6H8K
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![BU of 6h8k by Molmil](/molmil-images/mine/6h8k) | Crystal structure of a variant (Q133C in PSST) of Yarrowia lipolytica complex I | Descriptor: | FE2/S2 (INORGANIC) CLUSTER, IRON/SULFUR CLUSTER, NADH dehydrogenase [ubiquinone] flavoprotein 1, ... | Authors: | Wirth, C, Galemou Yoga, E, Zickermann, V, Hunte, C. | Deposit date: | 2018-08-02 | Release date: | 2018-12-26 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (3.79 Å) | Cite: | Locking loop movement in the ubiquinone pocket of complex I disengages the proton pumps. Nat Commun, 9, 2018
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4YBG
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![BU of 4ybg by Molmil](/molmil-images/mine/4ybg) | Crystal structure of the MAEL domain of Drosophila melanogaster Maelstrom | Descriptor: | 1,2-ETHANEDIOL, ACETATE ION, Protein maelstrom, ... | Authors: | Matsumoto, N, Ishitani, R, Nishimasu, H, Nureki, O. | Deposit date: | 2015-02-18 | Release date: | 2015-04-29 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (1.602 Å) | Cite: | Crystal Structure and Activity of the Endoribonuclease Domain of the piRNA Pathway Factor Maelstrom Cell Rep, 11, 2015
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6GIO
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7UM3
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![BU of 7um3 by Molmil](/molmil-images/mine/7um3) | Crystal structure of a Fab in complex with a peptide derived from the LAG-3 D1 domain loop insertion | Descriptor: | D1 domain loop peptide from Lymphocyte activation gene 3 protein, Fab heavy chain, Fab light chain | Authors: | Zorn, J.A, Lee, P.S, Rajpal, A, Strop, P. | Deposit date: | 2022-04-06 | Release date: | 2022-09-07 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (2.3983 Å) | Cite: | Preclinical Characterization of Relatlimab, a Human LAG-3-Blocking Antibody, Alone or in Combination with Nivolumab. Cancer Immunol Res, 10, 2022
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6EOI
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![BU of 6eoi by Molmil](/molmil-images/mine/6eoi) | Reductive Aminase from Aspergillus terreus in complex with NADPH and ethyl-5-oxohexanoate | Descriptor: | MAGNESIUM ION, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, Reductive Aminase, ... | Authors: | Sharma, M, Mangas-Sanchez, J, Turner, N.J, Grogan, G. | Deposit date: | 2017-10-09 | Release date: | 2018-10-31 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (1.76 Å) | Cite: | A Mechanism for Reductive Amination Catalyzed by Fungal Reductive Aminases Acs Catalysis, 2018
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6EOL
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![BU of 6eol by Molmil](/molmil-images/mine/6eol) | Human galectin-3c in complex with a galactose derivative | Descriptor: | (2~{R},3~{R},4~{S},5~{R},6~{R})-2-(3,4-dichlorophenyl)sulfanyl-6-(hydroxymethyl)-4-[4-[3,4,5-tris(fluoranyl)phenyl]-1,2,3-triazol-1-yl]oxane-3,5-diol, Galectin-3, THIOCYANATE ION | Authors: | Hakansson, M, Nilsson, U.J, Zetterberg, F, Logan, D.T. | Deposit date: | 2017-10-09 | Release date: | 2018-08-22 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (1.5 Å) | Cite: | Monosaccharide Derivatives with Low-Nanomolar Lectin Affinity and High Selectivity Based on Combined Fluorine-Amide, Phenyl-Arginine, Sulfur-pi , and Halogen Bond Interactions. ChemMedChem, 13, 2018
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6GRL
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6KG7
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![BU of 6kg7 by Molmil](/molmil-images/mine/6kg7) | Cryo-EM Structure of the Mammalian Tactile Channel Piezo2 | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Piezo-type mechanosensitive ion channel component 2 | Authors: | Wang, L, Zhou, H, Zhang, M, Liu, W, Deng, T, Zhao, Q, Li, Y, Lei, J, Li, X, Xiao, B. | Deposit date: | 2019-07-11 | Release date: | 2019-09-04 | Last modified: | 2020-07-29 | Method: | ELECTRON MICROSCOPY (3.8 Å) | Cite: | Structure and mechanogating of the mammalian tactile channel PIEZO2. Nature, 573, 2019
