PDB: 13422 resultsInfo pagesStatus searchChemie searchBIRD

---

4MHL	The crystal structure of human interleukin-11 Descriptor: FORMAMIDE, Interleukin-11, SULFATE ION Authors: Griffin, M.D.W. Deposit date: 2013-08-29 Release date: 2014-09-03 Last modified: 2023-09-20 Method: X-RAY DIFFRACTION (2.09 Å) Cite: The structure of human interleukin-11 reveals receptor-binding site features and structural differences from interleukin-6. Acta Crystallogr.,Sect.D, 70, 2014
4LVA	Fragment-based Identification of Amides Derived From trans-2-(Pyridin-3-yl)cyclopropanecarboxylic Acid as Potent Inhibitors of Human Nicotinamide Phosphoribosyltransferase (NAMPT) Descriptor: 1,2-ETHANEDIOL, N-(4-{[4-(pyrrolidin-1-yl)piperidin-1-yl]sulfonyl}benzyl)-2H-pyrido[4,3-e][1,2,4]thiadiazin-3-amine 1,1-dioxide, Nicotinamide phosphoribosyltransferase, ... Authors: Giannetti, A.M, Zheng, X, Skelton, N, Wang, W, Bravo, B, Feng, Y, Gunzner-Toste, J, Ho, Y, Hua, R, Wang, C, Zhao, Q, Liederer, B.M, Liu, Y, O'Brien, T, Oeh, J, Sampath, D, Shen, Y, Wang, L, Wu, H, Xiao, Y, Yuen, P, Zak, M, Zhao, G, Dragovich, P.S. Deposit date: 2013-07-26 Release date: 2013-09-25 Last modified: 2024-02-28 Method: X-RAY DIFFRACTION (1.55 Å) Cite: Identification of amides derived from 1H-pyrazolo[3,4-b]pyridine-5-carboxylic acid as potent inhibitors of human nicotinamide phosphoribosyltransferase (NAMPT). Bioorg.Med.Chem.Lett., 23, 2013
4LX3	Conserved Residues that Modulate Protein trans-Splicing of Npu DnaE Split Intein Descriptor: DNA polymerase III, alpha subunit, Nucleic acid binding, ... Authors: Wu, Q, Gao, Z, Wei, Y, Ma, G, Zheng, Y, Dong, Y, Liu, Y. Deposit date: 2013-07-29 Release date: 2014-06-25 Last modified: 2022-08-24 Method: X-RAY DIFFRACTION (1.5 Å) Cite: Conserved residues that modulate protein trans-splicing of Npu DnaE split intein. Biochem.J., 461, 2014
4GUL	Study on structure and function relationships in human ferric Pirin Descriptor: FE (III) ION, Pirin Authors: Liu, F, Rehmani, I, Fu, R, Esaka, S, Chen, L, Serrano, V, Liu, A. Deposit date: 2012-08-29 Release date: 2013-05-29 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (1.8 Å) Cite: Pirin is an iron-dependent redox regulator of NF-kappa B. Proc.Natl.Acad.Sci.USA, 110, 2013
2N0A	Atomic-resolution structure of alpha-synuclein fibrils Descriptor: Alpha-synuclein Authors: Tuttle, M.D, Comellas, G, Nieuwkoop, A.J, Covell, D.J, Berthold, D.A, Kloepper, K.D, Courtney, J.M, Kim, J.K, Schwieters, C.D, Lee, V.M, George, J.M, Rienstra, C.M. Deposit date: 2015-03-04 Release date: 2016-03-23 Last modified: 2024-05-15 Method: SOLID-STATE NMR Cite: Solid-state NMR structure of a pathogenic fibril of full-length human alpha-synuclein. Nat.Struct.Mol.Biol., 23, 2016
4LVG	Fragment-based Identification of Amides Derived From trans-2-(Pyridin-3-yl)cyclopropanecarboxylic Acid as Potent Inhibitors of Human Nicotinamide Phosphoribosyltransferase (NAMPT) Descriptor: (1S,2S)-N-[4-(phenylsulfonyl)phenyl]-2-(pyridin-3-yl)cyclopropanecarboxamide, 1,2-ETHANEDIOL, Nicotinamide phosphoribosyltransferase, ... Authors: Giannetti, A.M, Zheng, X, Skelton, N, Wang, W, Bravo, B, Feng, Y, Gunzner-Toste, J, Ho, Y, Hua, R, Wang, C, Zhao, Q, Liederer, B.M, Liu, Y, O'Brien, T, Oeh, J, Sampath, D, Shen, Y, Wang, L, Wu, H, Xiao, Y, Yuen, P, Zak, M, Zhao, G, Dragovich, P.S. Deposit date: 2013-07-26 Release date: 2013-09-25 Last modified: 2024-02-28 Method: X-RAY DIFFRACTION (1.702 Å) Cite: Identification of amides derived from 1H-pyrazolo[3,4-b]pyridine-5-carboxylic acid as potent inhibitors of human nicotinamide phosphoribosyltransferase (NAMPT). Bioorg.Med.Chem.Lett., 23, 2013
