4JJM
 
 | | Structure of a cyclophilin from Citrus sinensis (CsCyp) in complex with cyclosporin A | | Descriptor: | Peptidyl-prolyl cis-trans isomerase, cyclosporin A | | Authors: | Campos, B.M, Ambrosio, A.L.B, Souza, T.A.C.B, Barbosa, J.A.R.G, Benedetti, C.E. | | Deposit date: | 2013-03-08 | | Release date: | 2013-06-12 | | Last modified: | 2023-12-06 | | Method: | X-RAY DIFFRACTION (2.09 Å) | | Cite: | A redox 2-cys mechanism regulates the catalytic activity of divergent cyclophilins.
Plant Physiol., 162, 2013
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5VC0
 | | Crystal structure of human CYP3A4 bound to ritonavir | | Descriptor: | Cytochrome P450 3A4, PROTOPORPHYRIN IX CONTAINING FE, RITONAVIR | | Authors: | Sevrioukova, I. | | Deposit date: | 2017-03-30 | | Release date: | 2017-05-31 | | Last modified: | 2023-10-04 | | Method: | X-RAY DIFFRACTION (2.7 Å) | | Cite: | High-Level Production and Properties of the Cysteine-Depleted Cytochrome P450 3A4.
Biochemistry, 56, 2017
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5VCC
 | | Crystal structure of human CYP3A4 bound to glycerol | | Descriptor: | 1,2-ETHANEDIOL, Cytochrome P450 3A4, GLYCEROL, ... | | Authors: | Sevrioukova, I. | | Deposit date: | 2017-03-31 | | Release date: | 2017-05-31 | | Last modified: | 2023-10-04 | | Method: | X-RAY DIFFRACTION (1.7 Å) | | Cite: | High-Level Production and Properties of the Cysteine-Depleted Cytochrome P450 3A4.
Biochemistry, 56, 2017
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1KMJ
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5YZF
 | | X-ray crystal structure of met K42C sperm whale myoglobin | | Descriptor: | PROTOPORPHYRIN IX CONTAINING FE, sperm whale myoglobin | | Authors: | Yuan, H. | | Deposit date: | 2017-12-14 | | Release date: | 2018-03-07 | | Last modified: | 2023-11-22 | | Method: | X-RAY DIFFRACTION (1.77 Å) | | Cite: | Formation of Cys-heme cross-link in K42C myoglobin under reductive conditions with molecular oxygen
J. Inorg. Biochem., 182, 2018
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5LG3
 | | X-ray structure of a pentameric ligand gated ion channel from Erwinia chrysanthemi (ELIC) in complex with chlorpromazine | | Descriptor: | 3-(2-chloro-10H-phenothiazin-10-yl)-N,N-dimethylpropan-1-amine, Gamma-aminobutyric-acid receptor subunit beta-1 | | Authors: | Nys, M, Wijckmans, E, Farinha, A, Brams, M, Spurny, R, Ulens, C. | | Deposit date: | 2016-07-05 | | Release date: | 2016-10-26 | | Last modified: | 2024-01-31 | | Method: | X-RAY DIFFRACTION (3.567 Å) | | Cite: | Allosteric binding site in a Cys-loop receptor ligand-binding domain unveiled in the crystal structure of ELIC in complex with chlorpromazine.
Proc.Natl.Acad.Sci.USA, 113, 2016
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8YX6
 | | Structure of a Cys-loop Receptor in Zinc Binding State | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Ligand-gated cation channel ZACN, ... | | Authors: | Lu, X.H, Yang, X, Shen, Y.Q. | | Deposit date: | 2024-04-02 | | Release date: | 2025-01-01 | | Method: | ELECTRON MICROSCOPY (2.9 Å) | | Cite: | Structure of a Cys-loop Receptor in Zinc Binding State
To Be Published
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8YX7
 | | Structure of a Cys-loop Receptor under Acidic Condition | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Ligand-gated cation channel ZACN | | Authors: | Lu, X.H, Yang, X, Shen, Y.Q. | | Deposit date: | 2024-04-02 | | Release date: | 2025-01-01 | | Method: | ELECTRON MICROSCOPY (2.8 Å) | | Cite: | Structure of a Cys-loop Receptor under Acidic Condition
To Be Published
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3KM6
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3WNC
 | | Crystal structure of EF-Pyl in complex with GDP | | Descriptor: | GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, Protein translation elongation factor 1A | | Authors: | Yanagisawa, T, Ishii, R, Fukunaga, R, Sengoku, T, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI) | | Deposit date: | 2013-12-08 | | Release date: | 2014-12-10 | | Last modified: | 2024-10-16 | | Method: | X-RAY DIFFRACTION (1.9 Å) | | Cite: | A SelB/EF-Tu/aIF2 gamma-like protein from Methanosarcina mazei in the GTP-bound form binds cysteinyl-tRNA(Cys.).
