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8BWH	Small molecule stabilizer for 14-3-3/ChREBP (Cmd 42) Descriptor: 14-3-3 protein sigma, Carbohydrate-responsive element-binding protein, MAGNESIUM ION, ... Authors: Pennings, M.A.M, Visser, E.J, Ottmann, C. Deposit date: 2022-12-06 Release date: 2024-05-01 Method: X-RAY DIFFRACTION (2.1 Å) Cite: Molecular glues of the regulatory ChREBP/14-3-3 complex protect beta cells from glucolipotoxicity. Biorxiv, 2024
8BWE	Small molecule stabilizer for 14-3-3/ChREBP (Cmd 43) Descriptor: 14-3-3 protein sigma, Carbohydrate-responsive element-binding protein, MAGNESIUM ION, ... Authors: Visser, E.J, Pennings, M.A.M, Ottmann, C. Deposit date: 2022-12-06 Release date: 2024-05-01 Method: X-RAY DIFFRACTION (2 Å) Cite: Molecular glues of the regulatory ChREBP/14-3-3 complex protect beta cells from glucolipotoxicity. Biorxiv, 2024
8BTQ	Small molecule stabilizer for 14-3-3/ChREBP (Cmd1-soaking) Descriptor: 14-3-3 protein sigma, Carbohydrate-responsive element-binding protein, MAGNESIUM ION, ... Authors: Pennings, M.A.M, Visser, E.J, Ottmann, C. Deposit date: 2022-11-29 Release date: 2024-05-01 Method: X-RAY DIFFRACTION (1.6 Å) Cite: Molecular glues of the regulatory ChREBP/14-3-3 complex protect beta cells from glucolipotoxicity. Biorxiv, 2024
6ZBT	Structure of 14-3-3 gamma in complex with Nedd4-2 14-3-3 binding motif Ser342 Descriptor: 1,1,1,3,3,3-hexafluoropropan-2-ol, 14-3-3 protein gamma, E3 ubiquitin-protein ligase NEDD4-like Authors: Joshi, R, Kalabova, D, Obsil, T, Obsilova, V. Deposit date: 2020-06-09 Release date: 2021-07-21 Last modified: 2024-01-24 Method: X-RAY DIFFRACTION (1.79948521 Å) Cite: 14-3-3-protein regulates Nedd4-2 by modulating interactions between HECT and WW domains. Commun Biol, 4, 2021
6ZC9	Structure of 14-3-3 gamma in complex with Nedd4-2 14-3-3 binding motif Ser448 Descriptor: 1,1,1,3,3,3-hexafluoropropan-2-ol, 14-3-3 protein gamma, E3 ubiquitin-protein ligase NEDD4-like Authors: Pohl, P, Kalabova, D, Obsil, T, Obsilova, V. Deposit date: 2020-06-10 Release date: 2021-07-21 Last modified: 2024-01-24 Method: X-RAY DIFFRACTION (1.89895988 Å) Cite: 14-3-3-protein regulates Nedd4-2 by modulating interactions between HECT and WW domains. Commun Biol, 4, 2021
8C2G	14-3-3 sigma with Pin1 binding site pS72 and covalently bound CV1040 Descriptor: 14-3-3 protein sigma, 2-iodanyl-4-(2-phenylimidazol-1-yl)benzaldehyde, MAGNESIUM ION, ... Authors: Verhoef, C.J, Cossar, P. Deposit date: 2022-12-22 Release date: 2023-06-14 Last modified: 2023-07-05 Method: X-RAY DIFFRACTION (1.6 Å) Cite: Tracking the mechanism of covalent molecular glue stabilization using native mass spectrometry. Chem Sci, 14, 2023
8C3C	14-3-3 sigma with Pin1 binding site pS72 and bound Fusicoccin A Descriptor: 14-3-3 protein sigma, FUSICOCCIN, MAGNESIUM ION, ... Authors: Verhoef, C.J, Cossar, P. Deposit date: 2022-12-23 Release date: 2023-06-14 Last modified: 2023-07-05 Method: X-RAY DIFFRACTION (1.6 Å) Cite: Tracking the mechanism of covalent molecular glue stabilization using native mass spectrometry. Chem Sci, 14, 2023
8C2D	14-3-3 in complex with Pyrin pS208 Descriptor: 14-3-3 protein sigma, MAGNESIUM ION, Pyrin pS208 peptide Authors: Lau, R, Ottmann, C, Hann, M. Deposit date: 2022-12-22 Release date: 2023-07-26 Method: X-RAY DIFFRACTION (2.15 Å) Cite: Crystal structure and ligandability of the 14-3-3/pyrin interface. Biochem.Biophys.Res.Commun., 651, 2023
8C04	Co-soaked stabilizers for ERa - 14-3-3 interaction (884_AZ354) Descriptor: 14-3-3 protein sigma, 2-(4-chloranylphenoxy)-2-methyl-~{N}-(2-sulfanylethyl)propanamide, 4-chloranyl-7-propan-2-yloxy-1-benzothiophene-2-carboximidamide, ... Authors: Visser, E.J, Sijbesma, E, Ottmann, C. Deposit date: 2022-12-15 Release date: 2023-08-02 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (1.1 Å) Cite: From Tethered to Freestanding Stabilizers of 14-3-3 Protein-Protein Interactions through Fragment Linking. Angew.Chem.Int.Ed.Engl., 62, 2023