4FKO	Crystal structure of the cdk2 in complex with thiazolylpyrimidine inhibitor Descriptor: 2-chloro-N~4~-[4-(2,4-dimethyl-1,3-thiazol-5-yl)pyrimidin-2-yl]-N~1~,N~1~-dimethylbenzene-1,4-diamine, ACETATE ION, Cyclin-dependent kinase 2 Authors: Kang, Y.N, Stuckey, J.A. Deposit date: 2012-06-13 Release date: 2013-05-08 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (1.55 Å) Cite: Crystal structure of the cdk2 in complex with thiazolylpyrimidine inhibitor To be Published
4FKJ	Crystal structure of the cdk2 in complex with aminopyrazole inhibitor Descriptor: ACETATE ION, Cyclin-dependent kinase 2, N-(3-cyclopropyl-1H-pyrazol-5-yl)-2-[4-(2-pyrrolidin-1-ylethoxy)phenyl]acetamide Authors: Kang, Y.N, Stuckey, J.A. Deposit date: 2012-06-13 Release date: 2013-05-08 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (1.63 Å) Cite: Crystal structure of the cdk2 in complex with aminopyrazole inhibitor To be Published
4FKW	Crystal structure of the cdk2 in complex with oxindole inhibitor Descriptor: 2-methylpropyl (3Z)-2-oxo-3-[2-(4-sulfamoylphenyl)hydrazinylidene]-2,3-dihydro-1H-indole-5-carboxylate, Cyclin-dependent kinase 2, GLYCEROL Authors: Kang, Y.N, Stuckey, J.A. Deposit date: 2012-06-13 Release date: 2013-05-08 Last modified: 2013-05-22 Method: X-RAY DIFFRACTION (1.8 Å) Cite: Crystal structure of the cdk2 in complex with oxindole inhibitor To be Published
4FL5	Crystal structure of human 14-3-3 sigma in complex with a Tau-protein peptide surrounding pS214 Descriptor: 14-3-3 protein sigma, CALCIUM ION, CHLORIDE ION, ... Authors: Schumacher, B, Ottmann, C. Deposit date: 2012-06-14 Release date: 2013-12-11 Last modified: 2017-06-07 Method: X-RAY DIFFRACTION (1.9 Å) Cite: Involvement of 14-3-3 in tubulin instability and impaired axon development is mediated by Tau. FASEB J., 29, 2015
4M6P	Identification of Amides Derived From 1H-Pyrazolo[3,4-b]pyridine-5-carboxylic Acid as Potent Inhibitors of Human Nicotinamide Phosphoribosyltransferase (NAMPT) Descriptor: N-[4-(phenylsulfonyl)benzyl]-2H-pyrazolo[3,4-b]pyridine-5-carboxamide, Nicotinamide phosphoribosyltransferase, PHOSPHATE ION Authors: Giannetti, A.M, Zheng, X, Skelton, N, Wang, W, Bravo, B, Feng, Y, Gunzner-Toste, J, Ho, Y, Hua, R, Wang, C, Zhao, Q, Liederer, B.M, Liu, Y, O'Brien, T, Oeh, J, Sampath, D, Shen, Y, Wang, L, Wu, H, Xiao, Y, Yuen, P, Zak, M, Zhao, G, Dragovich, P.S. Deposit date: 2013-08-10 Release date: 2013-09-25 Last modified: 2024-02-28 Method: X-RAY DIFFRACTION (1.75 Å) Cite: Identification of amides derived from 1H-pyrazolo[3,4-b]pyridine-5-carboxylic acid as potent inhibitors of human nicotinamide phosphoribosyltransferase (NAMPT). Bioorg.Med.Chem.Lett., 23, 2013
4MHG	Crystal structure of ETV6 bound to a specific DNA sequence Descriptor: Complementary Specific 14 bp DNA, Specific 14 bp DNA, Transcription factor ETV6 Authors: Chan, A.C, De, S, Coyne III, H.J, Okon, M, Murphy, M.E, Graves, B.J, McIntosh, L.P. Deposit date: 2013-08-29 Release date: 2014-01-08 Last modified: 2024-02-28 Method: X-RAY DIFFRACTION (2.199 Å) Cite: Steric Mechanism of Auto-Inhibitory Regulation of Specific and Non-Specific DNA Binding by the ETS Transcriptional Repressor ETV6. J.Mol.Biol., 426, 2014
