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4MUY	IspH in complex with pyridin-4-ylmethyl diphosphate Descriptor: 4-hydroxy-3-methylbut-2-enyl diphosphate reductase, FE3-S4 CLUSTER, pyridin-4-ylmethyl trihydrogen diphosphate Authors: Span, I, Wang, K, Song, Y, Eisenreich, W, Bacher, A, Oldfield, E, Groll, M. Deposit date: 2013-09-23 Release date: 2014-06-11 Last modified: 2023-09-20 Method: X-RAY DIFFRACTION (1.8 Å) Cite: Insights into the Binding of Pyridines to the Iron-Sulfur Enzyme IspH. J.Am.Chem.Soc., 136, 2014
8UTJ	E. coli 70S ribosome with unmodified lys-tRNAPro(GGG) bound to slippery P-site CCC-C codon in the 0 frame Descriptor: 16S ribosomal RNA, 23S ribosomal RNA, 30S ribosomal protein S11, ... Authors: Kimbrough, E.M, Dunham, C.M, Nguyen, H.A. Deposit date: 2023-10-31 Release date: 2025-07-09 Method: ELECTRON MICROSCOPY (3.5 Å) Cite: An RNA modification prevents extended codon-anticodon interactions from facilitating +1 frameshifting Nat Commun, 2025
8UX8	E. coli 70S ribosome with unmodified Lys-tRNAPro(GGG) bound to slippery P-site CCC-C codon in the +1 mRNA reading frame Descriptor: 16S ribosomal RNA, 23S rRNA, 30S ribosomal protein S11, ... Authors: Kimbrough, E.M, Dunham, C.M, Nguyen, H.A. Deposit date: 2023-11-09 Release date: 2025-07-09 Method: ELECTRON MICROSCOPY (3.6 Å) Cite: An RNA modification prevents extended codon-anticodon interactions from facilitating +1 frameshifting Nat Commun, 2025
4MV0	IspH in complex with pyridin-2-ylmethyl diphosphate Descriptor: 4-hydroxy-3-methylbut-2-enyl diphosphate reductase, FE3-S4 CLUSTER, pyridin-2-ylmethyl trihydrogen diphosphate Authors: Span, I, Wang, K, Song, Y, Eisenreich, W, Bacher, A, Oldfield, E, Groll, M. Deposit date: 2013-09-23 Release date: 2014-06-11 Last modified: 2023-09-20 Method: X-RAY DIFFRACTION (1.9 Å) Cite: Insights into the Binding of Pyridines to the Iron-Sulfur Enzyme IspH. J.Am.Chem.Soc., 136, 2014
4XKT	E coli BFR variant Y149F Descriptor: Bacterioferritin, SULFATE ION Authors: Bradley, J.M, Hemmings, A.M, Le Brun, N.E. Deposit date: 2015-01-12 Release date: 2015-12-16 Last modified: 2024-01-10 Method: X-RAY DIFFRACTION (1.82 Å) Cite: Three Aromatic Residues are Required for Electron Transfer during Iron Mineralization in Bacterioferritin. Angew.Chem.Int.Ed.Engl., 54, 2015
6XZ2	Crystal structure of E. Coli purine nucleoside phosphorylase mutant Y160W with SO4 and Formycin A Descriptor: (1S)-1-(7-amino-1H-pyrazolo[4,3-d]pyrimidin-3-yl)-1,4-anhydro-D-ribitol, Purine nucleoside phosphorylase DeoD-type, SULFATE ION Authors: Narczyk, M, Bzowska, A. Deposit date: 2020-01-31 Release date: 2021-02-10 Last modified: 2024-01-24 Method: X-RAY DIFFRACTION (1.65000308 Å) Cite: Single tryptophan Y160W mutant of homooligomeric E. coli purine nucleoside phosphorylase implies that dimers forming the hexamer are functionally not equivalent. Sci Rep, 11, 2021
8FTN	E. coli ArnA dehydrogenase domain mutant - N492A Descriptor: Bifunctional UDP-4-amino-4-deoxy-L-arabinose formyltransferase/UDP-glucuronic acid oxidase ArnA, SULFATE ION Authors: Sousa, M.C, Mitchell, M.E. Deposit date: 2023-01-12 Release date: 2023-11-22 Method: X-RAY DIFFRACTION (2.8 Å) Cite: Targeting the Conformational Change in ArnA Dehydrogenase for Selective Inhibition of Polymyxin Resistance. Biochemistry, 62, 2023
4MV5	IspH in complex with 6-chloropyridin-3-ylmethyl diphosphate Descriptor: (6-chloropyridin-3-yl)methyl trihydrogen diphosphate, 4-hydroxy-3-methylbut-2-enyl diphosphate reductase, FE3-S4 CLUSTER Authors: Span, I, Wang, K, Song, Y, Eisenreich, W, Bacher, A, Oldfield, E, Groll, M. Deposit date: 2013-09-23 Release date: 2014-06-18 Last modified: 2023-09-20 Method: X-RAY DIFFRACTION (1.9 Å) Cite: Insights into the Binding of Pyridines to the Iron-Sulfur Enzyme IspH. J.Am.Chem.Soc., 136, 2014
