PDB: 292 resultsInfo pagesStatus searchChemie searchBIRD

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6LUE	Crystal structure of mouse Cryptochrome 1 in complex with compound KL201 Descriptor: 2-bromanyl-N-(5,6,7,8-tetrahydro-[1]benzothiolo[2,3-d]pyrimidin-4-yl)benzamide, Cryptochrome-1 Authors: Miller, S, Aikawa, Y, Hirota, T. Deposit date: 2020-01-27 Release date: 2020-06-10 Last modified: 2023-11-29 Method: X-RAY DIFFRACTION (2.1 Å) Cite: An Isoform-Selective Modulator of Cryptochrome 1 Regulates Circadian Rhythms in Mammals. Cell Chem Biol, 27, 2020
6NF0	Nocturnin with bound NADPH substrate Descriptor: CALCIUM ION, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, Nocturnin Authors: Estrella, M.A, Du, J, Korennykh, A. Deposit date: 2018-12-18 Release date: 2019-05-01 Last modified: 2023-10-11 Method: X-RAY DIFFRACTION (2.7 Å) Cite: The metabolites NADP+and NADPH are the targets of the circadian protein Nocturnin (Curled). Nat Commun, 10, 2019
7WVA	Crystal structure of mouse Cryptochrome 1 in complex with TH401 compound Descriptor: 2-(1-methylbenzimidazol-2-yl)sulfanyl-N-[(E)-(2,3,4-trimethoxyphenyl)methylideneamino]ethanamide, Cryptochrome-1 Authors: Miller, S.A, Hirota, T. Deposit date: 2022-02-10 Release date: 2022-09-07 Last modified: 2023-11-29 Method: X-RAY DIFFRACTION (2.05 Å) Cite: A methylbenzimidazole derivative regulates mammalian circadian rhythms by targeting Cryptochrome proteins. F1000Res, 11, 2022
8OSK	Cryo-EM structure of CLOCK-BMAL1 bound to a nucleosomal E-box at position SHL+5.8 (composite map) Descriptor: Basic helix-loop-helix ARNT-like protein 1, Circadian locomoter output cycles protein kaput, DNA (124-MER), ... Authors: Stoos, L, Michael, A.K, Kempf, G, Cavadini, S, Thoma, N.H. Deposit date: 2023-04-19 Release date: 2023-05-24 Last modified: 2024-07-24 Method: ELECTRON MICROSCOPY (3.6 Å) Cite: Cooperation between bHLH transcription factors and histones for DNA access. Nature, 619, 2023
8OSL	Cryo-EM structure of CLOCK-BMAL1 bound to the native Por enhancer nucleosome (map 2, additional 3D classification and flexible refinement) Descriptor: Basic helix-loop-helix ARNT-like protein 1, Circadian locomoter output cycles protein kaput, DNA (147-MER), ... Authors: Michael, A.K, Stoos, L, Kempf, G, Cavadini, S, Thoma, N. Deposit date: 2023-04-19 Release date: 2023-05-24 Last modified: 2024-07-24 Method: ELECTRON MICROSCOPY (4.9 Å) Cite: Cooperation between bHLH transcription factors and histones for DNA access. Nature, 619, 2023
5YZ8	Crystal Structure of N-terminal C1 domain of KaiC Descriptor: CHLORIDE ION, Circadian Clock Protein Kinase KaiC, MAGNESIUM ION, ... Authors: Mukaiyama, A, Furuike, Y, Abe, J, Akiyama, S. Deposit date: 2017-12-13 Release date: 2019-01-30 Last modified: 2023-11-22 Method: X-RAY DIFFRACTION (2.81 Å) Cite: Conformational rearrangements of the C1 ring in KaiC measure the timing of assembly with KaiB. Sci Rep, 8, 2018
8OSJ	Cryo-EM structure of CLOCK-BMAL1 bound to a nucleosomal E-box at position SHL-6.2 (DNA conformation 1) Descriptor: Basic helix-loop-helix ARNT-like protein 1, Circadian locomoter output cycles protein kaput, DNA (124-MER), ... Authors: Michael, A.K, Stoos, L, Kempf, G, Cavadini, S, Thoma, N.H. Deposit date: 2023-04-19 Release date: 2023-05-24 Last modified: 2024-07-24 Method: ELECTRON MICROSCOPY (6.2 Å) Cite: Cooperation between bHLH transcription factors and histones for DNA access. Nature, 619, 2023
8D7M	Human Casein kinase 1 delta in complex with phosphorylated human PERIOD2 FASP peptide Descriptor: Casein kinase I isoform delta, Period circadian protein homolog 2 peptide Authors: Philpott, J.M, Freeberg, A.M, Tripathi, S.M, Partch, C.L. Deposit date: 2022-06-07 Release date: 2023-05-17 Last modified: 2023-10-25 Method: X-RAY DIFFRACTION (2.25 Å) Cite: PERIOD phosphorylation leads to feedback inhibition of CK1 activity to control circadian period. Mol.Cell, 83, 2023
