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2H6B
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BU of 2h6b by Molmil
Crystal structure of oxidized CprK in complex with o-chlorophenolacetic acid
Descriptor: (3-CHLORO-4-HYDROXYPHENYL)ACETIC ACID, ChloroPhenol Reduction gene K, SULFATE ION
Authors:Joyce, M.G, Levy, C, Leys, D.
Deposit date:2006-05-31
Release date:2006-07-04
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:CprK Crystal Structures Reveal Mechanism for Transcriptional Control of Halorespiration.
J.Biol.Chem., 281, 2006
2CGP
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BU of 2cgp by Molmil
CATABOLITE GENE ACTIVATOR PROTEIN/DNA COMPLEX, ADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE
Descriptor: ADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE, DNA (5'-D(*AP*TP*TP*AP*AP*TP*GP*TP*GP*AP*CP*AP*TP*AP*T)-3'), DNA (5'-D(*GP*TP*CP*AP*CP*AP*TP*TP*AP*AP*T)-3'), ...
Authors:Passner, J.M, Steitz, T.A.
Deposit date:1997-01-31
Release date:1998-02-04
Last modified:2023-08-02
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:The structure of a CAP-DNA complex having two cAMP molecules bound to each monomer.
Proc.Natl.Acad.Sci.USA, 94, 1997
4F8A
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BU of 4f8a by Molmil
Cyclic nucleotide binding-homology domain from mouse EAG1 potassium channel
Descriptor: Potassium voltage-gated channel subfamily H member 1
Authors:Marques-Carvalho, M.J, Sahoo, N, Muskett, F.W, Vieira-Pires, R.S, Gabant, G, Cadene, M, Schonherr, R, Morais-Cabral, J.H.
Deposit date:2012-05-17
Release date:2012-07-11
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Structural, Biochemical, and Functional Characterization of the Cyclic Nucleotide Binding Homology Domain from the Mouse EAG1 Potassium Channel.
J.Mol.Biol., 423, 2012
3UKN
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BU of 3ukn by Molmil
Structure of the C-linker/CNBHD of zELK channels in C 2 2 21 space group
Descriptor: Novel protein similar to vertebrate potassium voltage-gated channel, subfamily H (Eag-related) family
Authors:Brelidze, T.I.
Deposit date:2011-11-09
Release date:2012-01-04
Last modified:2024-04-03
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Structure of the carboxy-terminal region of a KCNH channel.
Nature, 481, 2012
4I0A
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BU of 4i0a by Molmil
structure of the mutant Catabolite gene activator protein V132A
Descriptor: ADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE, Catabolite gene activator, GLYCEROL
Authors:Pohl, E, Townsend, P.D, Rodgers, T, Burnell, D, McLeish, T.C.B, Wilson, M.R, Cann, M.J.
Deposit date:2012-11-16
Release date:2013-10-30
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Modulation of global low-frequency motions underlies allosteric regulation: demonstration in CRP/FNR family transcription factors.
Plos Biol., 11, 2013
2GZW
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BU of 2gzw by Molmil
Crystal structure of the E.coli CRP-cAMP complex
Descriptor: ADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE, Catabolite gene activator
Authors:Kumarevel, T.S, Tanaka, T, Shinkai, A, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI)
Deposit date:2006-05-12
Release date:2007-05-15
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (2.21 Å)
Cite:Crystal structure of activated CRP protein from E coli
To be Published
3OF1
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BU of 3of1 by Molmil
Crystal Structure of Bcy1, the Yeast Regulatory Subunit of PKA
Descriptor: ADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE, cAMP-dependent protein kinase regulatory subunit
Authors:Rinaldi, J, Wu, J, Yang, J, Ralston, C.Y, Sankaran, B, Moreno, S, Taylor, S.S.
Deposit date:2010-08-13
Release date:2010-12-01
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (2.21 Å)
Cite:Structure of Yeast Regulatory Subunit: A Glimpse into the Evolution of PKA Signaling.
