6N45
Crystal structure of the cryptic polo box domain of human activated Plk4 variant 1
Summary for 6N45
| Entry DOI | 10.2210/pdb6n45/pdb |
| Descriptor | Chimera protein of Serine/threonine-protein kinase PLK4 and DDB1- and CUL4-associated factor 1 (1 entity in total) |
| Functional Keywords | polo-like kinase 4, protein phosphorylation, centriole duplication, pcm organization, phase separation, cell cycle |
| Biological source | Homo sapiens (Human) More |
| Total number of polymer chains | 2 |
| Total formula weight | 61180.73 |
| Authors | Zhang, L.,Park, J.-E.,Meng, L.,Lee, K.S. (deposition date: 2018-11-17, release date: 2019-09-04, Last modification date: 2023-10-11) |
| Primary citation | Park, J.E.,Zhang, L.,Bang, J.K.,Andresson, T.,DiMaio, F.,Lee, K.S. Phase separation of Polo-like kinase 4 by autoactivation and clustering drives centriole biogenesis. Nat Commun, 10:4959-4959, 2019 Cited by PubMed: 31672968DOI: 10.1038/s41467-019-12619-2 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (2.64 Å) |
Structure validation
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