8D7O	Human Casein kinase 1 delta in complex with phosphorylated human PERIOD2 FASP peptide Descriptor: Casein kinase I isoform delta, Period circadian protein homolog 2 peptide Authors: Philpott, J.M, Freeberg, A.M, Tripathi, S.M, Partch, C.L. Deposit date: 2022-06-07 Release date: 2023-05-17 Last modified: 2023-10-25 Method: X-RAY DIFFRACTION (1.65 Å) Cite: PERIOD phosphorylation leads to feedback inhibition of CK1 activity to control circadian period. Mol.Cell, 83, 2023
8D7P	Human Casein kinase 1 delta in complex with phosphorylated Drosophila PERIOD peptide Descriptor: Casein kinase I isoform delta, Period circadian protein peptide Authors: Philpott, J.M, Freeberg, A.M, Tripathi, S.M, Partch, C.L. Deposit date: 2022-06-07 Release date: 2023-05-17 Last modified: 2023-10-25 Method: X-RAY DIFFRACTION (2.25 Å) Cite: PERIOD phosphorylation leads to feedback inhibition of CK1 activity to control circadian period. Mol.Cell, 83, 2023
8D7N	Human Casein kinase 1 delta in complex with phosphorylated human PERIOD2 FASP peptide Descriptor: Casein kinase I isoform delta, Period circadian protein homolog 2 peptide Authors: Philpott, J.M, Freeberg, A.M, Tripathi, S.M, Partch, C.L. Deposit date: 2022-06-07 Release date: 2023-05-17 Last modified: 2023-10-25 Method: X-RAY DIFFRACTION (1.66 Å) Cite: PERIOD phosphorylation leads to feedback inhibition of CK1 activity to control circadian period. Mol.Cell, 83, 2023
6PXO	Human Casein Kinase 1 delta (anion-free crystallization conditions) Descriptor: Casein kinase I isoform delta Authors: Freeberg, A, Philpott, J.M, Tripathi, S.M, Partch, C.L. Deposit date: 2019-07-26 Release date: 2020-02-12 Last modified: 2023-10-11 Method: X-RAY DIFFRACTION (2 Å) Cite: Casein kinase 1 dynamics underlie substrate selectivity and the PER2 circadian phosphoswitch. Elife, 9, 2020
5SVW	Light-state Structure of Arabidopsis Thaliana Zeitlupe Descriptor: Adagio protein 1, FLAVIN MONONUCLEOTIDE Authors: Zoltowski, B, Pudasaini, A. Deposit date: 2016-08-07 Release date: 2017-03-08 Last modified: 2023-10-04 Method: X-RAY DIFFRACTION (2.29 Å) Cite: Kinetics of the LOV domain of ZEITLUPE determine its circadian function inArabidopsis. Elife, 6, 2017
6A1C	Crystal structure of the CK2a1-go289 complex Descriptor: 1,2-ETHANEDIOL, 5-bromanyl-2-methoxy-4-[(E)-(3-methylsulfanyl-5-phenyl-1,2,4-triazol-4-yl)iminomethyl]phenol, Casein kinase II subunit alpha, ... Authors: Kinoshita, T, Tsuyuguchi, M. Deposit date: 2018-06-07 Release date: 2019-03-06 Last modified: 2023-11-22 Method: X-RAY DIFFRACTION (1.68 Å) Cite: Cell-based screen identifies a new potent and highly selective CK2 inhibitor for modulation of circadian rhythms and cancer cell growth. Sci Adv, 5, 2019
3RTY	Structure of an Enclosed Dimer Formed by The Drosophila Period Protein Descriptor: 2,3-DIHYDROXY-1,4-DITHIOBUTANE, Period circadian protein Authors: King, H.A, Hoelz, A, Crane, B.R, Young, M.W. Deposit date: 2011-05-04 Release date: 2011-12-21 Method: X-RAY DIFFRACTION (2.85 Å) Cite: Structure of an enclosed dimer formed by the Drosophila period protein. J.Mol.Biol., 413, 2011
4JZY	Crystal structures of Drosophila Cryptochrome Descriptor: AMMONIUM ION, Cryptochrome-1, FLAVIN-ADENINE DINUCLEOTIDE, ... Authors: Czarna, A, Wolf, E. Deposit date: 2013-04-03 Release date: 2013-06-26 Last modified: 2024-02-28 Method: X-RAY DIFFRACTION (2.34 Å) Cite: Structures of Drosophila cryptochrome and mouse cryptochrome1 provide insight into circadian function. Cell(Cambridge,Mass.), 153, 2013
