4MIK
Crystal Structure of hPNMT in Complex with bisubstrate inhibitor (2R,3R,4S,5S)-2-(6-amino-9H-purin-9-yl)-5-(((2-(((7-nitro-1,2,3,4-tetrahydroisoquinolin-3-yl)methyl)amino)ethyl)thio)methyl)tetrahydrofuran-3,4-diol
Summary for 4MIK
Entry DOI | 10.2210/pdb4mik/pdb |
Related | 1HNN 2G72 |
Descriptor | Phenylethanolamine N-methyltransferase, 9-{5-S-[2-({[(3S)-7-nitro-1,2,3,4-tetrahydroisoquinolin-3-yl]methyl}amino)ethyl]-5-thio-alpha-L-lyxofuranosyl}-9H-purin-6-amine, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, ... (4 entities in total) |
Functional Keywords | methyltransferase, adrenaline synthesis, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 2 |
Total formula weight | 64969.37 |
Authors | Bart, A.G.,Scott, E.E. (deposition date: 2013-08-31, release date: 2014-09-10, Last modification date: 2018-01-24) |
Primary citation | Bart, A.G.,Scott, E.E. To be published To be Published, |
Experimental method | X-RAY DIFFRACTION (1.9506 Å) |
Structure validation
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