8SU9	E. coli SIR2-HerA complex (hexamer HerA bound with dodecamer Sir2) Descriptor: ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, Nucleoside triphosphate hydrolase, ... Authors: Shen, Z.F, Lin, Q.P, Fu, T.M. Deposit date: 2023-05-11 Release date: 2024-03-27 Method: ELECTRON MICROSCOPY (2.83 Å) Cite: Assembly-mediated activation of the SIR2-HerA supramolecular complex for anti-phage defense. Mol.Cell, 83, 2023
9CKT	X-ray diffraction structure of papain co-crystallized with E-64 Descriptor: METHANOL, N-[N-[1-HYDROXYCARBOXYETHYL-CARBONYL]LEUCYLAMINO-BUTYL]-GUANIDINE, Papain Authors: Vlahakis, N.W, Rodriguez, J.A. Deposit date: 2024-07-09 Release date: 2025-06-04 Last modified: 2025-06-11 Method: X-RAY DIFFRACTION (1.5 Å) Cite: Enzymatic combinatorial synthesis of E-64 and related cysteine protease inhibitors. Nat.Chem.Biol., 2025
6DNC	E.coli RF1 bound to E.coli 70S ribosome in response to UAU sense A-site codon Descriptor: 16S ribosomal RNA, 23S ribosomal RNA, 30S ribosomal protein S10, ... Authors: Svidritskiy, E, Demo, G, Korostelev, A.A. Deposit date: 2018-06-06 Release date: 2018-07-04 Last modified: 2024-03-13 Method: ELECTRON MICROSCOPY (3.7 Å) Cite: Mechanism of premature translation termination on a sense codon. J. Biol. Chem., 293, 2018
8UAF	E. coli Sir2_HerA complex (12:6) bound with NAD+ Descriptor: ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, ... Authors: Shen, Z.F, Lin, Q.P, Fu, T.M. Deposit date: 2023-09-20 Release date: 2023-12-27 Last modified: 2024-03-27 Method: ELECTRON MICROSCOPY (3.18 Å) Cite: Assembly-mediated activation of the SIR2-HerA supramolecular complex for anti-phage defense. Mol.Cell, 83, 2023
4MUX	IspH in complex with pyridin-3-ylmethyl diphosphate Descriptor: 4-hydroxy-3-methylbut-2-enyl diphosphate reductase, IRON/SULFUR CLUSTER, pyridin-3-ylmethyl trihydrogen diphosphate Authors: Span, I, Eisenreich, W, Bacher, A, Oldfield, E, Groll, M. Deposit date: 2013-09-23 Release date: 2014-06-18 Last modified: 2024-02-28 Method: X-RAY DIFFRACTION (1.7 Å) Cite: Insights into the Binding of Pyridines to the Iron-Sulfur Enzyme IspH. J.Am.Chem.Soc., 136, 2014
2NBS	Backbone 1H, 13C, and 15N Chemical Shift Assignments for designed protein E_1r26 Descriptor: E_1r26 Authors: Zhou, X. Deposit date: 2016-03-12 Release date: 2016-10-19 Last modified: 2024-05-15 Method: SOLUTION NMR Cite: Backbone 1H, 13C, and 15N Chemical Shift Assignments for designed protein E_1r26 To be Published
5MMO	E. coli DNA Gyrase B 24 kDa ATPase domain in complex with [3-(3-ethyl-ureido)-5-(pyridin-4-yl)-isoquinolin-8-yl-methyl]-carbamic acid prop-2-ynyl ester Descriptor: DNA gyrase subunit B, PHOSPHATE ION, prop-2-ynyl ~{N}-[[3-(ethylcarbamoylamino)-5-pyridin-4-yl-isoquinolin-8-yl]methyl]carbamate Authors: Panchaud, P, Bruyere, T, Blumstein, A.-C, Bur, D, Chambovey, A, Ertel, E.A, Gude, M, Hubschwerlen, C, Jacob, L, Kimmerlin, T, Pfeifer, T, Prade, L, Seiler, P, Ritz, D, Rueedi, G. Deposit date: 2016-12-12 Release date: 2017-04-26 Last modified: 2024-05-08 Method: X-RAY DIFFRACTION (1.81 Å) Cite: Discovery and Optimization of Isoquinoline Ethyl Ureas as Antibacterial Agents. J. Med. Chem., 60, 2017
1ZPR	E. COLI THYMIDYLATE SYNTHASE MUTANT E58Q IN COMPLEX WITH CB3717 AND 2'-DEOXYURIDINE 5'-MONOPHOSPHATE (DUMP) Descriptor: 10-PROPARGYL-5,8-DIDEAZAFOLIC ACID, 2'-DEOXYURIDINE 5'-MONOPHOSPHATE, THYMIDYLATE SYNTHASE Authors: Sage, C.R, Stout, T.J, Rutenber, E.E, Stroud, R.M. Deposit date: 1996-10-15 Release date: 1997-07-07 Last modified: 2024-11-20 Method: X-RAY DIFFRACTION (2.5 Å) Cite: An essential role for water in an enzyme reaction mechanism: the crystal structure of the thymidylate synthase mutant E58Q. Biochemistry, 35, 1996
