6H8K

Crystal structure of a variant (Q133C in PSST) of Yarrowia lipolytica complex I

This is a large structure.

Summary for 6H8K

DescriptorNADH-ubiquinone oxidoreductase chain 1, NADH-ubiquinone oxidoreductase chain 2,NADH dehydrogenase subunit 2, NADH-ubiquinone oxidoreductase chain 3, ... (50 entities in total)
Functional Keywordsmembrane protein, respiratory chain, mitochondrial, nadh:ubiquinone oxidoreductase, oxidoreductase
Biological sourceYarrowia lipolytica (Candida lipolytica)
Total number of polymer chains73
Total molecular weight580527.83
Authors
Wirth, C.,Galemou Yoga, E.,Zickermann, V.,Hunte, C. (deposition date: 2018-08-02, release date: 2018-12-26)
Primary citation
Cabrera-Orefice, A.,Yoga, E.G.,Wirth, C.,Siegmund, K.,Zwicker, K.,Guerrero-Castillo, S.,Zickermann, V.,Hunte, C.,Brandt, U.
Locking loop movement in the ubiquinone pocket of complex I disengages the proton pumps.
Nat Commun, 9:4500-4500, 2018
PubMed: 30374105 (PDB entries with the same primary citation)
DOI: 10.1038/s41467-018-06955-y
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (3.79 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliers 0.4195 3.5% 8.2%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution

More Asymmetric unit images

Molmil generated image of 6h8k
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Molmil generated image of 6h8k
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Molmil generated image of 6h8k
rotated about y axis by 90°
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