J. Struct. Funct. Genomics, 16, 2015
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3WNB
 | | Crystal structure of EF-Pyl in complex with GMPPNP | | Descriptor: | MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER, Protein translation elongation factor 1A | | Authors: | Yanagisawa, T, Ishii, R, Fukunaga, R, Sengoku, T, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI) | | Deposit date: | 2013-12-08 | | Release date: | 2014-12-10 | | Last modified: | 2024-11-20 | | Method: | X-RAY DIFFRACTION (1.7 Å) | | Cite: | A SelB/EF-Tu/aIF2 gamma-like protein from Methanosarcina mazei in the GTP-bound form binds cysteinyl-tRNA(Cys.).
J. Struct. Funct. Genomics, 16, 2015
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2WPN
 | | Structure of the oxidised, as-isolated NiFeSe hydrogenase from D. vulgaris Hildenborough | | Descriptor: | 3-[DODECYL(DIMETHYL)AMMONIO]PROPANE-1-SULFONATE, BIS-(MU-2-OXO),[(MU-3--SULFIDO)-BIS(MU-2--SULFIDO)-TRIS(CYS-S)-TRI-IRON] (AQUA)(GLU-O)IRON(II), CARBONMONOXIDE-(DICYANO) IRON, ... | | Authors: | Marques, M.C, Coelho, R, De Lacey, A.L, Pereira, I.A.C, Matias, P.M. | | Deposit date: | 2009-08-07 | | Release date: | 2010-01-12 | | Last modified: | 2025-04-09 | | Method: | X-RAY DIFFRACTION (2.04 Å) | | Cite: | The three-dimensional structure of [NiFeSe] hydrogenase from Desulfovibrio vulgaris Hildenborough: a hydrogenase without a bridging ligand in the active site in its oxidised, "as-isolated" state.
J.Mol.Biol., 396, 2010
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1OEV
 | | Oxidation state of protein tyrosine phosphatase 1B | | Descriptor: | MAGNESIUM ION, PROTEIN-TYROSINE PHOSPHATASE, NON-RECEPTOR TYPE 1 | | Authors: | van Montfort, R.L.M, Congreve, M, Tisi, D, Carr, R, Jhoti, H. | | Deposit date: | 2003-03-31 | | Release date: | 2003-06-12 | | Last modified: | 2023-12-13 | | Method: | X-RAY DIFFRACTION (2.2 Å) | | Cite: | Oxidation state of the active-site cysteine in protein tyrosine phosphatase 1B.
Nature, 423, 2003
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5OJT
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2IFQ
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3R1R
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1M2A
 | | Crystal structure at 1.5 Angstroms resolution of the wild type thioredoxin-like [2Fe-2S] ferredoxin from Aquifex aeolicus | | Descriptor: | FE2/S2 (INORGANIC) CLUSTER, SULFATE ION, ZINC ION, ... | | Authors: | Yeh, A.P, Ambroggio, X.I, Andrade, S.L.A, Einsle, O, Chatelet, C, Meyer, J, Rees, D.C. | | Deposit date: | 2002-06-22 | | Release date: | 2002-09-18 | | Last modified: | 2024-02-14 | | Method: | X-RAY DIFFRACTION (1.5 Å) | | Cite: | High-resolution crystal structures of the wild type and
Cys-55-->Ser and Cys-59-->Ser variants of the thioredoxin-like
[2Fe-2S] ferredoxin from Aquifex aeolicus
J.Biol.Chem., 277, 2002
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4KUF
 | | Crystal structure of the catalytic domain of botulinum neurotoxin BoNT/A C134 mutant with MTSEA modified Cys-165 causing stretch disorder | | Descriptor: | (2S)-2-hydroxybutanedioic acid, 1,2-ETHANEDIOL, Botulinum neurotoxin A light chain, ... | | Authors: | Stura, E.A, Vera, L, Ptchelkine, D, Bakirci, H, Garcia, S, Dive, V. | | Deposit date: | 2013-05-22 | | Release date: | 2014-07-09 | | Last modified: | 2023-09-20 | | Method: | X-RAY DIFFRACTION (1.697 Å) | | Cite: | Covalent modification of the active site cysteine stresses Clostridium botulinum neurotoxin A
To be Published
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3U8T
 | | Human thrombin complexed with D-Phe-Pro-D-Arg-Cys | | Descriptor: | (4S)-2-METHYL-2,4-PENTANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, CHLORIDE ION, ... | | Authors: | Figueiredo, A.C, Clement, C.C, Philipp, M, Pereira, P.J.B. | | Deposit date: | 2011-10-17 | | Release date: | 2012-04-11 | | Last modified: | 2024-10-30 | | Method: | X-RAY DIFFRACTION (1.861 Å) | | Cite: | Rational design and characterization of d-phe-pro-d-arg-derived direct thrombin inhibitors.
