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5FGH
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BU of 5fgh by Molmil
Yeast 20S proteasome beta5-K33A mutant (propeptide expressed in trans) in complex with MG132
Descriptor: CHLORIDE ION, MAGNESIUM ION, N-[(benzyloxy)carbonyl]-L-leucyl-N-[(2S)-1-hydroxy-4-methylpentan-2-yl]-L-leucinamide, ...
Authors:Huber, E.M, Groll, M.
Deposit date:2015-12-20
Release date:2016-03-23
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:A unified mechanism for proteolysis and autocatalytic activation in the 20S proteasome.
Nat Commun, 7, 2016
6BT2
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BU of 6bt2 by Molmil
Structure of the human Nocturnin catalytic domain with bound sulfate anion
Descriptor: MAGNESIUM ION, Nocturnin, SULFATE ION
Authors:Abshire, E.T, Chasseur, J, Del Rizzo, P, Trievel, R.
Deposit date:2017-12-04
Release date:2018-05-16
Last modified:2024-04-03
Method:X-RAY DIFFRACTION (2.411 Å)
Cite:The structure of human Nocturnin reveals a conserved ribonuclease domain that represses target transcript translation and abundance in cells.
Nucleic Acids Res., 46, 2018
2G08
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BU of 2g08 by Molmil
X-ray structure of mouse pyrimidine 5'-nucleotidase type 1, product-transition complex analog with Aluminum fluoride
Descriptor: ALUMINUM FLUORIDE, Cytosolic 5'-nucleotidase III, MAGNESIUM ION
Authors:Bitto, E, Bingman, C.A, Wesenberg, G.E, Phillips Jr, G.N, Center for Eukaryotic Structural Genomics (CESG)
Deposit date:2006-02-11
Release date:2006-04-04
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (2.35 Å)
Cite:Structure of pyrimidine 5'-nucleotidase type 1. Insight into mechanism of action and inhibition during lead poisoning.
J.Biol.Chem., 281, 2006
3E67
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BU of 3e67 by Molmil
Murine inos dimer with inhibitor 4-MAP bound
Descriptor: 4-METHYLPYRIDIN-2-AMINE, 5,6,7,8-TETRAHYDROBIOPTERIN, Nitric oxide synthase, ...
Authors:Garcin, E.D, Arvai, A.S, Rosenfeld, R.J, Kroeger, M.D, Crane, B.R, Andersson, G, Andrews, G, Hamley, P.J, Mallinder, P.R, Nicholls, D.J, St-Gallay, S.A, Tinker, A.C, Gensmantel, N.P, Mete, A, Cheshire, D.R, Connolly, S, Stueh, D.J, Aberg, A, Wallace, A.V, Tainer, J.A, Getzoff, E.D.
Deposit date:2008-08-14
Release date:2008-10-07
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Anchored plasticity opens doors for selective inhibitor design in nitric oxide synthase.
Nat.Chem.Biol., 4, 2008
5LLN
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BU of 5lln by Molmil
Crystal structure of human carbonic anhydrase isozyme XIII with 2,3,5,6-Tetrafluoro-4-(propylthio)benzenesulfonamide
Descriptor: 2,3,5,6-tetrafluoro-4-(propylsulfanyl)benzenesulfonamide, CITRIC ACID, Carbonic anhydrase 13, ...
Authors:Smirnov, A, Manakova, E, Grazulis, S.
Deposit date:2016-07-28
Release date:2017-08-16
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Crystal structure of human carbonic anhydrase isozyme XIII with 2,3,5,6-Tetrafluoro-4-(propylthio)benzenesulfonamide
To be published
3E6T
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BU of 3e6t by Molmil
Structure of murine INOS oxygenase domain with inhibitor AR-C118901
Descriptor: 5,6,7,8-TETRAHYDROBIOPTERIN, 5-(4'-AMINO-1'-ETHYL-5',8'-DIFLUORO-1'H-SPIRO[PIPERIDINE-4,2'-QUINAZOLINE]-1-YLCARBONYL)PICOLINONITRILE, Nitric oxide synthase, ...
Authors:Garcin, E.D, Arvai, A.S, Rosenfeld, R.J, Kroeger, M.D, Crane, B.R, Andersson, G, Andrews, G, Hamley, P.J, Mallinder, P.R, Nicholls, D.J, St-Gallay, S.A, Tinker, A.C, Gensmantel, N.P, Mete, A, Cheshire, D.R, Connolly, S, Stueh, D.J, Aberg, A, Wallace, A.V, Tainer, J.A, Getzoff, E.D.
