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7E87
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BU of 7e87 by Molmil
CryoEM structure of the human Kv4.2-DPP6S complex, transmembrane and intracellular region
Descriptor: Dipeptidyl aminopeptidase-like protein 6, Potassium voltage-gated channel subfamily D member 2
Authors:Kise, Y, Nureki, O.
Deposit date:2021-03-01
Release date:2021-10-13
Last modified:2024-06-05
Method:ELECTRON MICROSCOPY (3.4 Å)
Cite:Structural basis of gating modulation of Kv4 channel complexes.
Nature, 599, 2021
7JPL
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BU of 7jpl by Molmil
Rabbit Cav1.1 in the presence of 10 micromolar (S)-(-)-Bay K8644 in nanodiscs at 3.4 Angstrom resolution
Descriptor: 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOETHANOLAMINE, CALCIUM ION, ...
Authors:Yan, N, Gao, S.
Deposit date:2020-08-09
Release date:2020-11-18
Last modified:2021-03-10
Method:ELECTRON MICROSCOPY (3.4 Å)
Cite:Structural Basis of the Modulation of the Voltage-Gated Calcium Ion Channel Ca v 1.1 by Dihydropyridine Compounds*.
Angew.Chem.Int.Ed.Engl., 60, 2021
8ED9
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BU of 8ed9 by Molmil
cryo-EM structure of TRPM3 ion channel in the presence with PIP2 and PregS, state 2
Descriptor: (3beta,14beta,17beta,25R)-3-[4-methoxy-3-(methoxymethyl)butoxy]spirost-5-en, 1,2-DIACYL-GLYCEROL-3-SN-PHOSPHATE, SODIUM ION, ...
Authors:Zhao, C, MacKinnon, R.
Deposit date:2022-09-03
Release date:2022-11-09
Last modified:2023-01-18
Method:ELECTRON MICROSCOPY (3.4 Å)
Cite:Structural and functional analyses of a GPCR-inhibited ion channel TRPM3.
Neuron, 111, 2023
6NT3
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BU of 6nt3 by Molmil
Cryo-EM structure of a human-cockroach hybrid Nav channel.
Descriptor: (7E,21R,24S)-27-amino-24-hydroxy-18,24-dioxo-19,23,25-trioxa-24lambda~5~-phosphaheptacos-7-en-21-yl (9Z,12E)-octadeca-9,12-dienoate, 1,2-DIPALMITOYL-PHOSPHATIDYL-GLYCEROLE, 2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Clairfeuille, T, Rohou, A, Payandeh, J.
Deposit date:2019-01-28
Release date:2019-02-20
Last modified:2021-08-25
Method:ELECTRON MICROSCOPY (3.4 Å)
Cite:Cryo-EM structures of a human-cockroach hybrid Nav channel in the presence and absence of the alpha-scorpion toxin AaH2.
Science, 2019
8SEQ
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BU of 8seq by Molmil
Cryo-EM Structure of RyR1 + AMP
Descriptor: ADENOSINE MONOPHOSPHATE, Glutathione S-transferase class-mu 26 kDa isozyme,Peptidyl-prolyl cis-trans isomerase FKBP1B, Ryanodine receptor 1, ...
Authors:Cholak, S, Saville, J.W, Zhu, X, Berezuk, A.M, Tuttle, K.S, Haji-Ghassemi, O, Van Petegem, F, Subramaniam, S.
Deposit date:2023-04-10
Release date:2023-05-24
Last modified:2023-07-19
Method:ELECTRON MICROSCOPY (3.4 Å)
Cite:Allosteric modulation of ryanodine receptor RyR1 by nucleotide derivatives.
