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1KO3
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BU of 1ko3 by Molmil
VIM-2, a Zn-beta-lactamase from Pseudomonas aeruginosa with Cys221 reduced
Descriptor: ACETATE ION, CHLORIDE ION, HYDROXIDE ION, ...
Authors:Garcia-Saez, I, Docquier, J.-D, Rossolini, G.M, Dideberg, O.
Deposit date:2001-12-20
Release date:2003-09-02
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (1.91 Å)
Cite:The three-dimensional structure of VIM-2, a Zn-beta-lactamase from Pseudomonas aeruginosa in its reduced and oxidised form
J.Mol.Biol., 375, 2008
4LE6
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BU of 4le6 by Molmil
Crystal structure of the phosphotriesterase OPHC2 from Pseudomonas pseudoalcaligenes
Descriptor: 1,2-ETHANEDIOL, GLYCEROL, Organophosphorus hydrolase, ...
Authors:Gotthard, G, Hiblot, J, Chabriere, E, Elias, M.
Deposit date:2013-06-25
Release date:2013-11-13
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structural and Enzymatic Characterization of the Phosphotriesterase OPHC2 from Pseudomonas pseudoalcaligenes.
Plos One, 8, 2013
6C89
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BU of 6c89 by Molmil
NDM-1 Beta-Lactamase Exhibits Differential Active Site Sequence Requirements for the Hydrolysis of Penicillin versus Carbapenem Antibiotics
Descriptor: 1,2-ETHANEDIOL, Beta-lactamase, CHLORIDE ION, ...
Authors:Palzkill, T, Sun, Z, Sankaran, B.
Deposit date:2018-01-24
Release date:2018-12-12
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (1.75006151 Å)
Cite:Differential active site requirements for NDM-1 beta-lactamase hydrolysis of carbapenem versus penicillin and cephalosporin antibiotics.
Nat Commun, 9, 2018
6C6I
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BU of 6c6i by Molmil
Crystal structure of a chimeric NDM-1 metallo-beta-lactamase harboring the IMP-1 L3 loop
Descriptor: Metallo-beta-lactamase type 2 chimera, ZINC ION
Authors:Otero, L, Giannini, E, Klinke, S, Palacios, A, Mojica, M, Bonomo, R, Llarrull, L, Vila, A.
Deposit date:2018-01-18
Release date:2018-10-17
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:The Reaction Mechanism of Metallo-beta-Lactamases Is Tuned by the Conformation of an Active-Site Mobile Loop.
Antimicrob. Agents Chemother., 63, 2019
6CAC
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BU of 6cac by Molmil
Crystal structure of NDM-1 metallo-beta-lactamase harboring an insertion of a Pro residue in L3 loop
Descriptor: CADMIUM ION, CALCIUM ION, COBALT (II) ION, ...
Authors:Alzari, P.M, Giannini, E, Palacios, A, Mojica, M, Bonomo, R, Llarrull, L, Vila, A.
Deposit date:2018-01-30
Release date:2018-10-17
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (1.79 Å)
Cite:The Reaction Mechanism of Metallo-beta-Lactamases Is Tuned by the Conformation of an Active-Site Mobile Loop.
Antimicrob. Agents Chemother., 63, 2019
6CGY
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BU of 6cgy by Molmil
Structure of the Quorum Quenching lactonase from Alicyclobacillus acidoterrestris bound to a phosphate anion
Descriptor: 1,2-ETHANEDIOL, Beta-lactamase, COBALT (II) ION, ...
Authors:Bergonzi, C, Schwab, M, Naik, T, Daude, D, Chabriere, E, Elias, M.
Deposit date:2018-02-21
Release date:2018-08-15
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:Structural and Biochemical Characterization of AaL, a Quorum Quenching Lactonase with Unusual Kinetic Properties.
Sci Rep, 8, 2018
6D1D
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BU of 6d1d by Molmil
Crystal structure of NDM-1 complexed with compound 6
Descriptor: ACETATE ION, Metallo-beta-lactamase type 2, ZINC ION, ...
Authors:Pemberton, O.A, Chen, Y.
Deposit date:2018-04-11
Release date:2019-04-17
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:Heteroaryl Phosphonates as Noncovalent Inhibitors of Both Serine- and Metallocarbapenemases.
J.Med.Chem., 62, 2019
6D1I
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Crystal structure of NDM-1 complexed with compound 12
Descriptor: ACETATE ION, Metallo-beta-lactamase type 2, ZINC ION, ...
Authors:Pemberton, O.A, Chen, Y.
Deposit date:2018-04-11
Release date:2019-04-17
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (1.1 Å)
Cite:Heteroaryl Phosphonates as Noncovalent Inhibitors of Both Serine- and Metallocarbapenemases.
J.Med.Chem., 62, 2019
7U2R
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BU of 7u2r by Molmil
Structure of Paenibacillus sp. J14 Apyc1
Descriptor: Apyc1, ZINC ION
Authors:Hobbs, S.J, Wein, T, Lu, A, Morehouse, B.R, Schnabel, J, Sorek, R, Kranzusch, P.J.
