2GYO
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![BU of 2gyo by Molmil](/molmil-images/mine/2gyo) | Methanethiol-Cys 112 Inhibition Complex of E. Coli Ketoacyl Synthase III (FabH) and Coenzyme A | Descriptor: | 3-oxoacyl-[acyl-carrier-protein] synthase 3, COENZYME A, METHANETHIOL, ... | Authors: | Alhamadsheh, M.M, Musayev, F, Komissarov, A.A, Sachdeva, S, Wright, H.T, Scarsdale, N, Florova, G, Reynolds, K.A. | Deposit date: | 2006-05-09 | Release date: | 2007-06-05 | Last modified: | 2011-07-13 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Alkyl-CoA Disulfides as Inhibitors and Mechanistic Probes for FabH Enzymes. Chem.Biol., 14, 2007
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4AC3
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![BU of 4ac3 by Molmil](/molmil-images/mine/4ac3) | S.pneumoniae GlmU in complex with an antibacterial inhibitor | Descriptor: | BIFUNCTIONAL PROTEIN GLMU, N-{2,4-DIMETHOXY-5-[(2-PIPERIDIN-1-YLBENZYL)sulfamoyl]phenyl}acetamide, SULFATE ION | Authors: | Otterbein, L, Breed, J, Ogg, D.J. | Deposit date: | 2011-12-12 | Release date: | 2012-02-15 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Inhibitors of Acetyltransferase Domain of N-Acetylglucosamine-1-Phosphate-Uridyltransferase/ Glucosamine-1-Phosphate-Acetyltransferase (Glmu). Part 1: Hit to Lead Evaluation of a Novel Arylsulfonamide Series. Bioorg.Med.Chem.Lett., 22, 2012
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6NWC
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![BU of 6nwc by Molmil](/molmil-images/mine/6nwc) | PYL10 bound to the ABA pan-agonist 3CB | Descriptor: | 1-{[(4-cyano-3-cyclopropylphenyl)acetyl]amino}cyclohexane-1-carboxylic acid, Abscisic acid receptor PYL10 | Authors: | Peterson, F.C, Vaidya, A, Jensen, D.R, Volkman, B.F, Cutler, S.R. | Deposit date: | 2019-02-06 | Release date: | 2019-11-06 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (2.35 Å) | Cite: | Dynamic control of plant water use using designed ABA receptor agonists. Science, 366, 2019
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2H1U
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![BU of 2h1u by Molmil](/molmil-images/mine/2h1u) | Porcine pancreatic elastase complexed with MetPheLeuGlu at pH 5.0 | Descriptor: | CALCIUM ION, Elastase-1, MFLE, ... | Authors: | Liu, B, Schofield, C.J, Wilmouth, R.C. | Deposit date: | 2006-05-17 | Release date: | 2006-05-30 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (1.6 Å) | Cite: | Structural analyses on intermediates in serine protease catalysis. J.Biol.Chem., 281, 2006
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2PQM
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![BU of 2pqm by Molmil](/molmil-images/mine/2pqm) | |
2PUR
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![BU of 2pur by Molmil](/molmil-images/mine/2pur) | Structure of dihydrodipicolinate synthase mutant Thr44Ser at 1.7 A. | Descriptor: | Dihydrodipicolinate synthase, GLYCEROL, PHOSPHATE ION, ... | Authors: | Dobson, R.C.J, Jameson, G.B, Gerrard, J.A. | Deposit date: | 2007-05-09 | Release date: | 2008-05-27 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | Specificity versus catalytic potency: The role of threonine 44 in Escherichia coli dihydrodipicolinate synthase mediated catalysis. Biochimie, 91, 2009
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2Q1C
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![BU of 2q1c by Molmil](/molmil-images/mine/2q1c) | 2-keto-3-deoxy-D-arabinonate dehydratase complexed with calcium and 2-oxobutyrate | Descriptor: | 2-KETOBUTYRIC ACID, 2-keto-3-deoxy-D-arabinonate dehydratase, CALCIUM ION | Authors: | Barends, T, Brouns, S, Worm, P, Akerboom, J, Turnbull, A, Salmon, L. | Deposit date: | 2007-05-24 | Release date: | 2008-04-08 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Structural insight into substrate binding and catalysis of a novel 2-keto-3-deoxy-D-arabinonate dehydratase illustrates common mechanistic features of the FAH superfamily. J.Mol.Biol., 379, 2008
