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7E0F
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CryoEM structure of G51D alpha-synuclein amyloid fibril
Descriptor: Alpha-synuclein
Authors:Sun, Y.P, Long, H.F, Xia, W.C, Liu, C.
Deposit date:2021-01-27
Release date:2021-10-06
Last modified:2024-06-05
Method:ELECTRON MICROSCOPY (3.02 Å)
Cite:The hereditary mutation G51D unlocks a distinct fibril strain transmissible to wild-type alpha-synuclein.
Nat Commun, 12, 2021
7XO2
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Minor polymorph in alpha-synuclein fibril seeded by cerebrospinal fluid from a mid-to-late stage (mid-PD-4) Parkinson's disease patient
Descriptor: Alpha-synuclein
Authors:Fan, Y, Sun, Y.P, Wang, J, Liu, C.
Deposit date:2022-04-30
Release date:2022-11-30
Last modified:2024-07-03
Method:ELECTRON MICROSCOPY (3 Å)
Cite:Conformational change of alpha-synuclein fibrils in cerebrospinal fluid from different clinical phases of Parkinson's disease.
Structure, 31, 2023
7XO1
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Major polymorph in alpha-synuclein fibril seeded by cerebrospinal fluid from a mid-to-late stage (mid-PD-1) Parkinson's disease patient
Descriptor: Alpha-synuclein
Authors:Fan, Y, Sun, Y.P, Wang, J, Liu, C.
Deposit date:2022-04-30
Release date:2022-11-30
Last modified:2024-07-03
Method:ELECTRON MICROSCOPY (3 Å)
Cite:Conformational change of alpha-synuclein fibrils in cerebrospinal fluid from different clinical phases of Parkinson's disease.
Structure, 31, 2023
7XO0
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BU of 7xo0 by Molmil
Minor polymorph inalpha-synuclein fibril seeded by cerebrospinal fluid from a mid-to-late stage (mid-PD-1) Parkinson's disease patient
Descriptor: Alpha-synuclein
Authors:Fan, Y, Sun, Y.P, Wang, J, Liu, C.
Deposit date:2022-04-30
Release date:2022-11-30
Last modified:2024-07-03
Method:ELECTRON MICROSCOPY (3 Å)
Cite:Conformational change of alpha-synuclein fibrils in cerebrospinal fluid from different clinical phases of Parkinson's disease.
Structure, 31, 2023
7XO3
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Type 1C alpha-synuclein fibril seeded by cerebrospinal fluid from a mid-to-late stage (mid-PD-4) Parkinson's disease patient
Descriptor: Alpha-synuclein
Authors:Fan, Y, Sun, Y.P, Wang, J, Liu, C.
Deposit date:2022-04-30
Release date:2022-11-30
Last modified:2024-07-03
Method:ELECTRON MICROSCOPY (2.6 Å)
Cite:Conformational change of alpha-synuclein fibrils in cerebrospinal fluid from different clinical phases of Parkinson's disease.
Structure, 31, 2023
7XJX
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The cryo-EM structure of Fe3+ induced alpha-syn fibril.
Descriptor: Alpha-synuclein
Authors:Zhao, Q.Y, Tao, Y.Q, Zhao, K, Tao, Y.Q, Li, D.
Deposit date:2022-04-18
Release date:2023-01-18
Last modified:2024-07-03
Method:ELECTRON MICROSCOPY (2.7 Å)
Cite:Structural Insights of Fe3+ Induced alpha-synuclein Fibrillation in Parkinson' Disease
J.Mol.Biol., 435, 2023
7WMM
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alpha-synuclein fibril-F0502B complex
Descriptor: 2-bromanyl-4-[(~{E})-2-[6-[2-(2-fluoranylethoxy)ethyl-methyl-amino]-5-methyl-1,3-benzothiazol-2-yl]ethenyl]phenol, Alpha-synuclein
Authors:Tao, Y.Q, Zhao, Q.Y, Liu, C, Li, D.
