PDB: 45953 resultsInfo pagesStatus searchChemie searchBIRD

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7WZW	Cryo-EM structure of MEC1-DDC2-MMS Descriptor: DNA damage checkpoint protein LCD1, Serine/threonine-protein kinase MEC1 Authors: Zhang, Q, Zhang, Q. Deposit date: 2022-02-19 Release date: 2023-03-01 Last modified: 2024-06-26 Method: ELECTRON MICROSCOPY (4 Å) Cite: Structures of Mec1/ATR kinase endogenously stimulated by different genotoxins. Cell Discov, 8, 2022
7L69	Crystal structure of human polymerase eta complexed with syn N7-benzylguanine Descriptor: DNA (5'-D(*AP*GP*TP*GP*TP*GP*AP*G)-3'), DNA (5'-D(*CP*AP*TP*(7BG)P*CP*TP*CP*AP*CP*AP*CP*T)-3'), DNA polymerase eta Authors: Jung, H, Lee, S. Deposit date: 2020-12-23 Release date: 2022-01-05 Last modified: 2023-10-18 Method: X-RAY DIFFRACTION (1.91 Å) Cite: Crystal structure of human polymerase eta complexed with syn N7-benzylguanine To Be Published
2KW3	Heterotrimeric interaction between RFX5 and RFXAP Descriptor: DNA-binding protein RFX5, Regulatory factor X-associated protein Authors: Laird, K.M, Briggs, L.L, Boss, J.M, Summers, M.F, Garvie, C.W. Deposit date: 2010-03-30 Release date: 2010-08-25 Last modified: 2024-05-01 Method: SOLUTION NMR Cite: Solution structure of the heterotrimeric complex between RFX5 and RFXAP reveals molecular details associated with MHCII gene expression To be Published
7WZR	Cryo-EM structure of Mec1-HU Descriptor: DNA damage checkpoint protein LCD1, Serine/threonine-protein kinase MEC1 Authors: Zhang, Q, Zhang, Q. Deposit date: 2022-02-19 Release date: 2023-03-08 Last modified: 2024-06-26 Method: ELECTRON MICROSCOPY (4.7 Å) Cite: Structures of Mec1/ATR kinase endogenously stimulated by different genotoxins. Cell Discov, 8, 2022
4Z5T	The nucleosome containing human H3.5 Descriptor: DNA (146-MER), Histone H2A type 1-B/E, Histone H2B type 1-J, ... Authors: Urahama, T, Harada, A, Maehara, K, Horikoshi, N, Sato, K, Sato, Y, Shiraishi, K, Sugino, N, Osakabe, A, Tachiwana, H, Kagawa, W, Kimura, H, Ohkawa, Y, Kurumizaka, H. Deposit date: 2015-04-03 Release date: 2016-02-10 Last modified: 2023-11-08 Method: X-RAY DIFFRACTION (2.8 Å) Cite: Histone H3.5 forms an unstable nucleosome and accumulates around transcription start sites in human testis. Epigenetics Chromatin, 9, 2016
4K4V	Poliovirus polymerase elongation complex (r5+1_form) Descriptor: DNA/RNA (5'-R(*UP*GP*UP*UP*CP*GP*AP*CP*GP*AP*GP*AP*GP*AP*GP*A)-D(P*C)-3'), RNA (5'-R(*AP*AP*GP*UP*CP*UP*CP*CP*AP*GP*GP*UP*CP*UP*CP*UP*CP*UP*CP*GP*UP*CP*GP*AP*AP*A)-3'), RNA-directed RNA polymerase 3D-POL, ... Authors: Gong, P, Peersen, O.B. Deposit date: 2013-04-12 Release date: 2013-05-22 Last modified: 2024-02-28 Method: X-RAY DIFFRACTION (2.63 Å) Cite: Structures of coxsackievirus, rhinovirus, and poliovirus polymerase elongation complexes solved by engineering RNA mediated crystal contacts. Plos One, 8, 2013
