8H69
| Cryo-EM structure of influenza RNA polymerase | Descriptor: | Polymerase acidic protein, Polymerase basic protein 2, RNA (5'-R(*UP*AP*AP*AP*CP*UP*CP*CP*UP*GP*CP*UP*UP*UP*UP*GP*CP*U)-3'), ... | Authors: | Li, H, Wu, Y, Liang, H, Liu, Y. | Deposit date: | 2022-10-16 | Release date: | 2023-06-28 | Last modified: | 2023-11-15 | Method: | ELECTRON MICROSCOPY (3.7 Å) | Cite: | An intermediate state allows influenza polymerase to switch smoothly between transcription and replication cycles. Nat.Struct.Mol.Biol., 30, 2023
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2E9Z
| Foot-and-mouth disease virus RNA-polymerase in complex with a template- primer RNA, ATP and UTP | Descriptor: | 5'-R(*CP*AP*UP*GP*GP*GP*CP*CP*C)-3', 5'-R(*GP*GP*GP*CP*CP*CP*A)-3', MAGNESIUM ION, ... | Authors: | Ferrer-Orta, C, Arias, A, Perez-Luque, R, Escarmis, C, Domingo, E, Verdaguer, N. | Deposit date: | 2007-01-29 | Release date: | 2007-06-26 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (3 Å) | Cite: | Sequential structures provide insights into the fidelity of RNA replication Proc.Natl.Acad.Sci.Usa, 104, 2007
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2IJD
| Crystal Structure of the Poliovirus Precursor Protein 3CD | Descriptor: | Picornain 3C, RNA-directed RNA polymerase, SULFATE ION, ... | Authors: | Marcotte, L.L, Gohara, D.W, Filman, D.J, Hogle, J.M. | Deposit date: | 2006-09-29 | Release date: | 2007-02-13 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (3.4 Å) | Cite: | Crystal structure of poliovirus 3CD: virally-encoded protease and precursor to the RNA-dependent RNA polymerase. J.Virol., 81, 2007
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4P5J
| Crystal structure of the tRNA-like structure from Turnip Yellow Mosaic Virus (TYMV), a tRNA mimicking RNA | Descriptor: | IRIDIUM HEXAMMINE ION, MAGNESIUM ION, SPERMINE, ... | Authors: | Colussi, T.M, Costantino, D.A, Hammond, J.A, Ruehle, G.M, Nix, J.C, Kieft, J.S. | Deposit date: | 2014-03-17 | Release date: | 2014-06-04 | Last modified: | 2023-12-27 | Method: | X-RAY DIFFRACTION (1.9912 Å) | Cite: | The structural basis of transfer RNA mimicry and conformational plasticity by a viral RNA. Nature, 511, 2014
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7VH2
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7VH3
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1HI0
| RNA dependent RNA polymerase from dsRNA bacteriophage phi6 plus initiation complex | Descriptor: | DNA (5'-(*TP*TP*TP*CP*C)-3'), GUANOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ... | Authors: | Grimes, J.M, Butcher, S.J, Makeyev, E.V, Bamford, D.H, Stuart, D.I. | Deposit date: | 2000-12-31 | Release date: | 2001-03-27 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (3 Å) | Cite: | A Mechanism for Initiating RNA-Dependent RNA Polymerization Nature, 410, 2001
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1HHT
| RNA dependent RNA polymerase from dsRNA bacteriophage phi6 plus template | Descriptor: | DNA (5'-(*TP*TP*TP*CP*C)-3'), MANGANESE (II) ION, P2 PROTEIN | Authors: | Grimes, J.M, Butcher, S.J, Makeyev, E.V, Bamford, D.H, Stuart, D.I. | Deposit date: | 2000-12-28 | Release date: | 2001-03-27 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (2.9 Å) | Cite: | A Mechanism for Initiating RNA-Dependent RNA Polymerization Nature, 410, 2001
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1HI1
| RNA dependent RNA polymerase from dsRNA bacteriophage phi6 plus bound NTP | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, P2 PROTEIN | Authors: | Grimes, J.M, Butcher, S.J, Makeyev, E.V, Bamford, D.H, Stuart, D.I. | Deposit date: | 2001-01-01 | Release date: | 2001-03-27 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (3 Å) | Cite: | A Mechanism for Initiating RNA-Dependent RNA Polymerization Nature, 410, 2001
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1HI8
