4Y2U
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![BU of 4y2u by Molmil](/molmil-images/mine/4y2u) | Structure of soluble epoxide hydrolase in complex with tert-butyl 1,2,3,4-tetrahydroquinolin-3-ylcarbamate | Descriptor: | Bifunctional epoxide hydrolase 2, MAGNESIUM ION, tert-butyl (3R)-1,2,3,4-tetrahydroquinolin-3-ylcarbamate | Authors: | Amano, Y, Yamaguchi, T. | Deposit date: | 2015-02-10 | Release date: | 2015-05-06 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (2.75 Å) | Cite: | Identification of N-ethylmethylamine as a novel scaffold for inhibitors of soluble epoxide hydrolase by crystallographic fragment screening Bioorg.Med.Chem., 23, 2015
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6ABH
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![BU of 6abh by Molmil](/molmil-images/mine/6abh) | |
4XKW
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![BU of 4xkw by Molmil](/molmil-images/mine/4xkw) | Tailspike protein mutant D339N of E. coli bacteriophage HK620 in complex with pentasaccharide | Descriptor: | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, FORMIC ACID, SODIUM ION, ... | Authors: | Gohlke, U, Broeker, N.K, Heinemann, U, Seckler, R, Barbirz, S. | Deposit date: | 2015-01-12 | Release date: | 2016-01-20 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (1.45 Å) | Cite: | Enthalpic cost of water removal from a hydrophobic glucose binding cavity on HK620 tailspike protein. to be published
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4XLA
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![BU of 4xla by Molmil](/molmil-images/mine/4xla) | Tailspike protein mutant D339A of E. coli bacteriophage HK620 IN COMPLEX WITH PENTASACCHARIDE | Descriptor: | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, FORMIC ACID, SODIUM ION, ... | Authors: | Gohlke, U, Broeker, N.K, Heinemann, U, Seckler, R, Barbirz, S. | Deposit date: | 2015-01-13 | Release date: | 2016-01-20 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (1.47 Å) | Cite: | Enthalpic cost of water removal from a hydrophobic glucose binding cavity on HK620 tailspike protein. to be published
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4XM3
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![BU of 4xm3 by Molmil](/molmil-images/mine/4xm3) | Tailspike protein mutant E372A of E. coli bacteriophage HK620 in complex with pentasaccharide | Descriptor: | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, FORMIC ACID, SODIUM ION, ... | Authors: | Gohlke, U, Broeker, N.K, Heinemann, U, Seckler, R, Barbirz, S. | Deposit date: | 2015-01-14 | Release date: | 2016-01-27 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (1.27 Å) | Cite: | Enthalpic cost of water removal from a hydrophobic glucose binding cavity on HK620 tailspike protein. to be published
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4XN3
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![BU of 4xn3 by Molmil](/molmil-images/mine/4xn3) | Tailspike protein mutant E372A of E. coli bacteriophage HK620 in complex with hexasaccharide | Descriptor: | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, FORMIC ACID, SODIUM ION, ... | Authors: | Gohlke, U, Broeker, N.K, Heinemann, U, Seckler, R, Barbirz, S. | Deposit date: | 2015-01-15 | Release date: | 2016-01-27 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (1.65 Å) | Cite: | Enthalpic cost of water removal from a hydrophobic glucose binding cavity on HK620 tailspike protein. to be published
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2MUR
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2MUB
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![BU of 2mub by Molmil](/molmil-images/mine/2mub) | |
2N19
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![BU of 2n19 by Molmil](/molmil-images/mine/2n19) | STIL binding to the Polo-box domain 3 of PLK4 regulates centriole duplication | Descriptor: | Serine/threonine-protein kinase PLK4 | Authors: | Boehm, R, Arquint, C, Gabryjonczyk, A, Imseng, S, Sauer, E, Hiller, S, Nigg, E, Maier, T. | Deposit date: | 2015-03-24 | Release date: | 2015-08-12 | Last modified: | 2024-05-15 | Method: | SOLUTION NMR | Cite: | STIL binding to Polo-box 3 of PLK4 regulates centriole duplication. Elife, 4, 2015
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4XON