7D3V	Non-specific and specific interactions work cooperatively to promote cytidine deamination catalyzed by APOBEC3A Descriptor: DNA (5'-D(*AP*TP*TP*TP*TP*CP*AP*AP*TP*T)-3'), DNA dC->dU-editing enzyme APOBEC-3A, ZINC ION Authors: Cao, C.Y, Liu, Y.P, Lan, W.X. Deposit date: 2020-09-21 Release date: 2021-10-06 Last modified: 2024-05-15 Method: SOLUTION NMR Cite: Non-specific and specific interactions work cooperatively to promote cytidine deamination catalyzed by APOBEC3 To Be Published
3BUA	Crystal Structure of TRF2 TRFH domain and APOLLO peptide complex Descriptor: DNA cross-link repair 1B protein, Telomeric repeat-binding factor 2 Authors: Chen, Y, Yang, Y, van Overbeek, M, Donigian, J.R, Baciu, P, de Lange, T, Lei, M. Deposit date: 2008-01-02 Release date: 2008-02-19 Last modified: 2023-08-30 Method: X-RAY DIFFRACTION (2.5 Å) Cite: A shared docking motif in TRF1 and TRF2 used for differential recruitment of telomeric proteins. Science, 319, 2008
3NHZ	Structure of N-terminal Domain of MtrA Descriptor: MAGNESIUM ION, Two component system transcriptional regulator mtrA Authors: Barbieri, C.M, Mack, T.R, Robinson, V.L, Miller, M.T, Stock, A.M. Deposit date: 2010-06-14 Release date: 2010-08-11 Last modified: 2023-09-06 Method: X-RAY DIFFRACTION (2.5 Å) Cite: Regulation of response regulator autophosphorylation through interdomain contacts. J.Biol.Chem., 285, 2010
1ZAY	PURINE REPRESSOR-HYPOXANTHINE-MODIFIED-PURF-OPERATOR COMPLEX Descriptor: DNA (5'-D(*AP*AP*CP*GP*AP*AP*AP*AP*TP*(1AP)P*TP*TP*TP*TP*CP*GP*T)-3'), HYPOXANTHINE, PROTEIN (PURINE REPRESSOR) Authors: Zheleznova, E.E, Brennan, R.G. Deposit date: 1998-12-16 Release date: 1999-12-16 Last modified: 2023-08-23 Method: X-RAY DIFFRACTION (2.7 Å) Cite: The Roles of Exocyclic Groups in the Central Base-Pair Step in Modulating the Affinity of PurR for its Operator To be Published
1AGO	THE SOLUTION NMR STRUCTURE OF AN (S)-A-(N6-ADENYL)-STYRENE OXIDE-RAS61 OLIGODEOXYNUCLEOTIDE MODIFIED AT THE THIRD POSITION OF THE CODON 61 REGION, MINIMIZED AVERAGE STRUCTURE Descriptor: DNA (5'-D(*CP*GP*GP*AP*CP*AP*YP*GP*AP*AP*G)-3'), DNA (5'-D(*CP*TP*TP*CP*TP*TP*GP*TP*CP*CP*G)-3') Authors: Feng, B, Stone, M.P. Deposit date: 1997-03-25 Release date: 1997-08-20 Last modified: 2024-05-22 Method: SOLUTION NMR Cite: Major groove (S)-alpha-(N6-adenyl)styrene oxide adducts in an oligodeoxynucleotide containing the human N-ras codon 61 sequence: conformations of the S(61,2) and S(61,3) sequence isomers from 1H NMR. Biochemistry, 35, 1996
1AGZ	THE SOLUTION NMR STRUCTURE OF AN (R)-A-(N6-ADENYL)-STYRENE OXIDE-RAS61 OLIGODEOXYNUCLEOTIDE MODIFIED AT THE THIRD POSITION OF THE CODON 61 REGION, MINIMIZED AVERAGE STRUCTURE Descriptor: DNA (5'-D(*CP*GP*GP*AP*CP*AP*RP*GP*AP*AP*G)-3'), DNA (5'-D(*CP*TP*TP*CP*TP*TP*GP*TP*CP*CP*G)-3') Authors: Feng, B, Stone, M.P. Deposit date: 1997-03-26 Release date: 1997-08-20 Last modified: 2024-05-22 Method: SOLUTION NMR Cite: Major groove (R)-alpha-(N6-adenyl)styrene oxide adducts in an oligodeoxynucleotide containing the human N-ras codon 61 sequence: conformations of the R(61,2) and R(61,3) sequence isomers from 1H NMR. Biochemistry, 34, 1995
