PDB: 91 resultsInfo pagesStatus searchChemie searchBIRD

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6MUW	The structure of the Plasmodium falciparum 20S proteasome. Descriptor: 20S proteasome alpha-1 subunit, 20S proteasome alpha-2 subunit, 20S proteasome alpha-3 subunit, ... Authors: Metcalfe, R.D, Xie, S.C, Hanssen, E, Gillett, D.L, Leis, A.P, Tilley, L, Griffin, M.D.W. Deposit date: 2018-10-23 Release date: 2019-08-07 Last modified: 2024-03-13 Method: ELECTRON MICROSCOPY (3.6 Å) Cite: The structure of the PA28-20S proteasome complex from Plasmodium falciparum and implications for proteostasis. Nat Microbiol, 4, 2019
4R5X	Structure of the m1 alanylaminopeptidase from malaria complexed with a hydroxamic acid-based inhibitor Descriptor: 3-amino-N-{(1R)-2-(hydroxyamino)-2-oxo-1-[4-(1H-pyrazol-1-yl)phenyl]ethyl}benzamide, DIMETHYL SULFOXIDE, GLYCEROL, ... Authors: Drinkwater, N, Mcgowan, S. Deposit date: 2014-08-22 Release date: 2014-10-29 Last modified: 2024-02-28 Method: X-RAY DIFFRACTION (1.85 Å) Cite: Two-Pronged Attack: Dual Inhibition of Plasmodium falciparum M1 and M17 Metalloaminopeptidases by a Novel Series of Hydroxamic Acid-Based Inhibitors. J.Med.Chem., 57, 2014
4R76	Structure of the m17 leucyl aminopeptidase from malaria complexed with a hydroxamic acid-based inhibitor Descriptor: 3-amino-N-{(1R)-2-(hydroxyamino)-2-oxo-1-[4-(1H-pyrazol-1-yl)phenyl]ethyl}benzamide, CARBONATE ION, M17 family aminopeptidase, ... Authors: Drinkwater, N, Mcgowan, S. Deposit date: 2014-08-27 Release date: 2014-10-29 Last modified: 2023-09-20 Method: X-RAY DIFFRACTION (2.5 Å) Cite: Two-Pronged Attack: Dual Inhibition of Plasmodium falciparum M1 and M17 Metalloaminopeptidases by a Novel Series of Hydroxamic Acid-Based Inhibitors. J.Med.Chem., 57, 2014
4R5T	Structure of the m1 alanylaminopeptidase from malaria complexed with a hydroxamic acid-based inhibitor Descriptor: DIMETHYL SULFOXIDE, GLYCEROL, M1 family aminopeptidase, ... Authors: Drinkwater, N, Mcgowan, S. Deposit date: 2014-08-22 Release date: 2014-10-29 Last modified: 2023-09-20 Method: X-RAY DIFFRACTION (1.98 Å) Cite: Two-Pronged Attack: Dual Inhibition of Plasmodium falciparum M1 and M17 Metalloaminopeptidases by a Novel Series of Hydroxamic Acid-Based Inhibitors. J.Med.Chem., 57, 2014
4R6T	Structure of the m17 leucyl aminopeptidase from malaria complexed with a hydroxamic acid-based inhibitor Descriptor: CARBONATE ION, DIMETHYL SULFOXIDE, M17 leucyl aminopeptidase, ... Authors: Drinkwater, N, Mcgowan, S. Deposit date: 2014-08-26 Release date: 2014-10-29 Last modified: 2023-09-20 Method: X-RAY DIFFRACTION (2.6 Å) Cite: Two-Pronged Attack: Dual Inhibition of Plasmodium falciparum M1 and M17 Metalloaminopeptidases by a Novel Series of Hydroxamic Acid-Based Inhibitors. J.Med.Chem., 57, 2014
