5NI0

VIM-2_10c. Metallo-beta-Lactamase Inhibitors by Bioisosteric Replacement: Preparation, Activity and Binding

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0008800	molecular_function	beta-lactamase activity
E	0008800	molecular_function	beta-lactamase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	5
Details	binding site for residue ZN A 401

Chain	Residue
A	HIS116
A	HIS118
A	HIS196
A	8XW403
A	HOH527

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site_id	AC2
Number of Residues	6
Details	binding site for residue ZN A 402

Chain	Residue
A	8XW403
A	HOH527
A	ASP120
A	ARG121
A	CYS221
A	HIS263

---

site_id	AC3
Number of Residues	13
Details	binding site for residue 8XW A 403

Chain	Residue
A	PHE61
A	TYR67
A	TRP87
A	ASP120
A	HIS196
A	CYS221
A	ARG228
A	HIS263
A	ZN401
A	ZN402
A	HOH527
A	HOH644
E	HOH651

---

site_id	AC4
Number of Residues	5
Details	binding site for residue ZN E 401

Chain	Residue
E	HIS116
E	HIS118
E	HIS196
E	8XW403
E	HOH507

---

site_id	AC5
Number of Residues	6
Details	binding site for residue ZN E 402

Chain	Residue
E	ASP120
E	ARG121
E	CYS221
E	HIS263
E	8XW403
E	HOH507

---

site_id	AC6
Number of Residues	15
Details	binding site for residue 8XW E 403

Chain	Residue
E	PHE61
E	TYR67
E	TRP87
E	HIS118
E	ASP119
E	ASP120
E	HIS196
E	CYS221
E	ARG228
E	ASN233
E	HIS263
E	ZN401
E	ZN402
E	HOH507
E	HOH527

---