4K03	Crystal structure of Drosophila Cryprochrome Descriptor: Cryptochrome-1, FLAVIN-ADENINE DINUCLEOTIDE Authors: Berndt, A, Wolf, E. Deposit date: 2013-04-03 Release date: 2013-06-26 Method: X-RAY DIFFRACTION (3.2 Å) Cite: Structures of Drosophila cryptochrome and mouse cryptochrome1 provide insight into circadian function. Cell(Cambridge,Mass.), 153, 2013
3FY4	(6-4) Photolyase Crystal Structure Descriptor: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 6-4 photolyase, FLAVIN-ADENINE DINUCLEOTIDE, ... Authors: Hitomi, K, Arvai, A.S, Tainer, J.A, Getzoff, E.D. Deposit date: 2009-01-21 Release date: 2009-04-28 Last modified: 2024-02-21 Method: X-RAY DIFFRACTION (2.7 Å) Cite: Functional motifs in the (6-4) photolyase crystal structure make a comparative framework for DNA repair photolyases and clock cryptochromes. Proc.Natl.Acad.Sci.USA, 106, 2009
6PXN	Human Casein Kinase 1 delta Tau mutant (R178C) Descriptor: Casein kinase I isoform delta, SULFATE ION Authors: Philpott, J.M, Tripathi, S.M, Partch, C.L. Deposit date: 2019-07-26 Release date: 2020-02-12 Last modified: 2023-10-11 Method: X-RAY DIFFRACTION (1.551 Å) Cite: Casein kinase 1 dynamics underlie substrate selectivity and the PER2 circadian phosphoswitch. Elife, 9, 2020
4K0R	Crystal structure of mouse Cryptochrome 1 Descriptor: Cryptochrome-1 Authors: Czarna, A, Wolf, E. Deposit date: 2013-04-04 Release date: 2013-06-26 Method: X-RAY DIFFRACTION (2.65 Å) Cite: Structures of Drosophila cryptochrome and mouse cryptochrome1 provide insight into circadian function. Cell(Cambridge,Mass.), 153, 2013
6PXP	Human Casein Kinase 1 delta Site 2 mutant (K171E) Descriptor: Casein kinase I isoform delta, SULFATE ION Authors: Yee, L, Philpott, J.M, Tripathi, S.M, Partch, C.L. Deposit date: 2019-07-26 Release date: 2020-02-12 Last modified: 2023-10-11 Method: X-RAY DIFFRACTION (2.35 Å) Cite: Casein kinase 1 dynamics underlie substrate selectivity and the PER2 circadian phosphoswitch. Elife, 9, 2020
5X18	Crystal structure of Casein kinase I homolog 1 Descriptor: Casein kinase I homolog 1, GLYCEROL, MALONIC ACID Authors: Kikuchi, M, Shinohara, Y, Ueda, H.R, Umehara, T. Deposit date: 2017-01-25 Release date: 2017-10-04 Last modified: 2023-11-22 Method: X-RAY DIFFRACTION (1.8 Å) Cite: Temperature-Sensitive Substrate and Product Binding Underlie Temperature-Compensated Phosphorylation in the Clock Mol. Cell, 67, 2017
5X17	Crystal structure of murine CK1d in complex with ADP Descriptor: ADENOSINE-5'-DIPHOSPHATE, Casein kinase I isoform delta, SULFATE ION Authors: Kikuchi, M, Shinohara, Y, Ueda, H.R, Umehara, T. Deposit date: 2017-01-25 Release date: 2017-10-04 Last modified: 2023-11-22 Method: X-RAY DIFFRACTION (2 Å) Cite: Temperature-Sensitive Substrate and Product Binding Underlie Temperature-Compensated Phosphorylation in the Clock Mol. Cell, 67, 2017
6BB8	Crystal Structure of Frequency-Interacting RNA helicase (FRH) Descriptor: FRQ-interacting RNA helicase Authors: Morales, Y, Johnson, S.J, Olsen, K.J. Deposit date: 2017-10-17 Release date: 2018-08-29 Last modified: 2023-10-04 Method: X-RAY DIFFRACTION (3.49 Å) Cite: Structure of frequency-interacting RNA helicase from Neurospora crassa reveals high flexibility in a domain critical for circadian rhythm and RNA surveillance. PLoS ONE, 13, 2018
4IT6	Crystal structure of amino acid residues 1-120 of CG17282 Descriptor: CG17282, DI(HYDROXYETHYL)ETHER, FORMIC ACID Authors: Bouyain, S, Agyekum, B, Hall, D.R. Deposit date: 2013-01-17 Release date: 2013-08-14 Last modified: 2017-11-15 Method: X-RAY DIFFRACTION (1.9 Å) Cite: Noncanonical FK506-Binding Protein BDBT Binds DBT to Enhance Its Circadian Function and Forms Foci at Night. Neuron, 80, 2013

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