8FTN

E. coli ArnA dehydrogenase domain mutant - N492A

Summary for 8FTN

• Entry DOI: 10.2210/pdb8ftn/pdb
• Descriptor: Bifunctional UDP-4-amino-4-deoxy-L-arabinose formyltransferase/UDP-glucuronic acid oxidase ArnA, SULFATE ION (3 entities in total)
• Functional Keywords: polymyxin resistance, udp-glucuronic acid decarboxylase, oxidoreductase
• Biological source: Escherichia coli
• Total number of polymer chains: 1
• Total formula weight: 41402.97

Authors

Sousa, M.C.,Mitchell, M.E. (deposition date: 2023-01-12, release date: 2023-11-22)

• Primary citation: Mitchell, M.E.,Gatzeva-Topalova, P.Z.,Bargmann, A.D.,Sammakia, T.,Sousa, M.C.; Targeting the Conformational Change in ArnA Dehydrogenase for Selective Inhibition of Polymyxin Resistance.; Biochemistry, 62:2216-2227, 2023; PubMed: 37410993; DOI: 10.1021/acs.biochem.3c00227

Experimental method

X-RAY DIFFRACTION (2.8 Å)