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5FNR
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![BU of 5fnr by Molmil](/molmil-images/mine/5fnr) | Structure of the Keap1 Kelch domain in complex with a small molecule inhibitor. | Descriptor: | (3S)-3-(4-chlorophenyl)-3-(1-methylbenzotriazol-5-yl)propanoic acid, KELCH-LIKE ECH-ASSOCIATED PROTEIN 1 | Authors: | Davies, T.G, Wixted, W.E, Coyle, J.E, Griffiths-Jones, C, Hearn, K, McMenamin, R, Norton, D, Rich, S.J, Richardson, C, Saxty, G, Willems, H.M.G, Woolford, A.J, Cottom, J.E, Kou, J, Yonchuk, J.G, Feldser, H.G, Sanchez, Y, Foley, J.P, Bolognese, B.J, Logan, G, Podolin, P.L, Yan, H, Callahan, J.F, Heightman, T.D, Kerns, J.K. | Deposit date: | 2015-11-16 | Release date: | 2016-04-13 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (1.89 Å) | Cite: | Mono-Acidic Inhibitors of the Kelch-Like Ech-Associated Protein 1 : Nuclear Factor Erythroid 2-Related Factor 2 (Keap1:Nrf2) Protein-Protein Interaction with High Cell Potency Identified by Fragment-Based Discovery. J.Med.Chem., 59, 2016
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1C1F
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![BU of 1c1f by Molmil](/molmil-images/mine/1c1f) | LIGAND-FREE CONGERIN I | Descriptor: | PROTEIN (CONGERIN I) | Authors: | Shirai, T, Mitsuyama, C, Niwa, Y, Matsui, Y, Hotta, H, Yamane, T, Kamiya, H, Ishii, C, Ogawa, T, Muramoto, K. | Deposit date: | 1999-03-03 | Release date: | 1999-10-08 | Last modified: | 2023-12-27 | Method: | X-RAY DIFFRACTION (1.6 Å) | Cite: | High-resolution structure of the conger eel galectin, congerin I, in lactose-liganded and ligand-free forms: emergence of a new structure class by accelerated evolution. Structure Fold.Des., 7, 1999
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1BYM
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![BU of 1bym by Molmil](/molmil-images/mine/1bym) | SOLUTION STRUCTURES OF THE C-TERMINAL DOMAIN OF DIPHTHERIA TOXIN REPRESSOR | Descriptor: | PROTEIN (DIPHTHERIA TOXIN REPRESSOR) | Authors: | Wang, G, Wylie, G.P, Twigg, P.D, Caspar, D.L.D, Murphy, J.R, Logan, T.M. | Deposit date: | 1998-10-17 | Release date: | 1998-10-21 | Last modified: | 2024-05-22 | Method: | SOLUTION NMR | Cite: | Solution structure and peptide binding studies of the C-terminal src homology 3-like domain of the diphtheria toxin repressor protein. Proc.Natl.Acad.Sci.USA, 96, 1999
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1BMA
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![BU of 1bma by Molmil](/molmil-images/mine/1bma) | BENZYL METHYL AMINIMIDE INHIBITOR COMPLEXED TO PORCINE PANCREATIC ELASTASE | Descriptor: | (1R)-1-benzyl-1-methyl-1-(2-{[4-(1-methylethyl)phenyl]amino}-2-oxoethyl)-2-{(2S)-4-methyl-2-[(trifluoroacetyl)amino]pentanoyl}diazanium, CALCIUM ION, Chymotrypsin-like elastase family member 1, ... | Authors: | Peisach, E, Casebier, D, Gallion, S.L, Furth, P, Petsko, G.A, Hogan Jr, J.C, Ringe, D. | Deposit date: | 1995-05-01 | Release date: | 1995-12-07 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Interaction of a peptidomimetic aminimide inhibitor with elastase. Science, 269, 1995
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1C1L
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![BU of 1c1l by Molmil](/molmil-images/mine/1c1l) | LACTOSE-LIGANDED CONGERIN I | Descriptor: | PROTEIN (CONGERIN I), beta-D-galactopyranose-(1-4)-beta-D-glucopyranose | Authors: | Shirai, T, Mitsuyama, C, Niwa, Y, Matsui, Y, Hotta, H, Yamane, T, Kamiya, H, Ishii, C, Ogawa, T, Muramoto, K. | Deposit date: | 1999-03-03 | Release date: | 1999-10-08 | Last modified: | 2023-08-09 | Method: | X-RAY DIFFRACTION (1.5 Å) | Cite: | High-resolution structure of the conger eel galectin, congerin I, in lactose-liganded and ligand-free forms: emergence of a new structure class by accelerated evolution. Structure Fold.Des., 7, 1999
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5KMG