4FKR	Crystal structure of the cdk2 in complex with oxindole inhibitor Descriptor: (8Z)-8-{[(2,2-dioxido-1,3-dihydro-2-benzothiophen-5-yl)amino]methylidene}-6,8-dihydro-7H-[1,3]thiazolo[5,4-e]indol-7-one, Cyclin-dependent kinase 2, GLYCEROL Authors: Kang, Y.N, Stuckey, J.A. Deposit date: 2012-06-13 Release date: 2013-05-08 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (1.9 Å) Cite: Crystal structure of the cdk2 in complex with oxindole inhibitor To be Published
4M6Q	Identification of Amides Derived From 1H-Pyrazolo[3,4-b]pyridine-5-carboxylic Acid as Potent Inhibitors of Human Nicotinamide Phosphoribosyltransferase (NAMPT) Descriptor: 1-(5-O-phosphono-beta-D-ribofuranosyl)-N-(4-{[3-(trifluoromethyl)phenyl]sulfonyl}benzyl)-1H-pyrazolo[3,4-b]pyridine-5-carboxamide, Nicotinamide phosphoribosyltransferase, PHOSPHATE ION, ... Authors: Giannetti, A.M, Zheng, X, Skelton, N, Wang, W, Bravo, B, Feng, Y, Gunzner-Toste, J, Ho, Y, Hua, R, Wang, C, Zhao, Q, Liederer, B.M, Liu, Y, O'Brien, T, Oeh, J, Sampath, D, Shen, Y, Wang, L, Wu, H, Xiao, Y, Yuen, P, Zak, M, Zhao, G, Dragovich, P.S. Deposit date: 2013-08-10 Release date: 2013-09-25 Last modified: 2024-02-28 Method: X-RAY DIFFRACTION (2.406 Å) Cite: Identification of amides derived from 1H-pyrazolo[3,4-b]pyridine-5-carboxylic acid as potent inhibitors of human nicotinamide phosphoribosyltransferase (NAMPT). Bioorg.Med.Chem.Lett., 23, 2013
4FKV	Crystal structure of the cdk2 in complex with oxindole inhibitor Descriptor: (3Z)-N-[2-(1H-imidazol-4-yl)ethyl]-2-oxo-3-[2-(4-sulfamoylphenyl)hydrazinylidene]-2,3-dihydro-1H-indole-5-carboxamide, Cyclin-dependent kinase 2, GLYCEROL Authors: Kang, Y.N, Stuckey, J.A. Deposit date: 2012-06-13 Release date: 2013-05-08 Last modified: 2013-05-22 Method: X-RAY DIFFRACTION (1.7 Å) Cite: Crystal structure of the cdk2 in complex with oxindole inhibitor To be Published
4MO1	Crystal structure of antitermination protein Q from bacteriophage lambda. Northeast Structural Genomics Consortium target OR18A. Descriptor: Antitermination protein Q, BROMIDE ION, CHLORIDE ION, ... Authors: Vorobiev, S, Su, M, Nickels, B, Seetharaman, J, Sahdev, S, Xiao, R, Kogan, S, Maglaqui, M, Wang, D, Everett, J.K, Acton, T.B, Ebright, R.H, Montelione, G.T, Hunt, J, Tong, L, Northeast Structural Genomics Consortium (NESG) Deposit date: 2013-09-11 Release date: 2013-09-25 Last modified: 2017-10-25 Method: X-RAY DIFFRACTION (2.099 Å) Cite: Crystal structure of antitermination protein Q from bacteriophage lambda. To be Published
4FKP	Crystal structure of the cdk2 in complex with oxindole inhibitor Descriptor: 3-{[4-([AMINO(IMINO)METHYL]AMINOSULFONYL)ANILINO]METHYLENE}-2-OXO-2,3-DIHYDRO-1H-INDOLE, Cyclin-dependent kinase 2, SODIUM ION Authors: Kang, Y.N, Stuckey, J.A. Deposit date: 2012-06-13 Release date: 2013-05-08 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (1.6 Å) Cite: Crystal structure of the cdk2 in complex with oxindole inhibitor To be Published
4II5	Structure of PCDK2/CYCLINA bound to ADP and 1 MAGNESIUM ION Descriptor: ADENOSINE-5'-DIPHOSPHATE, Cyclin-A2, Cyclin-dependent kinase 2, ... Authors: Jacobsen, D.M, Bao, Z.-Q, O'Brien, P.J, Brooks III, C.L, Young, M.A. Deposit date: 2012-12-19 Release date: 2013-01-23 Method: X-RAY DIFFRACTION (2.15 Å) Cite: Price to be paid for two-metal catalysis: Magnesium ions that accelerate chemistry unavoidably limit product release from a PROTEIN KINASE J.Am.Chem.Soc., 134, 2012