Structure, 18, 2010
7ETS
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BU of 7ets by Molmil
Crystal structure of crp protein from Gardnerella Vaginalis
Descriptor: Crp/Fnr family transcriptional regulator, DI(HYDROXYETHYL)ETHER, GLYCEROL, ...
Authors:Dong, H.J, Wang, S, Zhang, J.M, Gu, L.
Deposit date:2021-05-13
Release date:2022-04-27
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (2.22 Å)
Cite:Crystal structure of crp protein from Gardnerella Vaginalis
To Be Published
7T4W
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BU of 7t4w by Molmil
Crystal Structure of cGMP-dependent Protein Kinase
Descriptor: (2R)-2-({(2S,3S)-1-[(1H-benzimidazol-2-yl)methyl]-2-phenylpiperidin-3-yl}oxy)-2-(3,5-dichlorophenyl)ethan-1-ol, CHLORIDE ION, cGMP-dependent protein kinase 1
Authors:Zebisch, M, Silvestre, L, Fischmann, T.O.
Deposit date:2021-12-10
Release date:2023-06-14
Last modified:2023-07-12
Method:X-RAY DIFFRACTION (2.23 Å)
Cite:Selective small molecule activation of PKG1alpha: structure and function
Commun Biol, 2023
5KHG
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BU of 5khg by Molmil
HCN2 CNBD in complex with cytidine-3', 5'-cyclic monophosphate (cCMP)
Descriptor: 4-amino-1-[(2S,4aR,6R,7R,7aS)-2,7-dihydroxy-2-oxidotetrahydro-4H-furo[3,2-d][1,3,2]dioxaphosphinin-6-yl]pyrimidin-2(1H)-one, Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2
Authors:Ng, L.C.T, Putrenko, I, Baronas, V, Van Petegem, F, Accili, E.A.
Deposit date:2016-06-14
Release date:2016-09-14
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (2.241 Å)
Cite:Cyclic Purine and Pyrimidine Nucleotides Bind to the HCN2 Ion Channel and Variably Promote C-Terminal Domain Interactions and Opening.
Structure, 24, 2016
2XKO
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BU of 2xko by Molmil
Crystal structure of the complex of NtcA with its transcriptional co- activator PipX
Descriptor: 2-OXOGLUTARIC ACID, GLOBAL NITROGEN REGULATOR, PIPX
Authors:Llacer, J.L, Castells, M.A, Rubio, V.
Deposit date:2010-07-11
Release date:2010-08-18
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:Structural Basis for the Regulation of Ntca-Dependent Transcription by Proteins Pipx and Pii.
Proc.Natl.Acad.Sci.USA, 107, 2010
6M63
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BU of 6m63 by Molmil
Crystal structure of a cAMP sensor G-Flamp1.
Descriptor: ADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE, Chimera of Cyclic nucleotide-gated potassium channel mll3241 and Yellow fluorescent protein
Authors:Zhou, Z, Chen, S, Wang, L, Chu, J.
Deposit date:2020-03-12
Release date:2021-09-22
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:A high-performance genetically encoded fluorescent indicator for in vivo cAMP imaging.
Nat Commun, 13, 2022
4ONU
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BU of 4onu by Molmil
cAMP-binding acyltransferase from Mycobacterium smegmatis, E234A mutant
Descriptor: Acetyltransferase Pat, CALCIUM ION
Authors:Podobnik, M, Rebolj, K, Visweswariah, S.S.
Deposit date:2014-01-29
Release date:2014-04-30
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:Allostery and Conformational Dynamics in cAMP-binding Acyltransferases.
J.Biol.Chem., 289, 2014
2Q0A
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BU of 2q0a by Molmil
Structure and rearrangements in the carboxy-terminal region of SpIH channels
Descriptor: CYCLIC GUANOSINE MONOPHOSPHATE, Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2
Authors:Flynn, G.E, Black, K.D, Islas, L.D, Sankaran, B, Zagotta, W.N.