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![BU of 5kmg by Molmil](/molmil-images/mine/5kmg) | Near-atomic cryo-EM structure of PRC1 bound to the microtubule | Descriptor: | GUANOSINE-5'-DIPHOSPHATE, GUANOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ... | Authors: | Kellogg, E.H, Howes, S, Ti, S.-C, Ramirez-Aportela, E, Kapoor, T.M, Chacon, P, Nogales, E. | Deposit date: | 2016-06-27 | Release date: | 2016-08-03 | Last modified: | 2024-03-06 | Method: | ELECTRON MICROSCOPY (3.5 Å) | Cite: | Near-atomic cryo-EM structure of PRC1 bound to the microtubule. Proc.Natl.Acad.Sci.USA, 113, 2016
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1C9Z
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![BU of 1c9z by Molmil](/molmil-images/mine/1c9z) | D232-CGTACG | Descriptor: | 1,3-DI[[[10-METHOXY-7H-PYRIDO[4,3-C]CARBAZOL-2-IUMYL]-ETHYL]-PIPERIDIN-4-YL]-PROPANE, 5'-D(*CP*GP*TP*AP*CP*G)-3' | Authors: | Williams, L.D. | Deposit date: | 1999-08-03 | Release date: | 2000-04-02 | Last modified: | 2024-04-17 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Effects of cationic charge on three-dimensional structures of intercalative complexes: structure of a bis-intercalated DNA complex solved by MAD phasing. Curr.Med.Chem., 7, 2000
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6H1B
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![BU of 6h1b by Molmil](/molmil-images/mine/6h1b) | Structure of amide bond synthetase Mcba K483A mutant from Marinactinospora thermotolerans | Descriptor: | 1-ethanoyl-9~{H}-pyrido[3,4-b]indole-3-carboxylic acid, ADENOSINE MONOPHOSPHATE, Fatty acid CoA ligase | Authors: | Rowlinson, B, Petchey, M, Cuetos, A, Frese, A, Dannevald, S, Grogan, G. | Deposit date: | 2018-07-11 | Release date: | 2018-09-05 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | The Broad Aryl Acid Specificity of the Amide Bond Synthetase McbA Suggests Potential for the Biocatalytic Synthesis of Amides. Angew. Chem. Int. Ed. Engl., 57, 2018
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1DKZ
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![BU of 1dkz by Molmil](/molmil-images/mine/1dkz) | THE SUBSTRATE BINDING DOMAIN OF DNAK IN COMPLEX WITH A SUBSTRATE PEPTIDE, DETERMINED FROM TYPE 1 NATIVE CRYSTALS | Descriptor: | SUBSTRATE BINDING DOMAIN OF DNAK, SUBSTRATE PEPTIDE (7 RESIDUES) | Authors: | Zhu, X, Zhao, X, Burkholder, W.F, Gragerov, A, Ogata, C.M, Gottesman, M.E, Hendrickson, W.A. | Deposit date: | 1996-06-03 | Release date: | 1996-12-07 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Structural analysis of substrate binding by the molecular chaperone DnaK. Science, 272, 1996
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1B3R
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![BU of 1b3r by Molmil](/molmil-images/mine/1b3r) | RAT LIVER S-ADENOSYLHOMOCYSTEIN HYDROLASE | Descriptor: | NICOTINAMIDE-ADENINE-DINUCLEOTIDE, PROTEIN (S-ADENOSYLHOMOCYSTEINE HYDROLASE) | Authors: | Hu, Y, Komoto, J, Huang, Y, Takusagawa, F, Gomi, T, Ogawa, H, Takata, Y, Fujioka, M. | Deposit date: | 1998-12-14 | Release date: | 1998-12-23 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Crystal structure of S-adenosylhomocysteine hydrolase from rat liver. Biochemistry, 38, 1999
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1CP8
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![BU of 1cp8 by Molmil](/molmil-images/mine/1cp8) | NMR STRUCTURE OF DNA (5'-D(TTGGCCAA)2-3') COMPLEXED WITH NOVEL ANTITUMOR DRUG UCH9 | Descriptor: | 1,2-HYDRO-1-OXY-3,4-HYDRO-3-(1-METHOXY-2-OXY-3,4-DIHYDROXYPENTYL)-8,9-DIHYDROXY-7-(SEC-BUTYL)-ANTHRACENE, DNA (5'-D(P*TP*TP*GP*GP*CP*CP*AP*A)-3'), MAGNESIUM ION, ... | Authors: | Katahira, R, Katahira, M, Yamashita, Y, Ogawa, H, Kyogoku, Y, Yoshida, M. | Deposit date: | 1999-06-11 | Release date: | 1999-07-01 | Last modified: | 2023-12-27 | Method: | SOLUTION NMR | Cite: | Solution structure of the novel antitumor drug UCH9 complexed with d(TTGGCCAA)2 as determined by NMR. Nucleic Acids Res., 26, 1998
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1DKY
