4ZFI

Structure of Mdm2 with low molecular weight inhibitor

Summary for 4ZFI

Entry DOI	10.2210/pdb4zfi/pdb
Descriptor	E3 ubiquitin-protein ligase Mdm2, (5S)-3,5-bis(4-chlorobenzyl)-4-(6-chloro-1H-indol-3-yl)-5-hydroxy-1-methyl-1,5-dihydro-2H-pyrrol-2-one (3 entities in total)
Functional Keywords	p53-binding protein mdm2, oncoprotein mdm2, double minute 2 protein, hdm2, small molecule inhibitor, ligase
Biological source	Homo sapiens (Human)
Cellular location	Nucleus, nucleoplasm: Q00987
Total number of polymer chains	4
Total formula weight	47644.81
Authors	Zak, K.M.,Twarda-Clapa, A.,Wrona, E.M.,Grudnik, P.,Dubin, G.,Holak, T.A. (deposition date: 2015-04-21, release date: 2016-10-19, Last modification date: 2024-01-10)
Primary citation	Surmiak, E.,Twarda-Clapa, A.,Zak, K.M.,Musielak, B.,Tomala, M.D.,Kubica, K.,Grudnik, P.,Madej, M.,Jablonski, M.,Potempa, J.,Kalinowska-Tluscik, J.,Domling, A.,Dubin, G.,Holak, T.A. A Unique Mdm2-Binding Mode of the 3-Pyrrolin-2-one- and 2-Furanone-Based Antagonists of the p53-Mdm2 Interaction. ACS Chem. Biol., 11:3310-3318, 2016 Cited by PubMed: 27709883 DOI: 10.1021/acschembio.6b00596 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2 Å)

Structure validation