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7FIH
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luteinizing hormone/choriogonadotropin receptor(S277I)-chorionic gonadotropin-Gs-Org43553 complex
Descriptor: 5-azanyl-N-tert-butyl-2-methylsulfanyl-4-[3-(2-morpholin-4-ylethanoylamino)phenyl]thieno[2,3-d]pyrimidine-6-carboxamide, Choriogonadotropin subunit beta 3, Engineered Guanine nucleotide-binding protein G(s) subunit alpha, ...
Authors:Duan, J, Xu, P, Cheng, X, Mao, C, Croll, T, He, X, Shi, J, Luan, X, Yin, W, You, E, Liu, Q, Zhang, S, Jiang, H, Zhang, Y, Jiang, Y, Xu, H.E.
Deposit date:2021-07-31
Release date:2021-09-29
Last modified:2022-02-16
Method:ELECTRON MICROSCOPY (3.2 Å)
Cite:Structures of full-length glycoprotein hormone receptor signalling complexes.
Nature, 598, 2021
7RMG
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Substance P bound to active human neurokinin 1 receptor in complex with miniGs/q70
Descriptor: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(s) subunit alpha isoforms short, ...
Authors:Harris, J.A, Faust, B, Gondin, A.B, Daemgen, M.A, Suomivuori, C.M, Veldhuis, N.A, Cheng, Y, Dror, R.O, Thal, D, Manglik, A.
Deposit date:2021-07-27
Release date:2021-11-03
Last modified:2022-01-05
Method:ELECTRON MICROSCOPY (3 Å)
Cite:Selective G protein signaling driven by substance P-neurokinin receptor dynamics.
Nat.Chem.Biol., 18, 2022
7RMH
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Substance P bound to active human neurokinin 1 receptor in complex with miniGs399
Descriptor: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(s) subunit alpha isoforms short, ...
Authors:Harris, J.A, Faust, B, Gondin, A.B, Daemgen, M.A, Suomivuori, C.M, Veldhuis, N.A, Cheng, Y, Dror, R.O, Thal, D, Manglik, A.
Deposit date:2021-07-27
Release date:2021-11-03
Last modified:2022-01-05
Method:ELECTRON MICROSCOPY (3.1 Å)
Cite:Selective G protein signaling driven by substance P-neurokinin receptor dynamics.
Nat.Chem.Biol., 18, 2022
7RMI
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SP6-11 biased agonist bound to active human neurokinin 1 receptor in complex with miniGs/q70
Descriptor: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(s) subunit alpha isoforms short, ...
Authors:Harris, J.A, Faust, B, Gondin, A.B, Daemgen, M.A, Suomivuori, C.M, Veldhuis, N.A, Cheng, Y, Dror, R.O, Thal, D, Manglik, A.
Deposit date:2021-07-27
Release date:2021-11-03
Last modified:2022-01-05
Method:ELECTRON MICROSCOPY (3.2 Å)
Cite:Selective G protein signaling driven by substance P-neurokinin receptor dynamics.
Nat.Chem.Biol., 18, 2022
7RM5
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BU of 7rm5 by Molmil
MicroED structure of the human adenosine receptor at 2.8A
Descriptor: 4-{2-[(7-amino-2-furan-2-yl[1,2,4]triazolo[1,5-a][1,3,5]triazin-5-yl)amino]ethyl}phenol, Adenosine receptor A2a/Soluble cytochrome b562 chimera, CHOLESTEROL, ...
Authors:Martynowycz, M.W, Shiriaeva, A, Ge, X, Hattne, J, Nannenga, B.L, Cherezov, V, Gonen, T.
Deposit date:2021-07-26
Release date:2021-09-08
Last modified:2023-10-18
Method:ELECTRON CRYSTALLOGRAPHY (2.79 Å)
Cite:MicroED structure of the human adenosine receptor determined from a single nanocrystal in LCP.
Proc.Natl.Acad.Sci.USA, 118, 2021
7RKY
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Binding mode of US27-Gi-scFv16 in OCL-state
Descriptor: Antibody fragment scFv16, G-protein coupled receptor homolog US27, GUANOSINE-5'-DIPHOSPHATE, ...