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2QL1
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![BU of 2ql1 by Molmil](/molmil-images/mine/2ql1) | Structural Characterization of a Mutated, ADCC-Enhanced Human Fc Fragment | Descriptor: | IGHM protein, ZINC ION, beta-D-galactopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)-[2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-3)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose | Authors: | Oganesyan, V, Wu, H, Dall'Acqua, W.F. | Deposit date: | 2007-07-12 | Release date: | 2008-04-01 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (2.534 Å) | Cite: | Structural characterization of a mutated, ADCC-enhanced human Fc fragment Mol.Immunol., 45, 2008
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2R23
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![BU of 2r23 by Molmil](/molmil-images/mine/2r23) | Crystal structure of S25-2 Fab in complex with Kdo analogues | Descriptor: | D-glycero-alpha-D-talo-oct-2-ulopyranosonic acid-(2-4)-prop-2-en-1-yl 3-deoxy-alpha-D-manno-oct-2-ulopyranosidonic acid, Fab, antibody fragment (IgG1k), ... | Authors: | Brooks, C.L, Evans, S.V. | Deposit date: | 2007-08-24 | Release date: | 2008-12-30 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (1.65 Å) | Cite: | Exploration of specificity in germline monoclonal antibody recognition of a range of natural and synthetic epitopes. J.Mol.Biol., 377, 2008
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2QWL
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![BU of 2qwl by Molmil](/molmil-images/mine/2qwl) | Crystal structure of bovine hsc70 (1-394aa)in the ADP state | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, GLYCEROL, Heat shock cognate 71 kDa protein, ... | Authors: | Jiang, J, Maes, E.G, Wang, L, Taylor, A.B, Hinck, A.P, Lafer, E.M, Sousa, R. | Deposit date: | 2007-08-10 | Release date: | 2007-12-18 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (1.75 Å) | Cite: | Structural basis of J cochaperone binding and regulation of Hsp70. Mol.Cell, 28, 2007
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2HLY
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![BU of 2hly by Molmil](/molmil-images/mine/2hly) | The crystal structure of genomics APC5867 | Descriptor: | Hypothetical protein Atu2299 | Authors: | Dong, A, Xu, X, Zheng, H, Kim, Y, Edwards, A.M, Joachimiak, A, Savchenko, A, Midwest Center for Structural Genomics (MCSG) | Deposit date: | 2006-07-10 | Release date: | 2006-07-18 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (1.6 Å) | Cite: | The crystal structure of genomics APC5867 TO BE PUBLISHED
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3LUH
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2QTF
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![BU of 2qtf by Molmil](/molmil-images/mine/2qtf) | Crystal structure of a GTP-binding protein from the hyperthermophilic archaeon Sulfolobus solfataricus | Descriptor: | ACETATE ION, CADMIUM ION, GTP-binding protein, ... | Authors: | Wu, H, Sun, L, Brouns, S.J, Fu, S, Rao, Z, Van der Oost, J. | Deposit date: | 2007-08-02 | Release date: | 2008-08-19 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Crystal structure of a GTP-binding protein from the hyperthermophilic archaeon Sulfolobus solfataricus. To be Published
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3WL2
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![BU of 3wl2 by Molmil](/molmil-images/mine/3wl2) | Monoclinic Lysozyme at 0.96 A resolution | Descriptor: | 1,2-ETHANEDIOL, Lysozyme C, NITRATE ION, ... | Authors: | Matsumoto, T, Yamano, A, Hasegawa, T, Maeyama, M. | Deposit date: | 2013-11-06 | Release date: | 2014-11-12 | Method: | X-RAY DIFFRACTION (0.96 Å) | Cite: | Evaluation of Rigaku XtaLAB P200 To be Published
