3PLQ

Crystal structure of PKA type I regulatory subunit bound with Rp-8-Br-cAMPS

Summary for 3PLQ

• Entry DOI: 10.2210/pdb3plq/pdb
• Descriptor: cAMP-dependent protein kinase type I-alpha regulatory subunit, (2R,4aR,6R,7R,7aS)-6-(6-amino-8-bromo-9H-purin-9-yl)tetrahydro-4H-furo[3,2-d][1,3,2]dioxaphosphinine-2,7-diol 2-sulfide, ZINC ION, ... (4 entities in total)
• Functional Keywords: pka, transferase inhibitor
• Biological source: Bos taurus (bovine)
• Total number of polymer chains: 1
• Total formula weight: 17829.14

Authors

Swaminathan, K. (deposition date: 2010-11-15, release date: 2010-12-01, Last modification date: 2023-11-01)

• Primary citation: Swaminathan, K.; Cyclic AMP analog blocks kinase activation by stabilizing inactive conformation: Conformational selection highlights a new concept in allosteric inhibitor design; To be Published,

Experimental method

X-RAY DIFFRACTION (2.3 Å)