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8IN9	The structure of the GfsA KSQ-AT didomain in complex with the GfsA ACP domain Descriptor: N-[2-(acetylamino)ethyl]-N~3~-[(2R)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alaninamide, Polyketide synthase Authors: Chisuga, T, Murakami, S, Miyanaga, A, Kudo, F, Eguchi, T. Deposit date: 2023-03-09 Release date: 2023-05-31 Last modified: 2023-06-28 Method: X-RAY DIFFRACTION (3.4 Å) Cite: Structure-Based Analysis of Transient Interactions between Ketosynthase-like Decarboxylase and Acyl Carrier Protein in a Loading Module of Modular Polyketide Synthase. Acs Chem.Biol., 18, 2023
4ZDN	Streptomyces platensis isomigrastatin ketosynthase domain MgsF KS4 Descriptor: 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, AT-less polyketide synthase, CHLORIDE ION Authors: Chang, C, Li, H, Endres, M, Bingman, C.A, Yennamalli, R, Lohman, J.R, Ma, M, Shen, B, Phillips Jr, G.N, Joachimiak, A, Midwest Center for Structural Genomics (MCSG), Enzyme Discovery for Natural Product Biosynthesis (NatPro) Deposit date: 2015-04-17 Release date: 2015-05-13 Last modified: 2023-03-22 Method: X-RAY DIFFRACTION (2.509 Å) Cite: Structural and evolutionary relationships of "AT-less" type I polyketide synthase ketosynthases. Proc.Natl.Acad.Sci.USA, 112, 2015
4B7V	Structure of wild type Pseudomonas aeruginosa FabF (KASII) Descriptor: 3-OXOACYL-[ACYL-CARRIER-PROTEIN] SYNTHASE 2, POTASSIUM ION Authors: Lecker, L, Baum, B, Zoltner, M, Hunter, W.N. Deposit date: 2012-08-22 Release date: 2013-09-04 Last modified: 2023-12-20 Method: X-RAY DIFFRACTION (1.73 Å) Cite: Structures of Pseudomonas Aeruginosa Beta-Keto-Acyl-(Acyl-Carrier-Protein) Synthase II (Fabf) and a C164Q Mutant Provide Templates for Antibacterial Drug Discovery and Identify a Buried Potassium Ion and a Ligand-Binding Site that is an Artefact of the Crystal Form Acta Crystallogr.,Sect.F, 71, 2015
7TUI	Structure of C. albicans FAS in an inhibited state Descriptor: FLAVIN MONONUCLEOTIDE, Fatty acid synthase subunit alpha, Fatty acid synthase subunit beta Authors: Lou, J.W, Mazhab-Jafari, M.T. Deposit date: 2022-02-02 Release date: 2023-02-15 Last modified: 2024-06-12 Method: ELECTRON MICROSCOPY (2.66 Å) Cite: Structure of C. albicans FAS in an inhibited state. Not published
6WC7	Acyl carrier protein (ACP) domain bound to dehydratase (DH) domain in fungal fatty acid synthase (FAS) Descriptor: Fatty acid synthase subunit alpha, Fatty acid synthase subunit beta Authors: Lou, J.W, Mazhab-Jafari, M.T. Deposit date: 2020-03-29 Release date: 2020-06-03 Last modified: 2024-03-06 Method: ELECTRON MICROSCOPY (5.8 Å) Cite: Steric occlusion regulates proximal interactions of acyl carrier protein domain in fungal fatty acid synthase. Commun Biol, 3, 2020
