PDB: 8861 resultsInfo pagesStatus searchChemie searchBIRD

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7MYO	Cryo-EM structure of p110alpha in complex with p85alpha inhibited by BYL-719 Descriptor: (2S)-N~1~-{4-methyl-5-[2-(1,1,1-trifluoro-2-methylpropan-2-yl)pyridin-4-yl]-1,3-thiazol-2-yl}pyrrolidine-1,2-dicarboxamide, Phosphatidylinositol 3-kinase regulatory subunit alpha, Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform Authors: Liu, X, Yang, S, Hart, J.R, Xu, Y, Zou, X, Zhang, H, Zhou, Q, Xia, T, Zhang, Y, Yang, D, Wang, M.-W, Vogt, P.K. Deposit date: 2021-05-21 Release date: 2021-11-10 Last modified: 2024-05-29 Method: ELECTRON MICROSCOPY (2.92 Å) Cite: Cryo-EM structures of PI3K alpha reveal conformational changes during inhibition and activation. Proc.Natl.Acad.Sci.USA, 118, 2021
6WJQ	Crystal structure of WDR5 in complex with the WIN peptide of PDPK1 Descriptor: 3-phosphoinositide-dependent protein kinase 1, WD repeat-containing protein 5 Authors: Zhao, B, Fesik, S. Deposit date: 2020-04-14 Release date: 2021-01-13 Last modified: 2023-10-18 Method: X-RAY DIFFRACTION (2.71 Å) Cite: Crystal structure of WDR5 in complex with the WIN peptide of PDPK1 Cell Rep, 2021
8B8T	Open conformation of the complex of DNA ligase I on PCNA and DNA in the presence of ATP Descriptor: DNA ligase 1, Proliferating cell nuclear antigen Authors: Blair, K, Tehseen, M, Raducanu, V.S, Shahid, T, Lancey, C, Cruehet, R, Hamdan, S, De Biasio, A. Deposit date: 2022-10-05 Release date: 2023-01-11 Last modified: 2024-07-24 Method: ELECTRON MICROSCOPY (4.2 Å) Cite: Mechanism of human Lig1 regulation by PCNA in Okazaki fragment sealing. Nat Commun, 13, 2022
6ISE	Crystal structure of AMPPNP bound CK2 alpha from C. neoformans Descriptor: 1,2-ETHANEDIOL, Casein kinase II subunit alpha, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, ... Authors: Cho, H.S. Deposit date: 2018-11-16 Release date: 2019-11-20 Last modified: 2023-11-22 Method: X-RAY DIFFRACTION (2.8 Å) Cite: Crystal structure of AMPPNP bound CK2 alpha from C. neoformans To be published
5UOJ	THE STRUCTURE OF THE MAP KINASE P38 AT 2.1 ANGSTROMS RESOLUTION Descriptor: Mitogen-activated protein kinase 14 Authors: CHLEBOWICZ, J, WANG, Z, GOLDSMITH, E.J. Deposit date: 2017-01-31 Release date: 2017-02-22 Last modified: 2023-10-04 Method: X-RAY DIFFRACTION (2.1 Å) Cite: The structure of mitogen-activated protein kinase p38 at 2.1-A resolution. Proc. Natl. Acad. Sci. U.S.A., 94, 1997
8PP6	human RYBP-PRC1 bound to H2AK118ub1 nucleosome Descriptor: DNA (215-MER), Histone H2A, Histone H2B, ... Authors: Ciapponi, M, Benda, C, Mueller, J. Deposit date: 2023-07-06 Release date: 2024-04-03 Last modified: 2024-07-31 Method: ELECTRON MICROSCOPY (3.18 Å) Cite: Structural basis of the histone ubiquitination read-write mechanism of RYBP-PRC1. Nat.Struct.Mol.Biol., 31, 2024
2JNJ	Solution structure of the p8 TFIIH subunit Descriptor: TFIIH basal transcription factor complex TTD-A subunit Authors: Vitorino, M, Atkinson, R.A, Moras, D, Poterszman, A, Kieffer, B, Structural Proteomics in Europe 2 (SPINE-2) Deposit date: 2007-01-26 Release date: 2007-04-10 Last modified: 2023-12-20 Method: SOLUTION NMR Cite: Solution Structure and Self-association Properties of the p8 TFIIH Subunit Responsible for Trichothiodystrophy J.Mol.Biol., 368, 2007