Deposit date:2007-05-21
Release date:2007-06-19
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:Structure and rearrangements in the carboxy-terminal region of SpIH channels.
Structure, 15, 2007
7T4V
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BU of 7t4v by Molmil
Crystal Structure of cGMP-dependent Protein Kinase
Descriptor: 4-({(2S,3S)-3-[(1S)-1-(3,5-dichlorophenyl)-2-hydroxyethoxy]-2-phenylpiperidin-1-yl}methyl)-3-methylbenzoic acid, CHLORIDE ION, cGMP-dependent protein kinase 1
Authors:Zebisch, M, Silvestre, L, Fischmann, T.O.
Deposit date:2021-12-10
Release date:2023-06-14
Last modified:2023-07-12
Method:X-RAY DIFFRACTION (2.28 Å)
Cite:Selective small molecule activation of PKG1alpha: structure and function
Commun Biol, 2023
3I59
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BU of 3i59 by Molmil
Crystal structure of MtbCRP in complex with N6-cAMP
Descriptor: (2R)-N6-(1-Methyl-2-phenylethyl)adenosine-3',5'-cyclic monophosphate, (2S)-N6-(1-Methyl-2-phenylethyl)adenosine-3',5'-cyclic monophosphate, CHLORIDE ION, ...
Authors:Reddy, M.C, Palaninathan, S.K, Bruning, J.B, Thurman, C, Smith, D, Sacchettini, J.C, TB Structural Genomics Consortium (TBSGC)
Deposit date:2009-07-03
Release date:2009-09-08
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (2.29 Å)
Cite:Structural Insights into the Mechanism of the Allosteric Transitions of Mycobacterium tuberculosis cAMP Receptor Protein.
J.Biol.Chem., 284, 2009
6H7E
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BU of 6h7e by Molmil
GEF regulatory domain
Descriptor: ADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE, SULFATE ION, cDNA FLJ56134, ...
Authors:Ferrandez, Y, Cherfils, J, Peurois, F.
Deposit date:2018-07-31
Release date:2020-02-19
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Membranes prime the RapGEF EPAC1 to transduce cAMP signaling.
Nat Commun, 14, 2023
3PLQ
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BU of 3plq by Molmil
Crystal structure of PKA type I regulatory subunit bound with Rp-8-Br-cAMPS
Descriptor: (2R,4aR,6R,7R,7aS)-6-(6-amino-8-bromo-9H-purin-9-yl)tetrahydro-4H-furo[3,2-d][1,3,2]dioxaphosphinine-2,7-diol 2-sulfide, ZINC ION, cAMP-dependent protein kinase type I-alpha regulatory subunit
Authors:Swaminathan, K.
Deposit date:2010-11-15
Release date:2010-12-01
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Cyclic AMP analog blocks kinase activation by stabilizing inactive conformation: Conformational selection highlights a new concept in allosteric inhibitor design
To be Published
3FWE
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BU of 3fwe by Molmil
Crystal Structure of the Apo D138L CAP mutant
Descriptor: Catabolite gene activator, PROLINE
Authors:Sharma, H, Wang, J, Kong, J, Yu, S, Steitz, T.
Deposit date:2009-01-17
Release date:2009-09-08
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structure of apo-CAP reveals that large conformational changes are necessary for DNA binding
Proc.Natl.Acad.Sci.USA, 106, 2009
1NE6
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BU of 1ne6 by Molmil
Crystal structure of Sp-cAMP binding R1a subunit of cAMP-dependent protein kinase
Descriptor: 6-(6-AMINO-PURIN-9-YL)-2-THIOXO-TETRAHYDRO-2-FURO[3,2-D][1,3,2]DIOXAPHOSPHININE-2,7-DIOL, cAMP-dependent protein kinase type I-alpha regulatory chain
Authors:Wu, J, Jones, J.M, Xuong, N.H, Taylor, S.S.