7UWR	KSQ+AT from first module of the pikromycin synthase Descriptor: Narbonolide/10-deoxymethynolide synthase PikA1, modules 1 and 2 Authors: Keatinge-Clay, A.T, Dickinson, M.S, Miyazawa, T, McCool, R.S. Deposit date: 2022-05-03 Release date: 2022-06-08 Last modified: 2024-06-12 Method: ELECTRON MICROSCOPY (2.61 Å) Cite: Priming enzymes from the pikromycin synthase reveal how assembly-line ketosynthases catalyze carbon-carbon chemistry. Structure, 30, 2022
4CW4	Crystal structure of the noncanonical ketosynthase FabY from P. aeruginosa Descriptor: BETA-KETOACYL SYNTHASE, CHLORIDE ION, SULFATE ION Authors: Bukhari, H.S.T, Jakob, R.P, Maier, T. Deposit date: 2014-04-01 Release date: 2014-12-17 Last modified: 2023-12-20 Method: X-RAY DIFFRACTION (1.349 Å) Cite: Evolutionary Origins of the Multienzyme Architecture of Giant Fungal Fatty Acid Synthase. Structure, 22, 2014
1H4F	E. COLI BETA-KETOACYL [ACYL CARRIER PROTEIN] SYNTHASE I K328R Descriptor: 3-OXOACYL-[ACYL-CARRIER-PROTEIN] SYNTHASE I, AMMONIUM ION Authors: Olsen, J.G, von Wettstein-Knowles, P, Mcguire, K.A, Henriksen, A. Deposit date: 2003-02-26 Release date: 2004-03-29 Last modified: 2023-12-13 Method: X-RAY DIFFRACTION (2 Å) Cite: Fatty acid synthesis. Role of active site histidines and lysine in Cys-His-His-type beta-ketoacyl-acyl carrier protein synthases. FEBS J., 273, 2006
4Z37	Structure of the ketosynthase of module 2 of C0ZGQ5 (trans-AT PKS) from Brevibacillus brevis Descriptor: Putative mixed polyketide synthase/non-ribosomal peptide synthetase Authors: Martin, S.F, Jakob, R.P, Herbst, D.A, Maier, T. Deposit date: 2015-03-31 Release date: 2016-04-13 Last modified: 2024-01-10 Method: X-RAY DIFFRACTION (1.998 Å) Cite: The structural organization of trans-AT polyketide synthases: ketoacyl synthase and trans-acting enoyl reductase To Be Published
7S6C	CryoEM structure of modular PKS holo-Lsd14 stalled at the condensation step and bound to antibody fragment 1B2, composite structure Descriptor: 2'-MONOPHOSPHOADENOSINE-5'-DIPHOSPHATE, 4'-PHOSPHOPANTETHEINE, 6-deoxyerythronolide-B synthase EryA2, ... Authors: Bagde, S.R, Kim, C.-Y, Fromme, J.C. Deposit date: 2021-09-13 Release date: 2021-11-03 Last modified: 2021-11-17 Method: ELECTRON MICROSCOPY (3.1 Å) Cite: Modular polyketide synthase contains two reaction chambers that operate asynchronously. Science, 374, 2021
7S6D	CryoEM structure of modular PKS holo-Lsd14 bound to antibody fragment 1B2, composite structure Descriptor: 2'-MONOPHOSPHOADENOSINE-5'-DIPHOSPHATE, 6-deoxyerythronolide-B synthase EryA2, modules 3 and 4, ... Authors: Bagde, S.R, Kim, C.-Y, Fromme, J.C. Deposit date: 2021-09-13 Release date: 2021-11-03 Last modified: 2021-11-17 Method: ELECTRON MICROSCOPY (3.1 Å) Cite: Modular polyketide synthase contains two reaction chambers that operate asynchronously. Science, 374, 2021
7S6B	Crystal structure of modular polyketide synthase apo-Lsd14 from the Lasalocid biosynthesis pathway, trapped in the transacylation step Descriptor: Polyketide synthase Authors: Bagde, S.R, Mathews, I.I, Kim, C.-Y. Deposit date: 2021-09-13 Release date: 2021-11-03 Last modified: 2024-05-22 Method: X-RAY DIFFRACTION (2.35 Å) Cite: Modular polyketide synthase contains two reaction chambers that operate asynchronously. Science, 374, 2021