7SC0	CryoEM structure of the Caveolin-1 8S complex Descriptor: Caveolin-1 Authors: Porta, J.P, Ohi, M.D, Kenworthy, A.K, Karakas, E. Deposit date: 2021-09-26 Release date: 2022-05-25 Last modified: 2024-06-05 Method: ELECTRON MICROSCOPY (3.4 Å) Cite: Molecular architecture of the human caveolin-1 complex. Sci Adv, 8, 2022
2Z7L	Unphosphorylated Mitogen Activated Protein Kinase ERK2 in Complex with (4-{[5-Carbamoyl-4-(3-Methylanilino)Pyrimidin 2-Yl]Amino}Phenyl)Acetic Acid Descriptor: BETA-MERCAPTOETHANOL, Mitogen-activated protein kinase 1, SULFATE ION, ... Authors: Katayama, N, Kurihara, H. Deposit date: 2007-08-27 Release date: 2008-08-12 Last modified: 2023-11-01 Method: X-RAY DIFFRACTION (2.41 Å) Cite: Identification of a key element for hydrogen-bonding patterns between protein kinases and their inhibitors Proteins, 73, 2008
8UI7	Cryo-EM map of human clmap-clamp loader ATAD5-RFC-gapped PCNA complex in intermediate state 3 Descriptor: ADENOSINE-5'-DIPHOSPHATE, ATPase family AAA domain-containing protein 5, MAGNESIUM ION, ... Authors: Wang, F, He, Q, Li, H. Deposit date: 2023-10-10 Release date: 2024-05-29 Last modified: 2024-06-26 Method: ELECTRON MICROSCOPY (4.2 Å) Cite: The human ATAD5 has evolved unique structural elements to function exclusively as a PCNA unloader. Nat.Struct.Mol.Biol., 2024
8UI9	Cryo-EM map of human clamp-clamp loader ATAD5-RFC-cracked PCNA complex in intermediate state 2 Descriptor: ADENOSINE-5'-DIPHOSPHATE, ATPase family AAA domain-containing protein 5, MAGNESIUM ION, ... Authors: Wang, F, He, Q, Li, H. Deposit date: 2023-10-10 Release date: 2024-05-29 Last modified: 2024-06-26 Method: ELECTRON MICROSCOPY (3.5 Å) Cite: The human ATAD5 has evolved unique structural elements to function exclusively as a PCNA unloader. Nat.Struct.Mol.Biol., 2024
8UII	Cryo-EM map of human clamp-clamp loader ATAD5-RFC-closed PCNA complex in intermediate state 1 Descriptor: ADENOSINE-5'-DIPHOSPHATE, ATPase family AAA domain-containing protein 5, MAGNESIUM ION, ... Authors: Wang, F, He, Q, Li, H. Deposit date: 2023-10-10 Release date: 2024-05-29 Last modified: 2024-06-26 Method: ELECTRON MICROSCOPY (3.04 Å) Cite: The human ATAD5 has evolved unique structural elements to function exclusively as a PCNA unloader. Nat.Struct.Mol.Biol., 2024
8UI8	Cryo-EM map of human clamp-clamp loader ATAD5-RFC-two PCNAs complex in intermediate state 3 Descriptor: ADENOSINE-5'-DIPHOSPHATE, ATPase family AAA domain-containing protein 5, MAGNESIUM ION, ... Authors: Wang, F, He, Q, Li, H. Deposit date: 2023-10-10 Release date: 2024-05-29 Last modified: 2024-06-26 Method: ELECTRON MICROSCOPY (3.1 Å) Cite: The human ATAD5 has evolved unique structural elements to function exclusively as a PCNA unloader. Nat.Struct.Mol.Biol., 2024