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![BU of 1dky by Molmil](/molmil-images/mine/1dky) | THE SUBSTRATE BINDING DOMAIN OF DNAK IN COMPLEX WITH A SUBSTRATE PEPTIDE, DETERMINED FROM TYPE 2 NATIVE CRYSTALS | Descriptor: | DNAK, PEPTIDE SUBSTRATE | Authors: | Zhu, X, Zhao, X, Burkholder, W.F, Gragerov, A, Ogata, C.M, Gottesman, M.E, Hendrickson, W.A. | Deposit date: | 1996-06-03 | Release date: | 1996-12-07 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Structural analysis of substrate binding by the molecular chaperone DnaK. Science, 272, 1996
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1DKX
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![BU of 1dkx by Molmil](/molmil-images/mine/1dkx) | THE SUBSTRATE BINDING DOMAIN OF DNAK IN COMPLEX WITH A SUBSTRATE PEPTIDE, DETERMINED FROM TYPE 1 SELENOMETHIONYL CRYSTALS | Descriptor: | SUBSTRATE BINDING DOMAIN OF DNAK, SUBSTRATE PEPTIDE (7 RESIDUES) | Authors: | Zhu, X, Zhao, X, Burkholder, W.F, Gragerov, A, Ogata, C.M, Gottesman, M.E, Hendrickson, W.A. | Deposit date: | 1996-06-03 | Release date: | 1996-12-07 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Structural analysis of substrate binding by the molecular chaperone DnaK. Science, 272, 1996
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3EBC
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![BU of 3ebc by Molmil](/molmil-images/mine/3ebc) | Structure of N141A HincII with Cognate DNA | Descriptor: | 5'-D(*DGP*DCP*DCP*DCP*DGP*DTP*DCP*DGP*DAP*DCP*DCP*DGP*DGP*DC)-3', 5'-D(*DGP*DCP*DCP*DGP*DGP*DTP*DCP*DGP*DAP*DCP*DGP*DGP*DGP*DC)-3', MANGANESE (II) ION, ... | Authors: | Little, E.J, Babic, A.C, Horton, N.C. | Deposit date: | 2008-08-27 | Release date: | 2008-12-23 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (2.55 Å) | Cite: | Early Interrogation and Recognition of DNA Sequence by Indirect Readout Structure, 16, 2008
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7VR5
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![BU of 7vr5 by Molmil](/molmil-images/mine/7vr5) | Crystal structure of CmABCB1 W114Y/W161Y/W363Y/W364Y/M391W (4WY/M391W) mutant | Descriptor: | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, DECYL-BETA-D-MALTOPYRANOSIDE, Probable ATP-dependent transporter ycf16 | Authors: | Inoue, Y, Ogawa, H, Kato, H. | Deposit date: | 2021-10-21 | Release date: | 2022-09-07 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (3 Å) | Cite: | Structure-based alteration of tryptophan residues of the multidrug transporter CmABCB1 to assess substrate binding using fluorescence spectroscopy. Protein Sci., 31, 2022
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4LOA
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![BU of 4loa by Molmil](/molmil-images/mine/4loa) | X-ray structure of the de-novo design amidase at the resolution 1.8A, Northeast Structural Genomics Consortium (NESG) Target OR398 | Descriptor: | CHLORIDE ION, DI(HYDROXYETHYL)ETHER, De-novo design amidase | Authors: | Kuzin, A, Lew, S, Vorobiev, S.M, Seetharaman, J, Sahdev, S, Xiao, R, Maglaqui, M, Kogan, S, Khersonsky, O, Everett, J.K, Acton, T.B, Montelione, G.T, Hunt, J.F, Tong, L, Northeast Structural Genomics Consortium (NESG) | Deposit date: | 2013-07-12 | Release date: | 2013-08-07 | Last modified: | 2023-12-06 | Method: | X-RAY DIFFRACTION (1.819 Å) | Cite: | Northeast Structural Genomics Consortium Target OR398 To be Published
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4LT9
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![BU of 4lt9 by Molmil](/molmil-images/mine/4lt9) | Crystal Structure of Engineered Protein, Northeast Structural Genomics Consortium Target OR404 | Descriptor: | Engineered Protein OR404 | Authors: | Vorobiev, S, Su, M, Bjelic, S, Kipnis, Y, Wang, L, Sahdev, S, Xiao, R, Kogan, S, Maglaqui, M, Baker, D, Everett, J.K, Acton, T.B, Montelione, G.T, Hunt, J.F, Tong, L, Northeast Structural Genomics Consortium (NESG) | Deposit date: | 2013-07-23 | Release date: | 2013-08-14 | Last modified: | 2023-12-06 | Method: | X-RAY DIFFRACTION (2.15 Å) | Cite: | Crystal Structure of Engineered Protein OR404. To be Published
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