4WI3
 
 | | Structural mapping of the human IgG1 binding site for FcRn: hu3S193 Fc mutation I253A | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, Ig gamma-1 chain C region | | Authors: | Farrugia, W, Burvenich, I.J.G, Scott, A.M, Ramsland, P.A. | | Deposit date: | 2014-09-25 | | Release date: | 2015-09-30 | | Last modified: | 2023-12-27 | | Method: | X-RAY DIFFRACTION (2.703 Å) | | Cite: | Structural and functional mapping of human IgG1 binding site for FcRn in vivo using human FcRn transgenic mice
To Be Published
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4ONO
 | | CD1c in complex with PM (phosphomycoketide) | | Descriptor: | (4R,8S,16S,20R)-4,8,12,16,20-pentamethylheptacosyl dihydrogen phosphate, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Beta-2-microglobulin/T-cell surface glycoprotein CD1c/T-cell surface glycoprotein CD1b chimeric protein, ... | | Authors: | Roy, S, Adams, E.J. | | Deposit date: | 2014-01-28 | | Release date: | 2014-10-08 | | Last modified: | 2020-07-29 | | Method: | X-RAY DIFFRACTION (2.705 Å) | | Cite: | Molecular basis of mycobacterial lipid antigen presentation by CD1c and its recognition by alpha beta T cells.
Proc.Natl.Acad.Sci.USA, 111, 2014
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5WES
 | | Crystal Structure H2-Dd with disulfide-linked 5mer peptide | | Descriptor: | Beta-2-microglobulin, GLYCINE, H-2 class I histocompatibility antigen, ... | | Authors: | Jiang, J.S, Natarajan, K, Boyd, L.F, Margulies, D.H. | | Deposit date: | 2017-07-10 | | Release date: | 2017-10-18 | | Last modified: | 2017-12-13 | | Method: | X-RAY DIFFRACTION (2.706 Å) | | Cite: | Crystal structure of a TAPBPR-MHC I complex reveals the mechanism of peptide editing in antigen presentation.
Science, 358, 2017
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5MEP
 | | Human Leukocyte Antigen A02 presenting ILGKFLHWL | | Descriptor: | 1,2-ETHANEDIOL, Beta-2-microglobulin, HLA class I histocompatibility antigen, ... | | Authors: | Rizkallah, P.J, Cole, D.K, Lloyd, A, Crowther, M, Sewell, A.K. | | Deposit date: | 2016-11-16 | | Release date: | 2016-12-07 | | Last modified: | 2024-01-17 | | Method: | X-RAY DIFFRACTION (2.71 Å) | | Cite: | Structural Mechanism Underpinning Cross-reactivity of a CD8+ T-cell Clone That Recognizes a Peptide Derived from Human Telomerase Reverse Transcriptase.
J. Biol. Chem., 292, 2017
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1KJ2
 | | Murine Alloreactive ScFv TCR-Peptide-MHC Class I Molecule Complex | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Allogeneic H-2Kb MHC Class I Molecule, Beta-2 microglobulin, ... | | Authors: | Reiser, J.-B, Gregoire, C, Darnault, C, Mosser, T, Guimezanes, A, Schmitt-Verhulst, A.-M, Fontecilla-Camps, J.C, Mazza, G, Malissen, B, Housset, D. | | Deposit date: | 2001-12-04 | | Release date: | 2002-03-27 | | Last modified: | 2023-08-16 | | Method: | X-RAY DIFFRACTION (2.71 Å) | | Cite: | A T cell receptor CDR3beta loop undergoes conformational changes of unprecedented magnitude upon binding to a peptide/MHC class I complex.
