PDB: 594 resultsInfo pagesStatus searchChemie searchBIRD

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2MRK	Fyn SH2 domain in complex with the natural inhibitory phosphotyrosine peptide Descriptor: C-terminal Tyrosine-protein kinase Fyn, Tyrosine-protein kinase Fyn Authors: Huculeci, R, Buts, L, Lenaerts, A.J, van Nuland, N. Deposit date: 2014-07-09 Release date: 2015-07-15 Last modified: 2016-12-14 Method: SOLUTION NMR Cite: Dynamically Coupled Residues within the SH2 Domain of FYN Are Key to Unlocking Its Activity. Structure, 24, 2016
5TNW	Phospholipase C gamma-1 C-terminal SH2 domain Descriptor: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 Authors: Wuttke, D.S, McKercher, M.A. Deposit date: 2016-10-14 Release date: 2017-04-19 Last modified: 2023-10-04 Method: X-RAY DIFFRACTION (1.4 Å) Cite: Multimodal Recognition of Diverse Peptides by the C-Terminal SH2 Domain of Phospholipase C-gamma 1 Protein. Biochemistry, 56, 2017
5TO4	Phospholipase C gamma-1 C-terminal SH2 domain, spacegroup P212121 Descriptor: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 Authors: Wuttke, D.S, McKercher, M.A. Deposit date: 2016-10-16 Release date: 2017-04-19 Last modified: 2023-10-04 Method: X-RAY DIFFRACTION (1.7 Å) Cite: Multimodal Recognition of Diverse Peptides by the C-Terminal SH2 Domain of Phospholipase C-gamma 1 Protein. Biochemistry, 56, 2017
5TQ1	Phospholipase C gamma-1 C-terminal SH2 domain bound to a phosphopeptide derived from the insulin receptor Descriptor: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1, Insulin receptor Authors: Wuttke, D.S, McKercher, M.A. Deposit date: 2016-10-21 Release date: 2017-04-19 Last modified: 2023-11-15 Method: X-RAY DIFFRACTION (1.485 Å) Cite: Multimodal Recognition of Diverse Peptides by the C-Terminal SH2 Domain of Phospholipase C-gamma 1 Protein. Biochemistry, 56, 2017
5U06	Grb7-SH2 with bicyclic peptide inhibitor containing a pY mimetic Descriptor: Growth factor receptor-bound protein 7, POTASSIUM ION, bicyclic peptide inhibitor: LYS-PHE-GLU-GLY-CMF-ASP-ASN-GLU-CST Authors: Watson, G.M, Wilce, J.A. Deposit date: 2016-11-22 Release date: 2017-11-15 Last modified: 2020-01-08 Method: X-RAY DIFFRACTION (2.1 Å) Cite: Discovery, Development, and Cellular Delivery of Potent and Selective Bicyclic Peptide Inhibitors of Grb7 Cancer Target. J. Med. Chem., 60, 2017
5TQS	Phospholipase C gamma-1 C-terminal SH2 domain bound to a phosphopeptide derived from the receptor tyrosine kinase ErbB2 Descriptor: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1, Receptor protein-tyrosine kinase Authors: Wuttke, D.S, McKercher, M.A. Deposit date: 2016-10-24 Release date: 2017-04-19 Last modified: 2023-11-15 Method: X-RAY DIFFRACTION (1.876 Å) Cite: Multimodal Recognition of Diverse Peptides by the C-Terminal SH2 Domain of Phospholipase C-gamma 1 Protein. Biochemistry, 56, 2017
5TYI	Grb7 SH2 with bicyclic peptide containing pY mimetic Descriptor: Growth factor receptor-bound protein 7, Peptide inhibitor Authors: Watson, G.M, Wilce, M.C.J, Wilce, J.A. Deposit date: 2016-11-20 Release date: 2017-11-15 Last modified: 2023-11-15 Method: X-RAY DIFFRACTION (2.15 Å) Cite: Discovery, Development, and Cellular Delivery of Potent and Selective Bicyclic Peptide Inhibitors of Grb7 Cancer Target. J. Med. Chem., 60, 2017
5U1Q	Grb7-SH2 with bicyclic peptide inhibitor Descriptor: CHLORIDE ION, Growth factor receptor-bound protein 7, LYS-PHE-GLU-GLY-TYR-ASP-ASN-GLU-CST Authors: Watson, G.M, Wilce, M.C.J, Wilce, J.A. Deposit date: 2016-11-28 Release date: 2017-11-15 Last modified: 2020-01-08 Method: X-RAY DIFFRACTION (2.1 Å) Cite: Discovery, Development, and Cellular Delivery of Potent and Selective Bicyclic Peptide Inhibitors of Grb7 Cancer Target. J. Med. Chem., 60, 2017
