3PLQ
Crystal structure of PKA type I regulatory subunit bound with Rp-8-Br-cAMPS
Summary for 3PLQ
Entry DOI | 10.2210/pdb3plq/pdb |
Descriptor | cAMP-dependent protein kinase type I-alpha regulatory subunit, (2R,4aR,6R,7R,7aS)-6-(6-amino-8-bromo-9H-purin-9-yl)tetrahydro-4H-furo[3,2-d][1,3,2]dioxaphosphinine-2,7-diol 2-sulfide, ZINC ION, ... (4 entities in total) |
Functional Keywords | pka, transferase inhibitor |
Biological source | Bos taurus (bovine) |
Total number of polymer chains | 1 |
Total formula weight | 17829.14 |
Authors | Swaminathan, K. (deposition date: 2010-11-15, release date: 2010-12-01, Last modification date: 2023-11-01) |
Primary citation | Swaminathan, K. Cyclic AMP analog blocks kinase activation by stabilizing inactive conformation: Conformational selection highlights a new concept in allosteric inhibitor design To be Published, |
Experimental method | X-RAY DIFFRACTION (2.3 Å) |
Structure validation
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