Deposit date:2008-08-15
Release date:2008-10-07
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Anchored plasticity opens doors for selective inhibitor design in nitric oxide synthase.
Nat.Chem.Biol., 4, 2008
4H9B
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BU of 4h9b by Molmil
Radiation damage study of lysozyme - 0.70 MGy
Descriptor: 1,2-ETHANEDIOL, CHLORIDE ION, Lysozyme C
Authors:Sutton, K.A, Snell, E.H.
Deposit date:2012-09-24
Release date:2013-05-15
Last modified:2017-11-15
Method:X-RAY DIFFRACTION (1.1998 Å)
Cite:Insights into the mechanism of X-ray-induced disulfide-bond cleavage in lysozyme crystals based on EPR, optical absorption and X-ray diffraction studies.
Acta Crystallogr.,Sect.D, 69, 2013
5FIK
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BU of 5fik by Molmil
Bovine mitochondrial ATP synthase state 3a
Descriptor: ATP SYNTHASE F(0) COMPLEX SUBUNIT B1, MITOCHONDRIAL, ATP SYNTHASE F(0) COMPLEX SUBUNIT C1, ...
Authors:Zhou, A, Rohou, A, Schep, D.G, Bason, J.V, Montgomery, M.G, Walker, J.E, Grigorieff, N, Rubinstein, J.L.
Deposit date:2015-09-28
Release date:2015-10-14
Last modified:2024-05-08
Method:ELECTRON MICROSCOPY (6.4 Å)
Cite:Structure and conformational states of the bovine mitochondrial ATP synthase by cryo-EM.
Elife, 4, 2015
1Z3H
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BU of 1z3h by Molmil
The exportin Cse1 in its cargo-free, cytoplasmic state
Descriptor: Importin alpha re-exporter, MAGNESIUM ION
Authors:Cook, A, Fernandez, E, Lindner, D, Ebert, J, Schlenstedt, G, Conti, E.
Deposit date:2005-03-12
Release date:2005-05-10
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:The structure of the nuclear export receptor cse1 in its cytosolic state reveals a closed conformation incompatible with cargo binding
Mol.Cell, 18, 2005
1ZNY
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BU of 1zny by Molmil
Crystal Structure Of Mycobacterium tuberculosis Guanylate Kinase In Complex With GDP
Descriptor: GUANOSINE-5'-DIPHOSPHATE, Guanylate kinase
Authors:Hible, G, Christova, P, Renault, L, Seclaman, E, Thompson, A, Girard, E, Munier-Lehmann, H, Cherfils, J.
Deposit date:2005-05-12
Release date:2005-11-29
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Unique GMP-binding site in Mycobacterium tuberculosis guanosine monophosphate kinase
Proteins, 62, 2006
4MQ4
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BU of 4mq4 by Molmil
Crystal Structure of hPNMT in Complex with bisubstrate inhibitor N-(3-((((2S,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl)thio)propyl)-1,2,3,4-tetrahydroisoquinoline-3-carboxamide
Descriptor: 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, 5'-S-(3-{[(3R)-1,2,3,4-tetrahydroisoquinolin-3-ylcarbonyl]amino}propyl)-5'-thioadenosine, Phenylethanolamine N-methyltransferase
Authors:Bart, A.G, Scott, E.E.
Deposit date:2013-09-15
Release date:2014-10-15
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (2.2042 Å)
Cite:To be Published
To be Published
2OHV
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BU of 2ohv by Molmil
Structural Basis for Glutamate Racemase Inhibition
Descriptor: (4S)-4-(2-NAPHTHYLMETHYL)-D-GLUTAMIC ACID, Glutamate Racemase
Authors:Kim, E.E.
