4Z46

X-ray structure of the bis-platinum lysozyme adduct formed in the reaction between the protein and the two drugs Cisplatin and Oxaliplatin

Summary for 4Z46

Entry DOI	10.2210/pdb4z46/pdb
Descriptor	Lysozyme C, 1,2-ETHANEDIOL, NITRATE ION, ... (7 entities in total)
Functional Keywords	cisplatin, oxaliplatin, protein platination, anticancer drugs, hydrolase
Biological source	Gallus gallus (Chicken)
Cellular location	Secreted: P00698
Total number of polymer chains	1
Total formula weight	15668.63
Authors	Merlino, A. (deposition date: 2015-04-01, release date: 2015-05-27, Last modification date: 2015-06-10)
Primary citation	Marasco, D.,Messori, L.,Marzo, T.,Merlino, A. Oxaliplatin vs. cisplatin: competition experiments on their binding to lysozyme. Dalton Trans, 44:10392-10398, 2015 Cited by PubMed: 25974859 DOI: 10.1039/c5dt01279a PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.85 Å)

Structure validation