5KS7
 
 | | Crystal structure of Listeria monocytogenes OpuCA CBS domain dimer in complex with cyclic-di-AMP | | Descriptor: | (2R,3R,3aS,5R,7aR,9R,10R,10aS,12R,14aR)-2,9-bis(6-amino-9H-purin-9-yl)octahydro-2H,7H-difuro[3,2-d:3',2'-j][1,3,7,9,2,8 ]tetraoxadiphosphacyclododecine-3,5,10,12-tetrol 5,12-dioxide, Carnitine transport ATP-binding protein OpuCA | | Authors: | Choi, P.H, Tong, L. | | Deposit date: | 2016-07-07 | | Release date: | 2016-07-20 | | Last modified: | 2024-04-03 | | Method: | X-RAY DIFFRACTION (2.9 Å) | | Cite: | Cyclic di-AMP targets the cystathionine beta-synthase domain of the osmolyte transporter OpuC.
Mol.Microbiol., 102, 2016
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8IDW
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7PZA
 | | Structure of the Clr-cAMP-DNA complex | | Descriptor: | ADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE, DNA (5'-D(*CP*TP*AP*GP*GP*TP*AP*AP*CP*AP*TP*TP*AP*CP*TP*CP*GP)-3'), DNA (5'-D(*GP*CP*GP*AP*GP*TP*AP*AP*TP*GP*TP*TP*AP*C)-3'), ... | | Authors: | Werel, L, Essen, L.-O. | | Deposit date: | 2021-10-11 | | Release date: | 2022-11-02 | | Last modified: | 2024-02-07 | | Method: | X-RAY DIFFRACTION (2.72 Å) | | Cite: | Structural Basis of Dual Specificity of Sinorhizobium meliloti Clr, a cAMP and cGMP Receptor Protein.
Mbio, 14, 2023
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3IED
 | | Crystal structure of N-terminal domain of Plasmodium falciparum Hsp90 (PF14_0417) in complex with AMPPN | | Descriptor: | AMP PHOSPHORAMIDATE, Heat shock protein | | Authors: | Pizarro, J.C, Wernimont, A.K, Lew, J, Hutchinson, A, Artz, J.D, Amaya, M.F, Plotnikova, O, Vedadi, M, Kozieradzki, I, Weigelt, J, Edwards, A.M, Arrowsmith, C.H, Bountra, C, Botchkarev, A, Hui, R, Hills, T, Structural Genomics Consortium (SGC) | | Deposit date: | 2009-07-22 | | Release date: | 2009-08-25 | | Last modified: | 2023-09-06 | | Method: | X-RAY DIFFRACTION (2.01 Å) | | Cite: | Crystal structure of N-terminal domain of Plasmodium falciparum Hsp90 (PF14_0417) in complex with AMPPN
TO BE PUBLISHED
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8VUX
 | | Cryo-EM structure of human ABC transporter (hABCC1) bound to cGAMP | | Descriptor: | CHOLESTEROL HEMISUCCINATE, Multidrug resistance-associated protein 1, cGAMP | | Authors: | Shinde, O, Li, P. | | Deposit date: | 2024-01-30 | | Release date: | 2024-12-25 | | Last modified: | 2025-01-29 | | Method: | ELECTRON MICROSCOPY (3.54 Å) | | Cite: | Structures of ATP-binding cassette transporter ABCC1 reveal the molecular basis of cyclic dinucleotide cGAMP export.
Immunity, 58, 2025
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1T8S
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1T8W
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1T8R
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1T8Y
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8T00
 | | Reconstituted E. coli RNA polymerase post-termination complex on negatively-supercoiled DNA: closed duplex DNA (rPTCc) | | Descriptor: | DNA (26-MER), DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, ... | | Authors: | Brewer, J.J, Darst, S.A, Campbell, E.A. | | Deposit date: | 2023-05-31 | | Release date: | 2025-04-02 | | Last modified: | 2025-06-04 | | Method: | ELECTRON MICROSCOPY (4.69 Å) | | Cite: | RapA opens the RNA polymerase clamp to disrupt post-termination complexes and prevent cytotoxic R-loop formation.