| RNA dependent RNA polymerase from dsRNA bacteriophage phi6 | Descriptor: | MAGNESIUM ION, P2 PROTEIN | Authors: | Grimes, J.M, Butcher, S.J, Makeyev, E.V, Bamford, D.H, Stuart, D.I. | Deposit date: | 2001-01-03 | Release date: | 2001-03-27 | Last modified: | 2019-09-18 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | A Mechanism for Initiating RNA-Dependent RNA Polymerization Nature, 410, 2001
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2XHW
| HCV-J4 NS5B Polymerase Trigonal Crystal Form | Descriptor: | RNA-directed RNA polymerase | Authors: | Harrus, D, Ahmed-El-Sayed, N, Simister, P.C, Miller, S, Triconnet, M, Hagedorn, C.H, Mahias, K, Rey, F.A, Astier-Gin, T, Bressanelli, S. | Deposit date: | 2010-06-21 | Release date: | 2010-08-04 | Last modified: | 2024-03-27 | Method: | X-RAY DIFFRACTION (2.66 Å) | Cite: | Further Insights Into the Roles of GTP and the C- Terminus of the Hepatitis C Virus Polymerase in the Initiation of RNA Synthesis J.Biol.Chem., 285, 2010
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2XHU
| HCV-J4 NS5B Polymerase Orthorhombic Crystal Form | Descriptor: | RNA-directed RNA polymerase, SULFATE ION | Authors: | Harrus, D, Ahmed-El-Sayed, N, Simister, P.C, Miller, S, Triconnet, M, Hagedorn, C.H, Mahias, K, Rey, F.A, Astier-Gin, T, Bressanelli, S. | Deposit date: | 2010-06-21 | Release date: | 2010-08-04 | Last modified: | 2024-03-27 | Method: | X-RAY DIFFRACTION (2.287 Å) | Cite: | Further Insights Into the Roles of GTP and the C- Terminus of the Hepatitis C Virus Polymerase in the Initiation of RNA Synthesis J.Biol.Chem., 285, 2010
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2R7T
| Crystal Structure of Rotavirus SA11 VP1/RNA (UGUGAACC) Complex | Descriptor: | RNA (5'-R(*UP*GP*UP*GP*AP*AP*CP*C)-3'), RNA-dependent RNA polymerase | Authors: | Lu, X, Harrison, S.C, Tao, Y.J, Patton, J.T, Nibert, M.L. | Deposit date: | 2007-09-10 | Release date: | 2008-07-29 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (3 Å) | Cite: | Mechanism for coordinated RNA packaging and genome replication by rotavirus polymerase VP1. Structure, 16, 2008
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2R7R
| Crystal Structure of Rotavirus SA11 VP1/RNA (UGUGACC) complex | Descriptor: | RNA (5'-R(*UP*GP*UP*GP*AP*CP*C)-3'), RNA-dependent RNA polymerase | Authors: | Lu, X, Harrison, S.C, Tao, Y.J, Patton, J.T, Nibert, M.L. | Deposit date: | 2007-09-09 | Release date: | 2008-07-29 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | Mechanism for coordinated RNA packaging and genome replication by rotavirus polymerase VP1. Structure, 16, 2008
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2R7V
| Crystal Structure of Rotavirus SA11 VP1/RNA (GGCUUU) Complex | Descriptor: | RNA (5'-R(*G*GP*CP*UP*UP*U)-3'), RNA-dependent RNA polymerase | Authors: | Lu, X, Harrison, S.C, Tao, Y.J, Patton, J.T, Nibert, M.L. | Deposit date: | 2007-09-10 | Release date: | 2008-07-29 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Mechanism for coordinated RNA packaging and genome replication by rotavirus polymerase VP1. Structure, 16, 2008
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2R7U
| Crystal Structure of Rotavirus SA11 VP1/RNA (AAAAGCC) Complex | Descriptor: | RNA (5'-R(*AP*A*AP*AP*GP*CP*C)-3'), RNA-dependent RNA polymerase | Authors: | Lu, X, Harrison, S.C, Tao, Y.J, Patton, J.T, Nibert, M.L. | Deposit date: | 2007-09-10 | Release date: | 2008-07-29 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (3.1 Å) | Cite: | Mechanism for coordinated RNA packaging and genome replication by rotavirus polymerase VP1. Structure, 16, 2008
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2XI2
| HCV-H77 NS5B Apo Polymerase | Descriptor: | RNA-directed RNA polymerase, SULFATE ION | Authors: | Harrus, D, Ahmed-El-Sayed, N, Simister, P.C, Miller, S, Triconnet, M, Hagedorn, C.H, Mahias, K, Rey, F.A, Astier-Gin, T, Bressanelli, S. | Deposit date: | 2010-06-25 | Release date: | 2010-08-04 | Last modified: | 2024-03-27 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Further Insights Into the Roles of GTP and the C- Terminus of the Hepatitis C Virus Polymerase in the Initiation of RNA Synthesis J.Biol.Chem., 285, 2010
