9NSE
| BOVINE ENDOTHELIAL NITRIC OXIDE SYNTHASE, ETHYL-ISOSELENOUREA COMPLEX | Descriptor: | 5,6,7,8-TETRAHYDROBIOPTERIN, ACETATE ION, CACODYLIC ACID, ... | Authors: | Li, H, Raman, C.S, Martasek, P, Kral, V, Masters, B.S.S, Poulos, T.L. | Deposit date: | 1999-01-13 | Release date: | 2000-10-25 | Last modified: | 2023-12-27 | Method: | X-RAY DIFFRACTION (2.24 Å) | Cite: | Mapping the active site polarity in structures of endothelial nitric oxide synthase heme domain complexed with isothioureas. J.Inorg.Biochem., 81, 2000
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9LDT
| DESIGN AND SYNTHESIS OF NEW ENZYMES BASED ON THE LACTATE DEHYDROGENASE FRAMEWORK | Descriptor: | LACTATE DEHYDROGENASE, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, OXAMIC ACID, ... | Authors: | Dunn, C.R, Holbrook, J.J, Muirhead, H. | Deposit date: | 1991-11-26 | Release date: | 1993-10-31 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Design and synthesis of new enzymes based on the lactate dehydrogenase framework. Philos.Trans.R.Soc.London,Ser.B, 332, 1991
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9LDB
| DESIGN AND SYNTHESIS OF NEW ENZYMES BASED ON THE LACTATE DEHYDROGENASE FRAMEWORK | Descriptor: | LACTATE DEHYDROGENASE, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, OXAMIC ACID, ... | Authors: | Dunn, C.R, Holbrook, J.J, Muirhead, H. | Deposit date: | 1991-11-26 | Release date: | 1993-10-31 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Design and synthesis of new enzymes based on the lactate dehydrogenase framework. Philos.Trans.R.Soc.London,Ser.B, 332, 1991
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9F40
| Crystal structure of the NTD domain from S. cerevisia Niemann-Pick type C protein NCR1 with ergosterol bound | Descriptor: | ACETONITRILE, DI(HYDROXYETHYL)ETHER, ERGOSTEROL, ... | Authors: | Nel, L, Olesen, E, Frain, K.M, Pedersen, B.P. | Deposit date: | 2024-04-26 | Release date: | 2024-05-29 | Method: | X-RAY DIFFRACTION (2.44 Å) | Cite: | Structural and biochemical analysis of ligand binding in yeast Niemann-Pick type C 1-related protein To Be Published
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9EO8
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9EO5
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9EO2
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9ENZ
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9BJU
| Crystal structure of the complex between VHL, ElonginB, ElonginC, and compound 5 | Descriptor: | 1,2-ETHANEDIOL, 3-PYRIDIN-4-YL-2,4-DIHYDRO-INDENO[1,2-.C.]PYRAZOLE, ACETATE ION, ... | Authors: | Murray, J.M, Wu, H, Fuhrmann, J, Fairbrother, W.J, DiPasquale, A. | Deposit date: | 2024-04-25 | Release date: | 2024-05-29 | Method: | X-RAY DIFFRACTION (2.47 Å) | Cite: | Potency-enhanced peptidomimetic VHL ligands with improved oral bioavailability To Be Published
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9B8E
| Structure of S-nitrosylated Legionella pneumophila Ceg10. | Descriptor: | 1,2-ETHANEDIOL, ACETATE ION, CHLORIDE ION, ... | Authors: | Tomchick, D.R, Heisler, D.B, Alto, N.M. | Deposit date: | 2024-03-29 | Release date: | 2024-04-10 | Last modified: | 2024-05-29 | Method: | X-RAY DIFFRACTION (1.4 Å) | Cite: | Exploiting bacterial effector proteins to uncover evolutionarily conserved antiviral host machinery. Plos Pathog., 20, 2024
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9AY7
| Crystal structure of CRAF/MEK1 complex with NST-628 and inactive RAF | Descriptor: | 1,2-ETHANEDIOL, ACETATE ION, Dual specificity mitogen-activated protein kinase kinase 1, ... | Authors: | Quade, B, Huang, X. | Deposit date: | 2024-03-07 | Release date: | 2024-04-17 | Method: | X-RAY DIFFRACTION (2.41 Å) | Cite: | The pan-RAF-MEK non degrading molecular glue NST-628 is a potent and brain penetrant inhibitor of the RAS-MAPK pathway with activity across diverse RAS- and RAF-driven cancers. Cancer Discov, 2024
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8YYO
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8YYN
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8YTQ
| The structure of apoCopC from Thioalkalivibrio paradoxus | Descriptor: | ACETATE ION, COPPER (II) ION, CopC domain-containing protein, ... | Authors: | Kulikova, O.G, Solovieva, A.Y, Varfolomeeva, L.A, Dergousova, N.I, Boyko, K.M, Tikhonova, T.V, Popov, V.O. | Deposit date: | 2024-03-26 | Release date: | 2024-04-24 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | The structure of apoCopC from Thioalkalivibrio paradoxus To Be Published
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8YTI
| Crystal Structure of Nucleosome-H1x Linker Histone Assembly (sticky-169a DNA fragment) | Descriptor: | CALCIUM ION, CHLORIDE ION, DNA (169-MER), ... | Authors: | Adhireksan, Z, Qiuye, B, Padavattan, S, Davey, C.A. | Deposit date: | 2024-03-26 | Release date: | 2024-04-03 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | Linker Histones Associate Heterogeneously with Nucleosomes in the Condensed State To Be Published