6M94	Monophosphorylated pSer33 b-Catenin peptide bound to b-TrCP/Skp1 Complex Descriptor: Catenin beta-1, DIMETHYL SULFOXIDE, F-box/WD repeat-containing protein 1A, ... Authors: Simonetta, K.R, Clifton, M.C, Walter, R.L, Ranieri, G.M, Carter, J.J. Deposit date: 2018-08-22 Release date: 2019-04-03 Last modified: 2019-04-10 Method: X-RAY DIFFRACTION (2.7 Å) Cite: Prospective discovery of small molecule enhancers of an E3 ligase-substrate interaction. Nat Commun, 10, 2019
6GYU	Cryo-EM structure of the CBF3-msk complex of the budding yeast kinetochore Descriptor: Centromere DNA-binding protein complex CBF3 subunit A, Centromere DNA-binding protein complex CBF3 subunit B, Centromere DNA-binding protein complex CBF3 subunit C, ... Authors: Yan, K, Zhang, Z, Yang, J, McLaughlin, S.H, Barford, D. Deposit date: 2018-07-02 Release date: 2018-12-05 Last modified: 2019-12-18 Method: ELECTRON MICROSCOPY (3 Å) Cite: Architecture of the CBF3-centromere complex of the budding yeast kinetochore. Nat. Struct. Mol. Biol., 25, 2018
5VHR	Conformational Landscape of the p28-Bound Human Proteasome Regulatory Particle Descriptor: 26S proteasome non-ATPase regulatory subunit 10, 26S proteasome non-ATPase regulatory subunit 2, 26S proteasome regulatory subunit 10B, ... Authors: Lu, Y, Wu, J, Dong, Y, Chen, S, Sun, S, Ma, Y.B, Ouyang, Q, Finley, D, Kirschner, M.W, Mao, Y. Deposit date: 2017-04-13 Release date: 2017-08-23 Last modified: 2024-03-13 Method: ELECTRON MICROSCOPY (7.7 Å) Cite: Conformational Landscape of the p28-Bound Human Proteasome Regulatory Particle. Mol. Cell, 67, 2017
5VHN	Conformational Landscape of the p28-Bound Human Proteasome Regulatory Particle Descriptor: 26S proteasome non-ATPase regulatory subunit 10, 26S proteasome non-ATPase regulatory subunit 2, 26S proteasome regulatory subunit 10B, ... Authors: Lu, Y, Wu, J, Dong, Y, Chen, S, Sun, S, Ma, Y.B, Ouyang, Q, Finley, D, Kirschner, M.W, Mao, Y. Deposit date: 2017-04-13 Release date: 2017-08-23 Last modified: 2024-03-13 Method: ELECTRON MICROSCOPY (7.3 Å) Cite: Conformational Landscape of the p28-Bound Human Proteasome Regulatory Particle. Mol. Cell, 67, 2017
5VHJ	Conformational Landscape of the p28-Bound Human Proteasome Regulatory Particle Descriptor: 26S proteasome non-ATPase regulatory subunit 10, 26S proteasome non-ATPase regulatory subunit 2, 26S proteasome regulatory subunit 10B, ... Authors: Lu, Y, Wu, J, Dong, Y, Chen, S, Sun, S, Ma, Y.B, Ouyang, Q, Finley, D, Kirschner, M.W, Mao, Y. Deposit date: 2017-04-13 Release date: 2017-08-23 Last modified: 2024-03-13 Method: ELECTRON MICROSCOPY (8.5 Å) Cite: Conformational Landscape of the p28-Bound Human Proteasome Regulatory Particle. Mol. Cell, 67, 2017
5VHQ	Conformational Landscape of the p28-Bound Human Proteasome Regulatory Particle Descriptor: 26S proteasome non-ATPase regulatory subunit 10, 26S proteasome non-ATPase regulatory subunit 2, 26S proteasome regulatory subunit 10B, ... Authors: Lu, Y, Wu, J, Dong, Y, Chen, S, Sun, S, Ma, Y.B, Ouyang, Q, Finley, D, Kirschner, M.W, Mao, Y. Deposit date: 2017-04-13 Release date: 2017-08-23 Last modified: 2024-03-13 Method: ELECTRON MICROSCOPY (8.9 Å) Cite: Conformational Landscape of the p28-Bound Human Proteasome Regulatory Particle. Mol. Cell, 67, 2017
