5O7N

Beta-lactamase VIM-2 in complex with (2R)-1-(2-Benzyl-3-mercaptopropanoyl)piperidine-2-carboxylic acid

Summary for 5O7N

• Entry DOI: 10.2210/pdb5o7n/pdb
• Descriptor: Beta-lactamase VIM-2, ZINC ION, (2~{R})-1-[(2~{S})-2-(phenylmethyl)-3-sulfanyl-propanoyl]piperidine-2-carboxylic acid, ... (6 entities in total)
• Functional Keywords: inhibitor, complex, mbl, beta-lactamase vim-2, (2r)-1-(2-benzyl-3-mercaptopropanoyl)piperidine-2-carboxylic acid, hydrolase
• Biological source: Klebsiella pneumoniae
• Total number of polymer chains: 2
• Total formula weight: 56333.03

Authors

Buettner, D.,Kramer, J.S.,Pogoryelov, D.,Proschak, E. (deposition date: 2017-06-09, release date: 2018-06-20, Last modification date: 2019-07-03)

• Primary citation: Buttner, D.,Kramer, J.S.,Klingler, F.M.,Wittmann, S.K.,Hartmann, M.R.,Kurz, C.G.,Kohnhauser, D.,Weizel, L.,Bruggerhoff, A.,Frank, D.,Steinhilber, D.,Wichelhaus, T.A.,Pogoryelov, D.,Proschak, E.; Challenges in the Development of a Thiol-Based Broad-Spectrum Inhibitor for Metallo-beta-Lactamases.; Acs Infect Dis., 4:360-372, 2018; PubMed: 29172434; DOI: 10.1021/acsinfecdis.7b00129

Experimental method

X-RAY DIFFRACTION (1.5 Å)