5TCJ

Crystal structure of tryptophan synthase from M. tuberculosis - aminoacrylate and BRD4592-bound form

Summary for 5TCJ

• Entry DOI: 10.2210/pdb5tcj/pdb
• Related: 5TCF 5TCG 5TCH 5TCI
• Descriptor: Tryptophan synthase alpha chain, Tryptophan synthase beta chain, MALONATE ION, ... (8 entities in total)
• Functional Keywords: plp, heterotetramer, amino acid biosynthesis, substrate channeling, allostery, structural genomics, center for structural genomics of infectious diseases, csgid, lyase
• Biological source: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv); More
• Total number of polymer chains: 8
• Total formula weight: 292675.20

Authors

Michalska, K.,Maltseva, N.,Jedrzejczak, R.,Wellington, S.,Nag, P.P.,Fisher, S.L.,Schreiber, S.L.,Hung, D.T.,Joachimiak, A.,Center for Structural Genomics of Infectious Diseases (CSGID) (deposition date: 2016-09-15, release date: 2017-05-31, Last modification date: 2023-10-04)

• Primary citation: Wellington, S.,Nag, P.P.,Michalska, K.,Johnston, S.E.,Jedrzejczak, R.P.,Kaushik, V.K.,Clatworthy, A.E.,Siddiqi, N.,McCarren, P.,Bajrami, B.,Maltseva, N.I.,Combs, S.,Fisher, S.L.,Joachimiak, A.,Schreiber, S.L.,Hung, D.T.; A small-molecule allosteric inhibitor of Mycobacterium tuberculosis tryptophan synthase.; Nat. Chem. Biol., 13:943-950, 2017; PubMed: 28671682; DOI: 10.1038/nchembio.2420

Experimental method

X-RAY DIFFRACTION (2.4 Å)