3UFJ
| Human Thymine DNA Glycosylase Bound to Substrate Analog 2'-fluoro-2'-deoxyuridine | Descriptor: | 5'-D(*CP*AP*GP*CP*TP*CP*TP*GP*TP*AP*CP*GP*TP*GP*AP*GP*CP*AP*GP*TP*GP*GP*A)-3', 5'-D(*CP*CP*AP*CP*TP*GP*CP*TP*CP*AP*(UF2)P*GP*TP*AP*CP*AP*GP*AP*GP*CP*TP*GP*T)-3', G/T mismatch-specific thymine DNA glycosylase | Authors: | Pozharski, E, Maiti, A, Drohat, A.C. | Deposit date: | 2011-11-01 | Release date: | 2012-04-25 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (2.967 Å) | Cite: | Lesion processing by a repair enzyme is severely curtailed by residues needed to prevent aberrant activity on undamaged DNA. Proc.Natl.Acad.Sci.USA, 109, 2012
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3UOB
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3UO7
| Crystal structure of Human Thymine DNA Glycosylase Bound to Substrate 5-carboxylcytosine | Descriptor: | 5'-D(*CP*AP*GP*CP*TP*CP*TP*GP*TP*AP*CP*AP*TP*GP*AP*GP*CP*AP*GP*TP*GP*GP*A)-3', 5'-D(*CP*CP*AP*CP*TP*GP*CP*TP*CP*AP*(1CC)P*GP*TP*AP*CP*AP*GP*AP*GP*CP*TP*GP*T)-3', G/T mismatch-specific thymine DNA glycosylase | Authors: | Zhang, L, He, C. | Deposit date: | 2011-11-16 | Release date: | 2012-02-15 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (3.002 Å) | Cite: | Thymine DNA glycosylase specifically recognizes 5-carboxylcytosine-modified DNA. Nat.Chem.Biol., 8, 2012
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5FF8
| TDG enzyme-product complex | Descriptor: | DNA, G/T mismatch-specific thymine DNA glycosylase | Authors: | Pozharski, E, Malik, S.S, Drohat, A.C. | Deposit date: | 2015-12-18 | Release date: | 2016-09-28 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | Structural basis of damage recognition by thymine DNA glycosylase: Key roles for N-terminal residues. Nucleic Acids Res., 44, 2016
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5H0K
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5H0J
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5HF7
| TDG enzyme-substrate complex | Descriptor: | DNA (28-MER), G/T mismatch-specific thymine DNA glycosylase | Authors: | Pozharski, E, Malik, S.S, Drohat, A.C. | Deposit date: | 2016-01-06 | Release date: | 2016-09-28 | Last modified: | 2024-03-06 | Method: | X-RAY DIFFRACTION (1.54 Å) | Cite: | Structural basis of damage recognition by thymine DNA glycosylase: Key roles for N-terminal residues. Nucleic Acids Res., 44, 2016
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3WDF
| Staphylococcus aureus UDG | Descriptor: | Uracil-DNA glycosylase | Authors: | Wang, H.C, Ko, T.P, Wang, A.H.J. | Deposit date: | 2013-06-18 | Release date: | 2014-02-05 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (1.48 Å) | Cite: | Staphylococcus aureus protein SAUGI acts as a uracil-DNA glycosylase inhibitor. Nucleic Acids Res., 42, 2013
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5H99
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5H9I
| Crystal structure of Geobacter metallireducens SMUG1 with xanthine | Descriptor: | BETA-MERCAPTOETHANOL, GLYCEROL, Geobacter metallireducens SMUG1, ... | Authors: | Xie, W, Cao, W, Zhang, Z, Shen, J. | Deposit date: | 2015-12-28 | Release date: | 2016-04-27 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (1.501 Å) | Cite: | Structural Basis of Substrate Specificity in Geobacter metallireducens SMUG1 Acs Chem.Biol., 11, 2016
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1LAU
| URACIL-DNA GLYCOSYLASE | Descriptor: | DNA (5'-D(*TP*TP*T)-3'), PROTEIN (URACIL-DNA GLYCOSYLASE (E.C.3.2.2.-)) | Authors: | Pearl, L.H, Savva, R. | Deposit date: | 1996-01-03 | Release date: | 1996-06-10 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | The structural basis of specific base-excision repair by uracil-DNA glycosylase. Nature, 373, 1995
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1L9G
| CRYSTAL STRUCTURE OF URACIL-DNA GLYCOSYLASE FROM T. MARITIMA | Descriptor: | Conserved hypothetical protein, IRON/SULFUR CLUSTER, SULFATE ION | Authors: | Rajashankar, K.R, Dodatko, T, Thirumuruhan, R.A, Sandigursky, M, Bresnik, A, Chance, M.R, Franklin, W.A, Almo, S.C, Burley, S.K, New York SGX Research Center for Structural Genomics (NYSGXRC) | Deposit date: | 2002-03-22 | Release date: | 2003-05-27 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Crystal Structure of uracil-DNA glycosylase from T. Maritima To be Published
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1MUG
| G:T/U MISMATCH-SPECIFIC DNA GLYCOSYLASE FROM E.COLI | Descriptor: | PROTEIN (G:T/U SPECIFIC DNA GLYCOSYLASE), SULFATE ION | Authors: | Barrett, T.E, Savva, R, Panayotou, G, Brown, T, Barlow, T, Jiricny, J, Pearl, L.H. | Deposit date: | 1998-07-10 | Release date: | 1998-07-15 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Crystal structure of a G:T/U mismatch-specific DNA glycosylase: mismatch recognition by complementary-strand interactions. Cell(Cambridge,Mass.), 92, 1998
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1MWJ