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4ADP
| HCV-J6 NS5B POLYMERASE V405I MUTANT | Descriptor: | RNA-DIRECTED RNA POLYMERASE | Authors: | Scrima, N, Bressanelli, S. | Deposit date: | 2012-01-02 | Release date: | 2012-05-02 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (1.902 Å) | Cite: | Two Crucial Early Steps in RNA Synthesis by the Hepatitis C Virus Polymerase Involve a Dual Role of Residue 405. J.Virol., 86, 2012
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1SH2
| Crystal Structure of Norwalk Virus Polymerase (Metal-free, Centered Orthorhombic) | Descriptor: | RNA Polymerase | Authors: | Ng, K.K, Pendas-Franco, N, Rojo, J, Boga, J.A, Machin, A, Alonso, J.M, Parra, F. | Deposit date: | 2004-02-24 | Release date: | 2004-03-09 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Crystal structure of norwalk virus polymerase reveals the carboxyl terminus in the active site cleft. J.Biol.Chem., 279, 2004
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1SH0
| Crystal Structure of Norwalk Virus Polymerase (Triclinic) | Descriptor: | RNA Polymerase | Authors: | Ng, K.K, Pendas-Franco, N, Rojo, J, Boga, J.A, Machin, A, Alonso, J.M, Parra, F. | Deposit date: | 2004-02-24 | Release date: | 2004-03-09 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (2.17 Å) | Cite: | Crystal structure of norwalk virus polymerase reveals the carboxyl terminus in the active site cleft. J.Biol.Chem., 279, 2004
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6Z8K
| La Crosse virus polymerase at elongation mimicking stage | Descriptor: | La Crosse virus 3' vRNA (1-16), La Crosse virus 5' vRNA (9-16), La Crosse virus 5' vRNA 1-10, ... | Authors: | Arragain, B, Effantin, G, Schoehn, G, Cusack, S, Malet, H. | Deposit date: | 2020-06-02 | Release date: | 2020-07-29 | Last modified: | 2024-05-01 | Method: | ELECTRON MICROSCOPY (3.02 Å) | Cite: | Pre-initiation and elongation structures of full-length La Crosse virus polymerase reveal functionally important conformational changes. Nat Commun, 11, 2020
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6Z6G
| Cryo-EM structure of La Crosse virus polymerase at pre-initiation stage | Descriptor: | 3'vRNA 1-16, 5'vRNA 1-10, 5'vRNA 9-16, ... | Authors: | Arragain, B, Effantin, G, Gerlach, P, Reguera, J, Schoehn, G, Cusack, S, Malet, H. | Deposit date: | 2020-05-28 | Release date: | 2020-07-29 | Last modified: | 2024-05-22 | Method: | ELECTRON MICROSCOPY (3.06 Å) | Cite: | Pre-initiation and elongation structures of full-length La Crosse virus polymerase reveal functionally important conformational changes. Nat Commun, 11, 2020
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3AGP
| Structure of viral polymerase form I | Descriptor: | CALCIUM ION, Elongation factor Ts, Elongation factor Tu, ... | Authors: | Takeshita, D, Tomita, K. | Deposit date: | 2010-04-06 | Release date: | 2010-09-01 | Last modified: | 2024-03-13 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Assembly of Q{beta} viral RNA polymerase with host translational elongation factors EF-Tu and -Ts Proc.Natl.Acad.Sci.USA, 107, 2010
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3AGQ
| Structure of viral polymerase form II | Descriptor: | Elongation factor Ts, Elongation factor Tu 1, LINKER, ... | Authors: | Takeshita, D, Tomita, K. | Deposit date: | 2010-04-06 | Release date: | 2010-09-01 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (3.22 Å) | Cite: | Assembly of Q{beta} viral RNA polymerase with host translational elongation factors EF-Tu and -Ts Proc.Natl.Acad.Sci.USA, 107, 2010
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3AQK
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