5O7N
Beta-lactamase VIM-2 in complex with (2R)-1-(2-Benzyl-3-mercaptopropanoyl)piperidine-2-carboxylic acid
Summary for 5O7N
Entry DOI | 10.2210/pdb5o7n/pdb |
Descriptor | Beta-lactamase VIM-2, ZINC ION, (2~{R})-1-[(2~{S})-2-(phenylmethyl)-3-sulfanyl-propanoyl]piperidine-2-carboxylic acid, ... (6 entities in total) |
Functional Keywords | inhibitor, complex, mbl, beta-lactamase vim-2, (2r)-1-(2-benzyl-3-mercaptopropanoyl)piperidine-2-carboxylic acid, hydrolase |
Biological source | Klebsiella pneumoniae |
Total number of polymer chains | 2 |
Total formula weight | 56333.03 |
Authors | Buettner, D.,Kramer, J.S.,Pogoryelov, D.,Proschak, E. (deposition date: 2017-06-09, release date: 2018-06-20, Last modification date: 2024-05-08) |
Primary citation | Buttner, D.,Kramer, J.S.,Klingler, F.M.,Wittmann, S.K.,Hartmann, M.R.,Kurz, C.G.,Kohnhauser, D.,Weizel, L.,Bruggerhoff, A.,Frank, D.,Steinhilber, D.,Wichelhaus, T.A.,Pogoryelov, D.,Proschak, E. Challenges in the Development of a Thiol-Based Broad-Spectrum Inhibitor for Metallo-beta-Lactamases. Acs Infect Dis., 4:360-372, 2018 Cited by PubMed: 29172434DOI: 10.1021/acsinfecdis.7b00129 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.5 Å) |
Structure validation
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