PDB: 35140 resultsInfo pagesStatus searchChemie searchBIRD

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5ND4	Microtubule-bound MKLP2 motor domain in the presence of ADP.AlFx Descriptor: ADENOSINE-5'-DIPHOSPHATE, GUANOSINE-5'-DIPHOSPHATE, GUANOSINE-5'-TRIPHOSPHATE, ... Authors: Atherton, J, Yu, I.-M, Cook, A, Muretta, J.M, Joseph, A.P, Major, J, Sourigues, Y, Clause, J, Topf, M, Rosenfeld, S.S, Houdusse, A, Moores, C.A. Deposit date: 2017-03-07 Release date: 2017-10-04 Last modified: 2024-05-15 Method: ELECTRON MICROSCOPY (4.4 Å) Cite: The divergent mitotic kinesin MKLP2 exhibits atypical structure and mechanochemistry. Elife, 6, 2017
5ND2	Microtubule-bound MKLP2 motor domain in the presence of ADP Descriptor: ADENOSINE-5'-DIPHOSPHATE, GUANOSINE-5'-DIPHOSPHATE, GUANOSINE-5'-TRIPHOSPHATE, ... Authors: Atherton, J, Yu, I.M, Cook, A, Muretta, J.M, Joseph, A.P, Major, J, Sourigues, Y, Clause, J, Topf, M, Rosenfeld, S.S, Houdusse, A, Moores, C.A. Deposit date: 2017-03-07 Release date: 2017-10-04 Last modified: 2024-05-15 Method: ELECTRON MICROSCOPY (5.8 Å) Cite: The divergent mitotic kinesin MKLP2 exhibits atypical structure and mechanochemistry. Elife, 6, 2017
5NP0	Closed dimer of human ATM (Ataxia telangiectasia mutated) Descriptor: Serine-protein kinase ATM Authors: Baretic, D, Pollard, H.K, Fisher, D.I, Johnson, C.M, Santhanam, B, Truman, C.M, Kouba, T, Fersht, A.R, Phillips, C, Williams, R.L. Deposit date: 2017-04-13 Release date: 2017-05-17 Last modified: 2024-05-15 Method: ELECTRON MICROSCOPY (5.7 Å) Cite: Structures of closed and open conformations of dimeric human ATM. Sci Adv, 3, 2017
6N7U	apo-BDBV223 Fab Descriptor: BDBV223 antibody heavy chain, BDBV223 antibody light chain Authors: King, L.B, West, B.R, Saphire, E.O. Deposit date: 2018-11-28 Release date: 2019-03-20 Last modified: 2023-10-11 Method: X-RAY DIFFRACTION (2.03 Å) Cite: Cross-reactive neutralizing human survivor monoclonal antibody BDBV223 targets the ebolavirus stalk. Nat Commun, 10, 2019
7T58	Crystal structure of Miz1 BTB domain Descriptor: DIMETHYL SULFOXIDE, Zinc finger and BTB domain-containing protein 17 Authors: Linhares, B.M, Cierpicki, T. Deposit date: 2021-12-11 Release date: 2022-12-14 Last modified: 2023-10-25 Method: X-RAY DIFFRACTION (2.05333114 Å) Cite: Prediction of BTB domain ligandability guided by protein dynamics To Be Published
6N3D	Structure of HIV Tat-specific factor 1 U2AF Homology Motif (APO-State) Descriptor: CHLORIDE ION, DI(HYDROXYETHYL)ETHER, GLYCEROL, ... Authors: Loerch, S, Jenkins, J.L, Kielkopf, C.L. Deposit date: 2018-11-15 Release date: 2019-01-02 Last modified: 2023-10-11 Method: X-RAY DIFFRACTION (1.13 Å) Cite: The pre-mRNA splicing and transcription factor Tat-SF1 is a functional partner of the spliceosome SF3b1 subunit via a U2AF homology motif interface. J. Biol. Chem., 294, 2019