Deposit date:2022-02-24
Release date:2022-04-20
Last modified:2022-06-01
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Phage anti-CBASS and anti-Pycsar nucleases subvert bacterial immunity.
Nature, 605, 2022
7U2S
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BU of 7u2s by Molmil
Structure of Paenibacillus xerothermodurans Apyc1 in the apo state
Descriptor: Apyc1, ZINC ION
Authors:Hobbs, S.J, Wein, T, Lu, A, Morehouse, B.R, Schnabel, J, Sorek, R, Kranzusch, P.J.
Deposit date:2022-02-24
Release date:2022-04-20
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (1.55 Å)
Cite:Phage anti-CBASS and anti-Pycsar nucleases subvert bacterial immunity.
Nature, 605, 2022
7TZ9
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BU of 7tz9 by Molmil
Structure of PQS Response Protein PqsE(E182W) Variant
Descriptor: FE (III) ION, Quinolone signal response protein
Authors:Jeffrey, P.D, Taylor, I.R, Bassler, B.L.
Deposit date:2022-02-15
Release date:2022-08-31
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.01 Å)
Cite:The PqsE Active Site as a Target for Small Molecule Antimicrobial Agents against Pseudomonas aeruginosa.
Biochemistry, 61, 2022
7TZA
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BU of 7tza by Molmil
Structure of PQS Response Protein PqsE in complex with N-(4-(3-neopentylureido)phenyl)-1H-indazole-7-carboxamide
Descriptor: 1,2-ETHANEDIOL, FE (III) ION, N-{4-[(2,2-dimethylpropyl)carbamamido]phenyl}-1H-indazole-7-carboxamide, ...
Authors:Jeffrey, P.D, Taylor, I.R, Bassler, B.L.
Deposit date:2022-02-15
Release date:2022-08-31
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:The PqsE Active Site as a Target for Small Molecule Antimicrobial Agents against Pseudomonas aeruginosa.
Biochemistry, 61, 2022
7U6G
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BU of 7u6g by Molmil
Structure of PQS Response Protein PqsE(E182W,E280A) Variant
Descriptor: FE (III) ION, Quinolone signal response protein
Authors:Jeffrey, P.D, Taylor, I.R, Bassler, B.L.
Deposit date:2022-03-04
Release date:2022-08-31
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.45 Å)
Cite:The PqsE Active Site as a Target for Small Molecule Antimicrobial Agents against Pseudomonas aeruginosa.
Biochemistry, 61, 2022
2M5C
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BU of 2m5c by Molmil
Solution Structure of the Bacillus cereus Metallo-Beta-Lactamase BcII
Descriptor: Beta-lactamase 2, ZINC ION
Authors:Karsisiotis, A.I, Damblon, C.F, Roberts, G.C.K.
Deposit date:2013-02-20
Release date:2013-10-09
Last modified:2024-05-15
Method:SOLUTION NMR
Cite:Solution structures of the Bacillus cereus metallo-beta-lactamase BcII and its complex with the broad spectrum inhibitor R-thiomandelic acid.
Biochem.J., 456, 2013
2M5D
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BU of 2m5d by Molmil
Solution Structure of the Bacillus cereus Metallo-Beta-Lactamase BcII in Complex with R-Thiomandelic Acid
Descriptor: (2R)-phenyl(sulfanyl)ethanoic acid, Beta-lactamase 2, ZINC ION
Authors:Karsisiotis, A.I, Damblon, C.F, Roberts, G.C.K.
Deposit date:2013-02-20
Release date:2013-10-09
Last modified:2024-05-15
Method:SOLUTION NMR
Cite:Solution structures of the Bacillus cereus metallo-beta-lactamase BcII and its complex with the broad spectrum inhibitor R-thiomandelic acid.
Biochem.J., 456, 2013
3RKJ
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BU of 3rkj by Molmil
Crystal Structure of New Delhi Metallo-Beta-Lactamase-1 from Klebsiella pnueumoniae
Descriptor: Beta-lactamase NDM-1, GLYCEROL, SULFATE ION
Authors:Kim, Y, Tesar, C, Jedrzejczak, R, Binkowski, T.A, Babnigg, G, Sacchettini, J, Joachimiak, A, Midwest Center for Structural Genomics (MCSG), Structures of Mtb Proteins Conferring Susceptibility to Known Mtb Inhibitors (MTBI)
Deposit date:2011-04-18
Release date:2011-05-18
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structure of Apo- and Monometalated Forms of NDM-1 A Highly Potent Carbapenem-Hydrolyzing Metallo-beta-Lactamase
Plos One, 6, 2011
3PG4
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BU of 3pg4 by Molmil
The crystal structure of New Delhi Metallo-beta lactamase (NDM-1)
Descriptor: Metallo-beta-lactamase
Authors:Kim, H.T, Cho, Y.S, Chang, H.J.