8BZA	single soak stabilizer for ERa - 14-3-3 interaction (AZ555) Descriptor: 14-3-3 protein sigma, 4-methyl-5-phenyl-thiophene-2-carboximidamide, ERalpha peptide, ... Authors: Visser, E.J, Sijbesma, E, Ottmann, C. Deposit date: 2022-12-14 Release date: 2023-08-02 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (1.25 Å) Cite: From Tethered to Freestanding Stabilizers of 14-3-3 Protein-Protein Interactions through Fragment Linking. Angew.Chem.Int.Ed.Engl., 62, 2023
8BYO	fragment-linked stabilizer for ERa - 14-3-3 interaction (1074361) Descriptor: 14-3-3 protein sigma, ERalpha peptide, MAGNESIUM ION, ... Authors: Visser, E.J, Vandenboorn, E.M.F, Ottmann, C. Deposit date: 2023-01-18 Release date: 2023-08-02 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (1.2 Å) Cite: From Tethered to Freestanding Stabilizers of 14-3-3 Protein-Protein Interactions through Fragment Linking. Angew.Chem.Int.Ed.Engl., 62, 2023
8BZ0	single soak stabilizer for ERa - 14-3-3 interaction (AZ275) Descriptor: 14-3-3 protein sigma, 4-ethoxy-1-benzothiophene-2-carboximidamide, ERalpha peptide, ... Authors: Visser, E.J, Sijbesma, E, Ottmann, C. Deposit date: 2022-12-14 Release date: 2023-08-02 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (1.2 Å) Cite: From Tethered to Freestanding Stabilizers of 14-3-3 Protein-Protein Interactions through Fragment Linking. Angew.Chem.Int.Ed.Engl., 62, 2023
8C4F	Small molecule amidine soak in 14-3-3/ERa (AZ037) Descriptor: 14-3-3 protein sigma, 5-(cyclohexylamino)-4-phenyl-thiophene-2-carboximidamide, ERalpha peptide, ... Authors: Visser, E.J, Sijbesma, E, Ottmann, C. Deposit date: 2023-01-03 Release date: 2023-08-02 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (1.4 Å) Cite: From Tethered to Freestanding Stabilizers of 14-3-3 Protein-Protein Interactions through Fragment Linking. Angew.Chem.Int.Ed.Engl., 62, 2023
8BYY	fragment-linked stabilizer for ERa - 14-3-3 interaction (1074395) Descriptor: 14-3-3 protein sigma, ERalpha peptide, ~{N}-[3-(5-carbamimidoylthiophen-3-yl)phenyl]-2-[(4-chlorophenyl)amino]-2-methyl-propanamide Authors: Visser, E.J, Vandenboorn, E.M.F, Ottmann, C. Deposit date: 2022-12-14 Release date: 2023-08-02 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (1.6 Å) Cite: From Tethered to Freestanding Stabilizers of 14-3-3 Protein-Protein Interactions through Fragment Linking. Angew.Chem.Int.Ed.Engl., 62, 2023
8BZW	Co-soaked stabilizers for ERa - 14-3-3 interaction (844_AZ210) Descriptor: 14-3-3 protein sigma, 2-(4-chloranylphenoxy)-2-methyl-~{N}-(2-sulfanylethyl)propanamide, 4-[(2~{R})-3-azanyl-2-methyl-propyl]-7-methoxy-1-benzothiophene-2-carboximidamide, ... Authors: Visser, E.J, Sijbesma, E, Ottmann, C. Deposit date: 2022-12-15 Release date: 2023-08-02 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (1.1 Å) Cite: From Tethered to Freestanding Stabilizers of 14-3-3 Protein-Protein Interactions through Fragment Linking. Angew.Chem.Int.Ed.Engl., 62, 2023
8C4G	Small molecule amidine soak in 14-3-3/ERa (AZ132) Descriptor: 14-3-3 protein sigma, ERalpha peptide, MAGNESIUM ION, ... Authors: Visser, E.J, Sijbesma, E, Ottmann, C. Deposit date: 2023-01-03 Release date: 2023-08-02 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (1.46 Å) Cite: From Tethered to Freestanding Stabilizers of 14-3-3 Protein-Protein Interactions through Fragment Linking. Angew.Chem.Int.Ed.Engl., 62, 2023
8BZB	co-soak stabilizers for ERa - 14-3-3 interaction (884_AZ275) Descriptor: 14-3-3 protein sigma, 2-(4-chloranylphenoxy)-2-methyl-~{N}-(2-sulfanylethyl)propanamide, 4-ethoxy-1-benzothiophene-2-carboximidamide, ... Authors: Visser, E.J, Sijbesma, E, Ottmann, C. Deposit date: 2022-12-14 Release date: 2023-08-02 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (1.7 Å) Cite: From Tethered to Freestanding Stabilizers of 14-3-3 Protein-Protein Interactions through Fragment Linking. Angew.Chem.Int.Ed.Engl., 62, 2023