Immunity, 16, 2002
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5YC5
 | | Crystal structure of human IgG-Fc in complex with aglycan and optimized Fc gamma receptor IIIa | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, CHLORIDE ION, Immunoglobulin gamma-1 heavy chain, ... | | Authors: | Caaveiro, J.M.M, Tamura, H, Tsumoto, K, Kiyoshi, M. | | Deposit date: | 2017-09-06 | | Release date: | 2018-03-21 | | Last modified: | 2023-11-22 | | Method: | X-RAY DIFFRACTION (2.71 Å) | | Cite: | Assessing the Heterogeneity of the Fc-Glycan of a Therapeutic Antibody Using an engineered Fc gamma Receptor IIIa-Immobilized Column.
Sci Rep, 8, 2018
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1XGY
 | | Crystal Structure of Anti-Meta I Rhodopsin Fab Fragment K42-41L | | Descriptor: | K42-41L Fab Heavy Chain, K42-41L Fab Light Chain, Rhodopsin Epitope Mimetic Peptide | | Authors: | Piscitelli, C.L, Angel, T.E, Bailey, B.W, Lawerence, C.M. | | Deposit date: | 2004-09-17 | | Release date: | 2005-09-27 | | Last modified: | 2023-08-23 | | Method: | X-RAY DIFFRACTION (2.71 Å) | | Cite: | Equilibrium between metarhodopsin-I and metarhodopsin-II is dependent on the conformation of the third cytoplasmic loop.
J.Biol.Chem., 281, 2006
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8F8W
 | | Crystal structure of Nb.X0 bound to the afucosylated human IgG1 fragment crystal form I | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Nb.X0, afucosylated IgG1 fragment | | Authors: | Goldgur, Y, Ravetch, J, Gupta, A, Kao, K, Oren, D. | | Deposit date: | 2022-11-22 | | Release date: | 2023-03-29 | | Last modified: | 2023-10-11 | | Method: | X-RAY DIFFRACTION (2.71 Å) | | Cite: | Mechanism of glycoform specificity and in vivo protection by an anti-afucosylated IgG nanobody.
Nat Commun, 14, 2023
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3EYU
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6LHH
 | | Crystal structure of chicken 8mer-BF2*1501 | | Descriptor: | ARG-ARG-ARG-GLU-GLN-THR-ASP-TYR, Beta-2-microglobulin, MHC class I | | Authors: | Liu, Y.J, Xia, C. | | Deposit date: | 2019-12-08 | | Release date: | 2020-12-09 | | Last modified: | 2023-11-22 | | Method: | X-RAY DIFFRACTION (2.71 Å) | | Cite: | The Combination of CD8 alpha alpha and Peptide-MHC-I in a Face-to-Face Mode Promotes Chicken gamma delta T Cells Response.
Front Immunol, 11, 2020
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3QXA
 | | HLA-DR1 bound with CLIP peptide | | Descriptor: | HLA class II histocompatibility antigen gamma chain peptide, HLA class II histocompatibility antigen, DR alpha chain, ... | | Authors: | Painter, C.A, Stern, L.J. | | Deposit date: | 2011-03-01 | | Release date: | 2011-11-16 | | Last modified: | 2023-09-13 | | Method: | X-RAY DIFFRACTION (2.712 Å) | | Cite: | Conformational lability in the class II MHC 310 helix and adjacent extended strand dictate HLA-DM susceptibility and peptide exchange.
Proc.Natl.Acad.Sci.USA, 108, 2011
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3UTS
 | | 1E6-A*0201-ALWGPDPAAA Complex, Monoclinic | | Descriptor: | 1E6 TCR Alpha Chain, 1E6 TCR Beta Chain, Beta-2-microglobulin, ... | | Authors: | Rizkallah, P.J, Cole, D.K, Sewell, A.K, Bulek, A.M. | | Deposit date: | 2011-11-26 | | Release date: | 2012-01-25 | | Last modified: | 2012-03-07 | | Method: | X-RAY DIFFRACTION (2.712 Å) | | Cite: | Structural basis for the killing of human beta cells by CD8(+) T cells in type 1 diabetes.