6N3Y	Human Histidine Triad Nucleotide Binding Protein 1 (Hint1) with Bound 5'-O-[(3-Indolyl)-1-Ethyl]Carbamoyl Guanosine Descriptor: 5'-O-{[2-(1H-indol-3-yl)ethyl]carbamoyl}guanosine, CHLORIDE ION, Histidine triad nucleotide-binding protein 1 Authors: Strom, A.M, Finzel, B.C. Deposit date: 2018-11-16 Release date: 2019-09-18 Last modified: 2023-10-11 Method: X-RAY DIFFRACTION (1.8 Å) Cite: Inhibition of HINT1 Modulates Spinal Nociception and NMDA Evoked Behavior in Mice. Acs Chem Neurosci, 10, 2019
7Q33	Solution structure of RBM39 RRM2 bound to 5'-AGCUUUG-3 Descriptor: RNA (5'-R(*AP*GP*CP*UP*UP*UP*G)-3'), RNA-binding protein 39 Authors: Campagne, S, Allain, F.H. Deposit date: 2021-10-26 Release date: 2023-02-08 Last modified: 2023-09-20 Method: SOLUTION NMR Cite: Molecular basis of RNA-binding and autoregulation by the cancer-associated splicing factor RBM39. Nat Commun, 14, 2023
8GNN	Crystal structure of the human RAD9-RAD1-HUS1-RAD17 complex Descriptor: Cell cycle checkpoint control protein RAD9A, Cell cycle checkpoint protein RAD1, Cell cycle checkpoint protein RAD17, ... Authors: Hara, K, Nagata, K, Iida, N, Hashimoto, H. Deposit date: 2022-08-24 Release date: 2023-03-08 Last modified: 2023-11-29 Method: X-RAY DIFFRACTION (2.119 Å) Cite: The 9-1-1 DNA clamp subunit RAD1 forms specific interactions with clamp loader RAD17, revealing functional implications for binding-protein RHINO. J.Biol.Chem., 299, 2023
8FL4	Human nuclear pre-60S ribosomal subunit (State I3) Descriptor: 28S rRNA, 5.8S rRNA, 5S rRNA, ... Authors: Vanden Broeck, A, Klinge, S. Deposit date: 2022-12-21 Release date: 2023-07-12 Last modified: 2023-07-19 Method: ELECTRON MICROSCOPY (2.89 Å) Cite: Principles of human pre-60 S biogenesis. Science, 381, 2023
8FCO	Cryo-EM structure of p97:UBXD1 meta state Descriptor: ADENOSINE-5'-DIPHOSPHATE, Transitional endoplasmic reticulum ATPase, UBX domain-containing protein 6 Authors: Braxton, J.R, Tucker, M.R, Tse, E, Southworth, D.R. Deposit date: 2022-12-01 Release date: 2023-06-21 Last modified: 2023-12-20 Method: ELECTRON MICROSCOPY (3.31 Å) Cite: The p97/VCP adaptor UBXD1 drives AAA+ remodeling and ring opening through multi-domain tethered interactions. Nat.Struct.Mol.Biol., 30, 2023
8GRM	Cryo-EM structure of PRC1 bound to H2AK119-UbcH5b-Ub nucleosome Descriptor: COMMD3 protein, DNA (144-MER), DNA (145-MER), ... Authors: Ai, H.S, Zebin, T, Zhihend, D, Jiakun, T, Liying, Z, Jia-Bin, L, Man, P, Liu, L. Deposit date: 2022-09-02 Release date: 2023-04-12 Last modified: 2024-07-03 Method: ELECTRON MICROSCOPY (3.05 Å) Cite: Synthetic E2-Ub-nucleosome conjugates for studying nucleosome ubiquitination. Chem, 2023
8FCL	Cryo-EM structure of p97:UBXD1 closed state Descriptor: ADENOSINE-5'-DIPHOSPHATE, Transitional endoplasmic reticulum ATPase, UBX domain-containing protein 6 Authors: Braxton, J.R, Tucker, M.R, Tse, E, Southworth, D.R. Deposit date: 2022-12-01 Release date: 2023-06-21 Last modified: 2023-12-20 Method: ELECTRON MICROSCOPY (3.51 Å) Cite: The p97/VCP adaptor UBXD1 drives AAA+ remodeling and ring opening through multi-domain tethered interactions. Nat.Struct.Mol.Biol., 30, 2023
