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4HBW

Crystal Structure of the first bromodomain of human BRD4 in complex with a quinazoline ligand

Functional Information from PDB Data
site_idAC1
Number of Residues7
DetailsBINDING SITE FOR RESIDUE EDO A 201
ChainResidue
AILE100
AILE101
ALYS102
ATHR103
AASN135
AHOH347
AHOH439

site_idAC2
Number of Residues9
DetailsBINDING SITE FOR RESIDUE 14Z A 202
ChainResidue
AASN140
AILE146
AMET149
AHOH308
AHOH324
AHOH325
AHOH335
ATRP81
AVAL87

site_idAC3
Number of Residues5
DetailsBINDING SITE FOR RESIDUE K A 203
ChainResidue
ATYR137
AILE138
AASN140
AGLU163
AHOH406

Functional Information from PROSITE/UniProt
site_idPS00633
Number of Residues60
DetailsBROMODOMAIN_1 Bromodomain signature. AwpFqqpvDavklnlpDYYkiIktpMdmgtIkkrlenny..Ywnaqeciqdfnt.MftNCyiY
ChainResidueDetails
AALA80-TYR139

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues1
DetailsSITE: Acetylated histone binding => ECO:0000269|PubMed:22464331
ChainResidueDetails
AASN140

site_idSWS_FT_FI2
Number of Residues2
DetailsCROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744|PubMed:28112733
ChainResidueDetails
ALYS99

218853

PDB entries from 2024-04-24

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