5MLU	Crystal structure of the PFV GAG CBS bound to a mononucleosome Descriptor: DNA (145-MER), Histone H2A type 1, Histone H2B, ... Authors: Pye, V.E, Maskell, D.P, Lesbats, P, Cherepanov, P. Deposit date: 2016-12-07 Release date: 2017-05-10 Last modified: 2024-01-17 Method: X-RAY DIFFRACTION (2.8 Å) Cite: Structural basis for spumavirus GAG tethering to chromatin. Proc. Natl. Acad. Sci. U.S.A., 114, 2017
332D	CRYSTAL STRUCTURE OF R(GUGUGUA)D(C) WITH TANDEM G-U/U-G WOBBLE PAIRS WITH STRAND SLIPPAGE Descriptor: DNA/RNA (5'-R(*GP*UP*GP*UP*GP*UP*AP*)-D(*C)-3') Authors: Biswas, R, Sundaralingam, M. Deposit date: 1997-05-14 Release date: 1997-09-23 Last modified: 2024-04-03 Method: X-RAY DIFFRACTION (1.58 Å) Cite: Crystal structure of r(GUGUGUA)dC with tandem G x U/U x G wobble pairs with strand slippage. J.Mol.Biol., 270, 1997
5FOS	HUMANISED MONOMERIC RADA IN COMPLEX WITH OLIGOMERISATION PEPTIDE Descriptor: DNA REPAIR AND RECOMBINATION PROTEIN RADA, GLYCEROL, PHOSPHATE ION Authors: Sharpe, T, Moschetti, T, Fischer, G, Marsh, M, Blundell, T.L, Abell, C, Hyvonen, M. Deposit date: 2015-11-26 Release date: 2016-10-19 Last modified: 2024-02-07 Method: X-RAY DIFFRACTION (1.35 Å) Cite: Engineering Archeal Surrogate Systems for the Development of Protein-Protein Interaction Inhibitors against Human RAD51. J.Mol.Biol., 428, 2016
4MDB	Structure of Mos1 transposase catalytic domain and Raltegravir with Mg Descriptor: MAGNESIUM ION, Mariner Mos1 transposase, N-(4-fluorobenzyl)-5-hydroxy-1-methyl-2-(1-methyl-1-{[(5-methyl-1,3,4-oxadiazol-2-yl)carbonyl]amino}ethyl)-6-oxo-1,6-di hydropyrimidine-4-carboxamide Authors: Richardson, J.M. Deposit date: 2013-08-22 Release date: 2014-01-22 Last modified: 2023-09-20 Method: X-RAY DIFFRACTION (1.7 Å) Cite: Structural Basis of Mos1 Transposase Inhibition by the Anti-retroviral Drug Raltegravir. Acs Chem.Biol., 9, 2014
4MDA	Structure of Mos1 transposase catalytic domain and Raltegravir with Mn Descriptor: MANGANESE (II) ION, Mariner Mos1 transposase, N-(4-fluorobenzyl)-5-hydroxy-1-methyl-2-(1-methyl-1-{[(5-methyl-1,3,4-oxadiazol-2-yl)carbonyl]amino}ethyl)-6-oxo-1,6-di hydropyrimidine-4-carboxamide Authors: Richardson, J.M. Deposit date: 2013-08-22 Release date: 2014-01-22 Last modified: 2023-09-20 Method: X-RAY DIFFRACTION (1.7 Å) Cite: Structural Basis of Mos1 Transposase Inhibition by the Anti-retroviral Drug Raltegravir. Acs Chem.Biol., 9, 2014
1AGK	THE SOLUTION NMR STRUCTURE OF AN (R)-A-(N6-ADENYL)-STYRENE OXIDE-RAS61 OLIGODEOXYNUCLEOTIDE MODIFIED AT THE SECOND POSITION OF THE CODON 61 REGION, MINIMIZED AVERAGE STRUCTURE Descriptor: DNA (5'-D(*CP*GP*GP*AP*CP*RP*AP*GP*AP*AP*G)-3'), DNA (5'-D(*CP*TP*TP*CP*TP*TP*GP*TP*CP*CP*G)-3') Authors: Feng, B, Stone, M.P. Deposit date: 1997-03-25 Release date: 1997-08-20 Last modified: 2024-05-22 Method: SOLUTION NMR Cite: Major groove (R)-alpha-(N6-adenyl)styrene oxide adducts in an oligodeoxynucleotide containing the human N-ras codon 61 sequence: conformations of the R(61,2) and R(61,3) sequence isomers from 1H NMR. Biochemistry, 34, 1995