Deposit date:2010-10-29
Release date:2011-11-16
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (2 Å)
Cite:The crystal structure of New Delhi Metallo-beta lactamase (NDM-1)
To be Published
3RKK
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BU of 3rkk by Molmil
Crystal Structure of New Delhi Metallo-Beta-Lactamase-1 from Klebsiella pneumoniae
Descriptor: ACETIC ACID, Beta-lactamase NDM-1, GLYCEROL, ...
Authors:Kim, Y, Tesar, C, Jedrzejczak, R, Binkowski, T.A, Babnigg, G, Sacchettini, J, Joachimiak, A, Midwest Center for Structural Genomics (MCSG), Structures of Mtb Proteins Conferring Susceptibility to Known Mtb Inhibitors (MTBI)
Deposit date:2011-04-18
Release date:2011-05-18
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (2.35 Å)
Cite:Structure of Apo- and Monometalated Forms of NDM-1 A Highly Potent Carbapenem-Hydrolyzing Metallo-beta-Lactamase
Plos One, 6, 2011
3S0Z
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BU of 3s0z by Molmil
Crystal structure of New Delhi Metallo-beta-lactamase (NDM-1)
Descriptor: Metallo-beta-lactamase, ZINC ION
Authors:Guo, Y, Wang, J, Niu, G.J, Shui, W.Q, Sun, Y.N, Lou, Z.Y, Rao, Z.H.
Deposit date:2011-05-13
Release date:2011-06-01
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:A structural view of the antibiotic degradation enzyme NDM-1 from a superbug.
Protein Cell, 2011
3Q6V
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BU of 3q6v by Molmil
Crystal Structure of Serratia fonticola Sfh-I: glycerol complex
Descriptor: Beta-lactamase, GLYCEROL, ZINC ION
Authors:Fonseca, F, Saavedra, M.J, Correia, A, Spencer, J.
Deposit date:2011-01-03
Release date:2011-07-13
Last modified:2024-03-20
Method:X-RAY DIFFRACTION (1.37 Å)
Cite:Crystal structure of Serratia fonticola Sfh-I: activation of the nucleophile in mono-zinc metallo-beta-lactamases.
J.Mol.Biol., 411, 2011
2NZE
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BU of 2nze by Molmil
Structure of beta-lactamase II from Bacillus cereus. R121H, C221S double mutant. Space group P3121.
Descriptor: ACETIC ACID, Beta-lactamase II, GLYCEROL, ...
Authors:Medrano Martin, F.J, Vila, A.J, Gonzalez, J.M.
Deposit date:2006-11-23
Release date:2007-05-29
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:The Zn2 position in metallo-beta-lactamases is critical for activity: a study on chimeric metal sites on a conserved protein scaffold.
J.Mol.Biol., 373, 2007
2NXA
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BU of 2nxa by Molmil
Structure of Zn-dependent Metallo-Beta-Lactamase from Bacillus Cereus R121H, C221D Double Mutant
Descriptor: Beta-lactamase II, ZINC ION
Authors:Medrano Martin, F.J, Vila, A.J, Gonzalez, J.M.
Deposit date:2006-11-17
Release date:2007-05-22
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (2.29 Å)
Cite:The Zn2 position in metallo-beta-lactamases is critical for activity: a study on chimeric metal sites on a conserved protein scaffold.
J.Mol.Biol., 373, 2007
2NYP
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BU of 2nyp by Molmil
Structure of beta-lactamase II from Bacillus cereus. R121H, C221D doble mutant with two zinc ions.
Descriptor: Beta-lactamase II, ZINC ION
Authors:Medrano Martin, F.J, Vila, A.J, Gonzalez, J.M.
Deposit date:2006-11-21
Release date:2007-05-22
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (1.84 Å)
Cite:The Zn2 position in metallo-beta-lactamases is critical for activity: a study on chimeric metal sites on a conserved protein scaffold.
J.Mol.Biol., 373, 2007
2NZF
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BU of 2nzf by Molmil
Structure of beta-lactamase II from Bacillus cereus. R121H, C221S double mutant. Space group C2.
Descriptor: Beta-lactamase II, ZINC ION
Authors:Medrano Martin, F.J, Vila, A.J, Gonzalez, J.M.
Deposit date:2006-11-23
Release date:2007-05-29
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (2.28 Å)
Cite:The Zn2 position in metallo-beta-lactamases is critical for activity: a study on chimeric metal sites on a conserved protein scaffold.
J.Mol.Biol., 373, 2007
3AJ3
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BU of 3aj3 by Molmil
Crystal structure of selenomethionine substituted 4-pyridoxolactonase from Mesorhizobium loti
Descriptor: 4-pyridoxolactonase, PHOSPHATE ION, ZINC ION
Authors:Kobayashi, J, Yoshikane, Y, Baba, S, Mikami, B, Yagi, T.
Deposit date:2010-05-21
Release date:2011-05-25
Last modified:2024-03-20
Method:X-RAY DIFFRACTION (1.577 Å)
Cite:Structure of 4-pyridoxolactonase from Mesorhizobium loti.
Acta Crystallogr.,Sect.F, 70, 2014

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數據於2024-06-26公開中

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