3S4X
| |
3SH9
| Crystal structure of fluorophore-labeled beta-lactamase PenP in complex with cefotaxime | Descriptor: | 1-[6-(dimethylamino)naphthalen-2-yl]ethanone, Beta-lactamase, CEFOTAXIME, ... | Authors: | Wong, W.-T, Zhao, Y.-X, Leung, Y.-C. | Deposit date: | 2011-06-16 | Release date: | 2011-07-27 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Increased structural flexibility at the active site of a fluorophore-conjugated beta-lactamase distinctively impacts its binding toward diverse cephalosporin antibiotics J.Biol.Chem., 286, 2011
|
|
3SH8
| Crystal structure of fluorophore-labeled beta-lactamase PenP in complex with cephaloridine | Descriptor: | 5-METHYL-2-[2-OXO-1-(2-THIOPHEN-2-YL-ACETYLAMINO)-ETHYL]-3,6-DIHYDRO-2H-[1,3]THIAZINE-4-CARBOXYLIC ACID, Beta-lactamase | Authors: | Wong, W.-T, Zhao, Y.-X, Leung, Y.-C. | Deposit date: | 2011-06-16 | Release date: | 2011-07-27 | Last modified: | 2024-03-20 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Increased structural flexibility at the active site of a fluorophore-conjugated beta-lactamase distinctively impacts its binding toward diverse cephalosporin antibiotics J.Biol.Chem., 286, 2011
|
|
6I30
| Crystal structure of the AmpC from Pseudomonas aeruginosa with 1C | Descriptor: | (3R)-3-(cyclohexylcarbonylamino)-2-oxidanyl-3,4-dihydro-1,2-benzoxaborinine-8-carboxylic acid, Class C beta-lactamase PDC-301 | Authors: | Brem, J, Cahill, S.T, McDonough, M.A, Schofield, C.J. | Deposit date: | 2018-11-02 | Release date: | 2019-02-20 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (2.21 Å) | Cite: | Studies on the inhibition of AmpC and other beta-lactamases by cyclic boronates. Biochim Biophys Acta Gen Subj, 1863, 2019
|
|
6K8X
| Crystal structure of a class C beta lactamase | Descriptor: | Beta-lactamase | Authors: | Bae, D.W, Jung, Y.E, An, Y.J, Na, J.H, Cha, S.S. | Deposit date: | 2019-06-13 | Release date: | 2019-10-16 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (1.59 Å) | Cite: | Structural Insights into Catalytic Relevances of Substrate Poses in ACC-1. Antimicrob.Agents Chemother., 63, 2019
|
|
6KA5
| Crystal structure of a class C beta-lactamase in complex with cefoxitin | Descriptor: | (2R)-2-{(1S)-1-methoxy-2-oxo-1-[(thiophen-2-ylacetyl)amino]ethyl}-5-methylidene-5,6-dihydro-2H-1,3-thiazine-4-carboxylic acid, Beta-lactamase | Authors: | Bae, D.W, Jung, Y.E, An, Y.J, Na, J.H, Cha, S.S. | Deposit date: | 2019-06-20 | Release date: | 2019-10-16 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (1.59 Å) | Cite: | Structural Insights into Catalytic Relevances of Substrate Poses in ACC-1. Antimicrob.Agents Chemother., 63, 2019
|
|
6KJC
| lovastatin esterase PcEST, wild type | Descriptor: | FORMIC ACID, Pc15g00720 protein | Authors: | Liang, Y.J, Lu, X.F. | Deposit date: | 2019-07-22 | Release date: | 2019-12-25 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (2.297 Å) | Cite: | Structural insights into the catalytic mechanism of lovastatin hydrolase J.Biol.Chem., 2019
|
|
6KJH
| Functional and structural insights into the unusual oxyanion hole-like geometry in macrolactin acyltransferase selective for dicarboxylic acyl donors | Descriptor: | Putative beta-lactamase, SULFATE ION | Authors: | Xiao, F, Sheng, D, Feng, Y, Li, W. | Deposit date: | 2019-07-22 | Release date: | 2020-07-29 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (1.68 Å) | Cite: | Structural Basis of Specificity for Carboxyl-Terminated Acyl Donors in a Bacterial Acyltransferase. J.Am.Chem.Soc., 142, 2020
|
|
6KJQ