5BP1	Condensing di-domain (KS-AT) of a mycocerosic acid synthase-like (MAS-like) PKS Descriptor: Mycocerosic acid synthase Authors: Jakob, R.P, Herbst, D.A, Zaehringer, F, Maier, T. Deposit date: 2015-05-27 Release date: 2016-03-09 Last modified: 2024-01-10 Method: X-RAY DIFFRACTION (2.203 Å) Cite: Mycocerosic acid synthase exemplifies the architecture of reducing polyketide synthases. Nature, 531, 2016
3G11	Structure of E. coli FabF(C163Q) in complex with dihydrophenyl platensimycin Descriptor: 3-({3-[(1S,4S,4aS,6S,7S,9S,9aR)-1,6-dimethyl-2-oxo-4-phenyldecahydro-6,9-epoxy-4a,7-methanobenzo[7]annulen-1-yl]propanoyl}amino)-2,4-dihydroxybenzoic acid, 3-oxoacyl-[acyl-carrier-protein] synthase 2 Authors: Soisson, S.M, Parthasarathy, G. Deposit date: 2009-01-29 Release date: 2009-03-17 Last modified: 2023-09-06 Method: X-RAY DIFFRACTION (2 Å) Cite: Synthesis and biological evaluation of platensimycin analogs. Bioorg.Med.Chem.Lett., 19, 2009
4DDO	Crystal structure of 3-oxoacyl-[acyl-carrier-protein] synthase ii from burkholderia vietnamiensis Descriptor: 3-oxoacyl-[acyl-carrier-protein] synthase 2, SODIUM ION Authors: Seattle Structural Genomics Center for Infectious Disease (SSGCID) Deposit date: 2012-01-19 Release date: 2012-05-23 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (1.9 Å) Cite: Combining functional and structural genomics to sample the essential Burkholderia structome. Plos One, 8, 2013
3G0Y	Structure of E. coli FabF(C163Q) in complex with dihydroplatensimycin Descriptor: 3-({3-[(1S,4aS,6S,7S,9S,9aR)-1,6-dimethyl-2-oxodecahydro-6,9-epoxy-4a,7-methanobenzo[7]annulen-1-yl]propanoyl}amino)-2,4-dihydroxybenzoic acid, 3-oxoacyl-[acyl-carrier-protein] synthase 2 Authors: Soisson, S.M, Parthasarathy, G. Deposit date: 2009-01-29 Release date: 2009-03-17 Last modified: 2023-09-06 Method: X-RAY DIFFRACTION (2.6 Å) Cite: Synthesis and biological evaluation of platensimycin analogs. Bioorg.Med.Chem.Lett., 19, 2009
7VEF	The structure of GfsA KSQ-AT didomain in complex with a malonate substrate analog Descriptor: GLYCEROL, N-(2-acetamidoethyl)-2-nitro-ethanamide, Polyketide synthase Authors: Chisuga, T, Miyanaga, A, Nagai, A, Kudo, F, Eguchi, T. Deposit date: 2021-09-08 Release date: 2022-01-12 Last modified: 2023-11-29 Method: X-RAY DIFFRACTION (2.65 Å) Cite: Structural Insight into the Reaction Mechanism of Ketosynthase-Like Decarboxylase in a Loading Module of Modular Polyketide Synthases. Acs Chem.Biol., 17, 2022
7VEE	The ligand-free structure of GfsA KSQ-AT didomain Descriptor: GLYCEROL, Polyketide synthase Authors: Chisuga, T, Miyanaga, A, Nagai, A, Kudo, F, Eguchi, T. Deposit date: 2021-09-08 Release date: 2022-01-12 Last modified: 2023-11-29 Method: X-RAY DIFFRACTION (2.55 Å) Cite: Structural Insight into the Reaction Mechanism of Ketosynthase-Like Decarboxylase in a Loading Module of Modular Polyketide Synthases. Acs Chem.Biol., 17, 2022
