4MDA

Structure of Mos1 transposase catalytic domain and Raltegravir with Mn

Summary for 4MDA

Entry DOI	10.2210/pdb4mda/pdb
Related	2F7T 3HOS 3HOT 4MDB
Descriptor	Mariner Mos1 transposase, MANGANESE (II) ION, N-(4-fluorobenzyl)-5-hydroxy-1-methyl-2-(1-methyl-1-{[(5-methyl-1,3,4-oxadiazol-2-yl)carbonyl]amino}ethyl)-6-oxo-1,6-di hydropyrimidine-4-carboxamide, ... (4 entities in total)
Functional Keywords	rnase-h fold, ddd motif, recombinase, dna transposition, dna integration, transposon dna, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
Biological source	Drosophila mauritiana (Fruit fly)
Cellular location	Nucleus (Probable): Q7JQ07
Total number of polymer chains	1
Total formula weight	27445.85
Authors	Richardson, J.M. (deposition date: 2013-08-22, release date: 2014-01-22, Last modification date: 2023-09-20)
Primary citation	Wolkowicz, U.M.,Morris, E.R.,Robson, M.,Trubitsyna, M.,Richardson, J.M. Structural Basis of Mos1 Transposase Inhibition by the Anti-retroviral Drug Raltegravir. Acs Chem.Biol., 9:743-751, 2014 Cited by PubMed: 24397848 DOI: 10.1021/cb400791u PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.7 Å)

Structure validation