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2QKX
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![BU of 2qkx by Molmil](/molmil-images/mine/2qkx) | N-acetyl glucosamine 1-phosphate uridyltransferase from Mycobacterium tuberculosis complex with N-acetyl glucosamine 1-phosphate | Descriptor: | 2-acetamido-2-deoxy-1-O-phosphono-alpha-D-glucopyranose, Bifunctional protein glmU | Authors: | Zhang, Z, Squire, C.J, Baker, E.N, TB Structural Genomics Consortium (TBSGC) | Deposit date: | 2007-07-11 | Release date: | 2008-07-15 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (2.75 Å) | Cite: | Structure and function of GlmU from Mycobacterium tuberculosis. Acta Crystallogr.,Sect.D, 65, 2009
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2QWQ
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![BU of 2qwq by Molmil](/molmil-images/mine/2qwq) | Crystal structure of disulfide-bond-crosslinked complex of bovine hsc70 (1-394aa)R171C and bovine Auxilin (810-910aa)D876C in the AMPPNP hydrolyzed form | Descriptor: | ACETIC ACID, ADENOSINE-5'-DIPHOSPHATE, GLYCEROL, ... | Authors: | Jiang, J, Maes, E.G, Wang, L, Taylor, A.B, Hinck, A.P, Lafer, E.M, Sousa, R. | Deposit date: | 2007-08-10 | Release date: | 2007-12-18 | Last modified: | 2021-10-20 | Method: | X-RAY DIFFRACTION (2.21 Å) | Cite: | Structural basis of J cochaperone binding and regulation of Hsp70. Mol.Cell, 28, 2007
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2QBV
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![BU of 2qbv by Molmil](/molmil-images/mine/2qbv) | Crystal Structure of Intracellular Chorismate Mutase from Mycobacterium Tuberculosis | Descriptor: | CHORISMATE MUTASE | Authors: | Ladner, J.E, Reddy, P.T, Kim, S.K, Reddy, S.-K, Nelson, B.C. | Deposit date: | 2007-06-18 | Release date: | 2007-06-26 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | A comparative biochemical and structural analysis of the intracellular chorismate mutase (Rv0948c) from Mycobacterium tuberculosis H(37)R(v) and the secreted chorismate mutase (y2828) from Yersinia pestis. Febs J., 275, 2008
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2QKH
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![BU of 2qkh by Molmil](/molmil-images/mine/2qkh) | Crystal structure of the extracellular domain of human GIP receptor in complex with the hormone GIP | Descriptor: | Cyclic 2,3-di-O-methyl-alpha-D-glucopyranose-(1-4)-2-O-methyl-alpha-D-glucopyranose-(1-4)-2,6-di-O-methyl-alpha-D-glucopyranose-(1-4)-2-O-methyl-alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose-(1-4)-3-O-methyl-alpha-D-glucopyranose, D(-)-TARTARIC ACID, Glucose-dependent insulinotropic polypeptide, ... | Authors: | Parthier, C, Kleinschmidt, M, Neumann, P, Rudolph, R, Manhart, S, Schlenzig, D, Fanghanel, J, Rahfeld, J.-U, Demuth, H.-U, Stubbs, M.T. | Deposit date: | 2007-07-11 | Release date: | 2007-08-14 | Last modified: | 2020-07-29 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Crystal structure of the incretin-bound extracellular domain of a G protein-coupled receptor Proc.Natl.Acad.Sci.Usa, 104, 2007
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2QLQ
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![BU of 2qlq by Molmil](/molmil-images/mine/2qlq) | Crystal structure of SRC kinase domain with covalent inhibitor RL3 | Descriptor: | (2E)-N-{4-[(3-bromophenyl)amino]quinazolin-6-yl}-4-(dimethylamino)but-2-enamide, Proto-oncogene tyrosine-protein kinase Src | Authors: | Michalczyk, A, Rode, H.B, Gruetter, C, Rauh, D. | Deposit date: | 2007-07-13 | Release date: | 2008-03-11 | Last modified: | 2021-10-20 | Method: | X-RAY DIFFRACTION (2.33 Å) | Cite: | Structural insights into how irreversible inhibitors can overcome drug resistance in EGFR. Bioorg.Med.Chem., 16, 2008