Deposit date:2022-01-15
Release date:2023-01-18
Last modified:2024-06-26
Method:ELECTRON MICROSCOPY (2.6 Å)
Cite:alpha-synuclein fibril-F0502B complex
To Be Published
7YK2
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BU of 7yk2 by Molmil
Cryo-EM structure of Apo-alpha-syn fibril
Descriptor: Alpha-synuclein
Authors:Xu, Q.H, Xia, W.C, Tao, Y.Q, Liu, C.
Deposit date:2022-07-21
Release date:2023-03-22
Last modified:2024-05-08
Method:ELECTRON MICROSCOPY (2.8 Å)
Cite:Conformational Dynamics of an alpha-Synuclein Fibril upon Receptor Binding Revealed by Insensitive Nuclei Enhanced by Polarization Transfer-Based Solid-State Nuclear Magnetic Resonance and Cryo-Electron Microscopy.
J.Am.Chem.Soc., 145, 2023
7YK8
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BU of 7yk8 by Molmil
Cryo-EM structure of dLAG3-alpha-syn fibril
Descriptor: Alpha-synuclein
Authors:Xu, Q.H, Xia, W.C, Tao, Y.Q, Liu, C.
Deposit date:2022-07-22
Release date:2023-03-22
Last modified:2024-05-08
Method:ELECTRON MICROSCOPY (2.8 Å)
Cite:Conformational Dynamics of an alpha-Synuclein Fibril upon Receptor Binding Revealed by Insensitive Nuclei Enhanced by Polarization Transfer-Based Solid-State Nuclear Magnetic Resonance and Cryo-Electron Microscopy.
J.Am.Chem.Soc., 145, 2023
1EKU
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BU of 1eku by Molmil
CRYSTAL STRUCTURE OF A BIOLOGICALLY ACTIVE SINGLE CHAIN MUTANT OF HUMAN IFN-GAMMA
Descriptor: Interferon gamma, SULFATE ION
Authors:Landar, A, Curry, B, Parker, M.H, DiGiacomo, R, Indelicato, S.R, Walter, M.R.
Deposit date:2000-03-09
Release date:2000-09-01
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Design, characterization, and structure of a biologically active single-chain mutant of human IFN-gamma.
J.Mol.Biol., 299, 2000
1FG9
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3:1 COMPLEX OF INTERFERON-GAMMA RECEPTOR WITH INTERFERON-GAMMA DIMER
Descriptor: INTERFERON GAMMA, INTERFERON-GAMMA RECEPTOR ALPHA CHAIN
Authors:Thiel, D.J, le Du, M.-H, Walter, R.L, D'Arcy, A, Chene, C, Fountoulakis, M, Garotta, G, Winkler, F.K, Ealick, S.E.
Deposit date:2000-07-28
Release date:2000-08-11
Last modified:2022-12-21
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Observation of an unexpected third receptor molecule in the crystal structure of human interferon-gamma receptor complex.
Structure Fold.Des., 8, 2000
1LP9
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Xenoreactive complex AHIII 12.2 TCR bound to p1049/HLA-A2.1
Descriptor: Beta-2-microglobulin, HLA class I histocompatibility antigen, A-2 alpha chain, ...
Authors:Buslepp, J, Wang, H, Biddison, W.E, Appella, E, Collins, E.J.
Deposit date:2002-05-07
Release date:2003-11-11
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (2 Å)
Cite:A correlation between TCR Valpha docking on MHC and CD8 dependence: implications for T cell selection.
Immunity, 19, 2003
3VFZ
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BU of 3vfz by Molmil
Crystal structure of -35 promoter binding domain of SigD of Mycobacterium tuberculosis
Descriptor: Probable RNA polymerase sigma-D factor
Authors:Jaiswal, R.K, Thakur, K.G, Gopal, B.