Authors:Tsutsumi, N, Jude, K.M, Garcia, K.C.
Deposit date:2021-07-22
Release date:2022-01-26
Method:ELECTRON MICROSCOPY (3.8 Å)
Cite:Atypical structural snapshots of human cytomegalovirus GPCR interactions with host G proteins
Sci Adv, 8, 2022
7RKN
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Structure of CX3CL1-US28-Gi-scFv16 in OC-state
Descriptor: Antibody fragment scFv16, Fractalkine, G-protein coupled receptor homolog US28, ...
Authors:Tsutsumi, N, Qu, Q, Jude, K.M, Skiniotis, G, Garcia, K.C.
Deposit date:2021-07-22
Release date:2022-01-26
Method:ELECTRON MICROSCOPY (3.6 Å)
Cite:Atypical structural snapshots of human cytomegalovirus GPCR interactions with host G proteins
Sci Adv, 8, 2022
7RKM
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Structure of CX3CL1-US28-Gi-scFv16 in C-state
Descriptor: Antibody fragment scFv16, CHOLESTEROL, Fractalkine, ...
Authors:Tsutsumi, N, Qu, Q, Jude, K.M, Skiniotis, G, Garcia, K.C.
Deposit date:2021-07-22
Release date:2022-01-26
Method:ELECTRON MICROSCOPY (3.5 Å)
Cite:Atypical structural snapshots of human cytomegalovirus GPCR interactions with host G proteins
Sci Adv, 8, 2022
7RKX
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Structure of US27-Gi-scFv16 in CL-state
Descriptor: Antibody fragment scFv16, G-protein coupled receptor homolog US27, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ...
Authors:Tsutsumi, N, Jude, K.M, Garcia, K.C.
Deposit date:2021-07-22
Release date:2022-01-26
Method:ELECTRON MICROSCOPY (3.1 Å)
Cite:Atypical structural snapshots of human cytomegalovirus GPCR interactions with host G proteins
Sci Adv, 8, 2022
7RKF
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Structure of CX3CL1-US28-G11iN18-scFv16 in TL-state
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Antibody fragment scFv16, Fractalkine, ...
Authors:Tsutsumi, N, Maeda, S, Qu, Q, Skiniotis, G, Kobilka, B.K, Garcia, K.C.
Deposit date:2021-07-22
Release date:2022-01-26
Method:ELECTRON MICROSCOPY (4 Å)
Cite:Atypical structural snapshots of human cytomegalovirus GPCR interactions with host G proteins
Sci Adv, 8, 2022
7FEE
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Crystal structure of the allosteric modulator ZCZ011 binding to CP55940-bound cannabinoid receptor 1
Descriptor: (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, 2-[(1R,2R,5R)-5-hydroxy-2-(3-hydroxypropyl)cyclohexyl]-5-(2-methyloctan-2-yl)phenol, 6-methyl-3-[(1S)-2-nitro-1-thiophen-2-yl-ethyl]-2-phenyl-1H-indole, ...
Authors:Wang, X, Zhao, C, Shao, Z.
Deposit date:2021-07-19
Release date:2022-06-15
Last modified:2024-04-03
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Molecular mechanism of allosteric modulation for the cannabinoid receptor CB1.
Nat.Chem.Biol., 18, 2022
7F9Y
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ghrelin-bound ghrelin receptor in complex with Gq
Descriptor: CHOLESTEROL, Engineered G-alpha-q subunit, Ghrelin-28, ...
Authors:Wang, Y, Zhuang, Y, Xu, P, Xu, H.E, Jiang, Y.
Deposit date:2021-07-05
Release date:2021-08-18
Last modified:2022-03-16
Method:ELECTRON MICROSCOPY (2.9 Å)
Cite:Molecular recognition of an acyl-peptide hormone and activation of ghrelin receptor.
Nat Commun, 12, 2021
7F9Z
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GHRP-6-bound ghrelin receptor in complex with Gq
Descriptor: 3-PYRIDIN-4-YL-2,4-DIHYDRO-INDENO[1,2-.C.]PYRAZOLE, Engineered G-alpha-q, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ...
Authors:Wang, Y, Zhuang, Y, Xu, P, Xu, H.E, Jiang, Y.
