4Z46

X-ray structure of the bis-platinum lysozyme adduct formed in the reaction between the protein and the two drugs Cisplatin and Oxaliplatin

Summary for 4Z46
DescriptorLysozyme C, 1,2-ETHANEDIOL, NITRATE ION, ... (7 entities in total)
Functional Keywordscisplatin, oxaliplatin, protein platination, anticancer drugs, hydrolase
Biological sourceGallus gallus (Chicken)
Cellular locationSecreted: P00698
Total number of polymer chains1
Total formula weight15668.63
Authors
Merlino, A. (deposition date: 2015-04-01, release date: 2015-05-27, Last modification date: 2015-06-10)
Primary citationMarasco, D.,Marzo, T.,Merlino, A.,Messori, L.
Oxaliplatin vs. cisplatin: competition experiments on their binding to lysozyme.
Dalton Trans, 44:10392-10398, 2015
PubMed: 25974859
DOI: 110.1039/c5dt01279a
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.85 Å)
Structure validation
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PDB entries from 2021-06-16