8QKE	PvSub1 Catalytic Domain in Complex with Peptidomimetic Inhibitor (MH-13) Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, Peptidomimetic Inhibitor (MH-13), ... Authors: Batista, F.A, Martinez, M, Bouillon, A, Mechaly, A, Alzari, P.M, Haouz, A, Barale, J.C. Deposit date: 2023-09-15 Release date: 2024-03-20 Last modified: 2024-05-01 Method: X-RAY DIFFRACTION (1.504 Å) Cite: Insights from structure-activity relationships and the binding mode of peptidic alpha-ketoamide inhibitors of the malaria drug target subtilisin-like SUB1. Eur.J.Med.Chem., 269, 2024
8QKJ	PvSub1 Catalytic Domain in Complex with Peptidomimetic Inhibitor (MAM-133) Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, Peptidomimetic Inhibitor (MAM-133), ... Authors: Batista, F.A, Martinez, M, Bouillon, A, Mechaly, A, Alzari, P.M, Haouz, A, Barale, J.C. Deposit date: 2023-09-15 Release date: 2024-03-20 Last modified: 2024-05-01 Method: X-RAY DIFFRACTION (1.767 Å) Cite: Insights from structure-activity relationships and the binding mode of peptidic alpha-ketoamide inhibitors of the malaria drug target subtilisin-like SUB1. Eur.J.Med.Chem., 269, 2024
8QKG	PvSub1 Catalytic Domain in Complex with Peptidomimetic Inhibitor (MAM-125) Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, Peptidomimetic Inhibitor (MAM-125), ... Authors: Batista, F.A, Martinez, M, Bouillon, A, Mechaly, A, Alzari, P.M, Haouz, A, Barale, J.C. Deposit date: 2023-09-15 Release date: 2024-03-20 Last modified: 2024-05-01 Method: X-RAY DIFFRACTION (1.538 Å) Cite: Insights from structure-activity relationships and the binding mode of peptidic alpha-ketoamide inhibitors of the malaria drug target subtilisin-like SUB1. Eur.J.Med.Chem., 269, 2024
4QT2	Crystal Structure of the FK506-Binding Domain of Plasmodium Falciparum FKBP35 in complex with Rapamycin Descriptor: FK506-binding protein (FKBP)-type peptidyl-propyl isomerase, IMIDAZOLE, RAPAMYCIN IMMUNOSUPPRESSANT DRUG Authors: Bianchin, A, Allemand, F, Bell, A, Chubb, A.J, Guichou, J.-F. Deposit date: 2014-07-07 Release date: 2015-06-10 Last modified: 2023-11-08 Method: X-RAY DIFFRACTION (1.44 Å) Cite: Two crystal structures of the FK506-binding domain of Plasmodium falciparum FKBP35 in complex with rapamycin at high resolution Acta Crystallogr.,Sect.D, 71, 2015
4R5V	Structure of the m1 alanylaminopeptidase from malaria complexed with a hydroxamic acid-based inhibitor Descriptor: GLYCEROL, M1 family aminopeptidase, N-{(1R)-2-(hydroxyamino)-2-oxo-1-[4-(1H-pyrazol-1-yl)phenyl]ethyl}-2,2-dimethylpropanamide, ... Authors: Drinkwater, N, Mcgowan, S. Deposit date: 2014-08-22 Release date: 2014-10-29 Last modified: 2023-09-20 Method: X-RAY DIFFRACTION (2.1 Å) Cite: Two-Pronged Attack: Dual Inhibition of Plasmodium falciparum M1 and M17 Metalloaminopeptidases by a Novel Series of Hydroxamic Acid-Based Inhibitors. J.Med.Chem., 57, 2014
4R7M	Structure of the m17 leucyl aminopeptidase from malaria complexed with a hydroxamic acid-based inhibitor Descriptor: 4-amino-N-{(1R)-2-(hydroxyamino)-2-oxo-1-[4-(1H-pyrazol-1-yl)phenyl]ethyl}benzamide, CARBONATE ION, DIMETHYL SULFOXIDE, ... Authors: Drinkwater, N, Mcgowan, S. Deposit date: 2014-08-28 Release date: 2014-10-29 Last modified: 2023-09-20 Method: X-RAY DIFFRACTION (2.85 Å) Cite: Two-Pronged Attack: Dual Inhibition of Plasmodium falciparum M1 and M17 Metalloaminopeptidases by a Novel Series of Hydroxamic Acid-Based Inhibitors. J.Med.Chem., 57, 2014
