4ZFI
Structure of Mdm2 with low molecular weight inhibitor
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D (A, B, C, D) | E3 ubiquitin-protein ligase Mdm2 | polymer | 97 | 11399.4 | 4 | UniProt (Q00987) Pfam (PF02201) | Homo sapiens (Human) | Double minute 2 protein,Hdm2,Oncoprotein Mdm2,p53-binding protein Mdm2 |
| 2 | E, F, G, H (A, B, C, D) | (5S)-3,5-bis(4-chlorobenzyl)-4-(6-chloro-1H-indol-3-yl)-5-hydroxy-1-methyl-1,5-dihydro-2H-pyrrol-2-one | non-polymer | 511.8 | 4 | Chemie (4NJ) | |||
| 3 | I, J, K, L (A, B, C, D) | water | water | 18.0 | 313 | Chemie (HOH) |
Sequence modifications
A, B, C, D: 18 - 113 (UniProt: Q00987)
| PDB | External Database | Details |
|---|---|---|
| Met 17 | - | initiating methionine |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 45597.5 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 2047.3 | |
| All* | Total formula weight | 47644.8 |