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![BU of 4xon by Molmil](/molmil-images/mine/4xon) | Tailspike protein double mutant D339N/E372Q of E. coli bacteriophage HK620 | Descriptor: | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, FORMIC ACID, SODIUM ION, ... | Authors: | Gohlke, U, Broeker, N.K, Heinemann, U, Seckler, R, Barbirz, S. | Deposit date: | 2015-01-16 | Release date: | 2016-01-27 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Enthalpic cost of water removal from a hydrophobic glucose binding cavity on HK620 tailspike protein. to be published
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2N3D
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![BU of 2n3d by Molmil](/molmil-images/mine/2n3d) | Atomic structure of the cytoskeletal bactofilin BacA revealed by solid-state NMR | Descriptor: | Bactofilin A | Authors: | Shi, C, Fricke, P, Lin, L, Chevelkov, V, Wegstroth, M, Giller, K, Becker, S, Thanbichler, M, Lange, A. | Deposit date: | 2015-05-29 | Release date: | 2015-12-16 | Last modified: | 2024-05-15 | Method: | SOLID-STATE NMR | Cite: | Atomic-resolution structure of cytoskeletal bactofilin by solid-state NMR. Sci Adv, 1, 2015
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2N1F
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![BU of 2n1f by Molmil](/molmil-images/mine/2n1f) | Structure and assembly of the mouse ASC filament by combined NMR spectroscopy and cryo-electron microscopy | Descriptor: | Apoptosis-associated speck-like protein | Authors: | Sborgi, L, Ravotti, F, Dandey, V, Dick, M, Mazur, A, Reckel, S, Chami, M, Scherer, S, Bockmann, A, Egelman, E, Stahlberg, H, Broz, P, Meier, B, Hiller, S. | Deposit date: | 2015-04-01 | Release date: | 2015-10-14 | Last modified: | 2024-05-15 | Method: | ELECTRON MICROSCOPY (4 Å), SOLID-STATE NMR | Cite: | Structure and assembly of the mouse ASC inflammasome by combined NMR spectroscopy and cryo-electron microscopy. Proc.Natl.Acad.Sci.USA, 112, 2015
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6AB8
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![BU of 6ab8 by Molmil](/molmil-images/mine/6ab8) | Crystal structure of Methanosarcina mazei PylRS(Y306A/Y384F) complexed with ZLys | Descriptor: | (2S)-2-azanyl-6-(phenylmethoxycarbonylamino)hexanoic acid, ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ... | Authors: | Yanagisawa, T, Kuratani, M, Yokoyama, S. | Deposit date: | 2018-07-20 | Release date: | 2019-04-17 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (1.753 Å) | Cite: | Structural Basis for Genetic-Code Expansion with Bulky Lysine Derivatives by an Engineered Pyrrolysyl-tRNA Synthetase. Cell Chem Biol, 26, 2019
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2N7I
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![BU of 2n7i by Molmil](/molmil-images/mine/2n7i) | |
4XQB
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![BU of 4xqb by Molmil](/molmil-images/mine/4xqb) | CRYSTAL STRUCTURE OF AD37 FIBER KNOB IN COMPLEX WITH TRIVALENT SIALIC ACID INHIBITOR ME0461 | Descriptor: | 2-(1-{2-[bis(2-{4-[2-({(6R)-5-(acetylamino)-3,5-dideoxy-6-[(1R,2R)-1,2,3-trihydroxypropyl]-beta-L-threo-hex-2-ulopyranonosyl}oxy)ethyl]-1H-1,2,3-triazol-1-yl}ethyl)amino]ethyl}-1H-1,2,3-triazol-4-yl)ethyl (6R)-5-(acetylamino)-3,5-dideoxy-6-[(1R,2R)-1,2,3-trihydroxypropyl]-beta-L-threo-hex-2-ulopyranosidonic acid, ACETATE ION, Fiber, ... | Authors: | Stehle, T, Liaci, A.M. | Deposit date: | 2015-01-19 | Release date: | 2015-07-29 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (1.597 Å) | Cite: | Triazole linker-based trivalent sialic acid inhibitors of adenovirus type 37 infection of human corneal epithelial cells. Org.Biomol.Chem., 13, 2015
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4XWY
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![BU of 4xwy by Molmil](/molmil-images/mine/4xwy) | Crystal structure of human sepiapterin reductase in complex with an N-acetylserotinin analogue | Descriptor: | N-[2-(5-hydroxy-2-methyl-1H-indol-3-yl)ethyl]-2-methoxyacetamide, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, SULFATE ION, ... | Authors: | Johnsson, K, Hovius, R, Gorszka, K.I, Pojer, F. | Deposit date: | 2015-01-29 | Release date: | 2015-07-01 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (2.35 Å) | Cite: | Reduction of Neuropathic and Inflammatory Pain through Inhibition of the Tetrahydrobiopterin Pathway. Neuron, 86, 2015
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2N7M
