5N6A
 
 | | Cardiac muscle myosin motor domain in the pre-powerstroke state | | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, GLYCEROL, MAGNESIUM ION, ... | | Authors: | Planelles-Herrero, V.J, Hartman, J.J, Robert-Paganin, J, Malik, F.I, Houdusse, A. | | Deposit date: | 2017-02-14 | | Release date: | 2017-08-09 | | Last modified: | 2024-01-17 | | Method: | X-RAY DIFFRACTION (3.1 Å) | | Cite: | Mechanistic and structural basis for activation of cardiac myosin force production by omecamtiv mecarbil.
Nat Commun, 8, 2017
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5W1A
 | | The first X-ray crystal structure of an insect muscle myosin. Drosophila melanogaster, skeletal muscle myosin II, an embryonic isoform, subfragment-1 | | Descriptor: | 1,2-ETHANEDIOL, CITRATE ANION, GLYCEROL, ... | | Authors: | Caldwell, J.T, Bernstein, S.I, Huxford, T. | | Deposit date: | 2017-06-02 | | Release date: | 2018-06-06 | | Last modified: | 2024-03-13 | | Method: | X-RAY DIFFRACTION (2.227 Å) | | Cite: | X-ray crystallographic and molecular dynamic analyses of Drosophila melanogaster embryonic muscle myosin define domains responsible for isoform-specific properties.
J.Mol.Biol., 2019
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5T45
 | | Chicken smooth muscle myosin motor domain co-crystallized with the specific CK-571 inhibitor, MgADP.BeFx form | | Descriptor: | 4-{[(2-chloro-3-fluorobenzyl)carbamoyl](methyl)amino}-3,4-dideoxy-5-O-(isoquinolin-3-ylcarbamoyl)-D-erythro-pentitol, ADENOSINE-5'-DIPHOSPHATE, BERYLLIUM TRIFLUORIDE ION, ... | | Authors: | Sirigu, S, Planelles-Herrero, V.J, Hartman, J, Houdusse, A. | | Deposit date: | 2016-08-29 | | Release date: | 2016-11-16 | | Last modified: | 2024-01-17 | | Method: | X-RAY DIFFRACTION (2.8 Å) | | Cite: | Highly selective inhibition of myosin motors provides the basis of potential therapeutic application.
Proc. Natl. Acad. Sci. U.S.A., 113, 2016
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5TBY
 | | HUMAN BETA CARDIAC HEAVY MEROMYOSIN INTERACTING-HEADS MOTIF OBTAINED BY HOMOLOGY MODELING (USING SWISS-MODEL) OF HUMAN SEQUENCE FROM APHONOPELMA HOMOLOGY MODEL (PDB-3JBH), RIGIDLY FITTED TO HUMAN BETA-CARDIAC NEGATIVELY STAINED THICK FILAMENT 3D-RECONSTRUCTION (EMD-2240) | | Descriptor: | Myosin light chain 3, Myosin regulatory light chain 2, ventricular/cardiac muscle isoform, ... | | Authors: | ALAMO, L, WARE, J.S, PINTO, A, GILLILAN, R.E, SEIDMAN, J.G, SEIDMAN, C.E, PADRON, R. | | Deposit date: | 2016-09-13 | | Release date: | 2017-06-07 | | Last modified: | 2020-01-08 | | Method: | ELECTRON MICROSCOPY (20 Å) | | Cite: | Effects of myosin variants on interacting-heads motif explain distinct hypertrophic and dilated cardiomyopathy phenotypes.
Elife, 6, 2017
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5I0I
 | | Crystal structure of myosin X motor domain with 2IQ motifs in pre-powerstroke state | | Descriptor: | 3[N-MORPHOLINO]PROPANE SULFONIC ACID, ADENOSINE-5'-DIPHOSPHATE, Calmodulin, ... | | Authors: | Isabet, T, Sweeney, H.L, Houdusse, A. | | Deposit date: | 2016-02-04 | | Release date: | 2016-09-07 | | Last modified: | 2024-05-08 | | Method: | X-RAY DIFFRACTION (3.15 Å) | | Cite: | The myosin X motor is optimized for movement on actin bundles.