1JYU	Xray Structure of Grb2 SH2 Domain Descriptor: GROWTH FACTOR RECEPTOR-BOUND PROTEIN 2 Authors: Nioche, P, Liu, W.-Q, Broutin, I, Charbonnier, F, Latreille, M.-T, Vidal, M, Roques, B, Garbay, C, Ducruix, A. Deposit date: 2001-09-13 Release date: 2002-03-13 Last modified: 2024-02-07 Method: X-RAY DIFFRACTION (2.75 Å) Cite: Crystal structures of the SH2 domain of Grb2: highlight on the binding of a new high-affinity inhibitor. J.Mol.Biol., 315, 2002
1JWO	Crystal Structure Analysis of the SH2 Domain of the Csk Homologous Kinase CHK Descriptor: Csk Homologous Kinase Authors: Murthy, T.V.S, Webster, G.D. Deposit date: 2001-09-04 Release date: 2001-09-12 Last modified: 2023-08-16 Method: X-RAY DIFFRACTION (2.5 Å) Cite: Recognition of the HER-2/neu Receptor by the SH2 Domain of the Csk Homologous Kinase To be Published
1JYQ	Xray Structure of Grb2 SH2 Domain Complexed with a Highly Affine Phospho Peptide Descriptor: GROWTH FACTOR RECEPTOR-BOUND PROTEIN 2, mAZ-pY-(alpha Me)pY-N-NH2 peptide inhibitor Authors: Nioche, P, Liu, W.-Q, Broutin, I, Charbonnier, F, Latreille, M.-T, Vidal, M, Roques, B, Garbay, C, Ducruix, A. Deposit date: 2001-09-13 Release date: 2002-03-13 Last modified: 2018-04-04 Method: X-RAY DIFFRACTION (2 Å) Cite: Crystal structures of the SH2 domain of Grb2: highlight on the binding of a new high-affinity inhibitor. J.Mol.Biol., 315, 2002
1KA7	SAP/SH2D1A bound to peptide n-Y-c Descriptor: SH2 DOMAIN PROTEIN 1A, peptide n-Y-c Authors: Hwang, P.M, Li, C, Morra, M, Lillywhite, J, Gertler, F, Terhorst, C, Kay, L.E, Pawson, T, Forman-Kay, J, Li, S.-C. Deposit date: 2001-10-31 Release date: 2001-11-07 Last modified: 2024-05-22 Method: SOLUTION NMR Cite: A "three-pronged" binding mechanism for the SAP/SH2D1A SH2 domain: structural basis and relevance to the XLP syndrome. EMBO J., 21, 2002
1KC2	structure of the triple (Lys(beta)D3Ala, Asp(beta)C8Ala, AspCD2Ala) mutant of the Src SH2 domain bound to the PQpYEEIPI peptide Descriptor: COBALT (II) ION, PQpYEEIPI peptide, Src Tyrosine kinase Authors: Lubman, O.Y, Waksman, G. Deposit date: 2001-11-07 Release date: 2002-04-17 Last modified: 2021-11-10 Method: X-RAY DIFFRACTION (2.1 Å) Cite: Dissection of the energetic coupling across the Src SH2 domain-tyrosyl phosphopeptide interface. J.Mol.Biol., 316, 2002
1KA6	SAP/SH2D1A bound to peptide n-pY Descriptor: SH2 DOMAIN PROTEIN 1A, peptide n-pY Authors: Hwang, P.M, Li, C, Morra, M, Lillywhite, J, Gertler, F, Terhorst, C, Kay, L.E, Pawson, T, Forman-Kay, J, Li, S.-C. Deposit date: 2001-10-31 Release date: 2001-11-07 Last modified: 2021-10-27 Method: SOLUTION NMR Cite: A "three-pronged" binding mechanism for the SAP/SH2D1A SH2 domain: structural basis and relevance to the XLP syndrome. EMBO J., 21, 2002
1LKK	HUMAN P56-LCK TYROSINE KINASE SH2 DOMAIN IN COMPLEX WITH THE PHOSPHOTYROSYL PEPTIDE AC-PTYR-GLU-GLU-ILE (PYEEI PEPTIDE) Descriptor: ACETYL GROUP, HUMAN P56 TYROSINE KINASE, PHOSPHOTYROSYL PEPTIDE AC-PTYR-GLU-GLU-ILE Authors: Tong, L. Deposit date: 1995-11-10 Release date: 1996-03-08 Last modified: 2024-06-05 Method: X-RAY DIFFRACTION (1 Å) Cite: Crystal structures of the human p56lck SH2 domain in complex with two short phosphotyrosyl peptides at 1.0 A and 1.8 A resolution. J.Mol.Biol., 256, 1996
1LKL	HUMAN P56-LCK TYROSINE KINASE SH2 DOMAIN IN COMPLEX WITH THE PHOSPHOTYROSYL PEPTIDE AC-PTYR-GLU-GLU-GLY (PYEEG PEPTIDE) Descriptor: HUMAN P56 TYROSINE KINASE, PHOSPHOTYROSYL PEPTIDE AC-PTYR-GLU-GLU-GLY Authors: Tong, L. Deposit date: 1995-11-10 Release date: 1996-03-08 Last modified: 2024-06-05 Method: X-RAY DIFFRACTION (1.8 Å) Cite: Crystal structures of the human p56lck SH2 domain in complex with two short phosphotyrosyl peptides at 1.0 A and 1.8 A resolution. J.Mol.Biol., 256, 1996