Structure, 31, 2023
6GYN
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BU of 6gyn by Molmil
Structure of human HCN4 hyperpolarization-activated cyclic nucleotide-gated ion channel
Descriptor: 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 1,2-Distearoyl-sn-glycerophosphoethanolamine, Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4
Authors:Shintre, C.A, Pike, A.C.W, Tessitore, A, Young, M, Bushell, S.R, Strain-Damerell, C, Mukhopadhyay, S, Burgess-Brown, N.A, Huiskonen, J.T, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Carpenter, E.P, Structural Genomics Consortium (SGC)
Deposit date:2018-06-30
Release date:2019-05-08
Last modified:2024-05-15
Method:ELECTRON MICROSCOPY (3.4 Å)
Cite:Structure of human HCN4 hyperpolarization-activated cyclic nucleotide-gated ion channel
To Be Published
6NQ2
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BU of 6nq2 by Molmil
Cryo-EM structure of human TPC2 channel in the ligand-bound closed state
Descriptor: (2R)-3-{[(S)-hydroxy{[(1S,2R,3R,4S,5S,6R)-2,4,6-trihydroxy-3,5-bis(phosphonooxy)cyclohexyl]oxy}phosphoryl]oxy}propane-1,2-diyl dioctanoate, Two pore calcium channel protein 2
Authors:She, J, Zeng, W, Guo, J, Chen, Q, Bai, X, Jiang, Y.
Deposit date:2019-01-18
Release date:2019-03-27
Last modified:2019-11-20
Method:ELECTRON MICROSCOPY (3.4 Å)
Cite:Structural mechanisms of phospholipid activation of the human TPC2 channel.
Elife, 8, 2019
8H9X
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BU of 8h9x by Molmil
Crystal structure of voltage-gated sodium channel NavAb N49K/L176Q mutant in sodium ion condition
Descriptor: 1,2-DIMYRISTOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, CHAPSO, DODECYL-BETA-D-MALTOSIDE, ...
Authors:Irie, K, Oda, Y.
Deposit date:2022-10-25
Release date:2023-07-26
Last modified:2024-05-29
Method:X-RAY DIFFRACTION (3.4 Å)
Cite:The structural basis of divalent cation block in a tetrameric prokaryotic sodium channel.
Nat Commun, 14, 2023
8H9Y
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BU of 8h9y by Molmil
Crystal structure of voltage-gated sodium channel NavAb N49K/L176Q mutant in calcium ion condition
Descriptor: 1,2-DIMYRISTOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, CALCIUM ION, CHAPSO, ...
Authors:Irie, K, Oda, Y.
Deposit date:2022-10-25
Release date:2023-07-26
Last modified:2024-05-29
Method:X-RAY DIFFRACTION (3.4 Å)
Cite:The structural basis of divalent cation block in a tetrameric prokaryotic sodium channel.
Nat Commun, 14, 2023
6GYO
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BU of 6gyo by Molmil
Structure of human HCN4 hyperpolarization-activated cyclic nucleotide-gated ion channel in complex with cAMP
Descriptor: 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOINOSITOL, 1,2-Distearoyl-sn-glycerophosphoethanolamine, ...
Authors:Shintre, C.A, Pike, A.C.W, Tessitore, A, Young, M, Bushell, S.R, Strain-Damerell, C, Mukhopadhyay, S, Burgess-Brown, N.A, Huiskonen, J.T, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Carpenter, E.P, Structural Genomics Consortium (SGC)
Deposit date:2018-06-30
Release date:2019-05-01
Last modified:2024-05-15
Method:ELECTRON MICROSCOPY (3.4 Å)
Cite:Structure of human HCN4 hyperpolarization-activated cyclic nucleotide-gated ion channel
To Be Published
8EOI
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BU of 8eoi by Molmil
Structure of a human EMC:human Cav1.2 channel complex in GDN detergent
Descriptor: (3beta,14beta,17beta,25R)-3-[4-methoxy-3-(methoxymethyl)butoxy]spirost-5-en, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Chen, Z, Mondal, A, Abderemane-Ali, F, Minor, D.L.
Deposit date:2022-10-03
Release date:2023-05-24
Last modified:2023-07-26
Method:ELECTRON MICROSCOPY (3.4 Å)
Cite:EMC chaperone-Ca V structure reveals an ion channel assembly intermediate.
