8DGN
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8DP5
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![BU of 8dp5 by Molmil](/molmil-images/mine/8dp5) | Structure of the PEAK3/14-3-3 complex | Descriptor: | 14-3-3 protein beta/alpha, 14-3-3 protein epsilon, Protein PEAK3, ... | Authors: | Torosyan, H, Paul, M, Jura, N, Verba, K.A. | Deposit date: | 2022-07-14 | Release date: | 2023-06-28 | Method: | ELECTRON MICROSCOPY (3.1 Å) | Cite: | Structural insights into regulation of the PEAK3 pseudokinase scaffold by 14-3-3. Nat Commun, 14, 2023
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8DGM
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![BU of 8dgm by Molmil](/molmil-images/mine/8dgm) | 14-3-3 epsilon bound to phosphorylated PEAK1 (pT1165) peptide | Descriptor: | 1,2-ETHANEDIOL, 14-3-3 protein epsilon, Inactive tyrosine-protein kinase PEAK1 | Authors: | Roy, M.J, Hardy, J.M, Lucet, I.S. | Deposit date: | 2022-06-24 | Release date: | 2023-06-07 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (3.2 Å) | Cite: | Structural mapping of PEAK pseudokinase interactions identifies 14-3-3 as a molecular switch for PEAK3 signaling. Nat Commun, 14, 2023
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8DGP
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![BU of 8dgp by Molmil](/molmil-images/mine/8dgp) | 14-3-3 epsilon bound to phosphorylated PEAK3 (pS69) peptide | Descriptor: | 1,2-ETHANEDIOL, 14-3-3 protein epsilon, Phosphorylated PEAK3 (pS69) peptide, ... | Authors: | Roy, M.J, Hardy, J.M, Lucet, I.S. | Deposit date: | 2022-06-24 | Release date: | 2023-06-07 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | Structural mapping of PEAK pseudokinase interactions identifies 14-3-3 as a molecular switch for PEAK3 signaling. Nat Commun, 14, 2023
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1A38
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![BU of 1a38 by Molmil](/molmil-images/mine/1a38) | 14-3-3 PROTEIN ZETA BOUND TO R18 PEPTIDE | Descriptor: | 14-3-3 PROTEIN ZETA, R18 PEPTIDE (PHCVPRDLSWLDLEANMCLP) | Authors: | Petosa, C, Masters, S.C, Pohl, J, Wang, B, Fu, H, Liddington, R.C. | Deposit date: | 1998-01-28 | Release date: | 1999-03-02 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (3.35 Å) | Cite: | 14-3-3zeta binds a phosphorylated Raf peptide and an unphosphorylated peptide via its conserved amphipathic groove. J.Biol.Chem., 273, 1998
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1A37
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![BU of 1a37 by Molmil](/molmil-images/mine/1a37) | 14-3-3 PROTEIN ZETA BOUND TO PS-RAF259 PEPTIDE | Descriptor: | 14-3-3 PROTEIN ZETA, PS-RAF259 PEPTIDE LSQRQRST(SEP)TPNVHM | Authors: | Petosa, C, Masters, S.C, Pohl, J, Wang, B, Fu, H, Liddington, R.C. | Deposit date: | 1998-01-28 | Release date: | 1999-03-02 | Last modified: | 2024-06-05 | Method: | X-RAY DIFFRACTION (3.6 Å) | Cite: | 14-3-3zeta binds a phosphorylated Raf peptide and an unphosphorylated peptide via its conserved amphipathic groove. J.Biol.Chem., 273, 1998
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8C2E
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8C2F
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5BTV
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![BU of 5btv by Molmil](/molmil-images/mine/5btv) | Crystal structure of human 14-3-3 sigma in complex with a Tau-protein peptide surrounding pS324 | Descriptor: | 14-3-3 protein sigma, CALCIUM ION, CHLORIDE ION, ... | Authors: | Ottmann, C, Schumacher, B, Bartel, M. | Deposit date: | 2015-06-03 | Release date: | 2016-07-20 | Last modified: | 2019-03-13 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | Involvement of 14-3-3 in tubulin instability and impaired axon development is mediated by Tau. Faseb J., 29, 2015
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4FL5
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4J6S
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6GHP
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![BU of 6ghp by Molmil](/molmil-images/mine/6ghp) | 14-3-3sigma in complex with a TASK3 peptide stabilized by semi-synthetic natural product FC-NAc | Descriptor: | 14-3-3 protein sigma, CHLORIDE ION, Potassium channel subfamily K member 9, ... | Authors: | Andrei, S.A, de Vink, P.J, Brunsveld, L, Ottmann, C, Higuchi, Y. | Deposit date: | 2018-05-08 | Release date: | 2018-08-01 | Last modified: | 2018-10-17 | Method: | X-RAY DIFFRACTION (1.95 Å) | Cite: | Rationally Designed Semisynthetic Natural Product Analogues for Stabilization of 14-3-3 Protein-Protein Interactions. Angew. Chem. Int. Ed. Engl., 57, 2018