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![BU of 2n7m by Molmil](/molmil-images/mine/2n7m) | NMR-SAXS/WAXS Structure of the core of the U4/U6 di-snRNA | Descriptor: | RNA (92-MER) | Authors: | Cornilescu, G, Didychuk, A.L, Rodgers, M.L, Michael, L.A, Burke, J.E, Montemayor, E.J, Hoskins, A.A, Butcher, S.E, Tonelli, M. | Deposit date: | 2015-09-14 | Release date: | 2015-12-30 | Last modified: | 2024-05-15 | Method: | SOLUTION NMR | Cite: | Structural Analysis of Multi-Helical RNAs by NMR-SAXS/WAXS: Application to the U4/U6 di-snRNA. J.Mol.Biol., 428, 2016
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4XR6
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![BU of 4xr6 by Molmil](/molmil-images/mine/4xr6) | Tailspike protein double mutant D339A/E372Q of E. coli bacteriophage HK620 in complex with hexasaccharide | Descriptor: | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, FORMIC ACID, SODIUM ION, ... | Authors: | Gohlke, U, Broeker, N.K, Heinemann, U, Seckler, R, Barbirz, S. | Deposit date: | 2015-01-20 | Release date: | 2016-01-27 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (1.78 Å) | Cite: | Enthalpic cost of water removal from a hydrophobic glucose binding cavity on HK620 tailspike protein. to be published
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6AEI
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![BU of 6aei by Molmil](/molmil-images/mine/6aei) | Cryo-EM structure of the receptor-activated TRPC5 ion channel | Descriptor: | 2-(HEXADECANOYLOXY)-1-[(PHOSPHONOOXY)METHYL]ETHYL HEXADECANOATE, CHOLESTEROL HEMISUCCINATE, SODIUM ION, ... | Authors: | Duan, J, Li, Z, Li, J, Zhang, J. | Deposit date: | 2018-08-05 | Release date: | 2019-08-07 | Last modified: | 2019-08-14 | Method: | ELECTRON MICROSCOPY (2.89 Å) | Cite: | Cryo-EM structure of TRPC5 at 2.8- angstrom resolution reveals unique and conserved structural elements essential for channel function. Sci Adv, 5, 2019
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5U27
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2MV2
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![BU of 2mv2 by Molmil](/molmil-images/mine/2mv2) | |
2N3K
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![BU of 2n3k by Molmil](/molmil-images/mine/2n3k) | Human Brd4 ET domain in complex with MLV Integrase C-term | Descriptor: | Bromodomain-containing protein 4, MLV integrase | Authors: | Crowe, B.L, Foster, M.P. | Deposit date: | 2015-06-03 | Release date: | 2016-03-02 | Last modified: | 2024-05-15 | Method: | SOLUTION NMR | Cite: | Structure of the Brd4 ET domain bound to a C-terminal motif from gamma-retroviral integrases reveals a conserved mechanism of interaction. Proc.Natl.Acad.Sci.USA, 113, 2016
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5U5U
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![BU of 5u5u by Molmil](/molmil-images/mine/5u5u) | CcP gateless cavity | Descriptor: | ISONICOTINAMIDINE, PROTOPORPHYRIN IX CONTAINING FE, Peroxidase | Authors: | Fischer, M, Shoichet, B.K. | Deposit date: | 2016-12-07 | Release date: | 2017-02-01 | Last modified: | 2024-03-06 | Method: | X-RAY DIFFRACTION (1.33 Å) | Cite: | Testing inhomogeneous solvation theory in structure-based ligand discovery. Proc. Natl. Acad. Sci. U.S.A., 114, 2017
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2MZ8
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![BU of 2mz8 by Molmil](/molmil-images/mine/2mz8) | Solution NMR structure of Salmonella Typhimurium transcriptional regulator protein Crl | Descriptor: | Sigma factor-binding protein Crl | Authors: | Cavaliere, P, Levi-Acobas, F, Monteil, V, Bellalou, J, Mayer, C, Norel, F, Sizun, C. | Deposit date: | 2015-02-07 | Release date: | 2015-12-23 | Last modified: | 2024-05-15 | Method: | SOLUTION NMR | Cite: | Binding interface between the Salmonella sigma (S)/RpoS subunit of RNA polymerase and Crl: hints from bacterial species lacking crl. Sci Rep, 5, 2015
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5U5Y
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![BU of 5u5y by Molmil](/molmil-images/mine/5u5y) | CcP gateless cavity | Descriptor: | 2-methylimidazo[1,2-a]pyridin-3-amine, PROTOPORPHYRIN IX CONTAINING FE, Peroxidase | Authors: | Fischer, M, Shoichet, B.K. | Deposit date: | 2016-12-07 | Release date: | 2017-02-01 | Last modified: | 2024-03-06 | Method: | X-RAY DIFFRACTION (1.3 Å) | Cite: | Testing inhomogeneous solvation theory in structure-based ligand discovery. Proc. Natl. Acad. Sci. U.S.A., 114, 2017
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