4QT3	Crystal structure resolution of Plasmodium falciparum FK506 binding domain (FKBP35) in complex with Rapamycin at 1.4A resolution Descriptor: (2S,3S)-1,4-DIMERCAPTOBUTANE-2,3-DIOL, FK506-binding protein (FKBP)-type peptidyl-propyl isomerase, RAPAMYCIN IMMUNOSUPPRESSANT DRUG Authors: Bianchin, A, Allemand, F, Bell, A, Chubb, A.J, Guichou, J.-F. Deposit date: 2014-07-07 Release date: 2015-06-10 Last modified: 2023-11-08 Method: X-RAY DIFFRACTION (1.4 Å) Cite: Two crystal structures of the FK506-binding domain of Plasmodium falciparum FKBP35 in complex with rapamycin at high resolution Acta Crystallogr.,Sect.D, 71, 2015
5FOD	Crystal structure of the P.falciparum cytosolic leucyl-tRNA synthetase editing domain (space group P1) containing deletions of insertions 1 and 3 Descriptor: 1,2-ETHANEDIOL, LEUCYL-TRNA SYNTHETASE Authors: Palencia, A, Sonoiki, E, Guo, D, Ahyong, V, Dong, C, Li, X, Hernandez, V.S, Gut, J, Legac, J, Cooper, R, Alley, M.R.K, Freund, Y.R, DeRisi, J, Cusack, S, Rosenthal, P.J. Deposit date: 2015-11-19 Release date: 2016-06-22 Last modified: 2024-05-01 Method: X-RAY DIFFRACTION (1.7 Å) Cite: Anti-Malarial Benzoxaboroles Target P. Falciparum Leucyl-tRNA Synthetase. Antimicrob.Agents Chemother., 60, 2016
5FO4	Crystal structure of the P.falciparum cytosolic leucyl-tRNA synthetase editing domain (space group P1) Descriptor: LEUCYL TRNA SYNTHASE Authors: Palencia, A, Sonoiki, E, Guo, D, Ahyong, V, Dong, C, Li, X, Hernandez, V.S, Gut, J, Legac, J, Cooper, R, Alley, M.R.K, Freund, Y.R, DeRisi, J, Cusack, S, Rosenthal, P.J. Deposit date: 2015-11-18 Release date: 2016-06-22 Last modified: 2024-05-01 Method: X-RAY DIFFRACTION (1.85 Å) Cite: Anti-Malarial Benzoxaboroles Target P. Falciparum Leucyl-tRNA Synthetase. Antimicrob.Agents Chemother., 60, 2016
5FOC	Crystal structure of the P.falciparum cytosolic leucyl-tRNA synthetase editing domain (space group P21) Descriptor: LEUCYL-TRNA SYNTHETASE Authors: Palencia, A, Sonoiki, E, Guo, D, Ahyong, V, Dong, C, Li, X, Hernandez, V.S, Gut, J, Legac, J, Cooper, R, Alley, M.R.K, Freund, Y.R, DeRisi, J, Cusack, S, Rosenthal, P.J. Deposit date: 2015-11-19 Release date: 2016-06-22 Last modified: 2024-05-01 Method: X-RAY DIFFRACTION (1.5 Å) Cite: Anti-Malarial Benzoxaboroles Target P. Falciparum Leucyl-tRNA Synthetase. Antimicrob.Agents Chemother., 60, 2016
5FOF	Crystal structure of the P.knowlesi cytosolic leucyl-tRNA synthetase editing domain Descriptor: LEUCYL-TRNA SYNTHETASE Authors: Palencia, A, Sonoiki, E, Guo, D, Ahyong, V, Dong, C, Li, X, Hernandez, V.S, Gut, J, Legac, J, Cooper, R, Alley, M.R.K, Freund, Y.R, DeRisi, J, Cusack, S, Rosenthal, P.J. Deposit date: 2015-11-19 Release date: 2016-06-22 Last modified: 2024-05-01 Method: X-RAY DIFFRACTION (2.4 Å) Cite: Anti-Malarial Benzoxaboroles Target P. Falciparum Leucyl-tRNA Synthetase. Antimicrob.Agents Chemother., 60, 2016

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