8FCR	Cryo-EM structure of p97:UBXD1 H4-bound state Descriptor: ADENOSINE-5'-DIPHOSPHATE, Transitional endoplasmic reticulum ATPase, UBX domain-containing protein 6 Authors: Braxton, J.R, Tucker, M.R, Tse, E, Southworth, D.R. Deposit date: 2022-12-01 Release date: 2023-06-21 Last modified: 2023-12-20 Method: ELECTRON MICROSCOPY (4.12 Å) Cite: The p97/VCP adaptor UBXD1 drives AAA+ remodeling and ring opening through multi-domain tethered interactions. Nat.Struct.Mol.Biol., 30, 2023
5NWG	Crystal structure of TNKS2 in complex with 7-chloro-2-{4-[(2-hydroxyethyl)(methyl)amino]phenyl}-3,4-dihydroquinazolin-4-one Descriptor: 7-chloranyl-2-[4-[2-hydroxyethyl(methyl)amino]phenyl]-3~{H}-quinazolin-4-one, GLYCEROL, SULFATE ION, ... Authors: Nkizinkiko, Y, Haikarainen, T, Lehtio, L. Deposit date: 2017-05-05 Release date: 2018-03-14 Last modified: 2024-01-17 Method: X-RAY DIFFRACTION (1.4 Å) Cite: 2-Phenylquinazolinones as dual-activity tankyrase-kinase inhibitors. Sci Rep, 8, 2018
8FCQ	Cryo-EM structure of p97:UBXD1 PUB-in state Descriptor: ADENOSINE-5'-DIPHOSPHATE, Transitional endoplasmic reticulum ATPase, UBX domain-containing protein 6 Authors: Braxton, J.R, Tucker, M.R, Tse, E, Southworth, D.R. Deposit date: 2022-12-01 Release date: 2023-06-21 Last modified: 2023-12-20 Method: ELECTRON MICROSCOPY (3.93 Å) Cite: The p97/VCP adaptor UBXD1 drives AAA+ remodeling and ring opening through multi-domain tethered interactions. Nat.Struct.Mol.Biol., 30, 2023
6N45	Crystal structure of the cryptic polo box domain of human activated Plk4 variant 1 Descriptor: Chimera protein of Serine/threonine-protein kinase PLK4 and DDB1- and CUL4-associated factor 1 Authors: Zhang, L, Park, J.-E, Meng, L, Lee, K.S. Deposit date: 2018-11-17 Release date: 2019-09-04 Last modified: 2023-10-11 Method: X-RAY DIFFRACTION (2.64 Å) Cite: Phase separation of Polo-like kinase 4 by autoactivation and clustering drives centriole biogenesis. Nat Commun, 10, 2019
7SUK	Structure of Bfr2-Lcp5 Complex Observed in the Small Subunit Processome Isolated from R2TP-depleted Yeast Cells Descriptor: 18S pre-rRNA, 40S ribosomal protein S11-A, 40S ribosomal protein S13, ... Authors: Rai, J, Zhao, Y, Li, H. Deposit date: 2021-11-17 Release date: 2022-07-06 Last modified: 2023-08-16 Method: ELECTRON MICROSCOPY (3.99 Å) Cite: Artificial intelligence-assisted cryoEM structure of Bfr2-Lcp5 complex observed in the yeast small subunit processome. Commun Biol, 5, 2022
8FCM	Cryo-EM structure of p97:UBXD1 open state Descriptor: ADENOSINE-5'-DIPHOSPHATE, Transitional endoplasmic reticulum ATPase, UBX domain-containing protein 6 Authors: Braxton, J.R, Tucker, M.R, Tse, E, Southworth, D.R. Deposit date: 2022-12-01 Release date: 2023-06-21 Last modified: 2023-12-20 Method: ELECTRON MICROSCOPY (3.27 Å) Cite: The p97/VCP adaptor UBXD1 drives AAA+ remodeling and ring opening through multi-domain tethered interactions. Nat.Struct.Mol.Biol., 30, 2023