1LUN	NMR Structure of the Itk SH2 domain, Pro287trans, energy minimized average structure Descriptor: Tyrosine-protein kinase ITK/TSK Authors: Mallis, R.J, Brazin, K.N, Fulton, D.B, Andreotti, A.H. Deposit date: 2002-05-22 Release date: 2002-11-27 Last modified: 2022-02-23 Method: SOLUTION NMR Cite: Structural characterization of a proline-driven conformational switch within the Itk SH2 domain Nat.Struct.Biol., 9, 2002
1LUI	NMR Structures of Itk SH2 domain, Pro287cis isoform, ensemble of 20 low energy structures Descriptor: Tyrosine-protein kinase ITK/TSK Authors: Mallis, R.J, Brazin, K.N, Fulton, B.F, Andreotti, A.M. Deposit date: 2002-05-22 Release date: 2002-11-27 Last modified: 2022-02-23 Method: SOLUTION NMR Cite: Structural characterization of a proline-driven conformational switch within the Itk SH2 domain Nat.Struct.Biol., 9, 2002
1LUK	NMR Structure of the Itk SH2 domain, Pro287cis, Energy minimized average structure Descriptor: Tyrosine-protein kinase ITK/TSK Authors: Mallis, R.J, Brazin, K.N, Fulton, B.F, Andreotti, A.H. Deposit date: 2002-05-22 Release date: 2002-11-27 Last modified: 2022-02-23 Method: SOLUTION NMR Cite: Structural characterization of a proline-driven conformational switch within the Itk SH2 domain Nat.Struct.Biol., 9, 2002
1LCJ	SH2 (SRC HOMOLOGY-2) DOMAIN OF HUMAN P56-LCK TYROSINE KINASE COMPLEXED WITH THE 11 RESIDUE PHOSPHOTYROSYL PEPTIDE EPQPYEEIPIYL Descriptor: P56==LCK== TYROSINE KINASE, PHOSPHOPEPTIDE EPQ(PHOSPHO)YEEIPIYL Authors: Eck, M, Harrison, S. Deposit date: 1994-12-12 Release date: 1995-10-15 Last modified: 2024-06-05 Method: X-RAY DIFFRACTION (1.8 Å) Cite: Recognition of a high-affinity phosphotyrosyl peptide by the Src homology-2 domain of p56lck. Nature, 362, 1993
1MW4	Solution structure of the human Grb7-SH2 domain in complex with a 10 amino acid peptide pY1139 Descriptor: Growth factor receptor-bound protein 7, Receptor protein-tyrosine kinase erbB-2 Authors: Ivancic, M, Lyons, B.A. Deposit date: 2002-09-27 Release date: 2003-09-09 Last modified: 2012-05-02 Method: SOLUTION NMR Cite: Solution structure of the human Grb7-SH2 domain/erbB2 peptide complex and structural basis for Grb7 binding to ErbB2 J.BIOMOL.NMR, 27, 2003
1MIL	TRANSFORMING PROTEIN Descriptor: SHC ADAPTOR PROTEIN Authors: Mikol, V. Deposit date: 1995-09-20 Release date: 1996-11-08 Last modified: 2024-02-14 Method: X-RAY DIFFRACTION (2.7 Å) Cite: Crystal structure of the SH2 domain from the adaptor protein SHC: a model for peptide binding based on X-ray and NMR data. J.Mol.Biol., 254, 1995
1M61	Crystal structure of the apo SH2 domains of ZAP-70 Descriptor: PHOSPHATE ION, TYROSINE-PROTEIN KINASE ZAP-70 Authors: Folmer, R.H.A, Geschwindner, S, Xue, Y. Deposit date: 2002-07-11 Release date: 2003-07-15 Last modified: 2024-02-14 Method: X-RAY DIFFRACTION (2.5 Å) Cite: Crystal structure and NMR studies of the apo SH2 domains of ZAP-70: two bikes rather than a tandem Biochemistry, 41, 2002
1LUM	NMR Structure of the Itk SH2 domain, Pro287trans, 20 low energy structures Descriptor: Tyrosine-protein kinase ITK/TSK Authors: Mallis, R.J, Brazin, K.N, Fulton, D.B, Andreotti, A.H. Deposit date: 2002-05-22 Release date: 2002-11-27 Last modified: 2022-02-23 Method: SOLUTION NMR Cite: Structural characterization of a proline-driven conformational switch within the Itk SH2 domain Nat.Struct.Biol., 9, 2002
1O4Q	CRYSTAL STRUCTURE OF SH2 IN COMPLEX WITH RU79256. Descriptor: PHENYL(SULFO)ACETIC ACID, PROTO-ONCOGENE TYROSINE-PROTEIN KINASE SRC Authors: Lange, G, Loenze, P, Liesum, A. Deposit date: 2003-06-15 Release date: 2004-02-17 Last modified: 2023-08-16 Method: X-RAY DIFFRACTION (1.7 Å) Cite: Requirements for specific binding of low affinity inhibitor fragments to the SH2 domain of (pp60)Src are identical to those for high affinity binding of full length inhibitors. J.Med.Chem., 46, 2003

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