Nat.Struct.Mol.Biol., 32, 2025
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8T0L
 | | E. coli Sw2/Snf2 ATPase RapA bound to both ADP-AlF3 and reconstituted E. coli RNA polymerase post-termination complex on negatively-supercoiled DNA | | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, ALUMINUM FLUORIDE, DNA (29-MER), ... | | Authors: | Brewer, J.J, Darst, S.A, Campbell, E.A. | | Deposit date: | 2023-06-01 | | Release date: | 2025-04-02 | | Last modified: | 2025-04-30 | | Method: | ELECTRON MICROSCOPY (3.62 Å) | | Cite: | RapA opens the RNA polymerase clamp to disrupt post-termination complexes and prevent cytotoxic R-loop formation.
Nat.Struct.Mol.Biol., 32, 2025
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8T02
 | | Reconstituted E. coli RNA polymerase post-termination complex on negatively-supercoiled DNA: unwinding duplex DNA (rPTCi) | | Descriptor: | DNA (25-MER), DNA (26-MER), DNA-directed RNA polymerase subunit alpha, ... | | Authors: | Brewer, J.J, Darst, S.A, Campbell, E.A. | | Deposit date: | 2023-05-31 | | Release date: | 2025-04-02 | | Last modified: | 2025-05-28 | | Method: | ELECTRON MICROSCOPY (3.79 Å) | | Cite: | RapA opens the RNA polymerase clamp to disrupt post-termination complexes and prevent cytotoxic R-loop formation.
Nat.Struct.Mol.Biol., 32, 2025
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1STC
 | | CAMP-DEPENDENT PROTEIN KINASE, ALPHA-CATALYTIC SUBUNIT IN COMPLEX WITH STAUROSPORINE | | Descriptor: | CAMP-DEPENDENT PROTEIN KINASE, PROTEIN KINASE INHIBITOR, STAUROSPORINE | | Authors: | Prade, L, Engh, R.A, Girod, A, Kinzel, V, Huber, R, Bossemeyer, D. | | Deposit date: | 1997-10-10 | | Release date: | 1998-02-25 | | Last modified: | 2024-11-20 | | Method: | X-RAY DIFFRACTION (2.3 Å) | | Cite: | Staurosporine-induced conformational changes of cAMP-dependent protein kinase catalytic subunit explain inhibitory potential.
Structure, 5, 1997
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5O4P
 | | Crystal structure of AMPylated GRP78 | | Descriptor: | 78 kDa glucose-regulated protein, ADENOSINE MONOPHOSPHATE, SULFATE ION | | Authors: | Yan, Y, Chen, R, Ron, D, Read, R. | | Deposit date: | 2017-05-30 | | Release date: | 2017-11-01 | | Last modified: | 2024-02-07 | | Method: | X-RAY DIFFRACTION (1.86 Å) | | Cite: | AMPylation targets the rate-limiting step of BiP's ATPase cycle for its functional inactivation.
Elife, 6, 2017
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8SI0
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1TXR
 | | X-ray crystal structure of bestatin bound to AAP | | Descriptor: | 2-(3-AMINO-2-HYDROXY-4-PHENYL-BUTYRYLAMINO)-4-METHYL-PENTANOIC ACID, Bacterial leucyl aminopeptidase, ZINC ION | | Authors: | Stamper, C.C, Holz, R.C, Ringe, D, Petsko, G.A. | | Deposit date: | 2004-07-06 | | Release date: | 2004-07-20 | | Last modified: | 2024-11-06 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | Spectroscopic and X-ray Crystallographic Characterization of Bestatin Bound to the Aminopeptidase from Aeromonas (Vibrio) proteolytica.