| Crystal Structure of a MUG-DNA pseudo substrate complex | Descriptor: | 5'-D(*CP*GP*CP*GP*A*GP*(DU)P*TP*CP*GP*CP*G)-3', G/U mismatch-specific DNA glycosylase | Authors: | Barrett, T.E, Scharer, O, Savva, R, Brown, T, Jiricny, J, Verdine, G.L, Pearl, L.H. | Deposit date: | 2002-09-30 | Release date: | 2002-10-11 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (2.85 Å) | Cite: | Crystal Structure of a thwarted mismatch glycosylase DNA repair complex Embo J., 18, 1999
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1MTL
| Non-productive MUG-DNA complex | Descriptor: | 5'-D(*CP*GP*CP*GP*AP*GP*(AAB)P*TP*CP*GP*CP*G)-3', G/U mismatch-specific DNA glycosylase | Authors: | Barrett, T.E, Savva, R, Barlow, T, Brown, T, Jiricny, J, Pearl, L.H. | Deposit date: | 2002-09-21 | Release date: | 2002-09-27 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Structure of a DNA base-excision product resembling a cisplatin inter-strand adduct. Nat.Struct.Biol., 5, 1998
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1MWI
| Crystal structure of a MUG-DNA product complex | Descriptor: | 5'-D(*CP*GP*CP*GP*AP*GP*(AAB)P*TP*CP*GP*CP*G)-3', G/U mismatch-specific DNA glycosylase | Authors: | Barrett, T.E, Savva, R, Panayotou, G, Brown, T, Barlow, T, Jiricny, J, Pearl, L.H. | Deposit date: | 2002-09-30 | Release date: | 2002-10-04 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (2.35 Å) | Cite: | Crystal structure of a G:T/U mismatch-specific DNA glycosylase: mismatch recognition by complementary-strand interactions. Cell(Cambridge,Mass.), 92, 1998
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1LQJ
| ESCHERICHIA COLI URACIL-DNA GLYCOSYLASE | Descriptor: | URACIL-DNA GLYCOSYLASE | Authors: | Saikrishnan, K, Sagar, M.B, Ravishankar, R, Roy, S, Purnapatre, K, Varshney, U, Vijayan, M. | Deposit date: | 2002-05-10 | Release date: | 2002-11-10 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (3.35 Å) | Cite: | Domain closure and action of uracil DNA glycosylase (UDG): structures of new crystal forms containing the Escherichia coli enzyme and a comparative study of the known structures involving UDG. Acta Crystallogr.,Sect.D, 58, 2002
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1UDH
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1UDG
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1UI1
| Crystal Structure Of Uracil-DNA Glycosylase From Thermus Thermophilus HB8 | Descriptor: | IRON/SULFUR CLUSTER, Uracil-DNA Glycosylase | Authors: | Hoseki, J, Okamoto, A, Masui, R, Shibata, T, Inoue, Y, Yokoyama, S, Kuramitsu, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI) | Deposit date: | 2003-07-14 | Release date: | 2003-10-14 | Last modified: | 2024-10-16 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Crystal Structure of a Family 4 Uracil-DNA Glycosylase from Thermus thermophilus HB8 J.Mol.Biol., 333, 2003
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1UI0
| Crystal Structure Of Uracil-DNA Glycosylase From Thermus Thermophilus HB8 | Descriptor: | IRON/SULFUR CLUSTER, SULFATE ION, URACIL, ... | Authors: | Hoseki, J, Okamoto, A, Masui, R, Shibata, T, Inoue, Y, Yokoyama, S, Kuramitsu, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI) | Deposit date: | 2003-07-14 | Release date: | 2003-10-14 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (1.5 Å) | Cite: | Crystal Structure of a Family 4 Uracil-DNA Glycosylase from Thermus thermophilus HB8 J.Mol.Biol., 333, 2003
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1VK2
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1SSP
| WILD-TYPE URACIL-DNA GLYCOSYLASE BOUND TO URACIL-CONTAINING DNA | Descriptor: | 5'-D(*AP*AP*AP*GP*AP*TP*AP*AP*CP*AP*G)-3', 5'-D(*CP*TP*GP*TP*(D1P)P*AP*TP*CP*TP*T)-3', URACIL, ... | Authors: | Parikh, S.S, Mol, C.D, Slupphaug, G, Bharati, S, Krokan, H.E, Tainer, J.A. | Deposit date: | 1999-04-28 | Release date: | 1999-05-06 | Last modified: | 2023-08-02 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Base excision repair initiation revealed by crystal structures and binding kinetics of human uracil-DNA glycosylase with DNA. EMBO J., 17, 1998
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4XEG
| Structure of the enzyme-product complex resulting from TDG action on a G/hmU mismatch | Descriptor: | 1,2-ETHANEDIOL, ACETIC ACID, DNA (28-MER), ... | Authors: | Pozharski, E, Malik, S.S, Drohat, A.C. | Deposit date: | 2014-12-23 | Release date: | 2015-09-09 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (1.72 Å) | Cite: | Thymine DNA glycosylase exhibits negligible affinity for nucleobases that it removes from DNA. Nucleic Acids Res., 43, 2015
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4Z47
| Structure of the enzyme-product complex resulting from TDG action on a GU mismatch in the presence of excess base | Descriptor: | 1,2-ETHANEDIOL, ACETIC ACID, DNA, ... | Authors: | Pozharski, E, Malik, S.S, Drohat, A.C. | Deposit date: | 2015-04-01 | Release date: | 2015-09-16 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (1.45 Å) | Cite: | Thymine DNA glycosylase exhibits negligible affinity for nucleobases that it removes from DNA. Nucleic Acids Res., 43, 2015
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