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2QW9
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![BU of 2qw9 by Molmil](/molmil-images/mine/2qw9) | Crystal structure of bovine hsc70 (1-394aa)in the apo state | Descriptor: | GLYCEROL, Heat shock cognate 71 kDa protein | Authors: | Jiang, J, Maes, E.G, Wang, L, Taylor, A.B, Hinck, A.P, Lafer, E.M, Sousa, R. | Deposit date: | 2007-08-10 | Release date: | 2007-12-18 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (1.85 Å) | Cite: | Structural basis of J cochaperone binding and regulation of Hsp70. Mol.Cell, 28, 2007
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2QTH
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![BU of 2qth by Molmil](/molmil-images/mine/2qth) | Crystal structure of a GTP-binding protein from the hyperthermophilic archaeon Sulfolobus solfataricus in complex with GDP | Descriptor: | ACETATE ION, CADMIUM ION, GTP-binding protein, ... | Authors: | Wu, H, Sun, L, Brouns, S.J, Fu, S, Rao, Z, Van der Oost, J. | Deposit date: | 2007-08-02 | Release date: | 2008-08-19 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Crystal structure of a GTP-binding protein from the hyperthermophilic archaeon Sulfolobus solfataricus. To be Published
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2QD0
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![BU of 2qd0 by Molmil](/molmil-images/mine/2qd0) | Crystal structure of mitoNEET | Descriptor: | FE2/S2 (INORGANIC) CLUSTER, Zinc finger CDGSH domain-containing protein 1 | Authors: | Lin, J, Zhou, T, Ye, K, Wang, J. | Deposit date: | 2007-06-20 | Release date: | 2007-08-28 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (1.81 Å) | Cite: | Crystal structure of human mitoNEET reveals distinct groups of iron sulfur proteins. Proc.Natl.Acad.Sci.Usa, 104, 2007
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2QI8
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![BU of 2qi8 by Molmil](/molmil-images/mine/2qi8) | Crystal structure of drug resistant SRC kinase domain | Descriptor: | GLYCEROL, Proto-oncogene tyrosine-protein kinase Src | Authors: | Michalczyk, A, Rode, H.B, Gruetter, C, Rauh, D. | Deposit date: | 2007-07-03 | Release date: | 2008-03-18 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (2.32 Å) | Cite: | Structural insights into how irreversible inhibitors can overcome drug resistance in EGFR. Bioorg.Med.Chem., 16, 2008
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4ASG
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![BU of 4asg by Molmil](/molmil-images/mine/4asg) | The structure of modified benzoquinone ansamycins bound to yeast N- terminal Hsp90 | Descriptor: | ATP-DEPENDENT MOLECULAR CHAPERONE HSP82, NICKEL (II) ION, [(3R,5S,6R,7R,11S,12Z,14E)-5,11,21-trimethoxy-3,7,9,15-tetramethyl-6-oxidanyl-16,20,22-tris(oxidanylidene)-19-phenyl-17-azabicyclo[16.3.1]docosa-1(21),8,12,14,18-pentaen-10-yl] carbamate | Authors: | Roe, S.M, Prodromou, C. | Deposit date: | 2012-05-01 | Release date: | 2013-04-03 | Last modified: | 2024-05-01 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Synthesis of 19-Substituted Geldanamycins with Altered Conformations and Their Binding to Heat Shock Protein Hsp90. Nat.Chem., 5, 2013
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2JBX
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![BU of 2jbx by Molmil](/molmil-images/mine/2jbx) | Crystal Structure of the myxoma virus anti-apoptotic protein M11L | Descriptor: | M11L PROTEIN | Authors: | Kvansakul, M, Van Delft, M.F, Lee, E.F, Gulbis, J.M, Fairlie, W.D, Huang, D.C.S, Colman, P.M. | Deposit date: | 2006-12-14 | Release date: | 2007-03-27 | Last modified: | 2024-05-01 | Method: | X-RAY DIFFRACTION (2.73 Å) | Cite: | A Structural Viral Mimic of Prosurvival Bcl-2: A Pivotal Role for Sequestering Proapoptotic Bax and Bak. Mol.Cell, 25, 2007
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