4IEA	14-3-3 isoform sigma in complex with a phosphorylated C-RAF peptide Descriptor: 14-3-3 protein sigma, RAF proto-oncogene serine/threonine-protein kinase Authors: Molzan, M, Ottmann, C. Deposit date: 2012-12-13 Release date: 2013-09-25 Last modified: 2023-09-20 Method: X-RAY DIFFRACTION (1.7 Å) Cite: Stabilization of Physical RAF/14-3-3 Interaction by Cotylenin A as Treatment Strategy for RAS Mutant Cancers. Acs Chem.Biol., 8, 2013
4FKL	Crystal structure of the cdk2 in complex with thiazolylpyrimidine inhibitor Descriptor: 4-(2,4-DIMETHYL-1,3-THIAZOL-5-YL)PYRIMIDIN-2-AMINE, Cyclin-dependent kinase 2 Authors: Kang, Y.N, Stuckey, J.A. Deposit date: 2012-06-13 Release date: 2013-05-08 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (1.26 Å) Cite: Crystal structure of the cdk2 in complex with thiazolylpyrimidine inhibitor To be Published
4G7L	Crystal Structure of rat Heme oxygenase-1 in complex with Heme and O2 Descriptor: FORMIC ACID, Heme oxygenase 1, OXYGEN MOLECULE, ... Authors: Sugishima, M, Moffat, K, Noguchi, M. Deposit date: 2012-07-20 Release date: 2012-10-31 Last modified: 2023-11-08 Method: X-RAY DIFFRACTION (1.8 Å) Cite: Discrimination between CO and O(2) in heme oxygenase: comparison of static structures and dynamic conformation changes following CO photolysis. Biochemistry, 51, 2012
4GCJ	CDK2 in complex with inhibitor RC-3-89 Descriptor: 1,2-ETHANEDIOL, 4-{[4-amino-5-(2-nitrobenzoyl)-1,3-thiazol-2-yl]amino}benzenesulfonamide, Cyclin-dependent kinase 2 Authors: Betzi, S, Alam, R, Han, H, Becker, A, Schonbrunn, E. Deposit date: 2012-07-30 Release date: 2012-10-31 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (1.42 Å) Cite: Development of highly potent and selective diaminothiazole inhibitors of cyclin-dependent kinases. J.Med.Chem., 56, 2013
4G99	Rat Heme Oxygenase-1 in complex with Heme and CO at 100 K after warming to 160 K Descriptor: CARBON MONOXIDE, FORMIC ACID, Heme oxygenase 1, ... Authors: Sugishima, M, Moffat, K, Noguchi, M. Deposit date: 2012-07-23 Release date: 2012-10-31 Last modified: 2023-11-08 Method: X-RAY DIFFRACTION (2.3 Å) Cite: Discrimination between CO and O(2) in heme oxygenase: comparison of static structures and dynamic conformation changes following CO photolysis. Biochemistry, 51, 2012
2P6B	Crystal Structure of Human Calcineurin in Complex with PVIVIT Peptide Descriptor: CALCIUM ION, Calcineurin subunit B isoform 1, Calmodulin-dependent calcineurin A subunit alpha isoform, ... Authors: Li, H, Zhang, L, Rao, A, Harrison, S.C, Hogan, P.G. Deposit date: 2007-03-16 Release date: 2007-06-05 Last modified: 2023-08-30 Method: X-RAY DIFFRACTION (2.3 Å) Cite: Structure of calcineurin in complex with PVIVIT peptide: Portrait of a low-affinity signalling interaction J.Mol.Biol., 369, 2007
4LJX	Crystal structure of an AT-rich interactive domain-containing protein 3A (ARID3A) from Homo sapiens at 2.21 A resolution Descriptor: AT-rich interactive domain-containing protein 3A Authors: Joint Center for Structural Genomics (JCSG), Partnership for Stem Cell Biology (STEMCELL) Deposit date: 2013-07-05 Release date: 2013-08-28 Last modified: 2023-12-06 Method: X-RAY DIFFRACTION (2.21 Å) Cite: Crystal structure of an AT-rich interactive domain-containing protein 3A (ARID3A) from Homo sapiens at 2.21 A resolution To be published

<483484485486487488489490491492493494495496497498>