Plos One, 7, 2012
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7LVZ
 | | Crystal structure of ADO | | Descriptor: | 2-aminoethanethiol dioxygenase, CHLORIDE ION, FE (II) ION, ... | | Authors: | Bingman, C.A, Fernandez, R.L, Smith, R.W, Fox, B.G, Brunold, T.C. | | Deposit date: | 2021-02-26 | | Release date: | 2022-01-05 | | Last modified: | 2024-04-03 | | Method: | X-RAY DIFFRACTION (1.89 Å) | | Cite: | The Crystal Structure of Cysteamine Dioxygenase Reveals the Origin of the Large Substrate Scope of This Vital Mammalian Enzyme.
Biochemistry, 60, 2021
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2IIY
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1OEU
 | | Oxidation state of protein tyrosine phosphatase 1B | | Descriptor: | MAGNESIUM ION, PROTEIN-TYROSINE PHOSPHATASE, NON-RECEPTOR TYPE 1 | | Authors: | van Montfort, R.L.M, Congreve, M, Tisi, D, Carr, R, Jhoti, H. | | Deposit date: | 2003-03-31 | | Release date: | 2003-06-12 | | Last modified: | 2024-11-13 | | Method: | X-RAY DIFFRACTION (2.5 Å) | | Cite: | Oxidation state of the active-site cysteine in protein tyrosine phosphatase 1B.
Nature, 423, 2003
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8YX8
 | | Structure of a Cys-loop Receptor in Apo State | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Ligand-gated cation channel ZACN | | Authors: | Lu, X.H, Yang, X, Shen, Y.Q. | | Deposit date: | 2024-04-02 | | Release date: | 2025-01-01 | | Method: | ELECTRON MICROSCOPY (2.8 Å) | | Cite: | Structure of a Cys-loop Receptor in Apo State
To Be Published
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6E8L
 | | Crystal Structure of Alkyl hydroperoxidase D (AhpD) from Streptococcus pneumoniae (Strain D39/ NCTC 7466) | | Descriptor: | Alkyl hydroperoxide reductase AhpD | | Authors: | Meng, Y, Davies, J, North, R, Coombes, D, Horne, C, Hampton, M, Dobson, R. | | Deposit date: | 2018-07-30 | | Release date: | 2019-08-28 | | Last modified: | 2024-03-13 | | Method: | X-RAY DIFFRACTION (2.3 Å) | | Cite: | Structure-function analyses of alkylhydroperoxidase D fromStreptococcus pneumoniaereveal an unusual three-cysteine active site architecture.
J.Biol.Chem., 295, 2020
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5XG8
 | | Galectin-13/Placental Protein 13 variant R53H crystal structure | | Descriptor: | GLYCEROL, Galactoside-binding soluble lectin 13 | | Authors: | Wang, Y, Su, J.Y. | | Deposit date: | 2017-04-12 | | Release date: | 2018-01-31 | | Last modified: | 2024-11-13 | | Method: | X-RAY DIFFRACTION (1.55 Å) | | Cite: | Galectin-13, a different prototype galectin, does not bind beta-galacto-sides and forms dimers via intermolecular disulfide bridges between Cys-136 and Cys-138
Sci Rep, 8, 2018
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