Nature, 619, 2023
7JPV
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BU of 7jpv by Molmil
Rabbit Cav1.1 in the presence of 1 micromolar (S)-(-)-Bay K8644 in nanodiscs at 3.4 Angstrom resolution
Descriptor: 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOETHANOLAMINE, CALCIUM ION, ...
Authors:Yan, N, Gao, S.
Deposit date:2020-08-10
Release date:2020-11-18
Last modified:2021-03-10
Method:ELECTRON MICROSCOPY (3.4 Å)
Cite:Structural Basis of the Modulation of the Voltage-Gated Calcium Ion Channel Ca v 1.1 by Dihydropyridine Compounds*.
Angew.Chem.Int.Ed.Engl., 60, 2021
7FBS
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BU of 7fbs by Molmil
structure of a channel
Descriptor: (3beta,14beta,17beta,25R)-3-[4-methoxy-3-(methoxymethyl)butoxy]spirost-5-en, 1-[2-[(2R)-2-oxidanyl-3-(propylamino)propoxy]phenyl]-3-phenyl-propan-1-one, 2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Jiang, D.J, Catterall, W.A.
Deposit date:2021-07-12
Release date:2021-09-22
Last modified:2022-02-16
Method:ELECTRON MICROSCOPY (3.4 Å)
Cite:Open-state structure and pore gating mechanism of the cardiac sodium channel.
Cell, 184, 2021
5WO8
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BU of 5wo8 by Molmil
Crystal Structure of Transient Receptor Potential (TRP) channel TRPV6*-Del1
Descriptor: 6-(5-METHYL-2-OXO-IMIDAZOLIDIN-4-YL)-HEXANOIC ACID, CALCIUM ION, Transient receptor potential cation channel subfamily V member 6
Authors:Singh, A.K, Saotome, K, Sobolevsky, A.I.
Deposit date:2017-08-01
Release date:2017-09-13
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (3.4 Å)
Cite:Swapping of transmembrane domains in the epithelial calcium channel TRPV6.
Sci Rep, 7, 2017
6C96
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BU of 6c96 by Molmil
Cryo-EM structure of mouse TPC1 channel in the apo state
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, SODIUM ION, ...
Authors:She, J, Guo, J, Chen, Q, Bai, X, Jiang, Y.
Deposit date:2018-01-25
Release date:2018-04-04
Last modified:2020-07-29
Method:ELECTRON MICROSCOPY (3.4 Å)
Cite:Structural insights into the voltage and phospholipid activation of the mammalian TPC1 channel.
Nature, 556, 2018
6U8A
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BU of 6u8a by Molmil
CBD-bound full-length rat TRPV2 in nanodiscs, state 1
Descriptor: Transient receptor potential cation channel subfamily V member 2, cannabidiol
Authors:Pumroy, R.A, Moiseenkova-Bell, V.Y.
Deposit date:2019-09-04
Release date:2019-10-16
Last modified:2024-03-20
Method:ELECTRON MICROSCOPY (3.4 Å)
Cite:Molecular mechanism of TRPV2 channel modulation by cannabidiol.
Elife, 8, 2019
7YIE
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BU of 7yie by Molmil
Human KCNH5-closed state 2
Descriptor: POTASSIUM ION, Potassium voltage-gated channel subfamily H member 5
Authors:Zhang, M.F.
Deposit date:2022-07-16
Release date:2023-04-05
Method:ELECTRON MICROSCOPY (3.4 Å)
Cite:Mechanism underlying delayed rectifying in human voltage-mediated activation Eag2 channel.
Nat Commun, 14, 2023
7YID
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BU of 7yid by Molmil
Human KCNH5 closed state 1
Descriptor: POTASSIUM ION, Potassium voltage-gated channel subfamily H member 5
Authors:Zhang, M.F.
Deposit date:2022-07-16
Release date:2023-04-05
Method:ELECTRON MICROSCOPY (3.4 Å)
Cite:Mechanism underlying delayed rectifying in human voltage-mediated activation Eag2 channel.