Nat.Immunol., 13, 2012
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7ZLG
 | | Cryo-EM structure of C-mannosyltransferase CeDPY19, in complex with acceptor peptide and bound to CMT2-Fab and anti-Fab nanobody | | Descriptor: | Anti-Fab nanobody, C-mannosyltransferase dpy-19, CMT2-Fab heavy chain, ... | | Authors: | Bloch, J.S, Mukherjee, S, Mao, R, Irobalieva, R, Kossiakoff, A.A, Goddard-Borger, E.D, Locher, K.P. | | Deposit date: | 2022-04-15 | | Release date: | 2023-01-11 | | Last modified: | 2023-05-10 | | Method: | ELECTRON MICROSCOPY (2.72 Å) | | Cite: | Structure, sequon recognition and mechanism of tryptophan C-mannosyltransferase.
Nat.Chem.Biol., 19, 2023
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1I9I
 | | NATIVE CRYSTAL STRUCTURE OF THE RECOMBINANT MONOCLONAL WILD TYPE ANTI-TESTOSTERONE FAB FRAGMENT | | Descriptor: | RECOMBINANT MONOCLONAL ANTI-TESTOSTERONE FAB FRAGMENT HEAVY CHAIN, RECOMBINANT MONOCLONAL ANTI-TESTOSTERONE FAB FRAGMENT LIGHT CHAIN | | Authors: | Valjakka, J, Takkinenz, K, Teerinen, T, Soderlund, H, Rouvinen, J. | | Deposit date: | 2001-03-20 | | Release date: | 2002-03-20 | | Last modified: | 2024-04-03 | | Method: | X-RAY DIFFRACTION (2.72 Å) | | Cite: | Structural insights into steroid hormone binding: the crystal structure of a recombinant anti-testosterone Fab fragment in free and testosterone-bound forms.
J.Biol.Chem., 277, 2002
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8ESH
 | | Structure of chimeric HLA-A*02:01 bound to CMV peptide | | Descriptor: | Beta-2-microglobulin, CMV peptide, HLA-A*02:01 | | Authors: | Florio, T.J, Ani, O, Young, M.C, Mallik, L, Sgourakis, N.G. | | Deposit date: | 2022-10-14 | | Release date: | 2023-01-25 | | Last modified: | 2023-10-25 | | Method: | X-RAY DIFFRACTION (2.72 Å) | | Cite: | Decoupling peptide binding from T cell receptor recognition with engineered chimeric MHC-I molecules.
Front Immunol, 14, 2023
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3PGD
 | | Crystal Structure of HLA-DR1 with CLIP106-120, canonical peptide orientation | | Descriptor: | HLA class II histocompatibility antigen gamma chain, HLA class II histocompatibility antigen, DR alpha chain, ... | | Authors: | Gunther, S, Schlundt, A, Sticht, J, Roske, Y, Heinemann, U, Wiesmuller, K.-H, Jung, G, Falk, K, Rotzschke, O, Freund, C. | | Deposit date: | 2010-11-01 | | Release date: | 2010-12-08 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (2.72 Å) | | Cite: | Bidirectional binding of invariant chain peptides to an MHC class II molecule.
Proc.Natl.Acad.Sci.USA, 107, 2010
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5KSU
 | | Crystal structure of HLA-DQ2.5-CLIP1 at 2.73 resolution | | Descriptor: | HLA class II histocompatibility antigen gamma chain, HLA class II histocompatibility antigen, DQ alpha 1 chain, ... | | Authors: | Nguyen, T.-B, Jayaraman, P, Bergseng, E, Madhusudhan, M.S, Kim, C.-Y, Sollid, L.M. | | Deposit date: | 2016-07-10 | | Release date: | 2017-04-05 | | Last modified: | 2023-10-04 | | Method: | X-RAY DIFFRACTION (2.73 Å) | | Cite: | Unraveling the structural basis for the unusually rich association of human leukocyte antigen DQ2.5 with class-II-associated invariant chain peptides.