Biochemistry, 43, 2004
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8SZW
 | | Reconstituted E. coli RNA polymerase post-termination complex on negatively-supercoiled DNA: open duplex DNA (rPTCo) | | Descriptor: | DNA (25-MER), DNA (27-MER), DNA-directed RNA polymerase subunit alpha, ... | | Authors: | Brewer, J.J, Darst, S.A, Campbell, E.A. | | Deposit date: | 2023-05-30 | | Release date: | 2025-04-02 | | Last modified: | 2025-04-30 | | Method: | ELECTRON MICROSCOPY (3.63 Å) | | Cite: | RapA opens the RNA polymerase clamp to disrupt post-termination complexes and prevent cytotoxic R-loop formation.
Nat.Struct.Mol.Biol., 32, 2025
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2I9D
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2VHE
 | | PglD-CoA complex: An acetyl transferase from Campylobacter jejuni | | Descriptor: | ACETYLTRANSFERASE, COENZYME A, SULFATE ION | | Authors: | Rangarajan, E.S, Ruane, K.M, Sulea, T, Watson, D.C, Proteau, A, Leclerc, S, Cygler, M, Matte, A, Young, N.M. | | Deposit date: | 2007-11-21 | | Release date: | 2008-01-29 | | Last modified: | 2024-01-31 | | Method: | X-RAY DIFFRACTION (1.8 Å) | | Cite: | Structure and Active Site Residues of Pgld, an N-Acetyltransferase from the Bacillosamine Synthetic Pathway Required for N-Glycan Synthesis in Campylobacter Jejuni
Biochemistry, 47, 2008
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6F9V
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7MWZ
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7RWS
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6E68
 | | NAMPT co-crystal with inhibitor compound 2 | | Descriptor: | (2E)-N-{4-[1-(3-aminobenzene-1-carbonyl)piperidin-4-yl]butyl}-3-(pyridin-3-yl)prop-2-enamide, Nicotinamide phosphoribosyltransferase, PHOSPHATE ION | | Authors: | Waight, A.B, Neumann, C.S. | | Deposit date: | 2018-07-24 | | Release date: | 2018-08-08 | | Last modified: | 2023-10-11 | | Method: | X-RAY DIFFRACTION (1.5 Å) | | Cite: | NAMPT co-crystal with inhibitor compound 2
to be published
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7RQD
 | | Crystal structure of the Thermus thermophilus 70S ribosome in complex with protein Y, A-site deacylated tRNA analog CACCA, P-site MTI-tripeptidyl-tRNA analog ACCA-ITM, and chloramphenicol at 2.50A resolution | | Descriptor: | (4S)-2-METHYL-2,4-PENTANEDIOL, 16S Ribosomal RNA, 23S Ribosomal RNA, ... | | Authors: | Syroegin, E.A, Flemmich, L, Klepacki, D, Vazquez-Laslop, N, Micura, R, Polikanov, Y.S. | | Deposit date: | 2021-08-06 | | Release date: | 2022-01-26 | | Last modified: | 2025-03-19 | | Method: | X-RAY DIFFRACTION (2.5 Å) | | Cite: | Structural basis for the context-specific action of the classic peptidyl transferase inhibitor chloramphenicol.
Nat.Struct.Mol.Biol., 29, 2022
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6X80
 | | Structure of the Campylobacter jejuni G508A Flagellar Filament | | Descriptor: | 5,7-diamino-3,5,7,9-tetradeoxy-L-glycero-alpha-L-manno-non-2-ulopyranosonic acid, Flagellin A | | Authors: | Kreutzberger, M.A.B, Wang, F, Egelman, E.H. | | Deposit date: | 2020-06-01 | | Release date: | 2020-07-08 | | Last modified: | 2025-06-04 | | Method: | ELECTRON MICROSCOPY (3.5 Å) | | Cite: | Atomic structure of the Campylobacter jejuni flagellar filament reveals how epsilon Proteobacteria escaped Toll-like receptor 5 surveillance.
Proc.Natl.Acad.Sci.USA, 117, 2020
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