| Functional and structural insights into the unusual oxyanion hole-like geometry in macrolactin acyltransferase selective for dicarboxylic acyl donors | Descriptor: | (3~{Z},5~{E},8~{S},9~{E},11~{E},14~{S},16~{R},17~{Z},19~{E},24~{R})-24-methyl-8,14,16-tris(oxidanyl)-1-oxacyclotetracosa-3,5,9,11,17,19-hexaen-2-one, Putative beta-lactamase | Authors: | Xiao, F, Dong, S, Feng, Y, Li, W. | Deposit date: | 2019-07-23 | Release date: | 2020-07-29 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (2.35 Å) | Cite: | Structural Basis of Specificity for Carboxyl-Terminated Acyl Donors in a Bacterial Acyltransferase. J.Am.Chem.Soc., 142, 2020
|
|
6KJF
| lovastatin esterase PcEST in complex with simvastatin | Descriptor: | Pc15g00720 protein, Simvastatin acid, TRIS-HYDROXYMETHYL-METHYL-AMMONIUM | Authors: | Liang, Y.J, Lu, X.F. | Deposit date: | 2019-07-22 | Release date: | 2019-12-25 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Structural insights into the catalytic mechanism of lovastatin hydrolase J.Biol.Chem., 2019
|
|
6KJT
| Functional and structural insights into the unusual oxyanion hole-like geometry in macrolactin acyltransferase selective for dicarboxylic acyl donors | Descriptor: | Putative beta-lactamase, SUCCINIC ACID | Authors: | Xiao, F, Dong, S, Feng, Y, Li, W. | Deposit date: | 2019-07-23 | Release date: | 2020-07-29 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (2.113 Å) | Cite: | Structural Basis of Specificity for Carboxyl-Terminated Acyl Donors in a Bacterial Acyltransferase. J.Am.Chem.Soc., 142, 2020
|
|
6K9T
| Crystal structure of a class C beta-lactamase in complex with cefotaxime | Descriptor: | Beta-lactamase, CEFOTAXIME, C3' cleaved, ... | Authors: | Bae, D.W, Jung, Y.E, An, Y.J, Na, J.H, Cha, S.S. | Deposit date: | 2019-06-17 | Release date: | 2019-10-16 | Last modified: | 2024-03-20 | Method: | X-RAY DIFFRACTION (1.459 Å) | Cite: | Structural Insights into Catalytic Relevances of Substrate Poses in ACC-1. Antimicrob.Agents Chemother., 63, 2019
|
|
6KJJ
| Functional and structural insights into the unusual oxyanion hole-like geometry in macrolactin acyltransferase selective for dicarboxylic acyl donors | Descriptor: | 4-(2-acetamidoethylsulfanyl)-4-oxidanylidene-butanoic acid, Putative beta-lactamase | Authors: | Xiao, F, Dong, S, Feng, Y, Li, W. | Deposit date: | 2019-07-22 | Release date: | 2020-07-29 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (2.492 Å) | Cite: | Structural Basis of Specificity for Carboxyl-Terminated Acyl Donors in a Bacterial Acyltransferase. J.Am.Chem.Soc., 142, 2020
|
|
6KBY
| Crystal structure of a class C beta lactamase in complex with AMP | Descriptor: | ADENOSINE MONOPHOSPHATE, Beta-lactamase | Authors: | Bae, D.W, Jung, Y.E, An, Y.J, Na, J.H, Cha, S.S. | Deposit date: | 2019-06-26 | Release date: | 2019-10-16 | Last modified: | 2019-11-06 | Method: | X-RAY DIFFRACTION (1.097 Å) | Cite: | Structural Insights into Catalytic Relevances of Substrate Poses in ACC-1. Antimicrob.Agents Chemother., 63, 2019
|
|
6KJE
| lovastatin esterase PcEST in complex with monacolin J | Descriptor: | (3R,5R)-3,5-dihydroxy-7-[(1S,2S,6R,8S,8aR)-8-hydroxy-2,6-dimethyl-1,2,6,7,8,8a-hexahydronaphthalen-1-yl]heptanoic acid, ACETATE ION, Pc15g00720 protein, ... | Authors: | Liang, Y.J, Lu, X.F. | Deposit date: | 2019-07-22 | Release date: | 2019-12-25 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (2.484 Å) | Cite: | Structural insights into the catalytic mechanism of lovastatin hydrolase J.Biol.Chem., 2019
|
|
6KJR