Nat Commun, 7, 2016
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1MMA
 | | X-RAY STRUCTURES OF THE MGADP, MGATPGAMMAS, AND MGAMPPNP COMPLEXES OF THE DICTYOSTELIUM DISCOIDEUM MYOSIN MOTOR DOMAIN | | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, MYOSIN | | Authors: | Gulick, A.M, Bauer, C.B, Thoden, J.B, Rayment, I. | | Deposit date: | 1997-07-18 | | Release date: | 1997-12-03 | | Last modified: | 2024-05-22 | | Method: | X-RAY DIFFRACTION (2.1 Å) | | Cite: | X-ray structures of the MgADP, MgATPgammaS, and MgAMPPNP complexes of the Dictyostelium discoideum myosin motor domain.
Biochemistry, 36, 1997
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1MMG
 | | X-RAY STRUCTURES OF THE MGADP, MGATPGAMMAS, AND MGAMPPNP COMPLEXES OF THE DICTYOSTELIUM DISCOIDEUM MYOSIN MOTOR DOMAIN | | Descriptor: | MAGNESIUM ION, MYOSIN, PHOSPHOTHIOPHOSPHORIC ACID-ADENYLATE ESTER | | Authors: | Gulick, A.M, Bauer, C.B, Thoden, J.B, Rayment, I. | | Deposit date: | 1997-07-18 | | Release date: | 1997-12-03 | | Last modified: | 2024-05-22 | | Method: | X-RAY DIFFRACTION (2.1 Å) | | Cite: | X-ray structures of the MgADP, MgATPgammaS, and MgAMPPNP complexes of the Dictyostelium discoideum myosin motor domain.
Biochemistry, 36, 1997
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1MMD
 | | TRUNCATED HEAD OF MYOSIN FROM DICTYOSTELIUM DISCOIDEUM COMPLEXED WITH MGADP-BEF3 | | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, BERYLLIUM TRIFLUORIDE ION, MAGNESIUM ION, ... | | Authors: | Fisher, A.J, Holden, H.M, Rayment, I. | | Deposit date: | 1995-03-21 | | Release date: | 1996-08-17 | | Last modified: | 2024-02-14 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | X-ray structures of the myosin motor domain of Dictyostelium discoideum complexed with MgADP.BeFx and MgADP.AlF4-.
Biochemistry, 34, 1995
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1MMN
 | | X-RAY STRUCTURES OF THE MGADP, MGATPGAMMAS, AND MGAMPPNP COMPLEXES OF THE DICTYOSTELIUM DISCOIDEUM MYOSIN MOTOR DOMAIN | | Descriptor: | MAGNESIUM ION, MYOSIN, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER | | Authors: | Gulick, A.M, Bauer, C.B, Thoden, J.B, Rayment, I. | | Deposit date: | 1997-07-18 | | Release date: | 1997-12-03 | | Last modified: | 2024-05-22 | | Method: | X-RAY DIFFRACTION (2.1 Å) | | Cite: | X-ray structures of the MgADP, MgATPgammaS, and MgAMPPNP complexes of the Dictyostelium discoideum myosin motor domain.
Biochemistry, 36, 1997
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2BKI
 | | Myosin VI nucleotide-free (MDinsert2-IQ) crystal structure | | Descriptor: | CALCIUM ION, CALMODULIN, SULFATE ION, ... | | Authors: | Menetrey, J, Bahloul, A, Yengo, C, Wells, A, Morris, C, Sweeney, H.L, Houdusse, A. | | Deposit date: | 2005-02-16 | | Release date: | 2005-06-07 | | Last modified: | 2023-12-13 | | Method: | X-RAY DIFFRACTION (2.9 Å) | | Cite: | The Structure of the Myosin Vi Motor Reveals the Mechanism of Directionality Reversal
Nature, 435, 2005
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2BKH
 | | Myosin VI nucleotide-free (MDInsert2) crystal structure | | Descriptor: | CALCIUM ION, CALMODULIN, GLYCEROL, ... | | Authors: | Menetrey, J, Bahloul, A, Yengo, C, Wells, A, Morris, C, Sweeney, H.L, Houdusse, A. | | Deposit date: | 2005-02-16 | | Release date: | 2005-06-07 | | Last modified: | 2023-12-13 | | Method: | X-RAY DIFFRACTION (2.4 Å) | | Cite: | The Structure of the Myosin Vi Motor Reveals the Mechanism of Directionality Reversal
Nature, 435, 2005
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2AKA
 | | Structure of the nucleotide-free myosin II motor domain from Dictyostelium discoideum fused to the GTPase domain of dynamin 1 from Rattus norvegicus | | Descriptor: | Dynamin-1, LINKER, myosin II heavy chain | | Authors: | Reubold, T.F, Eschenburg, S, Becker, A, Leonard, M, Schmid, S.L, Vallee, R.B, Kull, F.J, Manstein, D.J. | | Deposit date: | 2005-08-03 | | Release date: | 2005-08-23 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (1.9 Å) | | Cite: | Crystal structure of the GTPase domain of rat dynamin 1.