Deposit date:2007-01-10
Release date:2007-09-25
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structural basis for glutamate racemase inhibition
J.Mol.Biol., 372, 2007
3HMI
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BU of 3hmi by Molmil
The crystal structure of human ABL2 in complex with 5-AMINO-3-{[4-(AMINOSULFONYL)PHENYL]AMINO}-N-(2,6-DIFLUOROPHENYL)-1H-1,2,4-TRIAZOLE-1-CARBOTHIOAMIDE
Descriptor: 5-AMINO-3-{[4-(AMINOSULFONYL)PHENYL]AMINO}-N-(2,6-DIFLUOROPHENYL)-1H-1,2,4-TRIAZOLE-1-CARBOTHIOAMIDE, Tyrosine-protein kinase ABL2
Authors:Ugochukwu, E, Salah, E, Barr, A, Mahajan, P, Shrestha, B, Savitsky, P, Chaikuad, A, Allerston, C, von Delft, F, Bountra, C, Arrowsmith, C.H, Weigelt, J, Edwards, A, Knapp, S, Structural Genomics Consortium (SGC)
Deposit date:2009-05-29
Release date:2009-07-07
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:The crystal structure of human ABL2 in complex with 5-AMINO-3-{[4-(AMINOSULFONYL)PHENYL]AMINO}-N-(2,6-DIFLUOROPHENYL)-1H-1,2,4-TRIAZOLE-1-CARBOTHIOAMIDE
To be Published
4HBW
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BU of 4hbw by Molmil
Crystal Structure of the first bromodomain of human BRD4 in complex with a quinazoline ligand
Descriptor: 1,2-ETHANEDIOL, Bromodomain-containing protein 4, N-ethyl-3-methyl-2-oxo-1,2,3,4-tetrahydroquinazoline-6-sulfonamide, ...
Authors:Filippakopoulos, P, Picaud, S, Qi, J, Felletar, I, von Delft, F, Bountra, C, Arrowsmith, C.H, Edwards, A, Fish, P.V, Bunnage, M.E, Cook, A.S, Owen, D.R, Knapp, S, Structural Genomics Consortium (SGC)
Deposit date:2012-09-28
Release date:2012-10-31
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (1.69 Å)
Cite:Identification of a Chemical Probe for Bromo and Extra C-Terminal Bromodomain Inhibition through Optimization of a Fragment-Derived Hit.
J.Med.Chem., 55, 2012
4H73
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BU of 4h73 by Molmil
Thermostable aldehyde dehydrogenase from Pyrobaculum sp. complexed with NADP+
Descriptor: Aldehyde dehydrogenase, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, NICKEL (II) ION
Authors:Petrova, T, Shabalin, I.G, Bezsudnova, E.Y, Boyko, K.M, Mardanov, A.V, Gumerov, V.M, Ravin, N.V, Popov, V.O.
Deposit date:2012-09-20
Release date:2013-10-02
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Thermostable aldehyde dehydrogenase from Pyrobaculum sp. complexed with NADP+
To be Published
5K5E
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BU of 5k5e by Molmil
Discovery and Structure-Activity Relationships of a Highly Selective Butyrylcholinesterase Inhibitor by Structure-Based Virtual Screening
Descriptor: 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:De la Mora, E, Dighe, S.N, Deora, G.S, Ross, B.P, Nachon, F, Brazzolotto, X.
Deposit date:2016-05-23
Release date:2016-07-27
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Discovery and Structure-Activity Relationships of a Highly Selective Butyrylcholinesterase Inhibitor by Structure-Based Virtual Screening.
J.Med.Chem., 59, 2016
7WBJ
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BU of 7wbj by Molmil
Cryo-EM structure of N-terminal modified human vasoactive intestinal polypeptide receptor 2 (VIP2R) in complex with PACAP27 and Gs
Descriptor: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(s) subunit alpha isoforms short, ...
Authors:Xu, Y.N, Feng, W.B, Zhou, Q.T, Liang, A.Y, Li, J, Dai, A.T, Zhao, F.H, Yan, J.H, Chen, C.W, Li, H, Zhao, L.H, Xia, T, Jiang, Y, Xu, H.E, Yang, D.H, Wang, M.W.
Deposit date:2021-12-16
Release date:2022-05-18
Method:ELECTRON MICROSCOPY (3.42 Å)
Cite:A distinctive ligand recognition mechanism by the human vasoactive intestinal polypeptide receptor 2.
Nat Commun, 13, 2022
3T3S
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BU of 3t3s by Molmil
Human Cytochrome P450 2A13 in complex with Pilocarpine
Descriptor: (3S,4R)-3-ethyl-4-[(1-methyl-1H-imidazol-5-yl)methyl]dihydrofuran-2(3H)-one, Cytochrome P450 2A13, PROTOPORPHYRIN IX CONTAINING FE
Authors:DeVore, N.M, Scott, E.E.
Deposit date:2011-07-25
Release date:2011-12-07
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (3 Å)
Cite:Structural comparison of cytochromes P450 2A6, 2A13, and 2E1 with pilocarpine.
