4AAJ
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![BU of 4aaj by Molmil](/molmil-images/mine/4aaj) | Structure of N-(5'-phosphoribosyl)anthranilate isomerase from Pyrococcus furiosus | Descriptor: | N-(5'-PHOSPHORIBOSYL)ANTHRANILATE ISOMERASE, SULFATE ION | Authors: | Repo, H, Oeemig, J.S, Djupsjobacka, J.B, Iwai, H, Heikinheimo, P. | Deposit date: | 2011-12-04 | Release date: | 2012-10-31 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (1.75 Å) | Cite: | A Monomeric Tim-Barrel Structure from Pyrococcus Furiosus is Optimized for Extreme Temperatures Acta Crystallogr.,Sect.D, 68, 2012
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6Y2Y
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![BU of 6y2y by Molmil](/molmil-images/mine/6y2y) | The crystal structure of engineered cytochrome c peroxidase from Saccharomyces cerevisiae with Trp51 to S-Trp51 and Trp191Phe modifications | Descriptor: | 1,2-ETHANEDIOL, Cytochrome c peroxidase, mitochondrial, ... | Authors: | Ortmayer, M, Levy, C, Green, A.P. | Deposit date: | 2020-02-17 | Release date: | 2021-06-16 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | A Noncanonical Tryptophan Analogue Reveals an Active Site Hydrogen Bond Controlling Ferryl Reactivity in a Heme Peroxidase. Jacs Au, 1, 2021
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4YI7
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![BU of 4yi7 by Molmil](/molmil-images/mine/4yi7) | |
4M0R
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![BU of 4m0r by Molmil](/molmil-images/mine/4m0r) | Trianthranilate-like analogue bound to anthranilate phosphoribosyltransferase (AnPRT; TrpD). | Descriptor: | 2,6-bis[(2-carboxyphenyl)amino]benzoic acid, Anthranilate phosphoribosyltransferase, DIMETHYL SULFOXIDE, ... | Authors: | Evans, G.L, Baker, E.N, Lott, J.S, TB Structural Genomics Consortium (TBSGC) | Deposit date: | 2013-08-02 | Release date: | 2014-05-21 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (1.96 Å) | Cite: | Repurposing the Chemical Scaffold of the Anti-Arthritic Drug Lobenzarit to Target Tryptophan Biosynthesis in Mycobacterium tuberculosis. Chembiochem, 15, 2014
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2WUC
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![BU of 2wuc by Molmil](/molmil-images/mine/2wuc) | Crystal structure of HGFA in complex with the allosteric non- inhibitory antibody Fab40.deltaTrp and Ac-KQLR-chloromethylketone | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ACE-KQLR-CHLOROMETHYLKETONE INHIBITOR, FAB FRAGMENT FAB40.DELTATRP HEAVY CHAIN, ... | Authors: | Ganesan, R, Eigenbrot, C, Shia, S. | Deposit date: | 2009-10-01 | Release date: | 2009-12-15 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | Unraveling the Allosteric Mechanism of Serine Protease Inhibition by an Antibody Structure, 17, 2009
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1LBM
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![BU of 1lbm by Molmil](/molmil-images/mine/1lbm) | |
2WUB
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![BU of 2wub by Molmil](/molmil-images/mine/2wub) | Crystal structure of HGFA in complex with the allosteric non- inhibitory antibody Fab40.deltaTrp | Descriptor: | FAB FRAGMENT FAB40.DELTATRP HEAVY CHAIN, FAB FRAGMENT FAB40.DELTATRP LIGHT CHAIN, HEPATOCYTE GROWTH FACTOR ACTIVATOR LONG CHAIN, ... | Authors: | Ganesan, R, Eigenbrot, C, Shia, S. | Deposit date: | 2009-10-01 | Release date: | 2009-12-15 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (2.9 Å) | Cite: | Unraveling the Allosteric Mechanism of Serine Protease Inhibition by an Antibody Structure, 17, 2009
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3TWP
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![BU of 3twp by Molmil](/molmil-images/mine/3twp) | Crystal structure of M. tuberculosis TrpD in complex with an inhibitor | Descriptor: | 1-O-pyrophosphono-5-O-phosphono-alpha-D-ribofuranose, 2-HYDROXYBENZOIC ACID, Anthranilate phosphoribosyltransferase, ... | Authors: | Castell, A, Short, F.L, Lott, J.S. | Deposit date: | 2011-09-22 | Release date: | 2012-09-26 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (1.83 Å) | Cite: | The Substrate Capture Mechanism of Mycobacterium tuberculosis Anthranilate Phosphoribosyltransferase Provides a Mode for Inhibition. Biochemistry, 52, 2013
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8BFR
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![BU of 8bfr by Molmil](/molmil-images/mine/8bfr) | |
8BFT
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![BU of 8bft by Molmil](/molmil-images/mine/8bft) | |
4ZTV
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![BU of 4ztv by Molmil](/molmil-images/mine/4ztv) | Non-anthranilate-like inhibitor (TAMU-A7) complexed with anthranilate phosphoribosyltransferase (trpD) from Mycobacterium tuberculosis in absence of PRPP | Descriptor: | 4,4,4-trifluoro-1-(4-methoxyphenyl)butane-1,3-dione, Anthranilate phosphoribosyltransferase | Authors: | Evans, G.L, Eom, J, Baker, E.N, Lott, J.S, TB Structural Genomics Consortium (TBSGC) | Deposit date: | 2015-05-15 | Release date: | 2016-05-25 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (2.01 Å) | Cite: | Bioactive non-anthranilate-like fragment-like inhibitor provides alternative starting point for inhibitor design against anthranilate phosphoribosyl transferase from Mycobacterium tuberculosis. To be Published
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5BNE
