Lethier, M.
Deposit date:	2017-10-31
Release date:	2017-12-13
Last modified:	2024-01-17
Method:	X-RAY DIFFRACTION (2.7 Å)
Cite:	Capped RNA primer binding to influenza polymerase and implications for the mechanism of cap-binding inhibitors. Nucleic Acids Res., 46, 2018

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BU of 6euy by Molmil

Structure of the midlink and cap-binding domains of influenza A polymerase PB2 subunit with a bound azaindazole cap-binding inhibitor
Descriptor:	(2~{S},3~{S})-3-[[5-fluoranyl-2-(5-fluoranyl-1~{H}-pyrazolo[3,4-b]pyridin-3-yl)pyrimidin-4-yl]amino]bicyclo[2.2.2]octane-2-carboxylic acid, Polymerase basic protein 2, SULFATE ION
Authors:	Cusack, S, Gaudon, S.
Deposit date:	2017-10-31
Release date:	2017-12-13
Last modified:	2024-01-17
Method:	X-RAY DIFFRACTION (3 Å)
Cite:	Capped RNA primer binding to influenza polymerase and implications for the mechanism of cap-binding inhibitors. Nucleic Acids Res., 46, 2018

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BU of 6euw by Molmil

Crystal structure of the cap-binding domain of the PB2 subunit of influenza A/H5N1 polymerase bound to an azaindazole inhibitor
Descriptor:	(2~{S},3~{S})-3-[[5-fluoranyl-2-(5-fluoranyl-1~{H}-pyrazolo[3,4-b]pyridin-3-yl)pyrimidin-4-yl]amino]bicyclo[2.2.2]octane-2-carboxylic acid, GLYCEROL, Polymerase basic protein 2
Authors:	Cusack, S, Gaudon, S.
Deposit date:	2017-10-31
Release date:	2017-12-13
Last modified:	2024-01-17
Method:	X-RAY DIFFRACTION (1 Å)
Cite:	Capped RNA primer binding to influenza polymerase and implications for the mechanism of cap-binding inhibitors. Nucleic Acids Res., 46, 2018

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BU of 6evk by Molmil

Crystal structure of bat influenza A/H17N10 polymerase with viral RNA promoter and cap analogue m7GTP
Descriptor:	7-METHYL-GUANOSINE-5'-TRIPHOSPHATE, PHOSPHATE ION, Polymerase acidic protein, ...
Authors:	Pflug, A, Cusack, S.
Deposit date:	2017-11-01
Release date:	2017-12-13
Last modified:	2024-01-17
Method:	X-RAY DIFFRACTION (2.9 Å)
Cite:	Capped RNA primer binding to influenza polymerase and implications for the mechanism of cap-binding inhibitors. Nucleic Acids Res., 46, 2018

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BU of 6evj by Molmil

Crystal structure of bat influenza A/H17N10 polymerase with viral RNA promoter and capped RNA primer
Descriptor:	Polymerase acidic protein, Polymerase basic protein 2, RNA (5'-D((GDM))-R(PAPAPU)-3'), ...
Authors:	Pflug, A, Cusack, S.
Deposit date:	2017-11-01
Release date:	2017-12-13
Last modified:	2024-02-28
Method:	X-RAY DIFFRACTION (3.9 Å)
Cite:	Capped RNA primer binding to influenza polymerase and implications for the mechanism of cap-binding inhibitors. Nucleic Acids Res., 46, 2018

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