J. Biol. Chem., 292, 2017
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7SSH
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2OJZ
 | | Anti-DNA antibody ED10 | | Descriptor: | Fab ED10 heavy chain, Fab ED10 light chain | | Authors: | Stanfield, R.L, Sanguineti, S, Wilson, I.A, de Prat-Gay, G. | | Deposit date: | 2007-01-15 | | Release date: | 2007-06-12 | | Last modified: | 2023-08-30 | | Method: | X-RAY DIFFRACTION (2.73 Å) | | Cite: | Specific recognition of a DNA immunogen by its elicited antibody
J.Mol.Biol., 370, 2007
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6GGM
 | | HLA-E*01:03 in complex with the Mtb44 peptide variant: Mtb44*P2-Phe. | | Descriptor: | Beta-2-microglobulin, MHC class I antigen, Mtb44*P2-Phe peptide variant (ARG-PHE-PRO-ALA-LYS-ALA-PRO-LEU-LEU), ... | | Authors: | Walters, L.C, Gillespie, G.M, McMichael, A.J, Rozbesky, D, Jones, E.Y, Harlos, K. | | Deposit date: | 2018-05-03 | | Release date: | 2018-08-08 | | Last modified: | 2024-01-17 | | Method: | X-RAY DIFFRACTION (2.734 Å) | | Cite: | Pathogen-derived HLA-E bound epitopes reveal broad primary anchor pocket tolerability and conformationally malleable peptide binding.
Nat Commun, 9, 2018
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3O8X
 | | Recognition of Glycolipid Antigen by iNKT Cell TCR | | Descriptor: | (2S,3R)-3-HYDROXY-2-(TETRADECANOYLAMINO)OCTADECYL ALPHA-D-GALACTOPYRANOSIDURONIC ACID, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | Authors: | Zajonc, D.M, Li, Y. | | Deposit date: | 2010-08-03 | | Release date: | 2010-09-29 | | Last modified: | 2023-09-06 | | Method: | X-RAY DIFFRACTION (2.74 Å) | | Cite: | The V alpha 14 invariant natural killer T cell TCR forces microbial glycolipids and CD1d into a conserved binding mode.
J.Exp.Med., 207, 2010
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4FTV
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4MNQ
 | | TCR-peptide specificity overrides affinity enhancing TCR-MHC interactions | | Descriptor: | 1,2-ETHANEDIOL, Beta-2-microglobulin, GLYCEROL, ... | | Authors: | Rizkallah, P.J, Cole, D.K, Sewell, A.K, Jakobsen, B.K. | | Deposit date: | 2013-09-11 | | Release date: | 2013-11-13 | | Last modified: | 2017-08-02 | | Method: | X-RAY DIFFRACTION (2.742 Å) | | Cite: | T-cell receptor (TCR)-peptide specificity overrides affinity-enhancing TCR-major histocompatibility complex interactions.
J.Biol.Chem., 289, 2014
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6U3O
 | | JR51 DQ2-p.aeru-alpha2a complex | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, MHC class II HLA-DQ-alpha chain, MHC class II HLA-DQ-beta-1, ... | | Authors: | Petersen, J, Rossjohn, J. | | Deposit date: | 2019-08-22 | | Release date: | 2019-12-18 | | Last modified: | 2020-07-29 | | Method: | X-RAY DIFFRACTION (2.743 Å) | | Cite: | T cell receptor cross-reactivity between gliadin and bacterial peptides in celiac disease.
Nat.Struct.Mol.Biol., 27, 2020
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5UTZ
 | | Human IL-2/Fab complex | | Descriptor: | Fab 5111 heavy chain, Fab 5111 light chain, GLYCEROL, ... | | Authors: | Jude, K.M, Garcia, K.C. | | Deposit date: | 2017-02-15 | | Release date: | 2018-07-11 | | Last modified: | 2023-10-04 | | Method: | X-RAY DIFFRACTION (2.747 Å) | | Cite: | A human anti-IL-2 antibody that potentiates regulatory T cells by a structure-based mechanism.
Nat. Med., 24, 2018
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