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![BU of 5bne by Molmil](/molmil-images/mine/5bne) | |
5BO2
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![BU of 5bo2 by Molmil](/molmil-images/mine/5bo2) | |
5BYT
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![BU of 5byt by Molmil](/molmil-images/mine/5byt) | |
5BO3
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![BU of 5bo3 by Molmil](/molmil-images/mine/5bo3) | |
3QR9
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![BU of 3qr9 by Molmil](/molmil-images/mine/3qr9) | |
3QS8
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![BU of 3qs8 by Molmil](/molmil-images/mine/3qs8) | Anthranilate phosphoribosyltransferase (trpD) from Mycobacterium tuberculosis (complex with inhibitor ACS174) | Descriptor: | 1-O-pyrophosphono-5-O-phosphono-alpha-D-ribofuranose, 2-benzylbenzoic acid, Anthranilate phosphoribosyltransferase, ... | Authors: | Castell, A, Short, F.L, Lott, J.S, TB Structural Genomics Consortium (TBSGC) | Deposit date: | 2011-02-20 | Release date: | 2012-08-22 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | The Substrate Capture Mechanism of Mycobacterium tuberculosis Anthranilate Phosphoribosyltransferase Provides a Mode for Inhibition. Biochemistry, 52, 2013
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3QSA
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![BU of 3qsa by Molmil](/molmil-images/mine/3qsa) | Anthranilate phosphoribosyltransferase (trpD) from Mycobacterium tuberculosis (complex with inhibitor TAMU-A7) | Descriptor: | 1-O-pyrophosphono-5-O-phosphono-alpha-D-ribofuranose, 4,4,4-trifluoro-1-(4-methoxyphenyl)butane-1,3-dione, Anthranilate phosphoribosyltransferase, ... | Authors: | Castell, A, Short, F.L, Lott, J.S, TB Structural Genomics Consortium (TBSGC) | Deposit date: | 2011-02-20 | Release date: | 2012-08-22 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (2.18 Å) | Cite: | Inhibition of Mycobacterium tuberculosis anthranilate phosphoribosyltransferase by blocking of an active site entrance tunnel. To be Published
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5C1R
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![BU of 5c1r by Molmil](/molmil-images/mine/5c1r) | Stereoisomer of PRPP bound in the active site of Mycobacterium tuberculosis anthranilate phosphoribosyl (AnPRT; trpD) | Descriptor: | 5-O-[(R)-hydroxy(phosphonooxy)phosphoryl]-1-O-phosphono-alpha-D-ribofuranose, Anthranilate phosphoribosyltransferase, GLYCEROL, ... | Authors: | Evans, G.L, Baker, E.N, Lott, J.S, TB Structural Genomics Consortium (TBSGC) | Deposit date: | 2015-06-15 | Release date: | 2016-07-20 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (1.802 Å) | Cite: | Binding and mimicking of the phosphate-rich substrate, PRPP. To Be Published
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5C2L
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![BU of 5c2l by Molmil](/molmil-images/mine/5c2l) | |
5C7S
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![BU of 5c7s by Molmil](/molmil-images/mine/5c7s) | |
3QJA
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![BU of 3qja by Molmil](/molmil-images/mine/3qja) | |
3QQS
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![BU of 3qqs by Molmil](/molmil-images/mine/3qqs) | Anthranilate phosphoribosyltransferase (TRPD) from Mycobacterium tuberculosis (complex with inhibitor ACS172) | Descriptor: | 1-O-pyrophosphono-5-O-phosphono-alpha-D-ribofuranose, 2,2'-iminodibenzoic acid, Anthranilate phosphoribosyltransferase, ... | Authors: | Castell, A, Short, F.L, Lott, J.S, TB Structural Genomics Consortium (TBSGC) | Deposit date: | 2011-02-16 | Release date: | 2012-08-22 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (1.97 Å) | Cite: | The Substrate Capture Mechanism of Mycobacterium tuberculosis Anthranilate Phosphoribosyltransferase Provides a Mode for Inhibition. Biochemistry, 52, 2013
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3R88
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![BU of 3r88 by Molmil](/molmil-images/mine/3r88) | Anthranilate phosphoribosyltransferase (trpD) from Mycobacterium tuberculosis (complex with inhibitor ACS145) | Descriptor: | 1-O-pyrophosphono-5-O-phosphono-alpha-D-ribofuranose, 2-amino-4,5-dimethoxybenzoic acid, Anthranilate phosphoribosyltransferase, ... | Authors: | Castell, A, Short, F.L, Lott, J.S. | Deposit date: | 2011-03-23 | Release date: | 2012-09-26 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (1.73 Å) | Cite: | The Substrate Capture Mechanism of Mycobacterium tuberculosis Anthranilate Phosphoribosyltransferase Provides a Mode for Inhibition. Biochemistry, 52, 2013
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3R6C
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![BU of 3r6c by Molmil](/molmil-images/mine/3r6c) | Anthranilate phosphoribosyltransferase (trpD) from Mycobacterium tuberculosis (complex with inhibitor ACS179) | Descriptor: | 1-O-pyrophosphono-5-O-phosphono-alpha-D-ribofuranose, 8-methoxyphenanthro[3,4-d][1,3]dioxole-5,6-dicarboxylic acid, Anthranilate phosphoribosyltransferase, ... | Authors: | Castell, A, Short, F.L, Lott, J.S, TB Structural Genomics Consortium (TBSGC) | Deposit date: | 2011-03-21 | Release date: | 2012-09-26 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (1.83 Å) | Cite: | The Substrate Capture Mechanism of Mycobacterium tuberculosis Anthranilate Phosphoribosyltransferase Provides a Mode for Inhibition. Biochemistry, 52, 2013
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