Proc.Natl.Acad.Sci.Usa, 102, 2005
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2DFS
 | | 3-D structure of Myosin-V inhibited state | | Descriptor: | Calmodulin, Myosin-5A | | Authors: | Liu, J, Taylor, D.W, Krementsova, E.B, Trybus, K.M, Taylor, K.A. | | Deposit date: | 2006-03-03 | | Release date: | 2006-04-25 | | Last modified: | 2024-03-13 | | Method: | ELECTRON CRYSTALLOGRAPHY (24 Å) | | Cite: | Three-dimensional structure of the myosin V inhibited state by cryoelectron tomography
Nature, 442, 2006
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2EC6
 | | Placopecten Striated Muscle Myosin II | | Descriptor: | CALCIUM ION, Myosin essential light chain, Myosin heavy chain, ... | | Authors: | Yang, Y, Brown, J, Samudrala, G, Reutzel, R, Szent-Gyorgyi, A. | | Deposit date: | 2007-02-10 | | Release date: | 2008-02-26 | | Last modified: | 2024-05-29 | | Method: | X-RAY DIFFRACTION (3.25 Å) | | Cite: | Rigor-like structures from muscle myosins reveal key mechanical elements in the transduction pathways of this allosteric motor.
Structure, 15, 2007
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2Y8I
 | | Structural basis for the allosteric interference of myosin function by mutants G680A and G680V of Dictyostelium myosin-2 | | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, MYOSIN-2 HEAVY CHAIN | | Authors: | Preller, M, Bauer, S, Adamek, N, Fujita-Becker, S, Fedorov, R, Geeves, M.A, Manstein, D.J. | | Deposit date: | 2011-02-07 | | Release date: | 2011-07-20 | | Last modified: | 2023-12-20 | | Method: | X-RAY DIFFRACTION (3.132 Å) | | Cite: | Structural Basis for the Allosteric Interference of Myosin Function by Reactive Thiol Region Mutations G680A and G680V.
J.Biol.Chem., 286, 2011
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1DFL
 | | SCALLOP MYOSIN S1 COMPLEXED WITH MGADP:VANADATE-TRANSITION STATE | | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, CALCIUM ION, MAGNESIUM ION, ... | | Authors: | Houdusse, A, Szent-Gyorgyi, A.G, Cohen, C. | | Deposit date: | 1999-11-19 | | Release date: | 2000-10-25 | | Last modified: | 2024-02-07 | | Method: | X-RAY DIFFRACTION (4.2 Å) | | Cite: | Three conformational states of scallop myosin S1.
Proc.Natl.Acad.Sci.USA, 97, 2000
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1DFK
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8EFE
 | | Human beta-cardiac myosin II bound to ADP-MG2+ and the associated essential light chain | | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, Beta-cardiac myosin II, MAGNESIUM ION, ... | | Authors: | Doran, M.H, Lehman, W, Rynkiewicz, M.J. | | Deposit date: | 2022-09-08 | | Release date: | 2023-01-11 | | Last modified: | 2024-06-19 | | Method: | ELECTRON MICROSCOPY (3.8 Å) | | Cite: | Conformational changes linked to ADP release from human cardiac myosin bound to actin-tropomyosin.