3LRF	Crystal structure of beta-ketoacyl synthase from brucella melitensis Descriptor: Beta-ketoacyl synthase, SODIUM ION Authors: Abendroth, J, Edwards, T, Staker, B, Seattle Structural Genomics Center for Infectious Disease (SSGCID) Deposit date: 2010-02-11 Release date: 2010-03-31 Last modified: 2023-09-06 Method: X-RAY DIFFRACTION (1.6 Å) Cite: Structural characterization of beta-ketoacyl ACP synthase I bound to platencin and fragment screening molecules at two substrate binding sites. Proteins, 88, 2020
4NA2	Crystal Structure of the second ketosynthase from the bacillaene polyketide synthase bound to its natural intermediate Descriptor: Polyketide synthase PksJ Authors: Gay, D.C, Gay, G.R, Keatinge-Clay, A.T. Deposit date: 2013-10-21 Release date: 2014-02-19 Last modified: 2023-09-20 Method: X-RAY DIFFRACTION (2.3 Å) Cite: A close look at a ketosynthase from a trans-acyltransferase modular polyketide synthase. Structure, 22, 2014
4MZ0	Structure of a ketosynthase-acyltransferase di-domain from module CurL of the curacin A polyketide synthase Descriptor: CALCIUM ION, CurL Authors: Whicher, J.R, Smaga, S.S, Smith, J.L. Deposit date: 2013-09-28 Release date: 2014-01-29 Last modified: 2023-09-20 Method: X-RAY DIFFRACTION (2.8 Å) Cite: Cyanobacterial polyketide synthase docking domains: a tool for engineering natural product biosynthesis. Chem.Biol., 20, 2013
4NA1	Crystal Structure of the second ketosynthase from the bacillaene polyketide synthase Descriptor: Polyketide synthase PksJ, SULFATE ION Authors: Gay, D.C, Gay, G.R, Keatinge-Clay, A.T. Deposit date: 2013-10-21 Release date: 2014-02-19 Last modified: 2023-09-20 Method: X-RAY DIFFRACTION (1.95 Å) Cite: A close look at a ketosynthase from a trans-acyltransferase modular polyketide synthase. Structure, 22, 2014
4NA3	Crystal Structure of the second ketosynthase from the bacillaene polyketide synthase bound to a hexanoyl substrate mimic Descriptor: Polyketide synthase PksJ, SULFATE ION Authors: Gay, D.C, Gay, G.R, Keatinge-Clay, A.T. Deposit date: 2013-10-21 Release date: 2014-02-19 Last modified: 2023-09-20 Method: X-RAY DIFFRACTION (2.89 Å) Cite: A close look at a ketosynthase from a trans-acyltransferase modular polyketide synthase. Structure, 22, 2014
2GFX	Structure of E. coli FabF(C163Q) in complex with Platensimycin Descriptor: 3-oxoacyl-[acyl-carrier-protein] synthase 2, PLATENSIMYCIN Authors: Soisson, S.M, Parthasarathy, G. Deposit date: 2006-03-23 Release date: 2006-05-23 Last modified: 2024-02-14 Method: X-RAY DIFFRACTION (2.59 Å) Cite: Platensimycin is a selective FabF inhibitor with potent antibiotic properties. Nature, 441, 2006
2GFW	Structure of wild type E. coli FabF (KASII) Descriptor: 3-oxoacyl-[acyl-carrier-protein] synthase 2 Authors: Soisson, S.M, Parthasarathy, G. Deposit date: 2006-03-23 Release date: 2006-05-23 Last modified: 2023-08-30 Method: X-RAY DIFFRACTION (2.4 Å) Cite: Platensimycin is a selective FabF inhibitor with potent antibiotic properties. Nature, 441, 2006

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