5NI0

VIM-2_10c. Metallo-beta-Lactamase Inhibitors by Bioisosteric Replacement: Preparation, Activity and Binding

Summary for 5NI0

• Entry DOI: 10.2210/pdb5ni0/pdb
• Descriptor: Beta-lactamase class B VIM-2, ZINC ION, [(2~{R})-1-ethanoylsulfanyl-6-phenyl-hexan-2-yl]phosphonic acid, ... (4 entities in total)
• Functional Keywords: inhibition properties, bioisosters, thiols, metallo-beta-lactamase inhibitor, hydrolase
• Biological source: Pseudomonas aeruginosa
• Total number of polymer chains: 2
• Total formula weight: 57600.01

Authors

Skagseth, S.,Akhter, S.,Paulsen, M.H.,Samuelsen, O.,Muhammad, Z.,Leiros, H.-K.S.,Bayer, A. (deposition date: 2017-03-22, release date: 2017-04-26, Last modification date: 2024-01-17)

• Primary citation: Skagseth, S.,Akhter, S.,Paulsen, M.H.,Muhammad, Z.,Lauksund, S.,Leiros, H.S.,Bayer, A.; Metallo-beta-lactamase inhibitors by bioisosteric replacement: Preparation, activity and binding.; Eur J Med Chem, 135:159-173, 2017; PubMed: 28445786; DOI: 10.1016/j.ejmech.2017.04.035

Experimental method

X-RAY DIFFRACTION (1.673 Å)