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5OJT

Structure-Activity Relationships and Biological Characterization of a Novel, Potent and Serum Stable C-X-C chemokine receptor type 4 (CXCR4) Antagonist

Summary for 5OJT
Entry DOI10.2210/pdb5ojt/pdb
NMR InformationBMRB: 34165
DescriptorACE-ARG-ALA-(D)CYS-ARG-BNA-HIS-PEN (1 entity in total)
Functional Keywordscxcr4, peptide binding protein
Biological sourceHomo sapiens (Human)
Total number of polymer chains1
Total formula weight999.24
Authors
Brancaccio, D.,Carotenuto, A. (deposition date: 2017-07-24, release date: 2017-11-22, Last modification date: 2023-11-15)
Primary citationDi Maro, S.,Di Leva, F.S.,Trotta, A.M.,Brancaccio, D.,Portella, L.,Aurilio, M.,Tomassi, S.,Messere, A.,Sementa, D.,Lastoria, S.,Carotenuto, A.,Novellino, E.,Scala, S.,Marinelli, L.
Structure-Activity Relationships and Biological Characterization of a Novel, Potent, and Serum Stable C-X-C Chemokine Receptor Type 4 (CXCR4) Antagonist.
J. Med. Chem., 60:9641-9652, 2017
Cited by
PubMed: 29125295
DOI: 10.1021/acs.jmedchem.7b01062
PDB entries with the same primary citation
Experimental method
SOLUTION NMR
Structure validation

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