Deposit date:2021-07-05
Release date:2021-08-18
Last modified:2022-03-16
Method:ELECTRON MICROSCOPY (3.2 Å)
Cite:Molecular recognition of an acyl-peptide hormone and activation of ghrelin receptor.
Nat Commun, 12, 2021
7RAN
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BU of 7ran by Molmil
5-HT2AR bound to a novel agonist in complex with a mini-Gq protein and an active-state stabilizing single-chain variable fragment (scFv16) obtained by cryo-electron microscopy (cryoEM)
Descriptor: (3R)-3-methyl-5-(1H-pyrrolo[2,3-b]pyridin-3-yl)-1,2,3,6-tetrahydropyridin-1-ium, 5-hydroxytryptamine receptor 2A, G protein subunit q (Gi2-mini-Gq chimera), ...
Authors:Barros-Alvarez, X, Kim, K, Panova, O, Roth, B.L, Skiniotis, G.
Deposit date:2021-07-02
Release date:2022-07-06
Last modified:2022-11-02
Method:ELECTRON MICROSCOPY (3.45 Å)
Cite:Bespoke library docking for 5-HT 2A receptor agonists with antidepressant activity.
Nature, 610, 2022
7F8Y
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Crystal structure of the cholecystokinin receptor CCKAR in complex with devazepide
Descriptor: N-[(3S)-1-methyl-2-oxidanylidene-5-phenyl-3H-1,4-benzodiazepin-3-yl]-1H-indole-2-carboxamide, fusion protein of Cholecystokinin receptor type A and Endolysin
Authors:Zhang, X, He, C, Wang, M, Zhou, Q, Yang, D, Zhu, Y, Wu, B, Zhao, Q.
Deposit date:2021-07-02
Release date:2021-10-13
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structures of the human cholecystokinin receptors bound to agonists and antagonists.
Nat.Chem.Biol., 17, 2021
7F8V
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Cryo-EM structure of the cholecystokinin receptor CCKBR in complex with gastrin-17 and Gi
Descriptor: Gastrin-17, Gastrin/cholecystokinin type B receptor, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ...
Authors:Zhang, X, He, C, Wang, M, Zhou, Q, Yang, D, Zhu, Y, Wu, B, Zhao, Q.
Deposit date:2021-07-02
Release date:2021-10-13
Last modified:2022-02-16
Method:ELECTRON MICROSCOPY (3.3 Å)
Cite:Structures of the human cholecystokinin receptors bound to agonists and antagonists.
Nat.Chem.Biol., 17, 2021
7F8U
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BU of 7f8u by Molmil
Crystal structure of the cholecystokinin receptor CCKAR in complex with lintitript
Descriptor: 2-[2-[[4-(2-chlorophenyl)-1,3-thiazol-2-yl]carbamoyl]indol-1-yl]ethanoic acid, Fusion protein of Cholecystokinin receptor type A and Endolysin
Authors:Zhang, X, He, C, Wang, M, Zhou, Q, Yang, D, Zhu, Y, Wu, B, Zhao, Q.
Deposit date:2021-07-02
Release date:2021-10-13
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Structures of the human cholecystokinin receptors bound to agonists and antagonists.
Nat.Chem.Biol., 17, 2021
7F8W
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BU of 7f8w by Molmil
Cryo-EM structure of the cholecystokinin receptor CCKBR in complex with gastrin-17 and Gq
Descriptor: Gastrin-17, Gastrin/cholecystokinin type B receptor, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ...
Authors:Zhang, X, He, C, Wang, M, Zhou, Q, Yang, D, Zhu, Y, Wu, B, Zhao, Q.
Deposit date:2021-07-02
Release date:2021-10-13
Last modified:2022-02-16
Method:ELECTRON MICROSCOPY (3.1 Å)
Cite:Structures of the human cholecystokinin receptors bound to agonists and antagonists.
Nat.Chem.Biol., 17, 2021
7F8X
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Crystal structure of the cholecystokinin receptor CCKAR in complex with NN9056
Descriptor: ASP-SMF-NLE-GLY-TRP-NLE-OEM-MEA-NH2 (NN9056), Cholecystokinin receptor type A,Endolysin
Authors:Zhang, X, He, C, Wang, M, Zhou, Q, Yang, D, Zhu, Y, Wu, B, Zhao, Q.
