4MQ4

Crystal Structure of hPNMT in Complex with bisubstrate inhibitor N-(3-((((2S,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl)thio)propyl)-1,2,3,4-tetrahydroisoquinoline-3-carboxamide

Summary for 4MQ4

• Entry DOI: 10.2210/pdb4mq4/pdb
• Related: 1HNN 2G72 4MIK
• Descriptor: Phenylethanolamine N-methyltransferase, 5'-S-(3-{[(3R)-1,2,3,4-tetrahydroisoquinolin-3-ylcarbonyl]amino}propyl)-5'-thioadenosine, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, ... (4 entities in total)
• Functional Keywords: adrenaline synthesis, methyltransferase, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 2
• Total formula weight: 64935.39

Authors

Bart, A.G.,Scott, E.E. (deposition date: 2013-09-15, release date: 2014-10-15, Last modification date: 2018-01-24)

• Primary citation: Bart, A.G.,Scott, E.E.; To be Published; To be Published,

Experimental method

X-RAY DIFFRACTION (2.2042 Å)