4X1L	Structural basis for mutation-induced destabilization of Profilin 1 in ALS Descriptor: PHOSPHATE ION, Profilin-1 Authors: Silvas, T.V, Shandilya, S.M.D, Schiffer, C.A. Deposit date: 2014-11-24 Release date: 2015-06-10 Last modified: 2023-09-27 Method: X-RAY DIFFRACTION (2.16 Å) Cite: Structural basis for mutation-induced destabilization of profilin 1 in ALS. Proc.Natl.Acad.Sci.USA, 112, 2015
2RG6	Phenylalanine pyrrolotriazine p38 alpha map kinase inhibitor compound 11J Descriptor: 4-{[5-(methoxycarbamoyl)-2-methylphenyl]amino}-5-methyl-N-[(1S)-1-phenylethyl]pyrrolo[2,1-f][1,2,4]triazine-6-carboxamide, Mitogen-activated protein kinase 14 Authors: Sack, J.S. Deposit date: 2007-10-02 Release date: 2008-01-15 Last modified: 2024-02-21 Method: X-RAY DIFFRACTION (1.72 Å) Cite: Design, Synthesis, and Anti-inflammatory Properties of Orally Active 4-(Phenylamino)-pyrrolo[2,1-f][1,2,4]triazine p38alpha Mitogen-Activated Protein Kinase Inhibitors J.Med.Chem., 51, 2008
5VHO	Conformational Landscape of the p28-Bound Human Proteasome Regulatory Particle Descriptor: 26S proteasome non-ATPase regulatory subunit 10, 26S proteasome non-ATPase regulatory subunit 2, 26S proteasome regulatory subunit 10B, ... Authors: Lu, Y, Wu, J, Dong, Y, Chen, S, Sun, S, Ma, Y.B, Ouyang, Q, Finley, D, Kirschner, M.W, Mao, Y. Deposit date: 2017-04-13 Release date: 2017-08-23 Last modified: 2024-03-13 Method: ELECTRON MICROSCOPY (8.3 Å) Cite: Conformational Landscape of the p28-Bound Human Proteasome Regulatory Particle. Mol. Cell, 67, 2017
1LM8	Structure of a HIF-1a-pVHL-ElonginB-ElonginC Complex Descriptor: ELONGIN B, ELONGIN C, Hypoxia-inducible factor 1 alpha, ... Authors: Min, J.-H, Yang, H, Ivan, M, Gertler, F, Kaelin JR, W.G, Pavletich, N.P. Deposit date: 2002-04-30 Release date: 2002-06-12 Last modified: 2023-08-16 Method: X-RAY DIFFRACTION (1.85 Å) Cite: Structure of an HIF-1alpha -pVHL complex: hydroxyproline recognition in signaling. Science, 296, 2002
5VHM	Conformational Landscape of the p28-Bound Human Proteasome Regulatory Particle Descriptor: 26S proteasome non-ATPase regulatory subunit 10, 26S proteasome non-ATPase regulatory subunit 2, 26S proteasome regulatory subunit 10B, ... Authors: Lu, Y, Wu, J, Dong, Y, Chen, S, Sun, S, Ma, Y.B, Ouyang, Q, Finley, D, Kirschner, M.W, Mao, Y. Deposit date: 2017-04-13 Release date: 2017-08-23 Last modified: 2024-03-13 Method: ELECTRON MICROSCOPY (8.3 Å) Cite: Conformational Landscape of the p28-Bound Human Proteasome Regulatory Particle. Mol. Cell, 67, 2017
5VHP	Conformational Landscape of the p28-Bound Human Proteasome Regulatory Particle Descriptor: 26S proteasome non-ATPase regulatory subunit 10, 26S proteasome non-ATPase regulatory subunit 2, 26S proteasome regulatory subunit 10B, ... Authors: Lu, Y, Wu, J, Dong, Y, Chen, S, Sun, S, Ma, Y.B, Ouyang, Q, Finley, D, Kirschner, M.W, Mao, Y. Deposit date: 2017-04-13 Release date: 2017-08-23 Last modified: 2024-03-13 Method: ELECTRON MICROSCOPY (7.9 Å) Cite: Conformational Landscape of the p28-Bound Human Proteasome Regulatory Particle. Mol. Cell, 67, 2017

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