Deposit date:2021-07-02
Release date:2021-12-29
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (3 Å)
Cite:Structures of the human cholecystokinin receptors bound to agonists and antagonists.
Nat.Chem.Biol., 17, 2021
7F83
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Crystal Structure of a receptor in Complex with inverse agonist
Descriptor: (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, 2-(2-methylimidazo[2,1-b][1,3]thiazol-6-yl)-1-[2-[(1R)-5-(6-methylpyrimidin-4-yl)-2,3-dihydro-1H-inden-1-yl]-2,7-diazaspiro[3.5]nonan-7-yl]ethanone, Growth hormone secretagogue receptor type 1,Soluble cytochrome b562
Authors:Xu, Z, Shao, Z.
Deposit date:2021-07-01
Release date:2022-01-19
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (2.94 Å)
Cite:Molecular mechanism of agonism and inverse agonism in ghrelin receptor.
Nat Commun, 13, 2022
7P02
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Human Neurokinin 1 receptor (NK1R) substance P Gs complex
Descriptor: Antibody fragment scFv16, CHOLESTEROL, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ...
Authors:Thom, C, Ehrenmann, J, Vacca, S, Waltenspuhl, Y, Schoppe, J, Medalia, O, Pluckthun, A.
Deposit date:2021-06-29
Release date:2021-12-15
Method:ELECTRON MICROSCOPY (2.87 Å)
Cite:Structures of neurokinin 1 receptor in complex with G q and G s proteins reveal substance P binding mode and unique activation features.
Sci Adv, 7, 2021
7P00
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BU of 7p00 by Molmil
Human Neurokinin 1 receptor (NK1R) substance P Gq chimera (mGsqi) complex
Descriptor: Antibody fragment scFv16, CHOLESTEROL, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ...
Authors:Thom, C, Ehrenmann, J, Vacca, S, Waltenspuhl, Y, Schoppe, J, Medalia, O, Pluckthun, A.
Deposit date:2021-06-29
Release date:2021-12-15
Method:ELECTRON MICROSCOPY (2.71 Å)
Cite:Structures of neurokinin 1 receptor in complex with G q and G s proteins reveal substance P binding mode and unique activation features.
Sci Adv, 7, 2021
7F6H
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Cryo-EM structure of human bradykinin receptor BK2R in complex Gq proteins and bradykinin
Descriptor: Bradykinin, Bradykinin receptor BK2R, CHOLESTEROL, ...
Authors:Shen, J, Zhang, D, Fu, Y, Chen, A, Zhang, H.
Deposit date:2021-06-25
Release date:2022-01-05
Last modified:2023-01-18
Method:ELECTRON MICROSCOPY (2.9 Å)
Cite:Cryo-EM structures of human bradykinin receptor-G q proteins complexes.
Nat Commun, 13, 2022
7F6I
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Cryo-EM structure of human bradykinin receptor BK2R in complex Gq proteins and kallidin
Descriptor: Bradykinin receptor BK2R, CHOLESTEROL, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ...
Authors:Shen, J, Zhang, D, Fu, Y, Chen, A, Zhang, H.
Deposit date:2021-06-25
Release date:2022-01-05
Last modified:2023-01-18
Method:ELECTRON MICROSCOPY (2.8 Å)
Cite:Cryo-EM structures of human bradykinin receptor-G q proteins complexes.
Nat Commun, 13, 2022
7F61
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Crystal structure of human histamine receptor H3R in complex with antagonist PF03654746
Descriptor: CHOLESTEROL, Histamine H3 receptor, N-ethyl-3-fluoranyl-3-[3-fluoranyl-4-(pyrrolidin-1-ylmethyl)phenyl]cyclobutane-1-carboxamide, ...
Authors:Peng, X, Zhang, H.
Deposit date:2021-06-23
Release date:2022-10-26
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Structural basis for recognition of antihistamine drug by human histamine receptor.
Nat Commun, 13, 2022

221051

數據於2024-06-12公開中

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