Deposit date:2012-01-10
Release date:2013-02-13
Last modified:2013-10-09
Method:X-RAY DIFFRACTION (1.901 Å)
Cite:Mycobacterium tuberculosis RsdA provides a conformational rationale for selective regulation of sigma-factor activity by proteolysis
Nucleic Acids Res., 41, 2013
7DHP
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BU of 7dhp by Molmil
Crystal structure of MazF from Deinococcus radiodurans
Descriptor: Endoribonuclease MazF, SULFATE ION
Authors:Zhao, Y, Dai, J.
Deposit date:2020-11-17
Release date:2021-03-17
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (1.3 Å)
Cite:MazEF Toxin-Antitoxin System-Mediated DNA Damage Stress Response in Deinococcus radiodurans.
Front Genet, 12, 2021
3ONM
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BU of 3onm by Molmil
Effector binding Domain of LysR-Type transcription factor RovM from Y. pseudotuberculosis
Descriptor: Transcriptional regulator LrhA
Authors:Quade, N, Diekmann, M, Haffke, M, Heroven, A.K, Dersch, P, Heinz, D.W.
Deposit date:2010-08-30
Release date:2011-01-26
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Structure of the effector-binding domain of the LysR-type transcription factor RovM from Yersinia pseudotuberculosis.
Acta Crystallogr.,Sect.D, 67, 2011
6VCJ
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BU of 6vcj by Molmil
Crystal structure of hsDHFR in complex with NADP+, DAP, and R-naproxen
Descriptor: (2R)-2-(6-methoxynaphthalen-2-yl)propanoic acid, Dihydrofolate reductase, FOLIC ACID, ...
Authors:Pedersen, L.C, London, R.E, Gabel, S.A, Krahn, J.M, DeRose, E.F.
Deposit date:2019-12-21
Release date:2020-10-28
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (2.34 Å)
Cite:The Structural Basis for Nonsteroidal Anti-Inflammatory Drug Inhibition of Human Dihydrofolate Reductase.
J.Med.Chem., 63, 2020
5TN0
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BU of 5tn0 by Molmil
Solution Structure of the N-terminal DNA-binding domain of the master biofilm-regulator SinR from Bacillus subtilis
Descriptor: HTH-type transcriptional regulator SinR
Authors:Draughn, G.L, Bobay, B.G, Stowe, S.D, Thompson, R.J, Cavanagh, J.
Deposit date:2016-10-13
Release date:2017-10-25
Last modified:2024-05-01
Method:SOLUTION NMR
Cite:The Solution Structures and Interaction of SinR and SinI: Elucidating the Mechanism of Action of the Master Regulator Switch for Biofilm Formation in Bacillus subtilis.
J.Mol.Biol., 2019
4LRJ
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BU of 4lrj by Molmil
Bacterial Effector NleH1 Kinase Domain with AMPPNP and Mg2+
Descriptor: Effector NleH1, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER
Authors:Cygler, M, Grishin, A.M, Montreal-Kingston Bacterial Structural Genomics Initiative (BSGI)
Deposit date:2013-07-19
Release date:2014-01-22
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (1.619 Å)
Cite:NleH defines a new family of bacterial effector kinases.
Structure, 22, 2014
4LRK
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BU of 4lrk by Molmil
Bacterial Effector NleH2 Kinase Domain
Descriptor: Effector NleH2
Authors:Cygler, M, Grishin, A.M, Montreal-Kingston Bacterial Structural Genomics Initiative (BSGI)
Deposit date:2013-07-19
Release date:2014-01-22
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (2.274 Å)
Cite:NleH defines a new family of bacterial effector kinases.
Structure, 22, 2014
3PEE
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BU of 3pee by Molmil
Structure of the C. difficile TcdB cysteine protease domain
Descriptor: CALCIUM ION, INOSITOL HEXAKISPHOSPHATE, Toxin B
Authors:Lupardus, P.J, Garcia, K.C.
Deposit date:2010-10-26
Release date:2011-02-16
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Defining an allosteric circuit in the cysteine protease domain of Clostridium difficile toxins.
Nat.Struct.Mol.Biol., 18, 2011

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數據於2024-08-07公開中

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