J.Gen.Physiol., 155, 2023
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8EFD
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1FMV
 | | CRYSTAL STRUCTURE OF THE APO MOTOR DOMAIN OF DICTYOSTELLIUM MYOSIN II | | Descriptor: | CHLORIDE ION, MYOSIN II HEAVY CHAIN | | Authors: | Bauer, C.B, Holden, H.M, Thoden, J.B, Smith, R, Rayment, I. | | Deposit date: | 2000-08-18 | | Release date: | 2000-11-22 | | Last modified: | 2024-02-07 | | Method: | X-RAY DIFFRACTION (2.1 Å) | | Cite: | X-ray structures of the apo and MgATP-bound states of Dictyostelium discoideum myosin motor domain.
J.Biol.Chem., 275, 2000
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8EXW
 | | Drosophila melanogaster indirect flight muscle myosin II (subfragment-1) | | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, Isoform K of Myosin heavy chain, muscle, ... | | Authors: | Caldwell, J.T, Huxford, T, Bernstein, S.I, Stec, B. | | Deposit date: | 2022-10-25 | | Release date: | 2024-02-07 | | Method: | X-RAY DIFFRACTION (2.5 Å) | | Cite: | Drosophila melanogaster indirect flight muscle myosin II (subfragment-1)
To Be Published
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2Y0R
 | | Structural basis for the allosteric interference of myosin function by mutants G680A and G680V of Dictyostelium myosin-2 | | Descriptor: | MYOSIN-2 HEAVY CHAIN | | Authors: | Preller, M, Bauer, S, Adamek, N, Fujita-Becker, S, Fedorov, R, Geeves, M.A, Manstein, D.J. | | Deposit date: | 2010-12-07 | | Release date: | 2011-07-20 | | Last modified: | 2023-12-20 | | Method: | X-RAY DIFFRACTION (2.85 Å) | | Cite: | Structural Basis for the Allosteric Interference of Myosin Function by Reactive Thiol Region Mutations G680A and G680V.
J.Biol.Chem., 286, 2011
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2Y9E
 | | Structural basis for the allosteric interference of myosin function by mutants G680A and G680V of Dictyostelium myosin-2 | | Descriptor: | MYOSIN-2 | | Authors: | Preller, M, Bauer, S, Adamek, N, Fujita-Becker, S, Fedorov, R, Geeves, M.A, Manstein, D.J. | | Deposit date: | 2011-02-14 | | Release date: | 2011-07-20 | | Last modified: | 2023-12-20 | | Method: | X-RAY DIFFRACTION (3.397 Å) | | Cite: | Structural Basis for the Allosteric Interference of Myosin Function by Reactive Thiol Region Mutations G680A and G680V.
J.Biol.Chem., 286, 2011
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2XEL
 | | Molecular Mechanism of Pentachloropseudilin Mediated Inhibition of Myosin Motor Activity | | Descriptor: | 2,4-DICHLORO-6-(3,4,5-TRICHLORO-1H-PYRROL-2YL)PHENOL, ADP METAVANADATE, MAGNESIUM ION, ... | | Authors: | Chinthalapudi, K, Taft, M.H, Martin, R, Hartmann, F.K, Heissler, S.M, Tsiavaliaris, G, Gutzeit, H.O, Knoelker, H.J, Coluccio, L.M, Fedorov, R, Manstein, D.J. | | Deposit date: | 2010-05-16 | | Release date: | 2011-06-15 | | Last modified: | 2024-05-08 | | Method: | X-RAY DIFFRACTION (2.5 Å) | | Cite: | Mechanism and Specificity of Pentachloropseudilin-Mediated Inhibition of Myosin Motor Activity.
J.Biol.Chem., 286, 2011
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1FMW
 | | CRYSTAL STRUCTURE OF THE MGATP COMPLEX FOR THE MOTOR DOMAIN OF DICTYOSTELIUM MYOSIN II | | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, MYOSIN II HEAVY CHAIN | | Authors: | Bauer, C.B, Holden, H.M, Thoden, J.B, Smith, R, Rayment, I. | | Deposit date: | 2000-08-18 | | Release date: | 2000-11-22 | | Last modified: | 2024-02-07 | | Method: | X-RAY DIFFRACTION (2.15 Å) | | Cite: | X-ray structures of the apo and MgATP-bound states of Dictyostelium discoideum myosin motor domain.
J.Biol.Chem., 275, 2000
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