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4BG6
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![BU of 4bg6 by Molmil](/molmil-images/mine/4bg6) | 14-3-3 interaction with Rnd3 prenyl-phosphorylation motif | Descriptor: | 14-3-3 PROTEIN ZETA/DELTA, 2-{2-[2-(2-{2-[2-(2-ETHOXY-ETHOXY)-ETHOXY]-ETHOXY}-ETHOXY)-ETHOXY]-ETHOXY}-ETHANOL, FARNESYL, ... | Authors: | Riou, P, Kjaer, S, Purkiss, A, O'Reilly, N, McDonald, N.Q. | Deposit date: | 2013-03-23 | Release date: | 2013-05-29 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | 14-3-3 Proteins Interact with a Hybrid Prenyl-Phosphorylation Motif to Inhibit G Proteins. Cell(Cambridge,Mass.), 153, 2013
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8EXH
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![BU of 8exh by Molmil](/molmil-images/mine/8exh) | Agrobacterium tumefaciens Tpilus | Descriptor: | (14S,17R)-20-amino-17-hydroxy-11,17-dioxo-12,16,18-trioxa-17lambda~5~-phosphaicosan-14-yl tetradecanoate, Protein virB2 | Authors: | Beltran, L.C, Egelman, E.H. | Deposit date: | 2022-10-25 | Release date: | 2023-03-22 | Last modified: | 2024-06-19 | Method: | ELECTRON MICROSCOPY (3.5 Å) | Cite: | Archaeal DNA-import apparatus is homologous to bacterial conjugation machinery Nat Commun, 14, 2023
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6CR2
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![BU of 6cr2 by Molmil](/molmil-images/mine/6cr2) | Crystal structure of sterol 14-alpha demethylase (CYP51B) from Aspergillus fumigatus in complex with the VNI derivative N-(1-(2,4-dichlorophenyl)-2-(1H-imidazol-1-yl)ethyl)-4-(5-(2-fluoro-4-(2,2,2-trifluoroethoxy)phenyl)-1,3,4-oxadiazol-2-yl)benzamide | Descriptor: | 14-alpha sterol demethylase Cyp51B, N-[(1R)-1-(2,4-dichlorophenyl)-2-(1H-imidazol-1-yl)ethyl]-4-{5-[2-fluoro-4-(2,2,2-trifluoroethoxy)phenyl]-1,3,4-oxadiazol-2-yl}benzamide, PROTOPORPHYRIN IX CONTAINING FE | Authors: | Friggeri, L, Hargrove, T.Y, Wawrzak, Z, Lepesheva, G.I. | Deposit date: | 2018-03-16 | Release date: | 2018-06-27 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (2.38 Å) | Cite: | Sterol 14 alpha-Demethylase Structure-Based Design of VNI (( R)- N-(1-(2,4-Dichlorophenyl)-2-(1 H-imidazol-1-yl)ethyl)-4-(5-phenyl-1,3,4-oxadiazol-2-yl)benzamide)) Derivatives To Target Fungal Infections: Synthesis, Biological Evaluation, and Crystallographic Analysis. J. Med. Chem., 61, 2018
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8C3C
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8C2G
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7A6R
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7A6Y
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6GKF
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6GKG
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8C42
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8C43
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![BU of 8c43 by Molmil](/molmil-images/mine/8c43) | Ternary structure of 14-3-3sigma, strep-tagged PKA-responsive ERa phosphopeptide, and Fusicoccin-A. | Descriptor: | 14-3-3 protein sigma, De-acetylated Fusicoccin, Estrogen Receptor alpha phosphopeptide, ... | Authors: | Somsen, B.A, Ottmann, C. | Deposit date: | 2022-12-30 | Release date: | 2023-12-27 | Method: | X-RAY DIFFRACTION (1.4 Å) | Cite: | Molecular basis and dual ligand regulation of tetrameric estrogen receptor alpha /14-3-3 zeta protein complex. J.Biol.Chem., 299, 2023
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3AXY
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![BU of 3axy by Molmil](/molmil-images/mine/3axy) | Structure of Florigen Activation Complex Consisting of Rice Florigen Hd3a, 14-3-3 Protein GF14 and Rice FD Homolog OsFD1 | Descriptor: | 14-3-3-like protein GF14-C, Protein HEADING DATE 3A, Rice FD homolog OsFD1 | Authors: | Ohki, I, Furuita, K, Hayashi, K, Taoka, K, Tsuji, H, Nakagawa, A, Shimamoto, K, Kojima, C. | Deposit date: | 2011-04-19 | Release date: | 2011-08-03 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | 14-3-3 proteins act as intracellular receptors for rice Hd3a florigen Nature, 476, 2011
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7NMZ
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