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4HBW

Crystal Structure of the first bromodomain of human BRD4 in complex with a quinazoline ligand

Summary for 4HBW
Entry DOI10.2210/pdb4hbw/pdb
Related4HBV 4HBX 4HBY
DescriptorBromodomain-containing protein 4, 1,2-ETHANEDIOL, N-ethyl-3-methyl-2-oxo-1,2,3,4-tetrahydroquinazoline-6-sulfonamide, ... (5 entities in total)
Functional Keywordsbromodomain, cap, hunk1, mcap, protein binding-inhibitor complex, mitotic chromosome associated protein, cell cycle, structural genomics consortium, sgc, protein binding/inhibitor
Biological sourceHomo sapiens (human)
Cellular locationNucleus (By similarity): O60885
Total number of polymer chains1
Total formula weight15470.85
Authors
Primary citationFish, P.V.,Filippakopoulos, P.,Bish, G.,Brennan, P.E.,Bunnage, M.E.,Cook, A.S.,Federov, O.,Gerstenberger, B.S.,Jones, H.,Knapp, S.,Marsden, B.,Nocka, K.,Owen, D.R.,Philpott, M.,Picaud, S.,Primiano, M.J.,Ralph, M.J.,Sciammetta, N.,Trzupek, J.D.
Identification of a Chemical Probe for Bromo and Extra C-Terminal Bromodomain Inhibition through Optimization of a Fragment-Derived Hit.
J.Med.Chem., 55:9831-9837, 2012
Cited by
PubMed: 23095041
DOI: 10.1021/jm3010515
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.69 Å)
Structure validation

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