6N3V	Human Histidine Triad Nucleotide Binding Protein 1 (Hint1) with Bound 5'-O-[1-Ethyl]Carbamoyl Guanosine Descriptor: 5'-O-(ethylcarbamoyl)guanosine, CHLORIDE ION, Histidine triad nucleotide-binding protein 1 Authors: Strom, A.M, Finzel, B.C. Deposit date: 2018-11-16 Release date: 2019-09-18 Last modified: 2023-10-11 Method: X-RAY DIFFRACTION (1.45 Å) Cite: Inhibition of HINT1 Modulates Spinal Nociception and NMDA Evoked Behavior in Mice. Acs Chem Neurosci, 10, 2019
6N3E	Structure of HIV Tat-specific factor 1 U2AF Homology Motif bound to U2AF ligand motif 4 Descriptor: FORMIC ACID, GLYCEROL, HIV Tat-specific factor 1, ... Authors: Loerch, S, Jenkins, J.L, Kielkopf, C.L. Deposit date: 2018-11-15 Release date: 2019-01-02 Last modified: 2024-03-13 Method: X-RAY DIFFRACTION (1.893 Å) Cite: The pre-mRNA splicing and transcription factor Tat-SF1 is a functional partner of the spliceosome SF3b1 subunit via a U2AF homology motif interface. J. Biol. Chem., 294, 2019
6N7J	BDBV223 Fab bound to synthetic peptide of Bundibugyo virus Glycoprotein Stalk Descriptor: BDBV223 antibody heavy chain, BDBV223 antibody light chain, Envelope glycoprotein Authors: King, L.B, West, B.R, Saphire, E.O. Deposit date: 2018-11-27 Release date: 2019-03-20 Last modified: 2023-10-11 Method: X-RAY DIFFRACTION (3.684 Å) Cite: Cross-reactive neutralizing human survivor monoclonal antibody BDBV223 targets the ebolavirus stalk. Nat Commun, 10, 2019
8GAO	bacteriophage T4 stalled primosome with mutant gp41-E227Q Descriptor: DNA (70-mer), DNA primase, DnaB-like replicative helicase, ... Authors: Feng, X, Li, H. Deposit date: 2023-02-23 Release date: 2023-06-07 Last modified: 2023-08-23 Method: ELECTRON MICROSCOPY (4.1 Å) Cite: Structural basis of the T4 bacteriophage primosome assembly and primer synthesis. Nat Commun, 14, 2023
2YXW	The deletion mutant of Multicopper Oxidase CueO Descriptor: Blue copper oxidase cueO, COPPER (II) ION, CU-O-CU LINKAGE, ... Authors: Higuchi, Y, Komori, H. Deposit date: 2007-04-27 Release date: 2008-01-01 Last modified: 2024-05-29 Method: X-RAY DIFFRACTION (1.5 Å) Cite: Structure and function of the engineered multicopper oxidase CueO from Escherichia coli--deletion of the methionine-rich helical region covering the substrate-binding site J.Mol.Biol., 373, 2007
7U46	Cryo-EM structure of CENP-A nucleosome (palindromic alpha satellite DNA) in complex with CENP-N Descriptor: Centromere protein N, DNA (147-MER), Histone H2A, ... Authors: Zhou, K, Luger, K. Deposit date: 2022-02-28 Release date: 2022-03-16 Last modified: 2024-02-21 Method: ELECTRON MICROSCOPY (2.68 Å) Cite: CENP-N promotes the compaction of centromeric chromatin. Nat.Struct.Mol.Biol., 29, 2022

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