Nat Commun, 14, 2023
7WSW
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BU of 7wsw by Molmil
Cryo-EM structure of the Potassium channel AKT1 from Arabidopsis thaliana
Descriptor: PHOSPHATIDYLETHANOLAMINE, POTASSIUM ION, Potassium channel AKT1
Authors:Yang, G.H, Lu, Y.M, Zhang, Y.M, Jia, Y.T, Li, X.M, Lei, J.L.
Deposit date:2022-02-02
Release date:2022-11-09
Method:ELECTRON MICROSCOPY (3.4 Å)
Cite:Structural basis for the activity regulation of a potassium channel AKT1 from Arabidopsis.
Nat Commun, 13, 2022
7W6N
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BU of 7w6n by Molmil
CryoEM structure of human KChIP1-Kv4.3 complex
Descriptor: Isoform 2 of Potassium voltage-gated channel subfamily D member 3, Kv channel-interacting protein 1
Authors:Ma, D.M, Guo, J.T.
Deposit date:2021-12-02
Release date:2022-11-02
Method:ELECTRON MICROSCOPY (3.4 Å)
Cite:Structural basis for the gating modulation of Kv4.3 by auxiliary subunits.
Cell Res., 32, 2022
7XSU
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BU of 7xsu by Molmil
Cardiac sodium channel in complex with LqhIII
Descriptor: (3beta,14beta,17beta,25R)-3-[4-methoxy-3-(methoxymethyl)butoxy]spirost-5-en, 2-acetamido-2-deoxy-beta-D-glucopyranose, Alpha-like toxin Lqh3, ...
Authors:Jiang, D, Catterall, W.A.
Deposit date:2022-05-15
Release date:2023-11-29
Method:ELECTRON MICROSCOPY (3.4 Å)
Cite:Structural Basis for Nav1.5 Opening Modulated by a Gating Modifier Toxin
To Be Published
5YUB
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BU of 5yub by Molmil
Crystal structure of voltage-gated sodium channel NavAb E32Q mutant
Descriptor: CALCIUM ION, CHAPSO, DODECYL-BETA-D-MALTOSIDE, ...
Authors:Irie, K, Shimomura, T, Fujiyoshi, Y.
Deposit date:2017-11-21
Release date:2017-12-27
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (3.40004 Å)
Cite:Structural insight on the voltage dependence of prokaryotic voltage gated sodium channel NavAb.
FEBS Lett., 2017
5YUC
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BU of 5yuc by Molmil
Crystal structure of voltage-gated sodium channel NavAb N49K mutant
Descriptor: CALCIUM ION, CHAPSO, DODECYL-BETA-D-MALTOSIDE, ...
Authors:Irie, K, Shimomura, T, Fujiyoshi, Y.
Deposit date:2017-11-21
Release date:2017-12-27
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (3.40099168 Å)
Cite:Structural insight on the voltage dependence of prokaryotic voltage gated sodium channel NavAb.
FEBS Lett., 2017
4MTO
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BU of 4mto by Molmil
Structural Basis for Ca2+ Selectivity of a Voltage-gated Calcium Channel
Descriptor: 1,2-DIMYRISTOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, CALCIUM ION, Ion transport protein
Authors:Tang, L, Gamal El-Din, T.M, Payandeh, J, Martinez, G.Q, Heard, T.M, Scheuer, T, Zheng, N, Catterall, W.A.
Deposit date:2013-09-19
Release date:2013-11-27
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (3.402 Å)
Cite:Structural basis for Ca2+ selectivity of a voltage-gated calcium channel.
Nature, 505, 2014
7LQZ
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BU of 7lqz by Molmil
Structure of squirrel TRPV1 in complex with RTX
Descriptor: (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, Osm-9-like TRP channel 1, SODIUM ION, ...
Authors:Neuberger, A, Nadezhdin, K.D, Sobolevsky, A.I.
Deposit date:2021-02-15
Release date:2021-04-21
Last modified:2024-03-06
Method:ELECTRON MICROSCOPY (3.41 Å)
Cite:Extracellular cap domain is an essential component of the TRPV1 gating mechanism.
Nat Commun, 12, 2021

221051

數據於2024-06-12公開中

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