| Functional and structural insights into the unusual oxyanion hole-like geometry in macrolactin acyltransferase selective for dicarboxylic acyl donors | Descriptor: | 4-[[(3~{E},5~{Z},8~{S},9~{E},11~{E},14~{S},16~{R},17~{Z},19~{E},24~{R})-24-methyl-14,16-bis(oxidanyl)-2-oxidanylidene-1-oxacyclotetracosa-3,5,9,11,17,19-hexaen-8-yl]oxy]-4-oxidanylidene-butanoic acid, Putative beta-lactamase | Authors: | Xiao, F, Dong, S, Feng, Y, Li, W. | Deposit date: | 2019-07-23 | Release date: | 2020-07-29 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (2.361 Å) | Cite: | Structural Basis of Specificity for Carboxyl-Terminated Acyl Donors in a Bacterial Acyltransferase. J.Am.Chem.Soc., 142, 2020
|
|
7U1B
| Crystal structure of EstG in complex with tantalum cluster | Descriptor: | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, BICINE, Beta-lactamase domain-containing protein, ... | Authors: | Chen, Z, Gabelli, S.B. | Deposit date: | 2022-02-20 | Release date: | 2023-01-11 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (2.62 Å) | Cite: | EstG is a novel esterase required for cell envelope integrity in Caulobacter. Curr.Biol., 33, 2023
|
|
7U1C
| Structure of EstG crystalized with SO4 and Tris | Descriptor: | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, Beta-lactamase domain-containing protein, SODIUM ION, ... | Authors: | Gabelli, S.B, Chen, Z. | Deposit date: | 2022-02-20 | Release date: | 2023-01-11 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (2.09 Å) | Cite: | EstG is a novel esterase required for cell envelope integrity in Caulobacter. Curr.Biol., 33, 2023
|
|
4E6X
| ClbP in complex boron-based inhibitor | Descriptor: | ({[(chloromethyl)sulfonyl]amino}methyl)boronic acid, ClbP peptidase, PHOSPHATE ION | Authors: | Cougnoux, A, Delmas, J, Bonnet, R. | Deposit date: | 2012-03-16 | Release date: | 2013-03-27 | Last modified: | 2024-10-09 | Method: | X-RAY DIFFRACTION (2.24 Å) | Cite: | The NRP peptidase ClbP as a target for the inhibition
of genotoxicity, cell proliferation and tumorogenesis
mediated by pks-harboring bacteria To be Published
|
|
7TI1
| Structure of AmpC bound to RPX-7063 at 2.0A | Descriptor: | 1,2-ETHANEDIOL, Beta-lactamase, CHLORIDE ION, ... | Authors: | Clifton, M.C, Abendroth, J, Edwards, T.E, Hecker, S.J. | Deposit date: | 2022-01-12 | Release date: | 2023-01-25 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Broad-spectrum cyclic boronate beta-lactamase inhibitors featuring an intramolecular prodrug for oral bioavailability. Bioorg.Med.Chem., 62, 2022
|
|
4E6W
| ClbP in complex with 3-aminophenyl boronic acid | Descriptor: | ClbP peptidase, M-AMINOPHENYLBORONIC ACID, PHOSPHATE ION | Authors: | Cougnoux, A, Delmas, J, Bonnet, R. | Deposit date: | 2012-03-16 | Release date: | 2013-03-27 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (2.19 Å) | Cite: | The NRP peptidase ClbP as a target for the inhibition
of genotoxicity, cell proliferation and tumorogenesis
mediated by pks-harboring bacteria To be Published
|
|
7V21
| |
7V1Z
| human Serine beta-lactamase-like protein LACTB | Descriptor: | Serine beta-lactamase-like protein LACTB, mitochondrial | Authors: | Zhang, M.H, Yang, M.J. | Deposit date: | 2021-08-07 | Release date: | 2022-02-16 | Last modified: | 2024-06-12 | Method: | ELECTRON MICROSCOPY (2.98 Å) | Cite: | Structural basis for the catalytic activity of filamentous human serine beta-lactamase-like protein LACTB. Structure, 30, 2022
|
|
7V1Y
| |
4GDN
| Structure of FmtA-like protein | Descriptor: | 2-{2-[2-(2-{2-[2-(2-ETHOXY-ETHOXY)-ETHOXY]-ETHOXY}-ETHOXY)-ETHOXY]-ETHOXY}-ETHANOL, Protein flp | Authors: | Cougnoux, A, Gibold, L, Delmas, J, Robin, F, Dalmasso, G, Bonnet, R. | Deposit date: | 2012-08-01 | Release date: | 2012-10-03 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (3.2 Å) | Cite: | Analysis of Structure-Function Relationships in the Colibactin-Maturating Enzyme ClbP. J.Mol.Biol., 424, 2012
|
|