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6EWE

Crystal structure of BCII Metallo-beta-lactamase in complex with DZ-308

Summary for 6EWE
Entry DOI10.2210/pdb6ewe/pdb
Related5JMX 6EUM
DescriptorMetallo-beta-lactamase type 2, ZINC ION, SULFATE ION, ... (6 entities in total)
Functional Keywordsantimicrobial resistance, metallo beta lactamase, inhibitor, hydrolase
Biological sourceBacillus cereus
Total number of polymer chains1
Total formula weight25642.91
Authors
Stepanovs, D.,McDonough, M.A.,Schofield, C.J.,Zhang, D.,El-Husseiny, A.,Brem, J. (deposition date: 2017-11-03, release date: 2018-10-03, Last modification date: 2024-01-17)
Primary citationZhang, D.,Markoulides, M.S.,Stepanovs, D.,Rydzik, A.M.,El-Hussein, A.,Bon, C.,Kamps, J.J.A.G.,Umland, K.D.,Collins, P.M.,Cahill, S.T.,Wang, D.Y.,von Delft, F.,Brem, J.,McDonough, M.A.,Schofield, C.J.
Structure activity relationship studies on rhodanines and derived enethiol inhibitors of metallo-beta-lactamases.
Bioorg. Med. Chem., 26:2928-2936, 2018
Cited by
PubMed: 29655609
DOI: 10.1016/j.bmc.2018.02.043
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.46 Å)
Structure validation

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