8C0K	fragment-linked stabilizer for ERa - 14-3-3 interaction (1075302) Descriptor: 14-3-3 protein sigma, ERalpha peptide, MAGNESIUM ION, ... Authors: Visser, E.J, Vandenboorn, E.M.F, Ottmann, C. Deposit date: 2022-12-17 Release date: 2023-08-02 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (1.4 Å) Cite: From Tethered to Freestanding Stabilizers of 14-3-3 Protein-Protein Interactions through Fragment Linking. Angew.Chem.Int.Ed.Engl., 62, 2023
8BYZ	fragment-linked stabilizer for ERa - 14-3-3 interaction (AZ210) Descriptor: 14-3-3 protein sigma, 4-[(2~{S})-3-azanyl-2-methyl-propyl]-7-methoxy-1-benzothiophene-2-carboximidamide, ERalpha peptide, ... Authors: Visser, E.J, Sijbesma, E, Ottmann, C. Deposit date: 2022-12-14 Release date: 2023-08-02 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (1.4 Å) Cite: From Tethered to Freestanding Stabilizers of 14-3-3 Protein-Protein Interactions through Fragment Linking. Angew.Chem.Int.Ed.Engl., 62, 2023
6ZVC	14-3-3 Sigma in complex with phosphorylated Gab2pT391 peptide - 48h incubation Descriptor: 14-3-3 protein sigma, MAGNESIUM ION, phosphorylated Gab2pT391 peptide Authors: Ballone, A, Lau, R.A, Zweipfenning, F.P.A, Ottmann, C. Deposit date: 2020-07-24 Release date: 2021-08-04 Last modified: 2024-01-31 Method: X-RAY DIFFRACTION (2.51 Å) Cite: A new soaking procedure for X-ray crystallography structural determination of protein-peptide complexes To Be Published
6ZVB	14-3-3 Sigma in complex with phosphorylated Gab2pT391 peptide - 24h incubation Descriptor: 14-3-3 protein sigma, MAGNESIUM ION, phosphorylated Gab2pT391 peptide Authors: Ballone, A, Lau, R.A, Zweipfenning, F.P.A, Ottmann, C. Deposit date: 2020-07-24 Release date: 2021-08-04 Last modified: 2024-01-31 Method: X-RAY DIFFRACTION (2.51 Å) Cite: A new soaking procedure for X-ray crystallography structural determination of protein-peptide complexes To Be Published
8BZ9	single soak stabilizer for ERa - 14-3-3 interaction (AZ354) Descriptor: 14-3-3 protein sigma, 4-chloranyl-7-propan-2-yloxy-1-benzothiophene-2-carboximidamide, ERalpha peptide, ... Authors: Visser, E.J, Sijbesma, E, Ottmann, C. Deposit date: 2022-12-14 Release date: 2023-08-30 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (1.3 Å) Cite: From Tethered to Freestanding Stabilizers of 14-3-3 Protein-Protein Interactions through Fragment Linking. Angew.Chem.Int.Ed.Engl., 62, 2023
6ZVD	14-3-3 Sigma in complex with phosphorylated Gab2pT391 peptide - 96h incubation Descriptor: 14-3-3 protein sigma, MAGNESIUM ION, phosphorylated Gab2pT391 peptide Authors: Ballone, A, Lau, R.A, Zweipfenning, F.P.A, Ottmann, C. Deposit date: 2020-07-24 Release date: 2021-08-04 Last modified: 2024-01-31 Method: X-RAY DIFFRACTION (2.5 Å) Cite: A new soaking procedure for X-ray crystallography structural determination of protein-peptide complexes To Be Published
6ZVE	14-3-3 Sigma in complex with phosphorylated Gab2pT391 peptide - 1h incubation Descriptor: 14-3-3 protein sigma, MAGNESIUM ION, phosphorylated Gab2pT391 peptide Authors: Ballone, A, Lau, R.A, Zweipfenning, F.P.A, Ottmann, C. Deposit date: 2020-07-24 Release date: 2021-08-04 Last modified: 2024-01-31 Method: X-RAY DIFFRACTION (2.51 Å) Cite: A new soaking procedure for X-ray crystallography structural determination of protein-peptide complexes To Be Published
7A6Y	Structure of 14-3-3 gamma in complex with DAPK2 peptide stabilized by FC-A Descriptor: 14-3-3 protein gamma, DAPK2 C-terminal peptide, FUSICOCCIN Authors: Horvath, M, Obsilova, V, Obsil, T. Deposit date: 2020-08-27 Release date: 2021-08-25 Last modified: 2024-01-31 Method: X-RAY DIFFRACTION (2.5 Å) Cite: 14-3-3 proteins inactivate DAPK2 by promoting its dimerization and protecting key regulatory phosphosites. Commun Biol, 4, 2021

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