Deposit date:2002-12-10
Release date:2004-01-13
Last modified:2023-08-16
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Crystal Structures of RIalpha Subunit of Cyclic Adenosine 5'-Monophosphate (cAMP)-Dependent Protein Kinase Complexed with (R(p))-Adenosine 3',5'-Cyclic Monophosphothioate and (S(p))-Adenosine 3',5'-Cyclic Monophosphothioate, the Phosphothioate Analogues of cAMP.
Biochemistry, 43, 2004
5DZC
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BU of 5dzc by Molmil
Crystal structure of the cGMP-dependent protein kinase PKG from Plasmodium Vivax - AMPPNP bound
Descriptor: CHLORIDE ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, SODIUM ION, ...
Authors:Walker, J.R, El Bakkouri, M, Loppnau, P, Graslund, S, He, H, Seitova, A, Hutchinson, A, Bountra, C, Edwards, A.M, Arrowsmith, C.H, Hui, R, Amani, M, Structural Genomics Consortium (SGC)
Deposit date:2015-09-25
Release date:2015-10-14
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structures of the cGMP-dependent protein kinase in malaria parasites reveal a unique structural relay mechanism for activation.
Proc.Natl.Acad.Sci.USA, 116, 2019
2XHK
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BU of 2xhk by Molmil
Crystal structure of transcription factor NtcA from Synechococcus elongatus bound to 2-oxoglutarate
Descriptor: 2-OXOGLUTARIC ACID, GLOBAL NITROGEN REGULATOR
Authors:Llacer, J.L, Castells, M.A, Rubio, V.
Deposit date:2010-06-17
Release date:2010-08-18
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structural Basis for the Regulation of Ntca-Dependent Transcription by Proteins Pipx and Pii.
Proc.Natl.Acad.Sci.USA, 107, 2010
3TNP
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BU of 3tnp by Molmil
Structure and Allostery of the PKA RIIb Tetrameric Holoenzyme
Descriptor: cAMP-dependent protein kinase catalytic subunit alpha, cAMP-dependent protein kinase type II-beta regulatory subunit
Authors:Zhang, P, Smith-Nguyen, E.V, Keshwani, M.M, Deal, M.S, Kornev, A.P, Taylor, S.S.
Deposit date:2011-09-01
Release date:2012-02-01
Last modified:2013-02-27
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structure and allostery of the PKA RIIbeta tetrameric holoenzyme
Science, 335, 2012
3U10
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BU of 3u10 by Molmil
Tetramerization dynamics of the C-terminus underlies isoform-specific cAMP-gating in HCN channels
Descriptor: ADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE, Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2
Authors:Lolicato, M, Nardini, M, Gazzarrini, S, Moller, S, Bertinetti, D, Herberg, F.W, Bolognesi, M, Martin, H, Fasolini, M, Bertrand, J.A, Arrigoni, C, Thiel, G, Moroni, A.
Deposit date:2011-09-29
Release date:2011-10-26
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Tetramerization dynamics of C-terminal domain underlies isoform-specific cAMP gating in hyperpolarization-activated cyclic nucleotide-gated channels.
J.Biol.Chem., 286, 2011
1Q5O
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BU of 1q5o by Molmil
HCN2J 443-645 in the presence of cAMP, selenomethionine derivative
Descriptor: ADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE, Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2
Authors:Zagotta, W.N, Olivier, N.B, Black, K.D, Young, E.C, Olson, R, Gouaux, J.E.
Deposit date:2003-08-08
Release date:2003-09-09
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:STRUCTURAL BASIS FOR MODULATION AND AGONIST SPECIFICITY OF HCN PACEMAKER CHANNELS
Nature, 425, 2003

221716

數據於2024-06-26公開中

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