2PJJ	E. coli lytic transglycosylase MltA-D308A in apo-1 form Descriptor: Membrane-bound lytic murein transglycosylase A Authors: van Straaten, K.E, Dijkstra, B.W, Thunnissen, A.M.W.H. Deposit date: 2007-04-16 Release date: 2007-05-08 Last modified: 2023-08-30 Method: X-RAY DIFFRACTION (2.46 Å) Cite: Structure of Escherichia coli Lytic transglycosylase MltA with bound chitohexaose: implications for peptidoglycan binding and cleavage J.Biol.Chem., 282, 2007
9DDM	E. coli TolAQR conformation I Descriptor: Tol-Pal system protein TolA, Tol-Pal system protein TolQ, Tol-Pal system protein TolR Authors: Celia, H, Botos, I. Deposit date: 2024-08-28 Release date: 2025-07-09 Method: ELECTRON MICROSCOPY (2.94 Å) Cite: Cryo-EM structures of the E. coli Ton and Tol motor complexes Nat Commun, 16, 2025
8URM	E. coli 70S ribosome with unmodified tRNAPro(GGG) bound to slippery P-site CCC-C codon and tRNAVal(UAC) in the A site Descriptor: 13S ribosomal RNA, 16S ribosomal RNA, 30S ribosomal protein S11, ... Authors: Kimbrough, E.M, Dunham, C.M, Nguyen, H.A. Deposit date: 2023-10-26 Release date: 2025-07-09 Method: ELECTRON MICROSCOPY (3 Å) Cite: An RNA modification prevents extended codon-anticodon interactions from facilitating +1 frameshifting Nat Commun, 2025
9DDN	E. coli TolAQR conformation II Descriptor: Tol-Pal system protein TolA, Tol-Pal system protein TolQ, Tol-Pal system protein TolR Authors: Celia, H, Botos, I. Deposit date: 2024-08-28 Release date: 2025-07-09 Method: ELECTRON MICROSCOPY (3.18 Å) Cite: Cryo-EM structures of the E. coli Ton and Tol motor complexes Nat Commun, 16, 2025
9DDO	E. coli TonB-ExbBD TonB bound to ExbB chain C Descriptor: (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL STEARATE, Biopolymer transport protein ExbB, Biopolymer transport protein ExbD, ... Authors: Celia, H, Botos, I. Deposit date: 2024-08-28 Release date: 2025-07-09 Method: ELECTRON MICROSCOPY (2.8 Å) Cite: Cryo-EM structures of the E. coli Ton and Tol motor complexes Nat Commun, 16, 2025
9DDP	E. coli TonB-ExbBD TonB bound to ExbB chain E Descriptor: Biopolymer transport protein ExbB, Biopolymer transport protein ExbD, Protein TonB Authors: Celia, H, Botos, I. Deposit date: 2024-08-28 Release date: 2025-07-09 Method: ELECTRON MICROSCOPY (3.16 Å) Cite: Cryo-EM structures of the E. coli Ton and Tol motor complexes Nat Commun, 16, 2025
9DDQ	E. coli TonB-ExbBD TonB bound to ExbB chain A Descriptor: Biopolymer transport protein ExbB, Biopolymer transport protein ExbD, Protein TonB Authors: Celia, H, Botos, I. Deposit date: 2024-08-28 Release date: 2025-07-09 Method: ELECTRON MICROSCOPY (3.19 Å) Cite: Cryo-EM structures of the E. coli Ton and Tol motor complexes Nat Commun, 16, 2025
9CJN	Ligase Cp1B Descriptor: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, ADENOSINE, DI(HYDROXYETHYL)ETHER, ... Authors: Xin, Z, Yi, T. Deposit date: 2024-07-07 Release date: 2025-05-21 Method: X-RAY DIFFRACTION (2.7 Å) Cite: Enzymatic combinatorial synthesis of E-64 and related cysteine protease inhibitors. Nat.Chem.Biol., 2025
8SUW	E. coli SIR2-HerA complex (dodecamer SIR2 bound 4 protomers of HerA) Descriptor: ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, Nucleoside triphosphate hydrolase, ... Authors: Shen, Z.F, Lin, Q.P, Fu, T.M. Deposit date: 2023-05-13 Release date: 2024-03-27 Method: ELECTRON MICROSCOPY (3.15 Å) Cite: Assembly-mediated activation of the SIR2-HerA supramolecular complex for anti-phage defense. Mol.Cell, 83, 2023

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