1QKL	hRPABC14.4, essential subunit of human RNA polymerases I, II and III Descriptor: DNA-DIRECTED RNA POLYMERASE II 14.4 KD POLYPEPTIDE Authors: Del Rio-Portilla, F, Gaskell, A.G, Gilbert, D, Ladias, J.A.A, Wagner, G. Deposit date: 1999-07-26 Release date: 1999-11-07 Last modified: 2024-05-15 Method: SOLUTION NMR Cite: Solution Structure of the Hrpabc14.4 Subunit of Human RNA Polymerases Nat.Struct.Biol., 6, 1999
7Z5I	Transcription factor MYF5 bound to symmetrical site Descriptor: DNA (5'-D(P*AP*CP*GP*CP*GP*TP*CP*AP*GP*CP*TP*GP*AP*CP*GP*CP*GP*C)-3'), DNA (5'-D(P*GP*CP*GP*CP*GP*TP*CP*AP*GP*CP*TP*GP*AP*CP*GP*CP*GP*T)-3'), Myogenic factor 5 Authors: Morgunova, E, Popov, A, Yin, Y, Taipale, J. Deposit date: 2022-03-09 Release date: 2023-03-22 Last modified: 2024-02-07 Method: X-RAY DIFFRACTION (3 Å) Cite: Transcription factor MYF5 bound to symmetrical site To Be Published
7Z5K	Transcription factor MYF5 bound to non-symmetrical site Descriptor: DNA (5'-D(P*AP*CP*GP*CP*GP*TP*CP*AP*GP*CP*TP*GP*TP*TP*GP*CP*GP*C)-3'), DNA (5'-D(P*GP*CP*GP*CP*AP*AP*CP*AP*GP*CP*TP*GP*AP*CP*GP*CP*GP*T)-3'), Myogenic factor 5 Authors: Morgunova, E, Popov, A, Yin, Y, Taipale, J. Deposit date: 2022-03-09 Release date: 2023-03-22 Last modified: 2024-02-07 Method: X-RAY DIFFRACTION (2.28 Å) Cite: Transcription factor MYF5 bound to non-symmetrical site To Be Published
6BCH	I-LtrI E29D bound to cognate substrate (nicked complex) Descriptor: DNA (26-MER), DNA (5'-D(*GP*GP*TP*CP*TP*AP*AP*AP*CP*GP*TP*CP*GP*TP*AP*T)-3'), DNA (5'-D(*TP*AP*GP*GP*AP*GP*CP*AP*TP*TP*T)-3'), ... Authors: Brown, C, Zhang, K, McMurrough, T.A, Gloor, G.B, Edgell, D.R, Junop, M. Deposit date: 2017-10-20 Release date: 2018-10-24 Last modified: 2024-03-13 Method: X-RAY DIFFRACTION (3 Å) Cite: I-LtrI E29D bound to cognate substrate (nicked complex) To Be Published
8PI9	DNA binding domain of HNF-1A bound to P2-HNF4A promoter DNA variant (P2 -181G>A) Descriptor: Chains: E, Chains: F, Hepatocyte nuclear factor 1-alpha Authors: Kind, L, Myllykoski, M, Raasakka, A, Kursula, P. Deposit date: 2023-06-21 Release date: 2024-06-19 Method: X-RAY DIFFRACTION (2.8 Å) Cite: Molecular mechanism of HNF-1A-mediated HNF4A gene regulation and promoter-driven HNF4A-MODY diabetes. JCI Insight, 9, 2024
8PI7	DNA binding domain of HNF-1A bound to P2-HNF4A promoter DNA variant (P2 -169C>T) Descriptor: CHLORIDE ION, Chains: E, Chains: F, ... Authors: Kind, L, Myllykoski, M, Raasakka, A, Kursula, P. Deposit date: 2023-06-21 Release date: 2024-06-19 Method: X-RAY DIFFRACTION (3.2 Å) Cite: Molecular mechanism of HNF-1A-mediated HNF4A gene regulation and promoter-driven HNF4A-MODY diabetes. JCI Insight, 9, 2024
8PI8	DNA binding domain of HNF-1A bound to P2-HNF4A promoter DNA Descriptor: Chains: E, Chains: F, GLYCEROL, ... Authors: Kind, L, Myllykoski, M, Raasakka, A, Kursula, P. Deposit date: 2023-06-21 Release date: 2024-06-19 Method: X-RAY DIFFRACTION (2.3 Å) Cite: Molecular mechanism of HNF-1A-mediated HNF4A gene regulation and promoter-driven HNF4A-MODY diabetes. JCI Insight, 9, 2024

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