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8YRU
| Crystal structure of D-amino acid transaminase from Haliscomenobacter hydrossis (apo form) after 15 sec of soaking with phenylhydrazine | Descriptor: | ACETATE ION, Aminotransferase class IV, [6-methyl-5-oxidanyl-4-[(2-phenylhydrazinyl)methyl]pyridin-3-yl]methyl dihydrogen phosphate | Authors: | Matyuta, I.O, Bakunova, A.K, Minyaev, M.E, Popov, V.O, Boyko, K.M. | Deposit date: | 2024-03-21 | Release date: | 2024-04-17 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Crystal structure of D-amino acid transaminase from Haliscomenobacter hydrossis (apo form) after 15 sec of soaking with phenylhydrazine To Be Published
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8YM7
| Crystal structure of Lysine Specific Demethylase 1 (LSD1) with JH-45 | Descriptor: | 4-[5-(4-azanylpiperidin-1-yl)-8-(4-methylphenyl)pyrido[3,4-b]pyrazin-7-yl]-2-fluoranyl-benzenecarbonitrile, FLAVIN-ADENINE DINUCLEOTIDE, Lysine-specific histone demethylase 1A, ... | Authors: | Zhiyan, D, Danyan, C, Hong, J, Tongchao, L, Bing, X. | Deposit date: | 2024-03-08 | Release date: | 2024-05-22 | Method: | X-RAY DIFFRACTION (2.83 Å) | Cite: | Discovery of Novel LSD1 Inhibitors for the Treatment of Autosomal Dominant Polycystic Kidney Disease To Be Published
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8YJM
| Structure of human SPT16 MD-CTD and MCM2 HBD chaperoning a histone H3-H4 tetramer and a single chain H2B-H2A chimera | Descriptor: | DNA replication licensing factor MCM2, FACT complex subunit SPT16, Histone H2B 1/2/3/4/6,Histone H2A type 1-D, ... | Authors: | Gan, S.L, Yang, W.S, Xu, R.M. | Deposit date: | 2024-03-02 | Release date: | 2024-03-20 | Last modified: | 2024-03-27 | Method: | X-RAY DIFFRACTION (4.15 Å) | Cite: | Structure of a histone hexamer bound by the chaperone domains of SPT16 and MCM2. Sci China Life Sci, 2024
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8YJF
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8YHR
| DHODH in complex with furocoumavirin | Descriptor: | 4-methyl-8-[(S)-oxidanyl(phenyl)methyl]-9-phenyl-furo[2,3-h]chromen-2-one, ACETATE ION, Dihydroorotate dehydrogenase (quinone), ... | Authors: | Hara, K, Okumura, H, Nakahara, M, Sato, M, Hashimoto, H, Osada, H, Watanabe, K. | Deposit date: | 2024-02-28 | Release date: | 2024-05-22 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | Structural and Functional Analyses of Inhibition of Human Dihydroorotate Dehydrogenase by Antiviral Furocoumavirin. Biochemistry, 2024
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8YHL
| The Crystal Structure of Tgf-Beta Type I Receptor (Alk5) from Biortus | Descriptor: | 1,2-ETHANEDIOL, 2-fluoranyl-~{N}-[[5-(6-methylpyridin-2-yl)-4-([1,2,4]triazolo[1,5-a]pyridin-6-yl)-1~{H}-imidazol-2-yl]methyl]aniline, ACETATE ION, ... | Authors: | Wang, F, Cheng, W, Lv, Z, Meng, Q, Xu, Y. | Deposit date: | 2024-02-28 | Release date: | 2024-03-13 | Method: | X-RAY DIFFRACTION (1.47 Å) | Cite: | The Crystal Structure of Tgf-Beta Type I Receptor (Alk5) from Biortus To Be Published
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8Y1M
| Xylanase R from Bacillus sp. TAR-1 complexed with xylobiose. | Descriptor: | (4S)-2-METHYL-2,4-PENTANEDIOL, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, ACETATE ION, ... | Authors: | Nakamura, T, Kuwata, K, Takita, T, Mizutani, K, Mikami, B, Nakamura, S, Yasukawa, K. | Deposit date: | 2024-01-25 | Release date: | 2024-05-22 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Activity-stability trade-off observed in variants at position 315 of the GH10 xylanase XynR. Sci Rep, 14, 2024
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8XQB
| Mature virion portal vertex of bacteriophage lambda | Descriptor: | Capsid decoration protein, Head completion protein, Head-tail connector protein FII, ... | Authors: | Wang, J.W, Gu, Z.W. | Deposit date: | 2024-01-05 | Release date: | 2024-04-10 | Last modified: | 2024-05-29 | Method: | ELECTRON MICROSCOPY (4.07 Å) | Cite: | Structural morphing in the viral portal vertex of bacteriophage lambda. J.Virol., 98, 2024
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8XPX
| The Crystal Structure of PARP12 from Biortus. | Descriptor: | 1,2-ETHANEDIOL, ACETATE ION, DI(HYDROXYETHYL)ETHER, ... | Authors: | Wang, F, Cheng, W, Lv, Z, Qi, J, Shen, Z. | Deposit date: | 2024-01-04 | Release date: | 2024-03-06 | Method: | X-RAY DIFFRACTION (1.75 Å) | Cite: | The Crystal Structure of PARP12 from Biortus. To Be Published
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8XPT
| The Crystal Structure of EHMT1 from Biortus. | Descriptor: | Histone-lysine N-methyltransferase EHMT1, S-ADENOSYL-L-HOMOCYSTEINE, SULFATE ION, ... | Authors: | Wang, F, Cheng, W, Yuan, Z, Lin, D, Bao, C. | Deposit date: | 2024-01-04 | Release date: | 2024-01-24 | Method: | X-RAY DIFFRACTION (3.35 Å) | Cite: | The Crystal Structure of EHMT1 from Biortus. To Be Published
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