Febs J., 279, 2012
5LV0
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BU of 5lv0 by Molmil
Structure of Human Neurolysin (E475Q) in complex with amyloid-beta 35-40 peptide product
Descriptor: CHLORIDE ION, GLY-VAL-VAL amyloid 35-40 fragment, Neurolysin, ...
Authors:Masuyer, G, Berntsson, R.P.-A, Teixeira, P.F, Kmiec, B, Glaser, E, Stenmark, P.
Deposit date:2016-09-12
Release date:2017-12-06
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Structural and functional analysis of Neurolysin, a new component of the mitochondrial peptidolytic network
To Be Published
5LTS
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BU of 5lts by Molmil
Crystal structure of Lymphocytic choriomeningitis mammarenavirus endonuclease Mutant D118A
Descriptor: CHLORIDE ION, GLYCEROL, RNA-directed RNA polymerase L, ...
Authors:Saez-Ayala, M, Yekwa, E.L, Canard, B, Alvarez, K, Ferron, F.
Deposit date:2016-09-07
Release date:2017-09-13
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (2.51 Å)
Cite:Crystal structures ofLymphocytic choriomeningitis virusendonuclease domain complexed with diketo-acid ligands.
IUCrJ, 5, 2018
5WRB
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BU of 5wrb by Molmil
Crystal structure of hen egg-white lysozyme
Descriptor: CHLORIDE ION, Lysozyme C, SODIUM ION
Authors:Sugahara, M, Suzuki, M, Masuda, T, Inoue, S, Nango, E.
Deposit date:2016-12-01
Release date:2017-12-20
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (2.013 Å)
Cite:Hydroxyethyl cellulose matrix applied to serial crystallography
Sci Rep, 7, 2017
5LU8
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BU of 5lu8 by Molmil
CRYSTAL STRUCTURE OF YVAD-CMK BOUND HUMAN LEGUMAIN (AEP) IN COMPLEX WITH COMPOUND 11B
Descriptor: 2,4-di(morpholin-4-yl)aniline, 2-acetamido-2-deoxy-beta-D-glucopyranose, AC-TYR-VAL-ALA-ASP-CHLOROMETHYLKETONE, ...
Authors:Dall, E, Ye, K, Brandstetter, H.
Deposit date:2016-09-08
Release date:2017-03-29
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Inhibition of delta-secretase improves cognitive functions in mouse models of Alzheimer's disease.
Nat Commun, 8, 2017
8AIR
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BU of 8air by Molmil
Crystal structure of cutinase RgCutII from Rhizobacter gummiphilus
Descriptor: ACETATE ION, RgCutII
Authors:Zahn, M, Allen, M.D, Pickford, A.R, McGeehan, J.E.
Deposit date:2022-07-27
Release date:2023-03-08
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (1.08 Å)
Cite:Concentration-Dependent Inhibition of Mesophilic PETases on Poly(ethylene terephthalate) Can Be Eliminated by Enzyme Engineering.
ChemSusChem, 16, 2023
8AQW
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BU of 8aqw by Molmil
BA.4/5 SARS-CoV-2 Spike bound to mouse ACE2 (local)
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Processed angiotensin-converting enzyme 2,Ig gamma-2A chain C region, ...
Authors:Lau, K, Ni, D, Beckert, B, Nazarov, S, Myasnikov, A, Pojer, F, Stahlberg, H, Uchikawa, E.
Deposit date:2022-08-13
Release date:2023-03-15
Last modified:2023-04-19
Method:ELECTRON MICROSCOPY (3.3 Å)
Cite:Cryo-EM structures and binding of mouse and human ACE2 to SARS-CoV-2 variants of concern indicate that mutations enabling immune escape could expand host range.
Plos Pathog., 19, 2023
5LYN
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BU of 5lyn by Molmil
Structure of the Tpr Domain of Sgt2 in complex with yeast Ssa1 peptide fragment
Descriptor: PRO-THR-VAL-GLU-GLU-VAL-ASP, Small glutamine-rich tetratricopeptide repeat-containing protein 2, ZINC ION
Authors:Krysztofinska, E.M, Evans, N.J, Thapaliya, A, Murray, J.W, Morgan, R.M.L, Martinez-Lumbreras, S, Isaacson, R.L.
Deposit date:2016-09-28
Release date:2017-10-25
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structure and Interactions of the TPR Domain of Sgt2 with Yeast Chaperones and Ybr137wp.
Front Mol Biosci, 4, 2017

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數據於2024-08-21公開中

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